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Many Australian children are more sedentary than they should be, and almost one in five are currently overweight or obese. Some children may face difficulties finding opportunities to be active, having poor access to safe public open spaces or having low independent mobility limiting their access to places to play. This study aimed to examine children's access to places in their neighborhood for active free play and how these vary by age, sex and socioeconomic status (SES). Behavioral maps of the local neighborhood were completed by children (8–12 years) from five primary schools across different areas of Melbourne. Children living in low SES outer-urban neighborhoods had to travel greater distances to access local parks compared with those in inner-urban mid and high SES areas. One-third (32%) of children reported an independent mobility range of <100 m from home. In conclusion, for some children opportunities to engage in active free play in the local neighborhood may be limited due to lack of parks in close proximity to home and restricted independent mobility. It is important to collaborate with local governments, urban planners and community groups to improve access to neighborhood parks and to promote a sense of neighborhood safety.

The northern Gulf of Guinea is a part of the eastern tropical Atlantic where oceanic conditions due to the presence of coastal upwelling may influence the regional climate and fisheries. The dynamics of this coastal upwelling is still poorly understood. A sensitivity experiment based on the Regional Oceanic Modeling System (ROMS) is carried out to assess the role of the detachment of the Guinea Current as a potential mechanism for coastal upwelling. This idealized experiment is performed by canceling the inertia terms responsible for the advection of momentum in the equations and comparing with a realistic experiment. The results exhibit two major differences. First, the Guinea Current is found to be highly sensitive to inertia, as it is no longer detached from the coast in the idealized experiment. The Guinea Current adjusts on an inertial boundary layer, the inertial terms defining its lateral extension. Second, the upwelling east of Cape Palmas disappears in absence of the Guinea Current detachment. This is in contrast with the upwelling east of Cape Three Points, which is still present. The results suggest that two different generation processes of the coastal upwelling need to be considered: the upwelling east of Cape Palmas (which is due to inertia, topographic variations, and advective terms effects resulting in important vertical pumping) and the upwelling east of Cape Three Points (which is principally induced by local winds). In addition to recent work ruling out the role of eddies, this study clarifies the processes responsible for this coastal upwelling.

Human innate immunity against most African trypanosomes, including Trypanosoma brucei brucei, is mediated by a minor subclass of toxic serum HDL, called trypanosome lytic factor-1 (TLF-1). This HDL contains two primate specific proteins, apolipoprotein L-1 and haptoglobin (Hp)-related protein, as well as apolipoprotein A-1. These assembled proteins provide a powerful defense against trypanosome infection. Trypanosoma brucei rhodesiense causes human African sleeping sickness because it has evolved an inhibitor of TLF-1, serum resistance-associated (SRA) protein. Trypanosoma brucei gambiense lacks the SRA gene, yet it infects humans. As transfection of T. b. gambiense (group 1) is not possible, we initially used in vitro-selected TLF-1-resistant T. b. brucei to examine SRA-independent mechanisms of TLF-1 resistance. Here we show that TLF-1 resistance in T. b. brucel is caused by reduced expression of the Hp/Hb receptor gene (TbbHpHbR). Importantly, T. b. gambiense (group 1) also showed a marked reduction in uptake of TLF-1 and a corresponding decrease in expression of T. b. gambiense Hp/Hb receptor (TbgHpHbR). Ectopic expression of TbbHpHbR in TLF-1-resistant T. b. brucei rescued TLF-1 uptake, demonstrating that decreased TbbHpHbR expression conferred TLF-1 resistance. Ectopic expression of TbgHpHbR in TLF-1-resistant T. b. brucei failed to rescue TLF-1 killing, suggesting that coding sequence changes altered Hp/Hb receptor binding affinity for TLF-1. We propose that the combination of coding sequence mutations and decreased expression of TbgHpHbR directly contribute to parasite evasion of human innate immunity and infectivity of group 1 T. b. gambiense.

In two experiments in a simulated office space, temporary office personnel worked under one of six lighting conditions for a day. A previous paper reported the results of statistical tests for lighting conditions effects on perceptions, feelings and task performance. This paper reports mediated regression analyses testing the linked mechanisms by which lighting conditions affect health, well-being and task performance. Combined results from the two statistical approaches show that people who perceived their office lighting as being of higher quality rated the space as more attractive, reported more pleasant mood, and showed greater well-being at the end of the day. Direct—indirect lighting and personal control were favoured. Lighting conditions that improved visibility also improved task performance.

This paper describes two experiments concerning the effects of variations in lighting quality on office worker performance, health, and well-being. Experiment 1 had four experimental conditions: a regular array of fully direct recessed parabolic luminaires; direct/indirect luminaires with no control; direct/indirect luminaires with a switchable desk lamp; and, workstation-specific direct/indirect luminaires with control over the direct portion. Experiment 2 contrasted two conditions with no individual lighting control: a regular array of recessed prismatic lensed luminaires, and suspended direct/indirect luminaires. Participants considered the direct/indirect systems to be more comfortable than the direct-only systems, with a further increase in comfort associated with individual control in Experiment 1. There were no simple main effects of lighting quality on the performance of any task, although the expected changes in performance associated with task visibility, practice, and fatigue were found. Interactions between lighting quality and time suggested that having a degree of individual control of lighting tended to maintain motivation and vigilance over the day.

