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Variation recorded within species is often taken to represent evidence for local and ongoing adaptation, but often without the interpopulation variation being subject to analysis across the geographic distribution occupied by the taxon. Here we investigate the rhythmic song structure across the range of three known song types in a variable cicada, Pauropsalta annulata Goding and Froggatt. Statistical analysis of the structure of songs across individuals reveals four discrete clusters that are demonstrated to be independent and stable across extensive geographic space in areas of allopatry and, generally, also into areas of sympatry. This suggests that P. annulata is a cryptic species complex. Unique combinations of plant species are linked with each of the clusters, suggesting that the different populations have independent plant associations. These findings are discussed in relation to similar case studies on cicadas and other organisms, with particular emphasis on the most appropriate approach to testing variation across populations, especially when it is thought to represent populations in the initial stages of evolutionary divergence.

OBJECTIVE--To study the impact of skin surgery in general practice on the workload of a pathology laboratory and to identify what further training might be helpful. DESIGN--Analysis of skin biopsy specimens from general practitioners before and after their new contract to determine numbers of specimens, changes in diagnoses, adequacy of treatment of malignant tumours, and areas of low diagnostic accuracy. SETTING--District general hospital. SUBJECTS--All 1017 skin biopsy specimens from general practice for 15 months before and 12 months after the new general practitioner contract. RESULTS--The number of pathology specimens received increased from 16 to 65 per month (median = 6 submitted by each general practitioner in the post-contract year). The proportion of the more common pathological diagnoses was unchanged between the two periods, but the proportion of correctly diagnosed naevi, cysts, and seborrhoeic keratoses increased in the second. Although few diagnoses were overtly incorrect, accurate diagnosis of dermatofibromas and malignancies decreased after the contract, and the overall correct diagnosis rate for seborrhoeic keratoses, dermatofibromas, rashes, and malignancies was below 30%. Only nine out of 21 squamous cell carcinomas were adequately excised with tumour free margins, and follow up of malignant tumours may have been inadequate. CONCLUSIONS--Skin surgery in general practice has advantages but matters of concern are the increase in laboratory workload, the excision of some benign lesions, and the inappropriateness of biopsy of rashes. Squamous cell carcinoma and other malignant tumours submitted for pathological examination were often unsuspected and inadequately excised, and heightened suspicion is recommended. Pathology request forms may need redesigning to encourage provision of clinical details.

A 71-year-old man developed symptoms and signs of right ventricular outflow obstruction. After angiography, which showed multiple lobulated and well-defined filling defects in the right ventricular outflow tract, endomyocardial biopsy disclosed infiltration of the myocardium by a poorly differentiated malignant neoplasm. At necropsy he was found to have a small intestinal lymphoma.

A case of toxoplasma hepatitis presenting with cholestatic jaundice is described. The diagnosis was based on serological testing and evidence of hepatitis on biopsy.

Toxoplasma gondii, woman, cholestatic jaundice as presenting symptom of Toxoplasma hepatitis, case report

We present a case of Jaccoud's arthropathy in a 59-year-old woman. She developed painless correctable ulnar deviation at the metacarpophalangeal joints of both hands following 4 attacks of rheumatic fever. Radiology did not show the hook lesions previously described, but we do not consider this sign essential for the diagnosis. There was no clinical evidence of rheumatoid arthritis. We were able to examine 3 complete joints from the left little finger at necropsy. Pathological examination of this kind has been possible only once before. The histological findings were fibrous thickening of the joint capsule, secondary degenerative changes, presumably due to longstanding joint deformity, and no evidence of significant synovial pathology.