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Using an international sample of 16 countries, this paper examines if analyst- and country-specific characteristics explain the variation in target price (TP) accuracy. We find that significant variation in average TP accuracy across countries is due to differences in accounting disclosure quality, the origin of the legal system, cultural traits, and IFRS regulation. We also find that analysts exhibit differential and persistent ability to forecast target prices accurately, which confirms that some analysts have superior TP forecasting ability.

\"It's spring in St. Denis. The village choir is preparing for its Easter concert, the wildflowers are blooming, annd among the lazy whorls of the river a dead woman is found floating in a boat. This means another case for Bruno, the town's cherished chief of police. With the discovery of sinister markings and black candles near the body, it seems to Bruno that the occult might be involved. And as questions mount--most notably about a troubling real estate proposal in the region and the sudden reappearance of an elderly countess--Bruno and his colleagues are drawn ever closer to a climatic showdown in the Gouffre de Colombac: the place locals call the Devil's Cave.\"--Back cover.

The parasitic protist Trypanosoma brucei is the causative agent of Human African Trypanosomiasis, also known as sleeping sickness. The parasite enters the blood via the bite of the tsetse fly where it is wholly reliant on glycolysis for the production of ATP. Glycolytic enzymes have been regarded as challenging drug targets because of their highly conserved active sites and phosphorylated substrates. We describe the development of novel small molecule allosteric inhibitors of trypanosome phosphofructokinase (PFK) that block the glycolytic pathway resulting in very fast parasite kill times with no inhibition of human PFKs. The compounds cross the blood brain barrier and single day oral dosing cures parasitaemia in a stage 1 animal model of human African trypanosomiasis. This study demonstrates that it is possible to target glycolysis and additionally shows how differences in allosteric mechanisms may allow the development of species-specific inhibitors to tackle a range of proliferative or infectious diseases. Glycolytic enzymes are challenging drug targets due to their highly conserved active sites and phosphorylated substrates. Here, the authors identify fast acting allosteric inhibitors of Trypanosoma brucei phosphofructokinase that block trypanosome glycolysis and provide cure evidence in murine model.

\"When a British tourist fails to turn up for a luxurious cooking vacation in Bruno's usually idyllic Dordogne village of St. Denis, the worried hostess is quick to call on Bruno for help. Monica Felder is nowhere to be found, and her husband, a retired British major, is unreachable. And not long after Bruno discovers that Monica was traveling with a mysterious Irishman (her lover?), the two turn up dead\"-- Provided by publisher.

About the Authors: Matthew R. Behrend * E-mail: behrend04@gmail.com Affiliations Neglected Tropical Diseases, Bill & Melinda Gates Foundation, Seattle, Washington, United States of America, Blue Well 8, Seattle, Washington, United States of America ORCID logo http://orcid.org/0000-0002-5664-0520 María-Gloria Basáñez Affiliation: MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom Jonathan I. D. Hamley Affiliation: MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom Travis C. Porco Affiliation: Francis I. Proctor Foundation for Research in Ophthalmology, Department of Epidemiology and Biostatistics, and Department of Ophthalmology, University of California, San Francisco, United States of America Wilma A. Stolk Affiliation: Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands Martin Walker Affiliations London Centre for Neglected Tropical Disease Research, Department of Pathobiology and Population Sciences, Royal Veterinary College, Hatfield, Hertfordshire, United Kingdom, London Centre for Neglected Tropical Disease Research and Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom Sake J. de Vlas Affiliation: Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands ORCID logo http://orcid.org/0000-0002-1830-5668 for the NTD Modelling Consortium Introduction The neglected tropical diseases (NTDs) thrive mainly among the poorest populations of the world. Onchocerciasis (a filarial disease caused by infection with Onchocerca volvulus and transmitted by blackfly, Simulium, vectors) probably provides the best example of impactful modelling, with its long history of using evidence—mostly from the ONCHOSIM and EPIONCHO transmission models [7]—to support decision-making within ongoing multicountry control initiatives (Table 1). Onchocerciasis modelling and policy impact. https://doi.org/10.1371/journal.pntd.0008033.t001 From the start of the NTD Modelling Consortium in 2015, there have been several other examples of impactful modelling, which could be divided over three major scales of operations: (1) developing WHO guidelines (e.g., for triple-drug therapy, with ivermectin, diethylcarbamazine, and albendazole, against lymphatic filariasis [16, 17]); (2) informing funding decisions for new intervention tools (e.g., the development of a schistosomiasis vaccine [18]); and (3) guiding within-country targeting of control (e.g., local vector control for human African trypanosomiasis in the Democratic Republic of the Congo [19, 20] and Chad [21]). Relative word frequencies are represented by size of the font. https://doi.org/10.1371/journal.pntd.0008033.g002 Scoring the guidance statements Authors coded the data set individually (MRB, TCP, WAS, SJdV) and jointly (M-GB, JIDH, MW), producing five independently coded sets of data (S1 Table).

