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"WANG, LU"
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China's domestic and international migration development
This book offers the most comprehensive, up-to-date assessment of China's domestic and international migration. Restructuring economic development requires large numbers of educated and skilled talents, but this effort comes at a time when the size of China's domestic workforce is shrinking. In response, both national and regional governments in China have been keen to encourage overseas Chinese talents and professionals to return to the country. Meanwhile, the Chinese government has initiated a number of policies to attract international highly-skilled talents and enhance the country's competitiveness, and some Chinese policies have started attracting foreign talents, who are coming to the country to work, and even to stay. Since Chinese policies, mechanisms, and administration efforts to attract and retain skilled domestic or overseas talents are helping to reshape China's economy and are significantly affecting the cooperation on migration and talent mobility, these aspects, in addition to being of scholarly and research interest, hold considerable commercial potential.
Book
Nonlinear damage creep model of concrete considering the influence of temperature and its parameter variation law analysis
In order to study the creep characteristics of concrete under different temperatures, the uniaxial creep test of concrete is carried out. On this basis, the nonlinear creep model of concrete is established by using the fractal order derivative theory. According to the characteristics of the classical creep curve and the creep equation, the calculation method of creep parameters is determined. The variation law of each creep model parameter under different stress and temperature is analyzed. The results showed that the model can well reproduce the change trend of the curve during the creep process of concrete under different temperature conditions and stress levels, indicating that the model has strong adaptability and accuracy in capturing the creep law. In the later stage of concrete creep, the accelerated creep stage is often accompanied by complex situations such as rapid accumulation of internal damage and rapid deterioration of the structure. The traditional model has limitations in the accurate description of this stage, and the new model can effectively solve this problem. Undoubtedly, it enhances its value and advantages in practical applications. The elastic modulus of the elastomer controls the instantaneous strain. The elastic modulus, viscosity coefficient and fractal order of viscoelastic body control the viscoelastic creep and creep rate. Viscosity coefficient and fractal order of viscoplastic body control the viscoplastic creep and creep rate.
Journal Article
Research on logistics carbon emissions under the coupling and coordination scenario of logistics industry and financial industry
In order to measure the impact of the degree of coupling and coordination between logistics and financial industries on the carbon emissions of the logistics industry, a comprehensive evaluation index system for the logistics-financial industry from 2007 to 2017 was constructed, which was calculated using the multi-objective linear weighting method; and a combination of logistics and financial industry was constructed. The panel smooth conversion model of coordination degree and carbon emission of logistics industry. The empirical results show that the coupling coordination degree of logistics and financial industry in China’s 30 provinces is mostly in primary and medium coordination, and only a few provinces are on the verge of imbalance; the coupling coordination degree in the eastern region is overall moderate coordination, and the overall coordination degree in the central and western regions It is the primary coordination; with the growth of GDP per capita, the degree of coupling and coordination between the logistics and financial industries has promoted the increase of carbon emissions in various regions, but the promotion effect is an inverted U-shaped trend that first increases and then decreases.
Journal Article
الحزام والطريق : ماذا ستقدم الصين للعالم ؟
حاول هذا الكتاب الذي بين أيديكم أن يقدم إجابات معيارية قياسية لكافة الأسئلة الجذرية المتعلقة بمبادرة \"الحزام والطريق\" والتي تقدم الصين من خلالها حلا لاستغلال قدراتها التي لا تتوقف عن التنامي لتتبوأ مقعدها كمحرك للنمو الاقتصادي العالمي في المستقبل و المتشوقين للتعرف على الملامح الحقيقية للتنين الصيني وتجربته مع سياسة الإصلاح والانفتاح طوال أكثر من ثلاثين عاما ومبادرته الجديدة ذات السمات الفوق عولمية نقدم الحزام والطريق ماذا ستقدم الصين للعالم.
Book
Disrupted‐in‐schizophrenia‐1 protects synaptic plasticity in a transgenic mouse model of Alzheimer’s disease as a mitophagy receptor
Mitochondrial dysfunction is an early feature of Alzheimer's disease (AD). Accumulated damaged mitochondria, which are associated with impaired mitophagy, contribute to neurodegeneration in AD. We show levels of Disrupted‐in‐schizophrenia‐1 (DISC1), which is genetically associated with psychiatric disorders and AD, decrease in the brains of AD patients and transgenic model mice and in Aβ‐treated cultured cells. Disrupted‐in‐schizophrenia‐1 contains a canonical LC3‐interacting region (LIR) motif (210FSFI213), through which DISC1 directly binds to LC3‐I/II. Overexpression of DISC1 enhances mitophagy through its binding to LC3, whereas knocking‐down of DISC1 blocks Aβ‐induced mitophagy. We further observe overexpression of DISC1, but not its mutant (muFSFI) which abolishes the interaction of DISC1 with LC3, rescues Aβ‐induced mitochondrial dysfunction, loss of spines, suppressed long‐term potentiation (LTP). Overexpression of DISC1 via adeno‐associated virus (serotype 8, AAV8) in the hippocampus of 8‐month‐old APP/PS1 transgenic mice for 4 months rescues cognitive deficits, synaptic loss, and Aβ plaque accumulation, in a way dependent on the interaction of DISC1 with LC3. These results indicate that DISC1 is a novel mitophagy receptor, which protects synaptic plasticity from Aβ accumulation‐induced toxicity through promoting mitophagy.
