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result(s) for
"Volponi, Paul"
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Homestretch
Five months after losing his mother, seventeen-year-old Gas runs away from an abusive father and gets a job working at an Arkansas race track, surrounded by the illegal Mexican immigrants that he and his father blame for her death.
Book
The great G.O.A.T. debate : the best of the best in everything from sports to science
\"This book will expand the horizons of teen and pre-teen readers in an exciting and engaging way, by debating the Greatest of All Time in a variety of categories. Topics include the greatest athlete of all time, greatest band, greatest inventor, greatest scientist, greatest writer, greatest sci-fi franchise, and more\"-- Provided by publisher.
Book
'Hit Count,' by Chris Lynch
A story about a fanatical high school football player meshes with current attention on the sport's culture and risks.
Newspaper Article
Superhero smart : real-world facts behind comic book characters
\"In a fast-paced, accessible narrative, award-winning young adult author Paul Volponi explores the real-life science, history, and literature behind comic book superheroes' powers and origins\"-- Provided by publisher.
Book
Helmet Heads
IT'S ONE THING when a novel about a meaningful subject gets published at a time when a media storm surrounding that subject is beginning to brew. But add to the mix an author who can really get the crosswinds blowing and there is truly cause to marvel. That's the case with Chris Lynch's \"Hit Count,\" a powerful...
Book Review
Defining human mesenchymal and epithelial heterogeneity in response to oral inflammatory disease
Human oral soft tissues provide the first barrier of defence against chronic inflammatory disease and hold a remarkable scarless wounding phenotype. Tissue homeostasis requires coordinated actions of epithelial, mesenchymal, and immune cells. However, the extent of heterogeneity within the human oral mucosa and how tissue cell types are affected during the course of disease progression is unknown. Using single-cell transcriptome profiling we reveal a striking remodelling of the epithelial and mesenchymal niches with a decrease in functional populations that are linked to the aetiology of the disease. Analysis of ligand–receptor interaction pairs identify potential intercellular hubs driving the inflammatory component of the disease. Our work establishes a reference map of the human oral mucosa in health and disease, and a framework for the development of new therapeutic strategies.
Journal Article
Photobiomodulation—Underlying Mechanism and Clinical Applications
The purpose of this study is to explore the possibilities for the application of laser therapy in medicine and dentistry by analyzing lasers’ underlying mechanism of action on different cells, with a special focus on stem cells and mechanisms of repair. The interest in the application of laser therapy in medicine and dentistry has remarkably increased in the last decade. There are different types of lasers available and their usage is well defined by different parameters, such as: wavelength, energy density, power output, and duration of radiation. Laser irradiation can induce a photobiomodulatory (PBM) effect on cells and tissues, contributing to a directed modulation of cell behaviors, enhancing the processes of tissue repair. Photobiomodulation (PBM), also known as low-level laser therapy (LLLT), can induce cell proliferation and enhance stem cell differentiation. Laser therapy is a non-invasive method that contributes to pain relief and reduces inflammation, parallel to the enhanced healing and tissue repair processes. The application of these properties was employed and observed in the treatment of various diseases and conditions, such as diabetes, brain injury, spinal cord damage, dermatological conditions, oral irritation, and in different areas of dentistry.
Journal Article
Inclusion Biogenesis, Methods of Isolation and Clinical Application of Human Cellular Exosomes
Exosomes are a heterogenous subpopulation of extracellular vesicles 30–150 nm in range and of endosome-derived origin. We explored the exosome formation through different systems, including the endosomal sorting complex required for transport (ESCRT) and ESCRT-independent system, looking at the mechanisms of release. Different isolation techniques and specificities of exosomes from different tissues and cells are also discussed. Despite more than 30 years of research that followed their definition and indicated their important role in cellular physiology, the exosome biology is still in its infancy with rapidly growing interest. The reasons for the rapid increase in interest with respect to exosome biology is because they provide means of intercellular communication and transmission of macromolecules between cells, with a potential role in the development of diseases. Moreover, they have been investigated as prognostic biomarkers, with a potential for further development as diagnostic tools for neurodegenerative diseases and cancer. The interest grows further with the fact that exosomes were reported as useful vectors for drugs.
Journal Article