It's just another summer in St. Denis for Bruno, who must balance the constant barrage of demands on his time and expertise--including the complex affections of two powerful women, town politics (the mayor is having romantic problems of his own), his irrepressible puppy Balzac, and nights entertaining friends and visitors with ever-sumptuous repasts--with a new focus on a mounting crime wave, whose seemingly unrelated events Bruno begins to suspect are linked.

Albendazole (ALB) is administered annually to millions of children through global deworming programs targeting soil-transmitted helminths (STHs: Ascaris lumbricoides, Trichuris trichiura and hookworms, Necator americanus and Ancylostoma duodenale). However, due to the lack of large individual patient datasets collected using standardized protocols and the application of population-based statistical methods, little is known about factors that may affect individual responses to treatment. We re-analyzed 645 individual patient data from three standardized clinical trials designed to assess the efficacy of a single 400 mg oral dose of ALB against STHs in schoolchildren from different study sites, each with varying history of drug pressure based on duration of mass drug administration programs: Ethiopia, low; Lao People's Democratic Republic (PDR), moderate; Pemba Island (Tanzania), high. Using a Bayesian statistical modelling approach to estimate individual responses (individual egg reduction rates, ERRi), we found that efficacy was lower in Pemba Island, particularly for T. trichiura. For this STH, the proportion of participants with a satisfactory response (ERRi ≥50%), was 65% in Ethiopia, 61% in Lao PDR but only 29% in Pemba Island. There was a significant correlation between ERRi and infection intensity prior to drug administration (ERRi decreasing as a function of increasing infection intensity). Individual age and sex also affected the drug response, but these were of negligible clinical significance and not consistent across STHs and study sites. We found decreased efficacy of ALB against all the STHs analyzed in Pemba Island (Tanzania), an area with high drug pressure. This does not indicate causality, as this association may also be partially explained by differences in infection intensity prior to drug administration. Notwithstanding, our results indicate that without alternative treatment regimens, program targets will not be achievable on Pemba Island because of inadequate efficacy of ALB. The study was registered on Clinicaltrials.gov (ID: NCT03465488) on March 7, 2018.

Bruno's village of St. Denis has been called many things, but a hotbed of international intrigue has never been one of them ... until now. When an undercover agent is found murdered just as a prodigal son is set to return from a grim tour in the Middle East, the small town suddenly finds itself host to a determined global tribunal, threatening the usual cheer brought by St. Denis's annual wine festival.

Ocean bottom pressure recordings are a key observation for both ocean circulation and seafloor geodesy. New self‐calibrating instruments may solve a long‐time issue of instrument drift, allowing new high precision observations. However, instruments on the seafloor may settle over days to months, potentially contaminating results. Here we present evidence for likely settling of two self‐calibrating instruments deployed along the RAPID mooring array, on the order of 8–14 cm. Settling is expected, and we model the settling based on Terzaghi's consolidation theory, which is well known in civil engineering applications. After the settling correction the difference between the two pressure records has a standard deviation of ∼1 cm water height equivalent. Settling is likely an important factor that should be considered in oceanographic and geodetic experimental design. We recommend longer term deployments of 5–10 years to allow for settling and/or selection of sites with thinner sandy sediments to minimize settling.