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Vasilyev et al discuss pharmaceutical regulation in the Soviet Union from 1918 to 1990. The Soviet Union was politically centralized with a socialized economy. It had a universal health care system, supported by basic and applied research. Starting in 1918, The People's Commissariat of Public Health of the Russian Soviet Federative Socialist Republic (also known by its abbreviated name, Narkomzdrav), oversaw all medical matters. Of importance, it took control of the pharmaceutical industry after the 1917 Revolution, which included pharmaceutical research. Research on new drugs was a priority for the newly formed Soviet government, which sought to achieve independence from drugs manufactured in the \"bourgeois West.\" Archival documents indicate that as early as 1921, Soviet health care authorities requested that all new drugs introduced to medical practice be tested in clinical trials (mostly observational) and evaluated by the relevant department of the People's Commissariat of Public Health.

A series of heterometallic carboxylate 1D polymers of the general formula [LnIIICd2(piv)7(H2O)2]n·nMeCN (LnIII = Sm (1), Eu (2), Tb (3), Dy (4), Ho (5), Er (6), Yb (7); piv = anion of trimethylacetic acid) was synthesized and structurally characterized. The use of CdII instead of ZnII under similar synthetic conditions resulted in the formation of 1D polymers, in contrast to molecular trinuclear complexes with LnIIIZn2 cores. All complexes 1–7 are isostructural. The luminescent emission and excitation spectra for 2–4 have been studied, the luminescence decay kinetics for 2 and 3 was measured. Magnetic properties of the complexes 3–5 and 7 have been studied; 4 and 7 exhibited the properties of field-induced single-molecule magnets in an applied external magnetic field. Magnetic properties of 4 and 7 were modelled using results of SA-CASSCF/SO-RASSI calculations and SINGLE_ANISO procedure. Based on the analysis of the magnetization relaxation and the results of ab initio calculations, it was found that relaxation in 4 predominantly occurred by the sum of the Raman and QTM mechanisms, and by the sum of the direct and Raman mechanisms in the case of 7.

The article studies the development of methodology and results of validation of in silico 3D models of pharmacologically relevant target proteins on the example of protein kinase C theta. Using the IUPHAR / BPS database, information has been found about 5 reference inhibitors PRKCQ, recognized by the world scientific community. According to the received data, 3 most valid PRKCQ models (PDB-codes: 5F9E, 2JED, 4RA5) have been selected, which can later be used for docking of new inhibitors.

Although juvenile drug addiction is generally recognized as a global contemporary problem, it is often presented in largely simplified form. Insufficient attention has been paid to the historical roots of drug addiction and its various cultural forms. This is surprising, since interdisciplinary research on the history of drug addiction allows you to explore the intersection of medical theory, practical policy, social context, and cultural values. In the Russian context, the emergence of juvenile drug addiction as a social problem can be traced back to the years between the outbreak of World War I in 1914 and the end of the 1920s. Accordingly, this article focuses on medical texts from the period to establish how drug use by adolescents was constructed as a form of delinquency and a specific social problem requiring immediate intervention. The government and local public health authorities implemented many solutions by the end of the 1920s. Homeless children and prostitutes were no longer seen on the streets of Russian cities. Large sums of money were allocated to produce medical propaganda, sanitary education, and popular medical literature. Adapted from the source document.

Although juvenile drug addiction is generally recognized as a global contemporary problem, it is often presented in largely simplified form. Insufficient attention has been paid to the historical roots of drug addiction and its various cultural forms. This is surprising, since interdisciplinary research on the history of drug addiction allows you to explore the intersection of medical theory, practical policy, social context, and cultural values. In the Russian context, the emergence of juvenile drug addiction as a social problem can be traced back to the years between the outbreak of World War I in 1914 and the end of the 1920s. Accordingly, this article focuses on medical texts from the period to establish how drug use by adolescents was constructed as a form of delinquency and a specific social problem requiring immediate intervention. The government and local public health authorities implemented many solutions by the end of the 1920s. Homeless children and prostitutes were no longer seen on the streets of Russian cities. Large sums of money were allocated to produce medical propaganda, sanitary education, and popular medical literature.

A series of heterometallic carboxylate 1D polymers of the general formula [LnIIICd2(piv)7(H2O)2]n·nMeCN (LnIII = Sm (1), Eu (2), Tb (3), Dy (4), Ho (5), Er (6), Yb (7); piv = anion of trimethylacetic acid) was synthesized and structurally characterized. The use of CdII instead of ZnII under similar synthetic conditions resulted in the formation of 1D polymers, in contrast to molecular trinuclear complexes with LnIIIZn2 cores. All complexes 1–7 are isostructural. The luminescent emission and excitation spectra for 2–4 have been studied, the luminescence decay kinetics for 2 and 3 was measured. Magnetic properties of the complexes 3–5 and 7 have been studied; 4 and 7 exhibited the properties of field-induced single-molecule magnets in an applied external magnetic field. Magnetic properties of 4 and 7 were modelled using results of SA-CASSCF/SO-RASSI calculations and SINGLE_ANISO procedure. Based on the analysis of the magnetization relaxation and the results of ab initio calculations, it was found that relaxation in 4 predominantly occurred by the sum of the Raman and QTM mechanisms, and by the sum of the direct and Raman mechanisms in the case of 7.

Spanning Europe, Asia and the Pacific, Encounters with Emotions investigates experiences of face-to-face transcultural encounters from the seventeenth century to the present and the emotional dynamics that helped to shape them. Each of the case studies collected here investigates fascinating historiographical questions that arise from the study of emotion, from the strategies people have used to interpret and understand each other’s emotions to the roles that emotions have played in obstructing communication across cultural divides. Together, they explore the cultural aspects of nature as well as the bodily dimensions of nurture and trace the historical trajectories that shape our understandings of current cultural boundaries and effects of globalization.

This article describes the rationale for the development of a mathematical model of the thermal scheme of Vladivostok thermal power plant. Four types of turbines are installed at this plant, boiler units operate on coal and natural gas. This makes it difficult to effective load distribution between the turbine units. Application of simplified dependencies, built on the basis of the reporting data, allows to analyse the correctness of the load distribution between the units. The article provides an example of comparing the actual parameters of the plant and calculating based on the simplified characteristics of turbines. This example showing the loss of fuel equivalent from non-optimal load distribution. However, the use of such simplified characteristics has several shortcomings. These shortcomings do not allow using this as a universal method. There is a need to create a full-fledged mathematical model of thermal power plants. The model is developing on the basis of the Boiler Designer software package. The program has a modular structure and allows you to create mathematical models of each unit of equipment, and then, through the purpose of connections, assemble the thermal scheme of the station. This approach is actual for cross-linked heat and power plants, since it allows us to evaluate the efficiency of thermal scheme connections, and not just the operation of the equipment itself. The article provides a simplified model of the station, its advantages and disadvantages