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The MEG II experiment, based at the Paul Scherrer Institut in Switzerland, reports the result of a search for the decay μ + → e + γ from data taken in the first physics run in 2021. No excess of events over the expected background is observed, yielding an upper limit on the branching ratio of B ( μ + → e + γ ) < 7.5 × 10 - 13 (90% CL). The combination of this result and the limit obtained by MEG gives B ( μ + → e + γ ) < 3.1 × 10 - 13 (90% CL), which is the most stringent limit to date. A ten-fold larger sample of data is being collected during the years 2022–2023, and data-taking will continue in the coming years.

This study aims to clarify the development and utilization of highly accurate and open 3D city models (3DCMs), which began in Japan in 2020. The background of the project is explained based on a review of past efforts in Japan for making geospatial information accessible, the flow of data standardization around CityGML, and the introduction of Free and Open Source Software for Geo-spatial (FOSS4G) tools for data management and visualization. Two aspects of the analysis are reported: quantitative geospatial analysis of LOD1 building data and qualitative evaluation of 40 use cases using these data. The results indicate that approximately 18 million building data points covering 150 cities in Japan have been converted to open data in formats such as CityGML with high accuracy, complementing OpenStreetMap (OSM) data in urban areas. In addition, a total of 40 use cases for these data are demonstrated in new fields, such as urban planning, citizen participation, and even entertainment, with a few of these tools becoming open-source software. Through this project, data related to 3DCMs, which have not necessarily been produced in a unified format or specification in Japan, can now be easily handled as CityGML through a one-stop viewer, and the data are expected to be enhanced, and new geo-services using 3DCMs will be provided under the concept of openness, regardless of the city scale.

The cylindrical drift chamber is the most innovative part of the MEG II detector, the upgraded version of the MEG experiment. The MEG II chamber differs from the MEG one because it is a single volume cylindrical structure, instead of a segmented one, chosen to improve its resolutions and efficiency in detecting low energy positrons from muon decays at rest. In this paper, we show the characteristics and performances of this fundamental part of the MEG II apparatus and we discuss the impact of its higher resolution and efficiency on the sensitivity of the MEG II experiment. Because of its innovative structure and high quality resolution and efficiency the MEG II cylindrical drift chamber will be a cornerstone in the development of an ideal tracking detector for future positron-electron collider machines.

Unilateral hypoxia–ischemia (HI) was induced in C57/BL6 male mice on postnatal day (P) 5, 9, 21 and 60, corresponding developmentally to premature, term, juvenile and adult human brains, respectively. HI duration was adjusted to obtain a similar extent of brain injury at all ages. Apoptotic mechanisms (nuclear translocation of apoptosis-inducing factor, cytochrome c release and caspase-3 activation) were several-fold more pronounced in immature than in juvenile and adult brains. Necrosis-related calpain activation was similar at all ages. The CA1 subfield shifted from apoptosis-related neuronal death at P5 and P9 to necrosis-related calpain activation at P21 and P60. Oxidative stress (nitrotyrosine formation) was also similar at all ages. Autophagy, as judged by the autophagosome-related marker LC-3 II, was more pronounced in adult brains. To our knowledge, this is the first report demonstrating developmental regulation of AIF-mediated cell death as well as involvement of autophagy in a model of brain injury.

Investigations pursued during the last decade on neurodegenerative diseases have revealed a common mechanism underlying the development of such diseases: conformational disorder of certain proteins leads to the formation of misfolded protein oligomers, which subsequently develop into large protein aggregates. These aggregates entangle other denatured proteins and lipids to form disease-specific inclusion bodies. The failure of the ubiquitin-proteasome system to shred the protein aggregates has led investigators to focus their attention to autophagy, a bulk degradative system coupled with lysosomes, which is involved in non-selective shredding of large amounts of cytoplasmic components. Research in this field has demonstrated the accumulation of autophagic vacuoles and intracytoplasmic protein aggregates in patients with various neurodegenerative diseases. Although autophagy fails to degrade large protein aggregates once they are formed in the cytoplasm, drug-induced activation of autophagy is effective in preventing aggregate deposition, indicating that autophagy significantly contributes to the clearance of aggregate-prone proteins. The pivotal role of autophagy in the clearance of aggregate-prone proteins has been confirmed by a deductive approach using a brain-specific autophagy-ablated mouse model. In this review, we discuss the consequences of autophagy deficiency in neurons.

