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Centrosomes are the major microtubule organising centres of animal cells. Deregulation in their number occurs in cancer and was shown to trigger tumorigenesis in mice. However, the incidence, consequence and origins of this abnormality are poorly understood. Here, we screened the NCI-60 panel of human cancer cell lines to systematically analyse centriole number and structure. Our screen shows that centriole amplification is widespread in cancer cell lines and highly prevalent in aggressive breast carcinomas. Moreover, we identify another recurrent feature of cancer cells: centriole size deregulation. Further experiments demonstrate that severe centriole over-elongation can promote amplification through both centriole fragmentation and ectopic procentriole formation. Furthermore, we show that overly long centrioles form over-active centrosomes that nucleate more microtubules, a known cause of invasiveness, and perturb chromosome segregation. Our screen establishes centriole amplification and size deregulation as recurrent features of cancer cells and identifies novel causes and consequences of those abnormalities. Cancer cells are characterised by abnormalities in the number of centrosomes and this phenotype is linked with tumorigenesis. Here the authors report centriole length deregulation in a subset of cancer cell lines and suggest a link with subsequent alterations in centriole numbers and chromosomal instability.

A marauding squirrel triggered a fire at a high-voltage substation Thursday afternoon, dousing power to 8,600 customers for more than four hours and causing major headaches for public works crews and police. \"It took out all of our traffic signals, which caused us a problem,\" said San Fernando police Sgt. David Harvey. \"We had several minor traffic accidents and a lot of phones were down during this time.\" The fire began at the unmanned substation at 15001 Mission Blvd. about 12:20 p.m. when the squirrel crawled onto a circuit breaker and caused an electric arc, or \"flashover,\" said Steve Hansen, spokesman for Southern California Edison.

Miriam Carranza's 9-year-old son was about to board a plane headed for the Olympic Games in Atlanta, and it was all she could do but hold him tight in her arms and sob. Raul and five other Pacoima youths, clad in matching T-shirts and Olympic logo baseball caps, received an Olympic send-off with an entourage of well wishers, teary-eyed family members and media to record the event. It was a big deal for the youths who were going on an all-expense paid trip as spectators to watch the Olympic judo competitions. They also will get a chance to meet and work out with the American judo team.

San Fernando residents were encouraged Thursday night to take on powerful alcohol, billboard and advertising industries in what could be a brutal battle with their children's future lying in the balance. Two leaders in the fight against alcoholic beverage advertising told a group of about 30 at a forum sponsored by the San Fernando and Pacoima chapters of the Alcohol Prevention Coalition that billboards are luring young people into drinking beer and hard liquor, and that the east San Fernando Valley could join other communities that have successfully restricted such advertisements. The forum's goal was to educate community leaders about how alcohol and tobacco billboard advertisements affect youths and communities, said Xavier Flores, a coalition member and executive director of Pueblo Y Salud, a local alcohol prevention agency. Pueblo Y Salud means \"community and health.\"

The Girl Scouts thought they were in trouble, and Kazaam! Shaq was there to help. Newly signed Los Angeles Laker Shaquille O'Neal offered to pay up to $250 a year to allow Girl Scouts to sing songs like \"God Bless America\" and \"This Land is Your Land,\" when it appeared they would have to pay royalty fees or find new campfire favorites.

Leann D'Ercole of Lake Mary said she plans to stave off her jitters when daughter Stephanie starts kindergarten this year by becoming a volunteer at Lake Mary Elementary. \"I'm a little bit nervous about it,\" D'Ercole said, \"but because I plan to be very involved, I'll have a bird's-eye view of what's going on.\"

Let the state officials live on $7.93 per hour and see how fast it increases. Let's go to San Francisco's new minimum wage. Credit: [Larry Hollowell]; [Beth Zaremba]; [Bob Tracey]; [Kent Minor]; [Larry Russo]; [Mari Villarreal]; Frankz [Salazar Arias]; [Linda Stevens Miller]; [Jake Bourgraf]; [Joseph Walden]; [Vanessa Dennis]; [Richard P Horton]; [Francisco Javier Lopez]; STSA; [Becky Brett]; [Barron Kirkpatrick Frazier Brown]