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"Vaughn, Carrie"
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Steel
When Jill, a competitive high school fencer, goes with her family on vacation to the Bahamas, she is magically transported to an early-eighteenth-century pirate ship in the middle of the ocean.
Book
Mississippi roll
Now on its final voyage, the historical steamboat Natchez is known for her super-powered guest entertainers. But after the suspicious death of a crew member, retired NY police detective Leo Storgman decides to make this incident his personal case. His findings only lead to a growing number of questions. Is there some truth behind the ghostly sightings of the steamboat's first captain Wilbur Leathers? What secret does the current captain seem to be hiding? And could the Natchez be ferrying mysterious - and possibly dangerous - cargo onboard?
Book
Urban allies : ten brand-new collaborative stories
These collaborative stories unite two beloved characters from two different urban fantasy series in each of ten electrifying new stories.
Book
The Scientific Benefits of a Statewide, Standardized, Coastal Wetland Monitoring Program in Hawa'i
In this viewpoint, we provide a scientific justification for a statewide, standardized, coastal wetland monitoring program for Hawai'i, USA. Hawaiian coastal wetlands provide important habitat for endangered waterbirds, invertebrates, plants, and the Hawaiian hoary bat ('ōpe'ape'a;
) as well as support Indigenous food systems. Currently, numerous agencies and groups in Hawai'i collect data on coastal wetlands, but information is not typically shared and methods are not standardized. A statewide, standardized, coastal wetland monitoring program with a centralized database would allow managers to keep better track of progress toward restoration goals, population changes of conservation-reliant species, outbreaks and impacts of avian botulism, rates of coastal salinization, and many other critical issues across space and time. Monitoring combined with targeted research could fill critical knowledge gaps about the types, functions, values, and biodiversity of Hawaiian coastal wetlands. Ultimately, the improved knowledge gained from long-term coastal wetland monitoring could inform landscape-scale restoration actions and adaptive management of coastal wetlands under sea-level rise and climate change.
Journal Article
Antimicrobial Resistance Trends and Outbreak Frequency in United States Hospitals
We assessed resistance rates and trends for important antimicrobial-resistant pathogens (oxacillin-resistant Staphylococcus aureus [ORSA], vancomycin-resistant Enterococcus species [VRE], ceftazidime-resistant Klebsiella species [K-ESBL], and ciprofloxacin-resistant Escherichia coli [QREC]), the frequency of outbreaks of infection with these resistant pathogens, and the measures taken to control resistance in a stratified national sample of 670 hospitals. Four hundred ninety-four (74%) of 670 surveys were returned. Resistance rates were highest for ORSA (36%), followed by VRE (10%), QREC (6%), and K-ESBL (5%). Two-thirds of hospitals reported increasing ORSA rates, whereas only 4% reported decreasing rates, and 24% reported ORSA outbreaks within the previous year. Most hospitals (87%) reported having implemented measures to rapidly detect resistance, but only ∼50% reported having provided appropriate resources for antimicrobial resistance prevention (53%) or having implemented antimicrobial use guidelines (60%). The most common resistant pathogen in US hospitals is ORSA, which accounts for many recognized outbreaks and is increasing in frequency in most facilities. Current practices to prevent and control antimicrobial resistance are inadequate.
Journal Article
The Scientific Benefits of a Statewide, Standardized, Coastal Wetland Monitoring Program in Hawaiʻi
In this viewpoint, we provide a scientific justification for a statewide, standardized, coastal wetland monitoring program for Hawaiʻi, USA. Hawaiian coastal wetlands provide important habitat for endangered waterbirds, invertebrates, plants, and the Hawaiian hoary bat (ʻōpeʻapeʻa; Lasiurus semotus) as well as support Indigenous food systems. Currently, numerous agencies and groups in Hawaiʻi collect data on coastal wetlands, but information is not typically shared and methods are not standardized. A statewide, standardized, coastal wetland monitoring program with a centralized database would allow managers to keep better track of progress toward restoration goals, population changes of conservation‐reliant species, outbreaks and impacts of avian botulism, rates of coastal salinization, and many other critical issues across space and time. Monitoring combined with targeted research could fill critical knowledge gaps about the types, functions, values, and biodiversity of Hawaiian coastal wetlands. Ultimately, the improved knowledge gained from long‐term coastal wetland monitoring could inform landscape‐scale restoration actions and adaptive management of coastal wetlands under sea‐level rise and climate change. Coastal wetlands in Hawaiʻi provide habitat for endangered waterbirds, invertebrates, plants, and the Hawaiian hoary bat, as well as support Indigenous food systems. Establishment of a statewide, coordinated coastal wetland monitoring program could track the recovery of endangered species and improve management of natural and agricultural wetlands under climate change and sea‐level rise.
Journal Article
Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues
Brain tumors are typically resistant to conventional chemotherapeutics, most of which initiate apoptosis upstream of mitochondrial cytochrome c release. In this study, we demonstrate that directly activating apoptosis downstream of the mitochondria, with cytosolic cytochrome c, kills brain tumor cells but not normal brain tissue. Specifically, cytosolic cytochrome c is sufficient to induce apoptosis in glioblastoma and medulloblastoma cell lines. In contrast, primary neurons from the cerebellum and cortex are remarkably resistant to cytosolic cytochrome c. Importantly, tumor tissue from mouse models of both high-grade astrocytoma and medulloblastoma display hypersensitivity to cytochrome c when compared with surrounding brain tissue. This differential sensitivity to cytochrome c is attributed to high Apaf-1 levels in the tumor tissue compared with low Apaf-1 levels in the adjacent brain tissue. These differences in Apaf-1 abundance correlate with differences in the levels of E2F1, a previously identified activator of Apaf-1 transcription. ChIP assays reveal that E2F1 binds the Apaf-1 promoter specifically in tumor tissue, suggesting that E2F1 contributes to the expression of Apaf-1 in brain tumors. Together, these results demonstrate an unexpected sensitivity of brain tumors to postmitochondrial induction of apoptosis. Moreover, they raise the possibility that this phenomenon could be exploited therapeutically to selectively kill brain cancer cells while sparing the surrounding brain parenchyma.
Journal Article