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A woman in her 30s with type 2 diabetes and morbid obesity presented with flu-like symptoms, persistent cough and mild dyspnoea, unresponsive to pneumonia treatment. Diagnosed with acute myeloid leukaemia, she was started on induction chemotherapy. Despite prophylactic antifungal and antibacterial therapy, she developed a fever, a right upper lobe opacity and a complete airway obstruction by a large endobronchial mass in the right main stem. Bronchoscopy with biopsy and PCR confirmed mucormycosis. Although a combined antifungal regimen was started promptly, her condition worsened, leading to acute respiratory distress syndrome, tracheo-pleural fistulas and extensive necrotic mucosa in the airways. Surgical intervention was not feasible, and she was transitioned to hospice. Complete central airway obstruction and trachea-pleural fistula are rare manifestations of pulmonary mucormycosis. We conduct a literature review of endobronchial mucormycosis to highlight the importance of early recognition and a multimodal treatment approach to improve outcomes.

Objectives To determine whether international normalized ratio (INR), bilirubin, and creatinine predict bleeding risk following percutaneous liver biopsy. Methods A total of 870 consecutive patients (age 53 ± 14 years; 53% (459/870) male) undergoing non-targeted, ultrasound-guided, percutaneous liver biopsy at a single tertiary center from 01/2016 to 12/2019 were retrospectively reviewed. Results were analyzed using descriptive statistics and logistic regression models to evaluate the relationship between individual and combined laboratory values, and post-biopsy bleeding risk. Receiver operating characteristic (ROC) curves and area under ROC (AUC) curves were constructed to evaluate predictive ability. Results Post-biopsy bleeding occurred in 2.0% (17/870) of patients, with 0.8% (7/870) requiring intervention. The highest INR within 3 months preceding biopsy demonstrated the best predictive ability for post-biopsy bleeding and was superior to the most recent INR (AUC = 0.79 vs 0.61, p  = 0.003). Total bilirubin is an independent predictor of bleeding (AUC = 0.73) and better than the most recent INR (0.61). Multivariate regression analysis of the highest INR and total bilirubin together yielded no improvement in predictive performance compared to INR alone (0.80 vs 0.79). The MELD score calculated using the highest INR (AUC = 0.79) and most recent INR (AUC = 0.74) were similar in their predictive performance. Creatinine is a poor predictor of bleeding (AUC = 0.61). Threshold analyses demonstrate an INR of > 1.8 to have the highest predictive accuracy for bleeding. Conclusion The highest INR in 3 months preceding ultrasound-guided percutaneous liver biopsy is associated with, and a better predictor for, post-procedural bleeding than the most recent INR and should be considered in patient risk stratification. Clinical relevance statement Despite correction of coagulopathic indices, the highest international normalized ratio within the 3 months preceding percutaneous liver biopsy is associated with, and a better predictor for, bleeding and should considered in clinical decision-making and determining biopsy approach. Key Points • Bleeding occurred in 2% of patients following ultrasound-guided liver biopsy, and was non-trivial in 41% of those patients who needed additional intervention and had an associated 23% 30-day mortality rate. • The highest INR within 3 months preceding biopsy (AUC  =  0.79) is a better predictor of bleeding than the most recent INR (AUC  =  0.61). • The MELD score is associated with post-procedural bleeding, but with variable predictive performance largely driven by its individual laboratory components.

With the rising demands for energy storage in recent years, finding materials for battery production that are durable and environmentally friendly has been receiving wider attention among scientists than ever before. Among renewable energy sources, black liquor from rice husk pretreatment processes has been shown to possess huge potential for anodic electrodes in lithium-ion batteries due to their high silica content. In a similar manner, black liquor from rice straw material, which has not been widely investigated, can also be a prospective candidate with its high concentration of silica. This study, therefore, retrieved lignin-silica hybrids from black liquor originating from the rice straw pretreatment stage for lithium battery anode production. The carbonized lignin–silica material experienced an enhanced initial specific charge capacity of 1668 mAh g −1 and a stable cycling capacity at 100 cycles. Based on these achievements, the study created profound progress in valorizing black liquors to solve environmental problems as well as provided a new resource to support energy storage technology.

This study aims to provide broad information on integrated reporting, including authors, journals, countries and references. Using Scopus data source from 2012 to 2024 with 468 studies on integrated reports for bibliometric analysis with the support of VOS viewer software version 1.6.20. The results show that there are not many studies addressing IR, especially in developing countries, but only focus on a few large economies. Some research characteristics related to the topic of IR have also been pointed out such as the main type of documents are scientific articles (94%), some journals from reputable publishers have a large number of publications, the research fields related to IR are still business, management and accounting (93.8%). In addition, after using the techniques, there are 05 research directions that have been implemented related to integrated reporting: (1) Research on financial statements based on the aspects of capital costs and enterprise value, voluntary disclosure; (2) Research on financial statements based on agency theory, board of directors and financial statement disclosure risk; (3) Research on financial statements based on stakeholder theory and enterprise performance; (4) Research on financial statements based on financial statement templates and non-financial information; (5) Research on financial statements based on materiality and stakeholders. From there, it opens up future research expectations. However, this study only uses data sources from Scopus, so the analysis results may not cover all published studies. Further studies can add data from other sources to increase the objectivity of the research results.

