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رمز الذئب
تمثل رواية رمز الذئب مرافعة بليغة دفاعا عن الحرية كقيمة إنسانية عليا وتستند أحداثها إلى تجارب من حياة مؤلفها في مناطق المراعي التي تقع في أعماق منغوليا خلال الفترة بين عامي 1966 و1976، وهي فترة الثورة الثقافية، ومحاولة سبر أغوار تأثيراتها التي هدفت إلى تغيير نمط حياة البداوة وإنها تستثمر فضائل وأخلاق البداوة في منغوليا وتتناول الرواية في جملة موضوعاتها المتنوعة مسألة تدمير البيئة والحرية في ممارسة الطقوس الروحية والتهديد الذي تشكله الحداثة على حياة البساطة في الريف والبداوة.
Book
Structure and electrical properties of BCZT ceramics derived from microwave-assisted sol–gel-hydrothermal synthesized powders
A novel microwave-assisted sol–gel-hydrothermal method was employed to rapidly synthesize Ba
0.85
Ca
0.15
Zr
0.1
Ti
0.9
O
3
(BCZT) powders. The effects of reaction time on the structure, crystallinity, purity and morphology of the products were investigated. The results of XRD, FTIR, SEM and TEM indicated that BCZT powders could be obtained in even 60 min at a low synthesis temperature of 180 °C, which were well-crystallized with stoichiometric composition and uniform grain size (~ 85 nm). BCZT ceramic derived from the rapidly-synthesized powders had a dense microstructure and good electrical properties (ε
m
= 9579, d
33
= 496 pC/N, 2P
r
= 25.22 µC/cm
2
, 2E
c
= 7.52 kV/cm). The significant electrical properties were closely related to the high activity of the BCZT powders, resulting from the rapid microwave-assisted sol–gel-hydrothermal process.
Journal Article
Mg-gallate metal-organic framework-based sprayable hydrogel for continuously regulating oxidative stress microenvironment and promoting neurovascular network reconstruction in diabetic wounds
Chronic diabetic wounds are the most common complication for diabetic patients. Due to high oxidative stress levels affecting the entire healing process, treating diabetic wounds remains a challenge. Here, we present a strategy for continuously regulating oxidative stress microenvironment by the catalyst-like magnesium-gallate metal-organic framework (Mg-GA MOF) and developing sprayable hydrogel dressing with sodium alginate/chitosan quaternary ammonium salts to treat diabetic wounds. Chitosan quaternary ammonium salts with antibacterial properties can prevent bacterial infection. The continuous release of gallic acid (GA) effectively eliminates reactive oxygen species (ROS), reduces oxidative stress, and accelerates the polarization of M1-type macrophages to M2-type, shortening the transition between inflammation and proliferative phase and maintaining redox balance. Besides, magnesium ions adjuvant therapy promotes vascular regeneration and neuronal formation by activating the expression of vascular-associated genes. Sprayable hydrogel dressings with antibacterial, antioxidant, and inflammatory regulation rapidly repair diabetic wounds by promoting neurovascular network reconstruction and accelerating re-epithelialization and collagen deposition. This study confirms the feasibility of catalyst-like MOF-contained sprayable hydrogel to regulate the microenvironment continuously and provides guidance for developing the next generation of non-drug diabetes dressings.
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•An effective method for rapidly preparing magnesium-gallate MOF and regulating morphology and stability was developed.•A portable sprayable hydrogel dressing with antibacterial, anti-inflammatory, and antioxidant functions was constructed.•Oxidative stress level reduction and neurovascular network reconstruction are achieved in healing diabetic wounds.
Journal Article
Synthesis and mechanisms of action of novel harmine derivatives as potential antitumor agents
A series of novel harmine derivatives bearing a benzylindine substituent in position-1 of β-carboline ring were synthesized and evaluated as antitumor agents. The N2-benzylated β-carboline derivatives 3a–g represented the most interesting anticancer activities and compound 3c was found to be the most active agent to diverse cancer cell lines such as gastric carcinoma, melanoma and colorectal cancer. Notably, compound 3c showed low toxicity to normal cells. The treatment significantly induced cell apoptosis. Mechanistically, PI3K/AKT signaling pathway mediated compound 3c-induced apoptosis. Compound 3c inhibited phosphorylation of AKT and promoted the production of reactive oxygen species (ROS). The ROS scavenger, LNAC and GSH, could disturb the effect of compound 3c induced apoptosis and PI3K activity inhibitor LY294002 synergistically enhanced compound 3c efficacy. Moreover, the results from nude mice xenograft model showed that compound 3c treatment effectively inhibited tumor growth and decreased tumor weight. Collectively, our results demonstrated that compound 3c exerts apoptotic effect in cancer cells via suppression of phosphorylated AKT and evocation of ROS generation, which suggested that compound 3c might be served as a promising therapeutic agent for cancer treatment.
