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Laser–electron beam collisions that aim to generate electron–positron pairs require laser intensities I ≳ 1021 W cm−2, which can be obtained by focusing a 1-PW optical laser to a spot smaller than 10 μm. Spatial synchronization is a challenge because of the Poynting instability that can be a concern both for the interacting electron beam (if laser-generated) and the scattering laser. One strategy to overcome this problem is to use an electron beam coming from an accelerator (e.g., the planned E-320 experiment at FACET-II). Even using a stable accelerator beam, the plane wave approximation is too simplistic to describe the laser–electron scattering. This work extends analytical scaling laws for pair production, previously derived for the case of a plane wave and a short electron beam. We consider a focused laser beam colliding with electron beams of different shapes and sizes. The results take the spatial and temporal synchronization of the interaction into account, can be extended to arbitrary beam shapes, and prescribe the optimization strategies for near-future experiments.

The new generation of laser facilities is expected to deliver short (10 fs–100 fs) laser pulses with 10–100 PW of peak power. This opens an opportunity to study matter at extreme intensities in the laboratory and provides access to new physics. Here we propose to scatter GeV-class electron beams from laser-plasma accelerators with a multi-PW laser at normal incidence. In this configuration, one can both create and accelerate electron-positron pairs. The new particles are generated in the laser focus and gain relativistic momentum in the direction of laser propagation. Short focal length is an advantage, as it allows the particles to be ejected from the focal region with a net energy gain in vacuum. Electron-positron beams obtained in this setup have a low divergence, are quasi-neutral and spatially separated from the initial electron beam. The pairs attain multi-GeV energies which are not limited by the maximum energy of the initial electron beam. We present an analytical model for the expected energy cutoff, supported by 2D and 3D particle-in-cell simulations. The experimental implications, such as the sensitivity to temporal synchronisation and laser duration is assessed to provide guidance for the future experiments.

In this paper, we investigate the evolution of the energy spread and the divergence of electron beams while they interact with different laser pulses at intensities where quantum effects and radiation reaction are of relevance. The interaction is modelled with a quantum electrodynamic (QED)-PIC code and the results are compared with those obtained using a standard PIC code with a classical radiation reaction module. In addition, an analytical model is presented that estimates the value of the final electron energy spread after the interaction with the laser has finished. While classical radiation reaction is a continuous process, in QED, radiation emission is stochastic. The two pictures reconcile in the limit when the emitted photons energy is small compared to the energy of the emitting electrons. The energy spread of the electron distribution function always tends to decrease with classical radiation reaction, whereas the stochastic QED emission can also enlarge it. These two tendencies compete in the QED-dominated regime. Our analysis, supported by the QED module, reveals an upper limit to the maximal attainable energy spread due to stochasticity that depends on laser intensity and the electron beam average energy. Beyond this limit, the energy spread decreases. These findings are verified for different laser pulse lengths ranging from short ∼30 fs pulses presently available to the long ∼150 fs pulses expected in the near-future laser facilities, and compared with a theoretical model. Our results also show that near future experiments will be able to probe this transition and to demonstrate the competition between enhanced QED induced energy spread and energy spectrum narrowing from classical radiation reaction.

Plasma-based accelerators use the strong electromagnetic fields that can be supported by plasmas to accelerate charged particles to high energies. Accelerating field structures in plasma can be generated by powerful laser pulses or charged particle beams. This research field has recently transitioned from involving a few small-scale efforts to the development of national and international networks of scientists supported by substantial investment in large-scale research infrastructure. In this New Journal of Physics 2020 Plasma Accelerator Roadmap, perspectives from experts in this field provide a summary overview of the field and insights into the research needs and developments for an international audience of scientists, including graduate students and researchers entering the field.

Relativistic positron beams are required for fundamental research in nonlinear strong field QED, plasma physics, and laboratory astrophysics. Positrons are difficult to create and manipulate due to their short lifetime, and their energy gain is limited by the accelerator size in conventional facilities. Alternative compact accelerator concepts in plasmas are becoming more and more mature for electrons, but positron generation and acceleration remain an outstanding challenge. Here, we propose a new setup where we can generate, inject, and accelerate them in a single stage during the propagation of an intense laser in a plasma channel. The positrons are created from a laser-electron collision at 90°, where the injection and guiding are made possible by an 800-nC electron beam loading which reverses the sign of the background electrostatic field. We obtain a 17-fC positron beam, with GeV-level central energy within 0.5 mm of plasma.