Journal Article
الصين تربط العالم : الخلفية التي تستند إليها مبادرة الحزام والطريق = China connects the world : what behind the belt and road initiative /
يتناول كتاب (الصين تربط العالم : الخلفية التي تستند إليها مبادرة الحزام والطريق) والذي قام بتأليفه (وانغ ييوي) في حوالي (350) صفحة من القطع المتوسط موضوع (العلاقات الاقتصادية الخارجية للصين) مستعرضا أبرز المحتويات التالية : الفصل الأول : العالم المترابط، الفصل الثاني : مبادرة الحزام والطريق : منطق العولمة، الفصل الثالث : مبادرة الحزام والطريق : منطق الحضارة، الفصل الرابع : مبادرة الحزام والطريق : المنطق الاستراتيجي.
Book
Antimicrobial, Antioxidant, and α-Glucosidase-Inhibitory Activities of Prenylated p-Hydroxybenzoic Acid Derivatives from Oberonia ensiformis
Seven previously undescribed prenylated p-hydroxybenzoic acid derivatives, oberoniaensiformisins A–G, were isolated from an EtOH extract of the whole plant Oberonia ensiformis. Their structures were determined through spectroscopic analyses (IR, NMR) and HRESIMS analysis. The isolated compounds were tested for their antimicrobial, antioxidant, and α-glucosidase-inhibitory activity. Among them, compounds 6 and 12 exhibited potential antioxidant activity, while compounds 5, 6, 12, 13, and 15 showed varying degrees of α-glucosidase-inhibitory activity, with IC50 values ranging from 34.03 to 106.10 μg/mL.
Journal Article
تاريخ العلاقات بين الصين وعمان
يستعرض هذا الكتاب الجوانب التاريخية والسياسية والثقافية للعلاقات بين الصين وسلطنة عمان، منذ العصور القديمة وحتى العصر الحديث، مع تركيز خاص على التبادل التجاري والبحري الذي ازدهر بين الجانبين عبر طريق الحرير البحري. يبرز الكتاب كيف شكل التواصل الحضاري بين الصين وعمان أحد أقدم النماذج للعلاقات السلمية في التاريخ، حيث ساهم البحارة العمانيون في نقل السلع والثقافات بين الشرق الأقصى والجزيرة العربية. كما يتناول العلاقات الدبلوماسية الحديثة بين البلدين، وتطورها في إطار الشراكات الاقتصادية ومبادرة الحزام والطريق، مؤكدا على الاحترام المتبادل والتعاون المتوازن بين البلدين عبر القرون.
BOOK
Chlorogenic acid effectively treats cancers through induction of cancer cell differentiation
Inducing cancer differentiation is a promising approach to treat cancer. Here, we identified chlorogenic acid (CA), a potential differentiation inducer, for cancer therapy, and elucidated the molecular mechanisms underlying its differentiation-inducing effects on cancer cells.
Cancer cell differentiation was investigated by measuring malignant behavior, including growth rate, invasion/migration, morphological change, maturation, and ATP production. Gene expression was analyzed by microarray analysis, qRT-PCR, and protein measurement, and molecular biology techniques were employed for mechanistic studies. LC/MS analysis was the method of choice for chemical detection. Finally, the anticancer effect of CA was evaluated both
and
Results: Cancer cells treated with CA showed reduced proliferation rate, migration/invasion ability, and mitochondrial ATP production. Treating cancer cells with CA resulted in elevated SUMO1 expression through acting on its 3'UTR and stabilizing the mRNA. The increased SUMO1 caused c-Myc sumoylation, miR-17 family downregulation, and p21 upregulation leading to G
/G
arrest and maturation phenotype. CA altered the expression of differentiation-related genes in cancer cells but not in normal cells. It inhibited hepatoma and lung cancer growth in tumor-bearing mice and prevented new tumor development in naïve mice. In glioma cells, CA increased expression of specific differentiation biomarkers Tuj1 and GFAP inducing differentiation and reducing sphere formation. The therapeutic efficacy of CA in glioma cells was comparable to that of temozolomide. CA was detectable both in the blood and brain when administered intraperitoneally in animals. Most importantly, CA was safe even at very high doses.
CA might be a safe and effective differentiation-inducer for cancer therapy. \"Educating\" cancer cells to differentiate, rather than killing them, could be a novel therapeutic strategy for cancer.
Journal Article