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BackgroundPregnancy represents a challenge for patients with systemic lupus erythematosus. One of the major risk is the occurence of a flare during pregnancy. The influences are mutual, and the risk of complications depend mostly on the disease activity in the last 6–12 months before pregnancy. Therefore, these patients need a multidisciplinary approach, the obstetrician should collaborate with the rheumatologist and nephorologist.ObjectivesTo determinate the associations between disease activity and pregnancy outcomes, and the risk factors that predict pregnancy complications and flare.MethodsWe present a retrospective study conducted between january 2010 and december 2015. We enrolled 35 pregnant patients, diagnosed with SLE with ages between 21 and 46 years old. All patients were followed up since the beginning of the pregnancy until delivery. We tested the correlations between different biomarkers and clinical manifestations of disease activity and pregnancy outcomes.ResultsMaternal complications occured in 71,24% of the cases. The most common complications were: miscarriages, hematologic abnormalities (anemias, thrombocytopenia), premature birth and preeclampsia. The prematurity rate was 11% and most common delivery mode was the caesarian section. Also, the planning of the pregnancy was a predictor of a good fetal outcome (p=0,01). The presence of the lupus anticoagulant was associated with prematurity (p=0,046) at univaryate analysis. Antiphospholipidic syndrome was associated in 12% of the cases. Univaryate analysis did not show a correlation between the presence of the syndrome and any pregnancy outcome.Abstract AB0623 – Table 1Risk Estimate preeclampsia in patients with APSValue95% Confidence Interval LowerUpper Odds Ratio for Preeclampsia6667,60773 195For cohort APS=yes241711045292For cohort APS=no,363,0652014N of Valid Cases33ConclusionsPregnancy should be planned when the disease is in remission. Lupus nephritis, is an important risk factor for preeclampsia. Also, the presence of lupus anticoagulant is a risk factor for preeclampsia, and hematologic determinations during pregnancy. The risk factors for pregnancy complications were; secondary antiphospholipid syndrome, presence of lupus nephropaty, thrombocytopenia. our study showes that the exacerbations depend on the disease activity in the moment of conception.Disclosure of InterestNone declared

In the present work, optical, structural and morphological properties of CdS-doped phosphate films obtained by pulsed laser deposition (PLD) method were investigated. In the deposition process, a target based on a mixture composed of Li 2 O-Al 2 O 3 -BaO-La 2 O 3 -ZnO-P 2 O 5 glass and CdS powder as dopant was used. The phosphate glass target was obtained by non-conventional wet route of raw reagents processing followed by melt-quenching technique. The complex oxide composition of the glass as well as the final PLD target consisting in a mixture of glass and CdS powder followed by pressing and heat treatment represents the novelty of the work. CdS dopant particles were highlighted by X-ray diffraction analysis as well as by Raman spectroscopy. Thus, cubic CdS particles having less than 10 nm size corroborated with specific LO (longitudinal optical phonons) and 2LO CdS Raman peaks from 300 and 600 cm −1 , respectively, certified the presence of the dopant in the deposited films. Specific vibration modes for the vitreous phosphate matrix were revealed by fourier transform infrared spectroscopy, and spherulitic units characteristic to PLD technique were found by scanning electron microscopy and atomic force microscopy analyses. A relative large luminescence band located around 430 nm was provided by UV excitation, representative for CdS nanoparticles having about 9–10 nm size.

Despite patient selection, postoperative morbidity after reversal of Hartmann's procedure remains significant. The objective of this study was to investigate risk factors associated with morbidity after conversion of Hartmann's operation. We retrospectively analyzed data of 56 patients who underwent reversal procedures between January 2004 and May 2015 in a single center. We evaluated the following variables: demographic characteristics, medical comorbidities, etiology for Hartmann operation, preoperative lab values, intraoperative surgical details and short-term outcomes (hospital stay, medical and surgical complications, mortality). There were 37 men (66.1%) and the mean age was 57 years. The most frequent indications for Hartmann's procedure were colorectal cancer in 25 patients (44.6%) and complicated diverticulitis in 10 patients (17.9%). The mean time to the reversal procedure was 9 months. Morbidity rate was 16.1% (9 patients) with an anastomotic leakage rate of 3.6% (2 patients) and mortality rate was 3.6% (2 patients). The most common medical complication was diarrhea (4 patients, 7.2%). Bivariate analysis demonstrated that the only factor significantly associated with postoperative complications was presence of multiple comorbidities. Multiple medical comorbidities is the only predictive factor for postoperative complications after Hartmann's reversal and therefore patient selection for this type of surgery is critical.

