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This article considers the possibilities of écriture féminine in Peter Manson’s translations of Mallarmé, particularly focussing on the use of colour in Hérodiade, ‘Don du Poème’, and ‘Les Fenêtres’. In this work, I firstly trace an association between colour and the erotic in feminist theory and art, which can be seen in works such as Audré Lorde’s ‘Uses of the Erotic: The Erotic as Power’ (1978), Pipilotti Rist’s ‘Ever is Over All’ (1997), and in Meiling Cheng’s ‘The Unbearable Lightness of Sight’ (2003), in which she writes: 'the image seized for view, however deliberately designed, exists in a state of indifference, whereas the viewer is most likely already overdetermined by his/her interpretive desire. Perhaps the best we can do is to bypass the conundrum by pursuing the liberating potential of that discrepancy, recognizing the being of an image as light/intangible and the core of desire as heavy/matter-producing'. In translation, the translator negotiates with their source text, and with the sensual dimensions of the source language, in a manner that is comparable to this interpretation of colour vision. Julia Kristeva argues that Mallarmé’s work exemplifies écriture féminine because it draws the reader into a state anterior to language, which she compares to the pre-linguistic communion between mother and infant. In Mallarmé’s work, colour reveals the materiality of light, transforming it into a bodily force that Mallarmé initially codes (perhaps too simplistically) as feminine. I begin by reading reds and purples in Hérodiade as allusions to blood, then the golds of coloured glass in ‘Les Fênetres’ and ‘Don du Poème’ as a way of making conflicts between bodily abjection and transcendence visible (the pane of glass becoming a coloured body between the lyric ‘I’ and the sky). I finally consider Mallarmé’s use of the word ‘Azur’ as a metaphor for virginity (azure being associated, through lapis lazuli, with the blue of the Virgin Mary). Manson’s translations are particularly attuned to Mallarmé’s combinations of the ‘heavy/matter-producing’ and the ‘light/intangible’, and I argue that Manson’s word choices emphasise an erotic force in Mallarmé’s use of azure, treating this colour as a reservoir that, in Manson’s translation, threatens to ‘drown’ the ‘self-coloured cinders’ of Mallarmé’s speaker, colouring symbolic boundaries between languages and genders, and between self and other.

Backgrounds Colorectal liver metastases were historically considered a contraindication to liver transplantation, but dismal outcomes for those with metastatic colorectal cancer and advancements in liver transplantation (LT) have led to a renewed interest in the topic. We aim to compare the current evidence for liver transplantation for non-resectable colorectal liver metastases (NRCLM) with the current standard treatment of palliative chemotherapy. Methods A systematic review and meta-analysis of proportions was conducted following screening of MEDLINE, EMBASE, SCOPUS and CENTRAL for studies reporting liver transplantation for colorectal liver metastases. Post-operative outcomes measured included one-, three- and five-year survival, overall survival, disease-free survival and complication rate. Results Three non-randomised studies met the inclusion criteria, reporting a total of 48 patients receiving LT for NRCLM. Survival at one-, three- and five-years was 83.3–100%, 58.3–80% and 50–80%, respectively, with no significant difference detected ( p  = 0.22, p  = 0.48, p  = 0.26). Disease-free survival was 35–56% with the most common site of recurrence being lung. Thirteen out of fourteen deaths were due to disease recurrence. Conclusion Although current evidence suggests a survival benefit conferred by LT in NRCLM compared to palliative chemotherapy, the ethical implications of organ availability and allocation demand rigorous justification. Concomitant improvements in the management of patients following liver resection and of palliative chemotherapy regimens is paramount.

IntroductionCONTACT is a national multidisciplinary study assessing the impact of the COVID-19 pandemic upon diagnostic and treatment pathways among patients with pancreatic ductal adenocarcinoma (PDAC).MethodsThe treatment of consecutive patients with newly diagnosed PDAC from a pre-COVID-19 pandemic cohort (07/01/2019-03/03/2019) were compared to a cohort diagnosed during the first wave of the UK pandemic (‘COVID’ cohort, 16/03/2020-10/05/2020), with 12-month follow-up.ResultsAmong 984 patients (pre-COVID: n = 483, COVID: n = 501), the COVID cohort was less likely to receive staging investigations other than CT scanning (29.5% vs. 37.2%, p = 0.010). Among patients treated with curative intent, there was a reduction in the proportion of patients recommended surgery (54.5% vs. 76.6%, p = 0.001) and increase in the proportion recommended upfront chemotherapy (45.5% vs. 23.4%, p = 0.002). Among patients on a non-curative pathway, fewer patients were recommended (47.4% vs. 57.3%, p = 0.004) or received palliative anti-cancer therapy (20.5% vs. 26.5%, p = 0.045). Ultimately, fewer patients in the COVID cohort underwent surgical resection (6.4% vs. 9.3%, p = 0.036), whilst more patients received no anti-cancer treatment (69.3% vs. 59.2% p = 0.009). Despite these differences, there was no difference in median overall survival between the COVID and pre-COVID cohorts, (3.5 (IQR 2.8–4.1) vs. 4.4 (IQR 3.6–5.2) months, p = 0.093).ConclusionPathways for patients with PDAC were significantly disrupted during the first wave of the COVID-19 pandemic, with fewer patients receiving standard treatments. However, no significant impact on survival was discerned.