In this paper we elaborate on earlier work by the same authors in which a novel Bayesian inference framework for testing the strong-field dynamics of General Relativity using coalescing compact binaries was proposed. Unlike methods that were used previously, our technique addresses the question whether one or more 'testing coefficients' (e.g. in the phase) parameterizing deviations from GR are non-zero, rather than all of them differing from zero at the same time. The framework is well-adapted to a scenario where most sources have low signal-to-noise ratio, and information from multiple sources as seen in multiple detectors can readily be combined. In our previous work, we conjectured that this framework can detect generic deviations from GR that can in principle not be accomodated by our model waveforms, on condition that the change in phase near frequencies where the detectors are the most sensitive is comparable to that induced by simple shifts in the lower-order phase coefficients of more than a few percent (~ 5 radians at 150 Hz). To further support this claim, we perform additional numerical experiments in Gaussian and stationary noise according to the expected Advanced LIGO/Virgo noise curves, and coherently injecting signals into the network whose phasing differs structurally from the predictions of GR, but with the magnitude of the deviation still being small. We find that even then, a violation of GR can be established with good confidence.

IntroductionParks in disadvantaged suburbs often have low quality and few amenities, which is likely to result in them being underutilised for recreation and physical activity. Refurbishment of parks, including shade, walking paths and other amenities, may have broad health-related benefits.Methods and analysisThe study design, methods and planned analyses for a natural experiment examining the effects of refurbishments including built-shade added to parks in disadvantaged outer suburbs of Melbourne are described. Three intervention parks and three comparison parks matched for equivalence of park and neighbourhood characteristics were selected. Using mixed methods, the outcomes will be assessed during three consecutive spring–summer periods (T1: 2013–2014; T2: 2014–2015: T3: 2015–2016). Primary outcomes included: observed park use, physical activity and shade use. Self-reported social connectedness, community engagement and psychological well-being were assessed as secondary outcomes.Ethics and disseminationThis study was approved by Cancer Council Victoria's Human Research Ethics Committee. Studies such as ShadePlus can improve understanding of the broader effects of park refurbishments (including physical activity levels and sun protection behaviours, as well as social connectedness and psychological well-being). The study findings will be disseminated through established urban planning and parks and recreation networks, peer review publications and conference presentations.

Predicting the ocean state in a reliable and interoperable way, while ensuring high-quality products, requires forecasting systems that synergistically combine science-based methodologies with advanced technologies for timely, user-oriented solutions. Achieving this objective necessitates the adoption of best practices when implementing ocean forecasting services, resulting in the proper design of system components and the capacity to evolve through different levels of complexity. The vision of OceanPrediction Decade Collaborative Center, endorsed by the UN Decade of Ocean Science for Sustainable Development 2021-2030, is to support this challenge by developing a “predicted ocean based on a shared and coordinated global effort” and by working within a collaborative framework that encompasses worldwide expertise in ocean science and technology. To measure the capacity of ocean forecasting systems, the OceanPrediction Decade Collaborative Center proposes a novel approach based on the definition of an Operational Readiness Level (ORL). This approach is designed to guide and promote the adoption of best practices by qualifying and quantifying the overall operational status. Considering three identified operational categories - production, validation, and data dissemination - the proposed ORL is computed through a cumulative scoring system. This method is determined by fulfilling specific criteria, starting from a given base level and progressively advancing to higher levels. The goal of ORL and the computed scores per operational category is to support ocean forecasters in using and producing ocean data, information, and knowledge. This is achieved through systems that attain progressively higher levels of readiness, accessibility, and interoperability by adopting best practices that will be linked to the future design of standards and tools. This paper discusses examples of the application of this methodology, concluding on the advantages of its adoption as a reference tool to encourage and endorse services in joining common frameworks.

The three sub-species of Trypanosoma brucei are important pathogens of sub-Saharan Africa. T. b. brucei is unable to infect humans due to sensitivity to trypanosome lytic factors (TLF) 1 and 2 found in human serum. T. b. rhodesiense and T. b. gambiense are able to resist lysis by TLF. There are two distinct sub-groups of T. b. gambiense that differ genetically and by human serum resistance phenotypes. Group 1 T. b. gambiense have an invariant phenotype whereas group 2 show variable resistance. Previous data indicated that group 1 T. b. gambiense are resistant to TLF-1 due in-part to reduced uptake of TLF-1 mediated by reduced expression of the TLF-1 receptor (the haptoglobin-hemoglobin receptor (HpHbR)) gene. Here we investigate if this is also true in group 2 parasites. Isogenic resistant and sensitive group 2 T. b. gambiense were derived and compared to other T. brucei parasites. Both resistant and sensitive lines express the HpHbR gene at similar levels and internalized fluorescently labeled TLF-1 similar fashion to T. b. brucei. Both resistant and sensitive group 2, as well as group 1 T. b. gambiense, internalize recombinant APOL1, but only sensitive group 2 parasites are lysed. Our data indicate that, despite group 1 T. b. gambiense avoiding TLF-1, it is resistant to the main lytic component, APOL1. Similarly group 2 T. b. gambiense is innately resistant to APOL1, which could be based on the same mechanism. However, group 2 T. b. gambiense variably displays this phenotype and expression does not appear to correlate with a change in expression site or expression of HpHbR. Thus there are differences in the mechanism of human serum resistance between T. b. gambiense groups 1 and 2.