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The under-representation of several ethnic groups in existing genetic databases and studies have undermined our understanding of the genetic variations and associated traits or diseases in many populations. Cost and technology limitations remain the challenges in performing large-scale genome sequencing projects in many developing countries, including Vietnam. As one of the most rapidly adopted genetic tests, non-invasive prenatal testing (NIPT) data offers an alternative untapped resource for genetic studies. Here we performed a large-scale genomic analysis of 2683 pregnant Vietnamese women using their NIPT data and identified a comprehensive set of 8,054,515 single-nucleotide polymorphisms, among which 8.2% were new to the Vietnamese population. Our study also revealed 24,487 disease-associated genetic variants and their allele frequency distribution, especially 5 pathogenic variants for prevalent genetic disorders in Vietnam. We also observed major discrepancies in the allele frequency distribution of disease-associated genetic variants between the Vietnamese and other populations, thus highlighting a need for genome-wide association studies dedicated to the Vietnamese population. The resulted database of Vietnamese genetic variants, their allele frequency distribution, and their associated diseases presents a valuable resource for future genetic studies.

The paper introduces a design of a nonlinear observer for the estimation of load torque of induction motors based on the output of the stator currents. The observer is built in the synchronous reference frame d-q with three main steps. First, the nonlinear observer for the class of non-affine control systems is reviewed. Second, the induction motor model is written in an appropriate form as a non-affine control system with canonical form for the design of the nonlinear observer. The system state is composed of the stator currents, speed and load torque. Based on the stator currents, the rotor flux leakages are estimated via an open loop and used for the load torque observer. The observer is designed with a constant gain which is calculated by considering the trajectory of the rotor flux leakages. Both the load torque and rotor speed can be estimated by using the proposed observer. Finally, simulation and experiment are carried to validate the effectiveness and robustness of the proposed observer.

For the objective of improving the reliability of converters in electric drives, research on a method for early detection of intermittent open-circuit faults of power valves is reported in this article. Intermittent open circuit condition is the incipient form of power valve open-circuit fault in power converters. Prompt detection of this fault allows for timely remediation of permanent open circuit defects that is a commonly subsequent process. This study introduces an investigation of this fault, which occurs in the voltage source inverter of induction motor drives. Intermittent faults are created through interference with the control pulse of the power valve. Wavelet transform with the Mexican hat mother function is utilized for signal processing. Appropriate ranges of the scale are selected to obtain a high magnitude of the wavelet coefficient at faulty instants. The analysis for the direct current recorded at the DC-link in simulation and the electromagnetic signal measured at the DC-bus of the inverter can be effectively used for the fault diagnosis.

Despite efforts to adopt at-source waste separation, Tan An city’s solid waste management is under strain due to a lack of infrastructure. The demand of the scrap recycling market has resulted in the forming of a network of informal scrap trading establishments everywhere. Informal garbage workers efficiently collect (pick, buy) scraps from homes, grocery stores, businesses, workplaces, schools, parks, dump sites, and landfills. This boosts waste segregation at the source. Therefore, in Tan An city, most households separate recyclables for sale to informal waste workers. According to survey results, there are approximately 247 informal waste workers in Tan An City engaged in recyclables collection at a daily average rate of 69.66 kilograms per person. Thus, the total quantity of recyclables collected by this sector is approximately 17,260 kg per day, contributing to the daily diversion of 11.4% of waste from landfills. It helps that the annual savings to the city are estimated at VND 2.75 billion for waste collection and transportation and VND 2.47 billion for waste treatment. It also contributes to the creation of jobs, and the reduction of plastic emissions into the ocean because approximately 28.39% of recyclables are plastic waste, and the reduction of approximately 3.076 tons of CO 2 emissions into the atmosphere if this amount of waste is transported to a landfill. This study could initiate further research to find a way to introduce modern initiatives that aim to improve working conditions and the environmental impact of the informal sector and include the informal sector into the EPR scheme as their integration is related to social, labor, health, economic, and other issues.

Background Multi‐cancer early detection (MCED) through a single blood test significantly advances cancer diagnosis. However, most MCED tests rely on a single type of biomarkers, leading to limited sensitivity, particularly for early‐stage cancers. We previously developed SPOT‐MAS, a multimodal ctDNA‐based assay analyzing methylation and fragmentomic profiles to detect five common cancers. Despite its potential, SPOT‐MAS exhibited moderate sensitivities for early‐stage cancers. This study investigated whether integrating hotspot mutations into SPOT‐MAS could enhance its detection rates. Method A targeted amplicon sequencing approach was developed to profile 700 hotspot mutations in cell‐free DNA and integrated into the SPOT‐MAS assay, creating a single‐blood draw workflow. This workflow, namely SPOT‐MAS Plus was retrospectively validated in a cohort of 255 non‐metastatic cancer patients (breast, colorectal, gastric, liver, and lung) and 304 healthy individuals. Results Hotspot mutations were detected in 131 of 255 (51.4%) cancer patients, with the highest rates in liver cancer (96.5%), followed by colorectal (59.3%) and lung cancer (53.7%). Lower detection rates were found for cancers with low tumor mutational burden, such as breast (31.3%) and gastric (41.9%) cancers. In contrast, SPOT‐MAS demonstrated higher sensitivities for these cancers (51.6% for breast and 62.9% for gastric). The combination of hotspot mutations with SPOT‐MAS predictions improved early‐stage cancer detection, achieving an overall sensitivity of 78.5% at a specificity of 97.7%. Enhanced sensitivities were observed for colorectal (81.36%) and lung cancer (82.9%). Conclusion The integration of genetic and epigenetic alterations into a multimodal assay significantly enhances the early detection of various cancers. Further validation in larger cohorts is necessary to support broader clinical applications.