Background/ Aims: Despite the existence of an easy tool to diagnose biliary tract disease as an etiology for acute pancreatitis (AP), the sensitivity of abdominal ultrasound is around 80%, which can be even lower in certain conditions. We have retrospectively reviewed data of 146 patients admitted for acute pancreatitis between 1999 and 2013. Bivariate analysis for clinical and biochemical variables was performed with respect to etiology of AP (biliary versus non-biliary). Multivariate analysis was performed by using binary logistic regression. There were 87 males (59.6%) and 59 females (40.4%), with a median age of 51. The etiology of acute pancreatitis was biliary in 71 patients (48.6%). Bivariate analysis found the following as significant association (p=0.001) with biliary pancreatitis: older age, female gender, and elevated AST, ALT. A binary logistic regression analysis identified as predictor factors for biliary etiology of acute pancreatitis: age OR = 1.031 (95% CI 1.004 - 1.059, p = 0.024), sex (female) OR = 2.34 (95% CI 1.022 - 5.359, p = 0.044) and ALT OR = 1.004 (95% CI 1.001 - 1.007, p =0.004). The two clinical scores included the three variables (A.S.ALT scores) in categorical format were generated and then checked with the ROC curves (areas under curve are 0.768 and 0.778). Age, female gender, and elevated ALT can help identifying cases with biliary etiology of acute pancreatitis.

Azulene is a special monomer used to functionalize electrodes, due to its spontaneous electron drift from the seven-membered ring to the five-membered ring. The seven-membered ring of the molecule may act as electron acceptor, while the five-membered ring - as electron donor. This leads to very attractive properties for the synthesis of functional advanced materials like: materials with nonlinear optical and photorefractive properties, cathode materials for lithium batteries, or light emitting diodes based on organic materials. Azulene derivatives have been used rarely to the metal ions electroanalysis. Our study concerns the synthesis and electrochemical characterization of a new azulene based monomer 4-(azulen-1-yl)-2,6-bis((E)-2-(thiophen-3-yl)vinyl)pyridine (L). L has been used to obtain modified electrodes by electrochemical polymerization. PolyL films modified electrodes have been characterized by cyclic voltammetry in ferrocene solutions. The complexing properties of polyL based functional materials have been investigated towards heavy metals (Pb, Cd Hg, Cu) by preconcentration - anodic stripping technique in order to analyze the content of these cations from water samples.

Doped organic compounds are of great interest for optical communications and high-density optical data storage due to their large second-order nonlinearity and high-speed response. A promising approach in the fabrication of new materials for second-order nonlinear optics is sol–gel technique. The present paper reports on the sol–gel synthesis of some pyrazolone derivative doped SiO 2 –P 2 O 5 films. The precursors used for sol gel synthesis were tetraethylorthosilicate and phosphoric acid (H 3 PO 4 ). The organic compound was added under continuous stirring in the precursors’ mixture. The structure of the deposited azo-derivatives doped thin films was examined by Fourier transform infrared spectroscopy, and atomic force microscopy and their optical properties by UV–VIS spectroscopy. The nonlinear optical efficiencies due to the interaction of the NLO-active chromophores with the inorganic matrix has a significant influence on the second harmonic generation capabilities that was measured using a femtosecond Ti:sapphire laser. The properties of the films were investigated and correlated with the concentration of the organic dopant and the thermal treatment temperature.

