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"WŁOCH, J"
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Multivariate analysis of prognostic factors for differentiated thyroid carcinoma in children
At most centres, the standard treatment for differentiated thyroid cancer (DTC) comprises total thyroidectomy, radioiodine treatment and thyroid-stimulating hormone (TSH) suppressive therapy. There is, however, considerable disagreement over the appropriate treatment for DTC in children. Some dispute the use of total thyroidectomy and/or question the routine application of iodine-131 therapy in children. The aim of this study was to perform a retrospective analysis of treatment results and prognostic factors for DTC in children treated at our centre. The study included 109 children with DTC (aged 6-17 years). The primary treatment comprised total thyroidectomy in 81 cases, radioiodine therapy in 85 cases and TSH suppressive therapy with L-thyroxine in all patients. Uni- and multivariate analysis of prognostic factors for disease-free survival was performed using the Cox regression method. The actuarial survival rate was 100%, and the 5- and 10-year actuarial disease-free survival rates were 80% and 61% respectively. Univariate analysis revealed that older age, total thyroidectomy and radioiodine treatment had a positive impact on disease-free survival whereas there were no statistical differences with regard to the child's sex, histological type of cancer or lymph node status. On multivariate analysis, radical surgery was estimated to be the most significant factor (P=0.007) for disease-free survival, while less than total thyroidectomy increased the relative risk of relapse by a factor of 10. Radioiodine treatment decreased the relative risk of relapse by a factor of 5, but with borderline significance (P=0.07). Permanent postoperative complications were observed in 17% of children: in 11 laryngeal palsy occurred, in six there was hypoparathyroidism, and one suffered from both. It is concluded that total thyroidectomy and radioiodine treatment significantly improve recurrence-free survival in children and should be routinely applied even in young children as the primary treatment of DTC.
Journal Article
Total Thyroidectomy and Adjuvant Radioiodine Treatment Independently Decrease Locoregional Recurrence Risk in Childhood and Adolescent Differentiated Thyroid Cancer
We sought to assess whether extensive surgical treatment, postsurgical radioiodine therapy, or both decrease the risk of locoregional recurrence (LR) after curative primary treatment in children and adolescents diagnosed with differentiated thyroid cancer (DTC) at age
Journal Article
Is there loss or qualitative changes in the expression of thyroid peroxidase protein in thyroid epithelial cancer?
There is disagreement concerning the expression of thyroid peroxidase (TPO) in thyroid cancer, some studies finding qualitative as well as quantitative differences compared to normal tissue. To investigate TPO protein expression and its antigenic properties, TPO was captured from a solubilizate of thyroid microsomes by a panel of murine anti-TPO monoclonal antibodies and detected with a panel of anti-human TPO IgGκ Fab. TPO protein expression in 30 samples of malignant thyroid tissue was compared with TPO from adjacent normal tissues. Virtual absence of TPO expression was observed in 8 cases. In the remaining 22 malignant thyroid tumours the TPO protein level varied considerably from normal to nearly absent when compared to normal thyroid tissue or tissues from patients with Graves’ disease (range less than 0.5 to more than 12.5 μg mg
–1
of protein). When expressed TPO displayed similar epitopes, to that of TPO from Graves’ disease tissue. The results obtained by the TPO capturing method were confirmed by SDS-PAGE and Western blot analysis with both microsomes and their solubilizates. The present results show that in about two-thirds of differentiated thyroid carcinomas, TPO protein is expressed, albeit to a more variable extent than normal; when present, TPO in malignant tissues is immunologically normal. © 2001 Cancer Research Campaign
http://www.bjcancer.com
Journal Article
RET polymorphisms in codons 769 and 836 are not associated with predisposition to medullary thyroid carcinoma
The study was undertaken to verify whether the
RET gene polymorphisms are associated with MTC in patients negative for germline mutations.
Two hundred five patients with apparent sporadic MTC were subjected to genetic analysis of
RET exons 10, 11, 13, 14, 16 and 22
RET germline mutation carriers were identified with 10.7% frequency. The frequency among 26 patients not older than 30 was 27%. In patients excluded for known mutations we analyzed two polymorphic sites:
RET codon 769 and 836. As control group, 90 healthy subjects were investigated. In young patients the observed allelic frequencies were 32% for variant L769/CTG and 5% for variant S836/AGT. Although these values were higher than in older MTC patients (22 and 3%, respectively), as well as in the control group (27 and 2%) the difference was insignificant.
We conclude that in Polish patients polymorphisms at
RET codons 769 and 836 are not associated with medullary thyroid carcinoma.