Journal Article
Control of dynamic orbital response in ferromagnets via crystal symmetry
Transport of angular momentum is a key concept in condensed-matter physics. In solids, electrons can carry both spin and orbital angular momentum, leading to various applications in spintronics and orbitronics. A key difference between spin and orbital transport lies in their characteristic length scales in ferromagnets in which the dynamic orbital response is significantly long ranged compared with its spin counterpart. However, a comprehensive understanding of the physics behind the long-range nature of the orbital response is lacking. Here we demonstrate that the long-range dynamic orbital response in ferromagnets can be controlled by crystal symmetry. Our results manifest a clear difference in the characteristic length scale of orbital torque generation in atomically ordered and disordered CoPt alloys. This observation indicates that the long-range dynamic orbital response relies on the orbital-dependent energy splittings and hybridizations governed by crystal symmetry, which can be manipulated by atomic arrangements. Our results suggest the possibility of simultaneously controlling dynamic and static magnetic phenomena by manipulating orbital hybridization, which could be tailored for spintronic and orbitronic devices.
Manipulation of the electron’s orbital contribution to transport experiments is important for potential orbitronics device applications. Now the long-range dynamic orbital response is shown to be controlled by the arrangement of atoms in ferromagnets.
Journal Article
Genome-Based Mining of Carpatamides I–M and Their Candidate Biosynthetic Gene Cluster
Chemically investigating the marine-derived Streptomyces parvus 1268 led to the isolation of a new compound of carpatamide I (1). Subsequent genomic analysis identified its candidate biosynthetic gene cluster ctd of approximately 44 kb. In order to obtain more carpatamide derivatives, we conducted the upregulation of Ctd14, which is a positive regulator, and obtained improvement of carpatamide I and four new compounds of carpatamides J–M (2–5). The structures of the aforementioned five new isolates were identified by a combination of ESI-HRMS as well as one-dimensional (1D) and two-dimensional (2D) spectral NMR datasets. Bioassay results showed that compounds 1–5 displayed anti-inflammatory activity and weak cytotoxicity against cell lines of A549, HT-29, and HepG2.
Journal Article
Structural and electrical properties of BCZT ceramics synthesized by sol–gel-hydrothermal process at low temperature
A novel method, sol–gel-hydrothermal process, was employed to prepare Ba0.85Ca0.15Zr0.1Ti0.9O3 (BCZT) powders at a rather lower temperature of 180 °C. The effects of synthesis time on the structure, morphology and size distribution of the powders were studied by the means of XRD, SEM and FTIR. BCZT powders could be obtained at a suitable synthesis time of 12 h, which were well-crystallized and compositional uniform with an average particle size of 93 nm. BCZT ceramics sintered from the synthesized powders had a dense microstructure with a density of 5.59 g/cm3 (> 95%) and excellent properties (2Pr = 25.12 μC/cm2, 2Ec = 4.31 kV/cm, d33 = 492pC/N, εr = 9173), indicating the high activity of the BCZT powders by sol–gel-hydrothermal process.
Journal Article
Exosomal HSP90 induced by remote ischemic preconditioning alleviates myocardial ischemia/reperfusion injury by inhibiting complement activation and inflammation
Background/Aims
The activation of the complement system and subsequent inflammatory responses are important features of myocardial ischemia/reperfusion (I/R) injury. Exosomes are nanoscale extracellular vesicles that play a significant role in remote ischemic preconditioning (RIPC) cardioprotection. The present study aimed to test whether RIPC-induced plasma exosomes (RIPC-Exo) exert protective effects on myocardial I/R injury by inhibiting complement activation and inflammation and whether exosomal heat shock protein 90 (HSP90) mediates these effects.
Methods
Rat hearts underwent 30 min of coronary ligation followed by 2 h of reperfusion. Plasma exosomes were isolated from RIPC rats and injected into the infarcted myocardium immediately after ligation. Sixty rats were randomly divided into Sham, I/R, I/R + RIPC-Exo (50 µg/µl), and RIPC-Exo + GA (geldanamycin, 1 mg/kg, administration 30 min before ligation) groups. Cardiomyocyte apoptosis, the release of myocardial markers (LDH, cTnI and CK-MB), infarct size, the expression of HSP90, complement component (C)3, C5a, c-Jun N-terminal kinase (JNK), interleukin (IL)-1β, tumor necrosis factor (TNF)-alpha and intercellular adhesion molecule -1 (ICAM-1) were assessed.