The intensities of the order of 10 23–24  W/cm 2 are required to efficiently generate electron-positron pairs in laser-matter interaction when multiple laser beam collision is employed. To achieve such intense laser fields with the upcoming generation of 10 PW laser beams, focusing to sub-micron spot size is required. In this paper, the possibility of pair production cascade development is studied for the case of a standing wave created by two tightly focused colliding laser pulses. Even though the stronger ponderomotive force expels the seed particles from the interaction volume when a tightly focused laser beam is used, tight focusing allows to achieve cascade pair production due to the higher intensity in the focal spot. Optimizing the target density can compensate the expulsion by the ponderomotive force and lower the threshold power required for cascade pair production. This will in principle allow to produce pairs with 10 PW-class laser facilities which are now under construction and will become accessible soon.

Light–matter interactions driven by ultrahigh-intensity lasers have great potential to uncover the physics associated with quantum electrodynamics (QED) processes occurring in neutron stars and black holes. The Compton scattering between an ultra-relativistic electron beam and an intense laser can reveal a new interaction regime, known as strong-field QED. Here we present an experimental demonstration of nonlinear Compton scattering in a strong laser field, in which a laser-accelerated multi-gigaelectronvolt electron scatters off hundreds of laser photons and converts them into a single gamma-ray photon with several-hundred-megaelectronvolt energy. Along with particle-in-cell (PIC)-QED simulations and analytical calculations, our experimental measurement of gamma-ray spectra verifies the occurrence of Compton scattering in the strongly nonlinear regime, paving the road to examine nonlinear Breit–Wheeler pair production and QED cascades. Researchers demonstrate nonlinear Compton scattering in a strong laser field, in which a laser-accelerated multi-GeV electron scatters off hundreds of laser photons and converts them into a single gamma-ray photon with several-hundred-MeV energy.

Hepcidin-25 was identified as the main iron regulator in the human body, and it by binds to the sole iron-exporter ferroportin. Studies showed that the N-terminus of hepcidin is responsible for this interaction, the same N-terminus that encompasses a small copper(II)-binding site known as the ATCUN (amino-terminal Cu(II)- and Ni(II)-binding) motif. Interestingly, this copper-binding property is largely ignored in most papers dealing with hepcidin-25. In this context, detailed investigations of the complex formed between hepcidin-25 and copper could reveal insight into its biological role. The present work focuses on metal-bound hepcidin-25 that can be considered the biologically active form. The first part is devoted to the reversed-phase chromatographic separation of copper-bound and copper-free hepcidin-25 achieved by applying basic mobile phases containing 0.1% ammonia. Further, mass spectrometry (tandem mass spectrometry (MS/MS), high-resolution mass spectrometry (HRMS)) and nuclear magnetic resonance (NMR) spectroscopy were employed to characterize the copper-peptide. Lastly, a three-dimensional (3D) model of hepcidin-25 with bound copper(II) is presented. The identification of metal complexes and potential isoforms and isomers, from which the latter usually are left undetected by mass spectrometry, led to the conclusion that complementary analytical methods are needed to characterize a peptide calibrant or reference material comprehensively. Quantitative nuclear magnetic resonance (qNMR), inductively-coupled plasma mass spectrometry (ICP-MS), ion-mobility spectrometry (IMS) and chiral amino acid analysis (AAA) should be considered among others.

Abstract Plasma-based accelerators use the strong electromagnetic fields that can be supported by plasmas to accelerate charged particles to high energies. Accelerating field structures in plasma can be generated by powerful laser pulses or charged particle beams. This research field has recently transitioned from involving a few small-scale efforts to the development of national and international networks of scientists supported by substantial investment in large-scale research infrastructure. In this New Journal of Physics 2020 Plasma Accelerator Roadmap, perspectives from experts in this field provide a summary overview of the field and insights into the research needs and developments for an international audience of scientists, including graduate students and researchers entering the field.

The new generation of multi-PetaWatt laser facilities will allow tests of Strong Field QED, as well as provide an opportunity for novel photon and lepton sources. The first experiments are planned to study the (nearly) head-on scattering of intense, focused laser pulses with either relativistic electron beams or high-energy photon sources. In this work, we present a numerical framework that can provide fast predictions of the asymptotic particle and photon distributions after the scattering. The works presented in this manuscript includes multiple features such as spatial and temporal misalignment between the laser and the scattering beam, broadband electron beams, and beam divergence. The expected mean energy, energy spread, divergence or other observables are calculated by combining an analytical description and numerical integration. This method can provide results within minutes on a personal computer, which would otherwise require full-scale 3D QED-PIC simulations using thousands of cores. The model, which has been compiled into an open-source code QScatter, may be used to support the analysis of large-size data sets from high-repetition rate experiments, leveraging its speed for optimization or reconstruction of experimental parameters.