Prochlorococcus and Synechococcus are abundant marine picocyanobacteria that contribute significantly to ocean primary production. Recent genome sequencing efforts, including those presented here, have yielded a large number of high-quality reference genomes, enabling the classification of these picocyanobacteria in marine metagenomic sequence data at high phylogenetic resolution. When combined with environmental data, these classifications can guide cluster/clade/grade assignments and offer insights into niche differentiation within these populations. Here we present ProSynTax, a curated protein sequence dataset and accompanying classification workflow aimed at enhancing the taxonomic resolution of Prochlorococcus and Synechococcus classification. ProSynTax includes proteins from 1,260 genomes of Prochlorococcus and Synechococcus , including single-amplified genomes, high-quality draft genomes, and newly closed genomes. Additionally, ProSynTax incorporates proteins from 41,753 genomes of marine heterotrophic bacteria, archaea, and viruses to assess microbial and viral communities surrounding Prochlorococcus and Synechococcus . This resource enables accurate classification of picocyanobacterial clusters/clades/grades in metagenomic data – even when present at 0.15% of reads for Prochlorococcus or 0.03% of reads for Synechococcus .

The objective of this study was to determine influence of various factors on the ability to apply integrated reporting (IR) as well as IR's impact on firm performance (FP), from the perspectives of auditors. Data were collected via a questionnaire completed by 386 auditors at five career levels currently working at auditing firms in Vietnam. The results showed that the ability to apply IR in listed enterprises is affected by six factors: (a) firm size, (b) business sector, (c) business profitability, (d) management's perspective, (e) legal regulations (positive impact), and (f) pressure from stakeholders (negative impact). Business profitability was the most influential factor. This study also shows that there is a positive relationship between the ability to apply IR and FP; however, both moderating variables (information disclosure and auditors' career level) did not have a statistically significant impact on this relationship. The results of this study enrich other empirical studies related to IR and FP of listed enterprises.

Mediastinal masses are commonly identified in the pediatric population with cross-sectional imaging central to the diagnosis and management of these lesions. With greater anatomical definition afforded by cross-sectional imaging, classification of mediastinal masses into the traditional anterior, middle and posterior mediastinal compartments — as based on the lateral chest radiograph — has diminishing application. In recent years, the International Thymic Malignancy Interest Group (ITMIG) classification system of mediastinal masses, which is cross-sectionally based, has garnered acceptance by multiple thoracic societies and been applied in adults. Therefore, there is a need for pediatric radiologists to clearly understand the ITMIG classification system and how it applies to the pediatric population. The main purpose of this article is to provide an updated review of common pediatric mediastinal masses and mediastinal manifestations of systemic disease processes in the pediatric population based on the new ITMIG classification system.

This study applies the Stimulus-Organism-Response (S-O-R) to clarify how the characteristics of Key Opinion Leaders (KOLs) in live streaming commerce affect impulsive buying behavior. While prior studies primarily focused on marketing activities rather than the direct impact of KOLs' perceived persuasiveness, this study addresses that gap by offering a fully understanding of KOL's impact in both live-streaming features and KOLs themselves. The data from 360 Gen Z participants analyzed via SmartPLS 4.0 and SPSS software 26.0 confirmed that these attributes including popularity, attractiveness, trustworthiness, expertise and all live stream characteristics significantly impact KOLs' perceived persuasiveness in terms of driving impulse buying behaviors. Notably, fear of missing out (FOMO) and deal proneness do not moderate perceived persuasiveness and impulse buying, challenging conventional assumptions in livestreaming commerce. These findings suggest that enterprises should incorporate KOLs with specific characteristics in live streaming commerce to drive purchases among Vietnamese Gen Z users. They can effectively decide on KOLs by applying the verified criteria gained through our study. Moreover, brands should not make excessive use of and rely heavily on deal proneness and FOMO because consumers are becoming wiser in the era of technology.

The gradual loss of kidney function due to increasing age is accompanied by structural changes such as fibrosis of the tissue. The underlying molecular mechanisms are complex, but not yet fully understood. Non-fibrillar collagen type VIII (COL8) could be a potential factor in the fibrosis processes of the aging kidney. A pathophysiological significance of COL8 has already been demonstrated in the context of diabetic kidney disease, with studies showing that it directly influences both the development and progression of renal fibrosis occurring. The aim of this study was to investigate whether COL8 impacts age-related micro-anatomical and functional changes in a mouse model. The kidneys of wild-type (Col8-wt) and COL8-knockout (Col8-ko) mice of different age and sex were characterized with regard to the expression of molecular fibrosis markers, the development of nephrosclerosis and renal function. The age-dependent regulation of COL8 mRNA expression in the wild-type revealed sex-dependent effects that were not observed with collagen IV (COL4). Histochemical staining and protein analysis of profibrotic cytokines TGF-β1 (transforming growth factor) and CTGF (connective tissue growth factor) in mouse kidneys showed significant age effects as well as interactions of the factors age, sex and Col8 genotype. There were also significant age and Col8 genotype effects in the renal function data analyzed by urinary cystatin C. In summary, the present study shows, for the first time, that COL8 is regulated in an age- and sex-dependent manner in the mouse kidney and that the expression of COL8 influences the severity of age-induced renal fibrosis and function.

A plethora of present studies has the purpose of analyzing the connection related to the effect of environmental, social, and governance (ESG) on business performance. However, it has still not been able to bring out comprehensive results because of using a single metric to measure performance. Due to that, this research will: (i) use the data envelopment analysis (DEA) method to measure transportation firms’ performance and (ii) use OLS regression to explore the relationship between ESG combined score and business performance. In the first stage, we found out that 43 out of 56 firms work inefficiently. The managers of those companies should utilize their resources and refer to the benchmarking as a sample to follow. The environmental and social scores positively affect business performance in the second stage. Thus, managers should consider ESG as an investment, primarily when transportation is categorized as an “environmentally sensitive industry”. Besides, investors should pay more attention to a company that has ESG activities because that firm has the chance to improve its business performance and deal with its commitments.