Climate change adaptation indicators have played a critical role in the increased understanding of potential climate change impacts. In this research, 6 climate change adaptation indicators were identified for Can Tho City in the Mekong Delta of Vietnam: (1) Rice production from wastewater during winter-spring crop; (2) % of irrigation water demand satisfied by treated wastewater; (3) % of nutrient demand satisfied by treated wastewater; (4) % remaining flow downstream of Can Tho in the Hau River; (5) environmental benefits; and (6) total investment cost for wastewater treatment. These indices were selected to assess various options/strategies for wastewater management and reuse in Can Tho City as a means to improve the City’s resilience to climate change. From an environmental perspective, this study shows the benefits for Can Tho City to set up a strategy to treat and reuse wastewater from catfish farming as the priority among four assessed scenarios with different climate change impact factors. It is concluded that adaptation can be assessed by the indicators because they can define whether adaptation policies and measures are implemented and whether vulnerability is reduced through effective actions.

Recently, the use of DC microgrid distribution system has become more attractive than traditional AC systems due to their energy efficiency and ability to easily integrate with renewable energy sources and batteries. This paper proposes a 500 V DC microgrid which consists of a 20 kWp photovoltaic panel, batteries, and DC loads. A hierarchical control strategy to ensure balance power of the DC microgrid and the maintenance of common DC bus voltage is presented. The capability of exchanging power energy of the microgrid with the power system of neighborhood buildings is also considered. Typical operation modes are simulated in the Matlab/simulink environment to confirm the good performance of the controllers and the efficiency of appropriately controlling the charge–discharge of the battery system. This research is expected to bring benefits to the design and operation of the system, such as reducing the capacity of batteries, increasing the self-supply of buildings, and decreasing the electricity demand from the AC grid.

The under-representation of several ethnic groups in existing genetic databases and studies have undermined our understanding of the genetic variations and associated traits or diseases in many populations. Cost and technology limitations remain the challenges in performing large-scale genome sequencing projects in many developing countries, including Vietnam. As one of the most rapidly adopted genetic tests, non-invasive prenatal testing (NIPT) data offers an alternative untapped resource for genetic studies. Here we performed a large-scale genomic analysis of 2,683 pregnant Vietnamese women using their NIPT data and identified a comprehensive set of 8,054,515 single-nucleotide polymorphisms, among which 8.2% were new to the Vietnamese population. Our study also revealed 24,487 disease-associated genetic variants and their allele frequency distribution, especially 5 pathogenic variants for prevalent genetic disorders in Vietnam. We also observed major discrepancies in the allele frequency distribution of disease-associated genetic variants between the Vietnamese and other populations, thus highlighting a need for genome-wide association studies dedicated to the Vietnamese population. The resulted database of Vietnamese genetic variants, their allele frequency distribution, and their associated diseases presents a valuable resource for future genetic studies.

The coronavirus disease (COVID-19) pandemic has impacted the economy, livelihood, and physical and mental well-being of people worldwide. This study aimed to compare the mental health status during the pandemic in the general population of seven middle income countries (MICs) in Asia (China, Iran, Malaysia, Pakistan, Philippines, Thailand, and Vietnam). All the countries used the Impact of Event Scale–Revised (IES-R) and Depression, Anxiety and Stress Scale (DASS-21) to measure mental health. There were 4479 Asians completed the questionnaire with demographic characteristics, physical symptoms and health service utilization, contact history, knowledge and concern, precautionary measure, and rated their mental health with the IES-R and DASS-21. Descriptive statistics, One-Way analysis of variance (ANOVA), and linear regression were used to identify protective and risk factors associated with mental health parameters. There were significant differences in IES-R and DASS-21 scores between 7 MICs (p<0.05). Thailand had all the highest scores of IES-R, DASS-21 stress, anxiety, and depression scores whereas Vietnam had all the lowest scores. The risk factors for adverse mental health during the COVID-19 pandemic include age <30 years, high education background, single and separated status, discrimination by other countries and contact with people with COVID-19 (p<0.05). The protective factors for mental health include male gender, staying with children or more than 6 people in the same household, employment, confidence in doctors, high perceived likelihood of survival, and spending less time on health information (p<0.05). This comparative study among 7 MICs enhanced the understanding of metal health in the general population during the COVID-19 pandemic.

Novel coronavirus disease 19 (COVID-19) is a global threat to millions of lives. Enormous efforts in knowledge production have been made in the last few months, requiring a comprehensive analysis to examine the research gaps and to help guide an agenda for further studies. This study aims to explore the current research foci and their country variations regarding levels of income and COVID-19 transmission features. This textual analysis of 5780 publications extracted from the Web of Science, Medline, and Scopus databases was performed to explore the current research foci and propose further research agenda. The Latent Dirichlet allocation was used for topic modeling. Regression analysis was conducted to examine country variations in the research foci. Results indicate that publications are mainly contributed by the United States, China, and European countries. Guidelines for emergency care and surgical, viral pathogenesis, and global responses in the COVID-19 pandemic are the most common topics. There is variation in the research approaches to mitigate COVID-19 problems in countries with different income and transmission levels. Findings highlighted the need for global research collaborations among high- and low/middle-income countries in the different stages of pandemic prevention and control.