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We report experimental test-beam results on dielectric-loaded waveguide detectors that utilize microwave Cherenkov signals to time and characterize high energy particle showers. These results are used to validate models and produce high-fidelity simulations of timing plane systems that yield picosecond time tags and millimeter-level spatial coordinates for the shower centroid. These timing planes, based on the Askaryan effect in solid dielectrics, are most effective at the high center-of-momentum energies planned for the Future Circular Collider (FCC-hh). They will be of particular interest in the forward region due to their high radiation immunity. We use our beam test results and geant4 simulations to validate a hybrid microwave detector model, which is used to simulate a reference timing plane design for the FCC forward calorimeters. Our results indicate that 0.5–3 ps particle timing is possible for a wide range of collision products in the reference FCC hadron collider detector, even with current technology.

We report on the first measurements of coherent microwave impulses from high-energy particle-induced electromagnetic showers generated via the Askaryan effect in a dielectric-loaded waveguide. Bunches of 12.16 GeV electrons with total bunch energy of∼103–104GeVwere preshowered in tungsten, and then measured with WR-51 rectangular (12.6 mm by 6.3 mm) waveguide elements loaded with solid alumina (Al2O3) bars. In the 5–8 GHzTE10single-mode band determined by the presence of the dielectric in the waveguide, we observed band-limited microwave impulses with amplitude proportional to bunch energy. Signals in different waveguide elements measuring the same shower were used to estimate relative time differences with 2.3 ps precision. These measurements establish a basis for using arrays of alumina-loaded waveguide elements, with exceptional radiation hardness, as very high precision timing planes for high-energy physics detectors.

A bstract We present measurements of the branching fractions for the decays B → Kμ + μ − and B → Ke + e − , and their ratio ( R K ), using a data sample of 711 fb − 1 that contains 772 × 10 6 B B ¯ events. The data were collected at the ϒ(4 S ) resonance with the Belle detector at the KEKB asymmetric-energy e + e − collider. The ratio R K is measured in five bins of dilepton invariant-mass-squared ( q 2 ): q 2 ∈ (0 . 1 , 4 . 0) , (4 . 00 , 8 . 12) , (1 . 0 , 6 . 0), (10 . 2 , 12 . 8) and ( > 14 . 18) GeV 2 /c 4 , along with the whole q 2 region. The R K value for q 2 ∈ (1 . 0 , 6 . 0) GeV 2 /c 4 is 1.03 − 0.24 + 0.28 ± 0 . 01. The first and second uncertainties listed are statistical and systematic, respectively. All results for R K are consistent with Standard Model predictions. We also measure CP -averaged isospin asymmetries in the same q 2 bins. The results are consistent with a null asymmetry, with the largest difference of 2.6 standard deviations occurring for the q 2 ∈ (1 . 0 , 6 . 0) GeV 2 /c 4 bin in the mode with muon final states. The measured differential branching fractions, d ℬ /dq 2 , are consistent with theoretical predictions for charged B decays, while the corresponding values are below the expectations for neutral B decays. We have also searched for lepton-flavor-violating B → Kμ ± e ∓ decays and set 90% confidence-level upper limits on the branching fraction in the range of 10 − 8 for B + → K + μ ± e ∓ , and B 0 → K 0 μ ± e ∓ modes.

A bstract Charged lepton flavor violation is forbidden in the Standard Model but possible in several new physics scenarios. In many of these models, the radiative decays τ ± → ℓ ± γ ( ℓ = e, μ ) are predicted to have a sizeable probability, making them particularly interesting channels to search at various experiments. An updated search via τ ± → ℓ ± γ using full data of the Belle experiment, corresponding to an integrated luminosity of 988 fb − 1 , is reported for charged lepton flavor violation. No significant excess over background predictions from the Standard Model is observed, and the upper limits on the branching fractions, B ( τ ± → μ ± γ ) ≤ 4 . 2 × 10 − 8 and B ( τ ± → e ± γ ) ≤ 5 . 6 × 10 − 8 , are set at 90% confidence level.

A bstract We report a new measurement of the e + e − → ϒ( nS ) π + π − ( n = 1 , 2 , 3) cross sections at energies from 10 . 52 to 11 . 02 GeV using data collected with the Belle detector at the KEKB asymmetric-energy e + e − collider. We observe a new structure in the energy dependence of the cross sections; if described by a Breit-Wigner function its mass and width are found to be M = 10752.7 ± 5.9 − 1.1 + 0.7 MeV / c 2 and Γ = 35.5 − 11.3 − 3.3 + 17.6 + 3.9 MeV, where the first error is statistical and the second is systematic. The global significance of the new structure including systematic uncertainty is 5.2 standard deviations. We also find evidence for the e + e − → ϒ (1 S ) π + π − process at the energy 10 . 52 GeV, which is below the B B ¯ threshold.

RRx-001 is a cysteine-directed anticancer alkylating agent with activity in a Phase II study in platinum refractory small cell lung cancer. Here, we describe the design of REPLATINUM, an open-label, Phase III trial. 120 patients with previously platinum-treated small cell lung cancer in third line will be randomized 1:1 to receive RRx-001 followed by four cycles of a platinum doublet, and then alternating cycles of RRx-001 and single agent platinum until progression versus four cycles of a platinum doublet. At radiologic progression on the platinum doublet, patients may cross over to the RRx-001 arm. Primary objective: to demonstrate superior progression-free survival in the RRx-001 population. Secondary objectives: to demonstrate superiority for overall survival and objective response rate. Clinical Trial registration: NCT03699956

A bstract We report a measurement of the electric dipole moment of the τ lepton ( dτ ) using an 833 fb − 1 data sample collected near the Υ(4 S ) resonance, with the Belle detector at the KEKB asymmetric-energy e + e − collider. Using an optimal observable method, we obtain the real and imaginary parts of d τ as Re( d τ ) = ( − 0 . 62 ± 0 . 63) × 10 − 17 e cm and Im( d τ ) = ( − 0 . 40 ± 0 . 32) × 10 − 17 e cm, respectively. These results are consistent with null electric dipole moment at the present level of experimental sensitivity and improve the sensitivity by about a factor of three.