Journal Article
High frequency of recurrent mutations in BRCA1 and BRCA2 genes in Polish families with breast and ovarian cancer
Germ‐line mutations in BRCA1 and BRCA2 genes result in a significantly increased risk of breast and ovarian cancer. Other genes involved in an increased predisposition to breast cancer include the TP53 gene, mutated in Li‐Fraumeni syndrome. To estimate the frequency of germ‐line mutations in these three genes in Upper Silesia, we have analyzed 47 breast/ovarian cancer families from that region. We found five different disease predisposing mutations in 17 (36%) families. Twelve families (25.5%) carried known BRCA1 mutations (5382insC and C61G), four families (8.5%) carried novel BRCA2 mutations (9631delC and 6886delGAAAA), and one family (2%) harbored novel mutation 1095del8 in the TP53 gene, which is the largest germline deletion in coding sequence of this gene identified thus far. The 5382insC mutation in BRCA1 was found in 11 families and the 9631delC mutation in BRCA2 occurred in three families. These two mutations taken together contribute to 82% of all mutations found in this study, and 30% of the families investigated harbor one of these mutations. The very high frequency of common mutations observed in these families can only be compared to that reported for Ashkenazi Jewish, Icelandic, and Russian high‐risk families. This frequency, however, may not be representative for the entire Polish population. The observed distribution of mutations will favor routine pre‐screening of predisposed families using a simple and cost‐effective test. Hum Mutat 16:482–490, 2000. © 2000 Wiley‐Liss, Inc.
Journal Article
Differential Cross Section for Proton Induced Deuteron Breakup at 108 MeV
The differential cross sections for the proton-deuteron breakup reaction have been measured for more than 200 angular configurations of outgoing protons in the range of polar angles from 13 to 27 degrees with a proton beam at 108 MeV. The paper presents the experimental results of the selected configurations, which are compared to state-of-the-art theoretical calculations. In some regions of the phase space, a strong influence of the Coulomb interaction is observed.
Journal Article
Recent Advances in the Control of Clinically Important Biofilms
Biofilms are complex structures formed by bacteria, fungi, or even viruses on biotic and abiotic surfaces, and they can be found in almost any part of the human body. The prevalence of biofilm-associated diseases has increased in recent years, mainly because of the frequent use of indwelling medical devices that create opportunities for clinically important bacteria and fungi to form biofilms either on the device or on the neighboring tissues. As a result of their resistance to antibiotics and host immunity factors, biofilms have been associated with the development or persistence of several clinically important diseases. The inability to completely eradicate biofilms drastically increases the burden of disease on both the patient and the healthcare system. Therefore, it is crucial to develop innovative ways to tackle the growth and development of biofilms. This review focuses on dental- and implant-associated biofilm infections, their prevalence in humans, and potential therapeutic intervention strategies, including the recent advances in pharmacology and biomedical engineering. It lists current strategies used to control the formation of clinically important biofilms, including novel antibiotics and their carriers, antiseptics and disinfectants, small molecule anti-biofilm agents, surface treatment strategies, and nanostructure functionalization, as well as multifunctional coatings particularly suitable for providing antibacterial effects to the surface of implants, to treat either dental- or implant-related bacterial infections.
Journal Article
Studies of efficiency of the Kratta detectors in the deuteron breakup experiment
An experiment focused on studies of relativistic effects in the proton-deuteron breakup reaction has been performed at Cyclotron Center Bronowice in Kraków, Poland with the use of the Kratta detectors. Thirty Kratta modules have been arranged in a planar symmetric around beam axis configuration at few selected polar angles at which significant relativistic effects have been predicted. In front of each Kratta module 4 thin plastic scintillators were installed acting as a fast timing detectors to improve a trigger system. Determination of acceptance and efficiency of the detectors is discussed.
Journal Article
Search for beyond standard model physics in free neutron decay
Applying a Mott polarimetry for measurement of the transverse polarization components of electrons from free neutron decay as well as proton momentum reconstruction using the combination of the time of flight method and the kinematical constrains of this three body decay, one gets access to eleven correlation coefficients of the neutron β -decay. Successful measurement of some of these coefficients would allow for an unique access to exotic scalar and tensor couplings of weak interactions and obtaining new constraints on their imaginary part, known with much worse accuracy. Results of the performance studies of some key experimental components of the prototype setup performed during the test run in 2021 at ILL PF1B neutron beam line are presented.
Journal Article
Experimental Studies of the Three Nucleon System Dynamics in the Proton Induced Deuteron Breakup at 108 MeV
The differential cross sections for the 2H(p,pp)n reaction have been measured for more than 80 angular configurations of the outgoing protons in the range of polar angles from 13∘ to 33∘ with a proton beam at 108 MeV. Data have been collected at the first experimental run in the Cyclotron Center Bronowice (CCB) at the Institute of Nuclear Physics PAS in Cracow, using the BINA detector setup. Analysis leading to determination of the breakup cross section values is described. Absolute normalization is obtained by normalization to the simultaneously measured 1H(d,d)p scattering events. Experimental results are compared to the state-of-the-art theoretical calculations. Global analysis shows significant influence of the Coulomb interaction and small effects of three nucleon force in the studied phase space region.
Journal Article