Silicate and silicophosphate films doped with CdSe/ZnS quantum dots (QDs) have been deposited on silicon substrate, by sol–gel method, spin-coating technique. A precursor solution (PS) composed of tetraethoxysilane (TEOS) and ethanol (EtOH) has been prepared in the case of silicate films (T) and in the case of silicophosphate films (TPT), the same precursors for T films and triethylphosphate were used. In each PS, dimethylformamide and CdSe/ZnS (QD) were added. Spectroscopic ellipsometry shows that absorption of TPT films in the visible (400–700 nm) decreases over 400 nm, due to dimensional quantum effect of semiconductor doping particles embedded in the silicophosphate matrix. The same manner is noticed in the case of refractive index dependency on wavelength. Raman spectra were recorded by 785 nm excitation and put in evidence specific bands for the inorganic matrix as well as a low-intensity band characteristic for CdSe doping. The morphology of the films was investigated by transmission electron microscopy revealing semiconductor doping dots with average dimension 3.3 nm and a homogeneous distribution of the doping particles in the inorganic matrix. SEM image of the cross-section of the TPT film reveals a thickness of about 500 nm. The fluorescence spectra of CdSe/ZnS-doped films exhibit an emission band at about 530 nm, provided by 350 nm excitation, whose characteristics are close to those of CdSe compound.

Thin films of phosphate glasses were prepared by pulsed laser deposition in oxygen atmosphere on ITO-coated glass and silicon substrates respectively, using a Nd:YAG laser (266 nm). The targets were Li 2 O–Al 2 O 3 –P 2 O 5 bulk glasses doped with Pr and Nd. Infrared transmission-, energy dispersive X-ray- and X-ray photoemission spectroscopy investigations carried out on targets as well as on the deposited films proved a satisfactory compositions transfer on both substrates. Scanning electron microscopy and atomic force microscopy show continuous films with glassy spheres. Processes where substrates were positioned perpendicularly to targets produced discontinuous drops free films.

Aluminophosphate glasses belonging to the Li2O–BaO–Al2O3– La2O3–P2O5 system doped with Tb3+ were prepared and investigated. Methods as Induced Coupled Plasma-Mass Spectrometry (ICP-MS), Induced Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) and X-ray diffraction (XRD) have been used to establish the elemental composition of these vitreous materials. The influence of the Tb3+ ions on the optical properties of the phosphate glasses has been investigated in relation with the structural characteristics of the vitreous matrix. The optical behavior has been studied by ultra-violet-visible (UV–Vis) spectroscopy, revealing electronic transitions specific for terbium ions. Fluorescence spectroscopy measurements have been performed by excitation in the UV and visible domains (377 nm and 488 nm) which resulted in the most significant fluorescence peaks in the Vis domain (540 and 547 nm). Structural information via vibration modes were provided by Fourier Transform Infrared (FTIR) absorption spectra in the 400–4000 cm−1 range. Absorption peaks specific for the vitreous phosphate matrix were put in evidence as P-O-P symmetrical and asymmetrical stretching vibration modes, P-O-P bend, PO2- symmetrical and asymmetrical stretching vibration modes, P=O stretching vibration mode as well as P-O-H water absorbance. Raman spectra acquired in the 100–4000 cm−1 range by 488, 514 and 633 nm laser excitation sources disclosed peaks also specific for the phosphate matrix, proving the role of phosphorous oxide as a vitreous network former. Differential Scanning Calorimetry and Thermogravimetric Analysis (DSC-TGA) provided information regarding the phase transformations that took place during the heating process and the associated thermal effects.

Phosphosilicate films with 90%SiO2-10%P2O5 molar composition, derived from tetraethoxysilane as SiO2 precursor and triethylphosphate, triethylphosphite or phosphoric acid as P2O5 precursors were prepared using the sol-gel method. The films were deposited on glass and ITO coated glass supports. The influence of the type of P2O5 precursor, type of substrate and of the thermal treatment (200, 300 and 500°C) on their structure and properties was studied. By spectroellipsometric and XPS measurements the high vaporization of the phosphorous during the densification of the films by thermal treatment was noticed when alkoxide were used, underlying that the mentioned precursors are not recommended for thin phosphosilicate films preparation. The phosphoric acid that forms chemical bond with silica network during the sol-gel process lead to better incorporation of P in the silica network as compared to the P-alkoxides.