Results
RIPC-Exo treatment significantly reduced I/R-induced cardiomyocyte apoptosis, the release of myocardial markers (LDH, cTnI and CK-MB) and infarct size. These beneficial effects were accompanied by decreased C3 and C5a expression, decreased inflammatory factor levels (IL-1β, TNF-α, and ICAM-1), decreased JNK and Bax, and increased Bcl-2 expression. Meanwhile, the expression of HSP90 in the exosomes from rat plasma increased significantly after RIPC. However, treatment with HSP90 inhibitor GA significantly reversed the cardioprotection of RIPC-Exo, as well as activated complement component, JNK signalling and inflammation, indicating that HSP90 in exosomes isolated from the RIPC was important in mediating the cardioprotective effects during I/R.
Conclusion
Exosomal HSP90 induced by RIPC played a significant role in cardioprotection against I/R injury, and its function was in part linked to the inhibition of the complement system, JNK signalling and local and systemic inflammation, ultimately alleviating I/R-induced myocardial injury and apoptosis by the upregulation of Bcl-2 expression and the downregulation of proapoptotic Bax.
Journal Article
One-Step LCVD Fabrication of Binder-Free Porous Graphene@SiC Heterostructures for Lithium-Ion Battery Anodes
The potential of silicon carbide (SiC) as a promising high-capacity and stable anode material is hindered by poor electronic conductivity and slow lithium diffusion kinetics. Here, we report a one-step laser chemical vapor deposition (LCVD) process to directly synthesize porous graphene@SiC heterostructures on carbon fiber substrates. This in situ method yields an integral, binder-free electrode architecture that enhances mechanical robustness against pulverization. A critical feature of this heterostructure is the built-in electric field at the graphene–SiC interface, which is revealed by theoretical calculations to significantly accelerate charge transport and lithium-ion diffusion. The resulting anode delivers a high reversible capacity of 668 mAh·g−1 after 100 cycles at 0.1 A·g−1. More remarkably, a unique multi-stage activation mechanism is discovered, leading to an unprecedented capacity rebound to 735 mAh·g−1 after cycling at rates up to 5 A·g−1. This activation process is observed to accelerate with increasing current density in the 0.1–2 A·g−1 range. Furthermore, post-cycling analysis via XRD, TEM, and XPS confirms both the structural durability of the electrode and a reversible lithium intercalation mechanism, providing a critical foundation for the future design of high-performance LIB anodes.
Journal Article
Skipping the Biopsy: Real-World Experience of Whole-Exome Sequencing as First-Tier Testing in Pediatric Muscular Disorders
Muscle biopsy has long been regarded as the cornerstone for diagnosing pediatric muscular disorders; however, it is invasive and may be limited by sampling error and inconclusive histopathological findings. This study aimed to evaluate whether whole-exome sequencing (WES) can effectively replace muscle biopsy as a first-line diagnostic approach in children with suspected neuromuscular disorders. Between January 2018 and December 2025, we prospectively enrolled 47 pediatric patients presenting with clinical features suggestive of muscular disorders at a tertiary medical center in Taiwan. The cohort included patients with suspected muscular dystrophies (n = 21), congenital myopathies (n = 23), and multiplex ligation-dependent probe amplification (MLPA)-negative Duchenne muscular dystrophy (DMD; n = 3). All patients underwent WES as the initial diagnostic test without prior muscle biopsy. Trio-based analysis using parental samples was performed in 29.8% of cases. Variant interpretation followed the American College of Medical Genetics and Genomics (ACMG) guidelines. WES identified a definitive molecular diagnosis in 72.3% of patients (34/47). Diagnostic yields varied by subgroup: 100% (3/3) in MLPA-negative DMD, 71.4% (15/21) in muscular dystrophies, and 69.6% (16/23) in congenital myopathies. Pathogenic or likely pathogenic variants were detected in 31 distinct genes, including COL6A1 and COL6A3, which are associated with Ullrich congenital muscular dystrophy. Notably, 58.8% of diagnosed patients (20/34) received molecular diagnoses that differed from their initial clinical impression, encompassing conditions such as ZSWIM6-associated neurodevelopmental disorders, GJB2-related hearing loss, OCRL-associated Lowe syndrome, and various metabolic or syndromic disorders. In all three MLPA-negative DMD cases, WES identified point mutations amenable to mutation-specific therapies. No patient required a muscle biopsy for diagnostic confirmation during the study period. First-tier WES demonstrates high diagnostic utility in pediatric muscular disorders while avoiding invasive muscle biopsy. The high rate of diagnostic reclassification underscores the substantial phenotypic overlap between primary neuromuscular diseases and other neurological or systemic conditions. These findings support the early implementation of genetic testing to enable accurate diagnosis and timely initiation of targeted therapies.
Journal Article