Radiotherapy is a well-established treatment for cancer. However, the existence of radioresistant cells is one of the major obstacles in radiotherapy. In order to understand the mechanism of cellular radioresistance and develop more effective radiotherapy, we have established clinically relevant radioresistant (CRR) cell lines, which continue to proliferate under daily exposure to 2 Gray (Gy) of X-rays for >30 days. X-ray irradiation significantly induced autophagic cells in parental cells, which was exiguous in CRR cells, suggesting that autophagic cell death is involved in cellular radiosensitivity. An autophagy inducer, rapamycin sensitized CRR cells to the level of parental cells and suppressed cell growth. An autophagy inhibitor, 3-methyladenine induced radioresistance of parental cells. Furthermore, inhibition of autophagy by knockdown of Beclin-1 made parental cells radioresistant to acute radiation. These suggest that the suppression of autophagic cell death but not apoptosis is mainly involved in cellular radioresistance. Therefore, the enhancement of autophagy may have a considerable impact on the treatment of radioresistant tumor.

The Regional Oceanic Modeling System (ROMS) is applied in a nested configuration with realistic forcing to the Southern California Bight (SCB) to analyze the variability in semidiurnal internal wave generation and propagation. The SCB has a complex topography with supercritical slopes that generate linear internal waves at the forcing frequency. The model predicts the observed barotropic and baroclinic tides reasonably well, although the observed baroclinic tides feature slightly larger amplitudes. The strongest semidiurnal barotropic to baroclinic energy conversion occurs on a steep sill slope of the 1900-m-deep Santa Cruz Basin. This causes a forced, near-resonant, semidiurnal Poincaré wave that rotates clockwise in the basin and is of the first mode along the radial, azimuthal, and vertical directions. The associated tidal-mean, depth-integrated energy fluxes and isotherm oscillation amplitudes in the basin reach maximum values of about 5 kW m−1 and 100 m and are strongly modulated by the spring–neap cycle. Most energy is locally dissipated, and only 10% escapes the basin. The baroclinic energy in the remaining basins is orders of magnitudes smaller. High-resolution coastal models are important in locating overlooked mixing hotspots such as the Santa Cruz Basin. These mixing hotspots may be important for ocean mixing and the overturning circulation.

This letter reports the result of the search for the decay μ + → e + γ undertaken at the Paul Scherrer Institut in Switzerland with the MEG II experiment using the data collected in the 2021–2022 physics runs. The sensitivity of the branching ratio measurement in this search is 2.2 × 10 - 13 , a factor of 2.4 better than that of the full MEG dataset and obtained in a data taking period of about one fourth that of MEG, thanks to the superior performances of the new detector. The observed data are consistent with the expected background, yielding an upper limit on the branching ratio of B ( μ + → e + γ ) < 1.5 × 10 - 13 (90% C.L.). Additional improvements are expected with the data collected during the years 2023–2024. The data-taking will continue in the coming years.

The observation of a resonance structure in the opening angle of the electron-positron pairs in the 7 Li(p,e + e - ) 8 Be reaction was claimed and interpreted as the production and subsequent decay of a hypothetical particle (X17). Similar excesses, consistent with this particle, were later observed in processes involving 4 He and 12 C nuclei with the same experimental technique. The MEG II apparatus at PSI, designed to search for the μ + → e + γ decay, can be exploited to investigate the existence of this particle and study its nature. Protons from a Cockroft–Walton accelerator, with an energy up to 1.1 MeV, were delivered on a dedicated Li-based target. The γ and the e + e - pair emerging from the 8 Be ∗ transitions were studied with calorimeters and a spectrometer, featuring a broader angular acceptance than previous experiments. We present in this paper the analysis of a four-week data-taking in 2023 with a beam energy of 1080 keV, resulting in the excitation of two different resonances with Q-value 17.6 and 18.1 MeV. No significant signal was found, and limits at 90% C.L. on the branching ratios (relative to the γ emission) of the two resonances to X17 were set, R 17.6 < 1.8 × 10 - 6 and R 18.1 < 1.2 × 10 - 5 in the mass range between 16.5 MeV / c 2 and 17.1 MeV / c 2 .

We use the vortex force formalism to analyze the effect of rip currents on their own wave forcing. The vortex force formalism allows us to decompose the wave forcing into the nonconservative flux of momentum due to wave breaking and the conservative vortex force. Following Yu and Slinn (2003), we consider rip currents initially generated by alongshore variation of wave breaking due to a perturbation of a barred bottom topography. This variation is reduced in magnitude by two current effects on waves: wave ray bending and the flux of wave energy by currents. We compute the change in wave energy caused by these two effects on their own and use this to show that their relative magnitude scales with the square of the ratio of the length to width of the rip current. Both effects increase the wave height over the channels of the longshore bar, which leads to more wave breaking and counterbalances its longshore variation due to bottom refraction. In comparison to wave breaking, the change in the vortex force is negligible. Next, we show how the reduction in wave breaking is similar to an enhanced bottom friction. We then analyze the dependence of this relationship on the breaking parameterization, angle of incidence of the waves, and bottom drag law. Key Points The scaling of wave ray bending to the current flux of wave energy The relation of a feedback loop on currents to bottom friction Narrow‐banded wave breaking may be treated using only two parameters