Background The effect of analgesic modalities on short‐term outcomes in acute pancreatitis remains unknown. However, preclinical models have raised safety concerns regarding opioid use in patients with acute pancreatitis. Objective This study aimed to assess the association between analgesics, particularly opioids, and severity and mortality in hospitalised patients with acute pancreatitis. Methods This prospective multicentre cohort study recruited consecutive patients admitted with a first episode of acute pancreatitis between April 1 and 30 June 2022, with a 1‐month follow‐up. Data on aetiology, clinical course, and analgesic treatment were collected. The primary outcome was the association between opioid analgesia and acute pancreatitis severity, which was analysed using univariate and multivariate analyses. Results Among a total of 1768 patients, included from 118 centres across 27 countries, 1036 (59%) had opioids administered on admission day, and 167 (9%) received opioids after admission day. On univariate analysis, moderately severe or severe acute pancreatitis was associated with male sex, Asian ethnicity, alcohol aetiology, comorbidity, predicted severe acute pancreatitis, higher pain scores, longer pain duration and opioid treatment (all p < 0.001). On multivariate analysis, comorbidity, alcohol aetiology, longer pain duration and higher pain scores increased the risk of moderately severe or severe acute pancreatitis (all p < 0.001). Furthermore, opioids administered after admission day (but not on admission day) doubled the risk of moderately severe or severe disease (OR 2.07 (95% CI, 1.29–3.33); p = 0.003). Opioid treatment for 6 days or more was an independent risk factor for moderately severe or severe acute pancreatitis (OR 3.21 (95% CI, 2.16–4.79; p < 0.001). On univariate analysis, longer opioid duration was associated with mortality. Conclusion Opioid treatment increased the risk of more severe acute pancreatitis only when administered after admission day or for 6 days or more. Future randomised studies should re‐evaluate whether opioids might be safe in acute pancreatitis.

Background Since there is no current international consensus on the optimal approach for pain management in acute pancreatitis (AP), analgesic practices may vary across different healthcare settings. Objective This study explored global disparities in analgesic use, in particular opioids, during admission and at discharge in hospitalised AP patients. Methods This was a post hoc analysis of the prospective PAINAP database, which included all admissions for AP between April and June 2022 with a 1‐month follow‐up. Demographic details, analgesic use, and clinical outcomes were recorded during admission and at discharge. Odds ratios (ORs) for opioid use during admission and at discharge were identified using multivariable regression analyses. Results Amongst the 1864 patients (52% males, median age 56 (interquartile range, 41–71)) across three different continents, simple analgesics were predominantly used as the primary analgesic (70%). Opioid use during admission was lowest in European centres (67%). Admission in Asian (OR, 2.53 (95% confidence interval (CI), 1.59–4.04), p < 0.001), and Australian (OR, 5.81 (95% CI, 3.19–10.56), p < 0.001) centres was associated with opioid administration during admission compared with European centres. Increased pain severity, longer pre‐admission pain duration, organ failure, and longer length of admission increased opioid use during admission. At discharge, Asian (OR, 2.01 (95% CI, 1.40–2.88), p < 0.001) and Australian (OR, 1.91 (95% CI, 1.28–2.85), p = 0.002) centres were associated with opioid prescription compared with European centres. Increased pain severity, longer pre‐admission pain duration, acute necrotic collections, and walled‐off necrosis also increased the likelihood of opioid prescription at discharge. Conclusion There are substantial intercontinental differences in opioid use for AP pain. Accordingly, there is a need for international guidelines on pain management in AP.

Now the Travellers' 15-acre camp has been fenced off into 16 plots - and 2,000 tonnes of paving chips have been laid over three acres.

The registrar who performed the operation, Dr [Mark Sopher], said it was more difficult to fit my pacemaker because my muscles were bigger and more developed than those of elderly patients. The pacemaker is coated in titanium to prevent rejection. Once the device was in the pocket, I needed to pass the polyurethanecovered leads to the heart. Then we connected the leads to the pacemaker, and sewed up the two incisions. I am pleased with the healing of [Paul Taylor]'s wound, his pacemaker's function and his progress.

[Mark Huggins] - who suffers from hip disorder Bilateral Perethes Disease, epilepsy, asthma and Raynaud's Syndrome - was in for a magical treat when the postman called at his Swindon home. Inside the parcel was the complete series of limited edition [HARRY Potter] adventures on tape, sent to him after [JK Rowling] heard of Mark's plight from a local radio station.

[Faye Tozer], 26, chose a glorious Norman church in her hometown of Dunstable, Beds, to wed Danish drummer Jasper. But she was jeered by 150 fans who wanted to see her self-designed pounds 15,000 dress of ivory satin and gold.

She and computer worker [Alvin Timothy] met that same year and married in 1998. They have a child together, [Fiona Timothy]'s fifth. But as soon as warped [Adrian Hodge] found out Alvin was on the scene, he started a vicious campaign to undermine him. Finally Alvin snapped and threatened to kill Hodge - who reported him to police. \"Alvin was charged with threats to kill. But the case was thrown out and the police came to fit panic alarms in the house. NEW LOVE: Fiona with victim Alvin; Picture: INS; THE HIRED THUGS; [Derek Danso], Mushbir [Hussain] and [William Phillips]; THE GUN; Alvin was blasted full in the face with a modified Brocock ME 28 Magnum air pistol; THE CAR; Flash Hodge always drove a Ferrari; THE BRUTE; Hodge abused and beat Fiona, but couldn't bear her finding true love