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Passions will be tested and young hearts will be broken. Ultimately, talent, dedication and hard work will triumph. Centers around a group of dancers, singers, musicians and actors at the New York City High School of Performing Arts, and their spirited drive to live out their dreams of stardom. In an incredibly competitive atmosphere, each student must shine amidst the tumult of school work, deep friendships, budding romance and self-discovery.

Ethnographers today find themselves experimenting with new approaches to digital ethnography amid pandemic-related restrictions on research. Yet such developments only accelerate a broader trend toward the dissolution of the traditional ethnographic ‘field’ due to new communications technologies and the emergence of a globalized ‘knowledge economy’. Through six contributions from around the world, this forum explores how the emergence of a more diffuse, interconnected ethnographic field is impacting fieldwork’s status as a rite of passage, creating new affective entanglements and shifting power relationships between researchers and participants. Despite the potential for influence and surveillance that new technologies cede to already powerful institutions, the discussions underline how ethnographic interlocutors are auteurs in their own right—and that ethnographers are also often bit characters in other people’s stories.

Shame is omnipresent in women's lives in the suburban conglomerations of the city of Gilgit in northern Pakistan, in the adjacent villages and nearby valleys. Women express their modesty through shame. Being singled out individually in a society with strict collective orientation turns a woman into an object of gossip and threatens the loss of one's family's honour. Accordingly, the performance of modesty and shame follows an inner drive for self-discipline in front of men and is, speaking with Bourdieu, a significant part of women's \"habitus\". With the help of Csordas's methodological paradigm of \"embodiment\" as bodily experience and \"preobjective\" perception, I analyse shame and sexuality in its public and private context: from gender segregation to the sexual relationship between spouses. There is no gap between conforming to social norms and an inner sense of shame for women in the rural areas in and around Gilgit. Just as Butler describes the power of speech as \"performativity\", repeated actions inscribe moral ideas into body and soul. Women's continuous physical practice of shame fuses both outer obedience and inner feelings; through \"doing shame\" the moral code is truly embodied.

Muslim marriages have been the focus of considerable public debate in Europe and beyond, in Muslim-majority countries as well as in settings where Muslims are a minority. Most academic work has focused on how the majority Sunni Muslims conclude marriages. This volume, in contrast, focuses on Twelver Shi'a Muslims in Iran, Pakistan, Oman, Indonesia, Norway, and the Netherlands. The volume makes an original contribution to understanding the global dynamics of Shi'a marriage practices in a wide range of contexts--not only its geographical spread but also by providing a critical analysis of the socio-economic, religious, ethnic, and political discourses of each context. The book sheds light on new marriage forms presented through a bottom up approach focusing on the lived experiences of Shi'a Muslims negotiating a diverse range of relationships and forms of belonging.

Abstract Ethnographers today find themselves experimenting with new approaches to digital ethnography amid pandemic-related restrictions on research. Yet such developments only accelerate a broader trend toward the dissolution of the traditional ethnographic ‘field’ due to new communications technologies and the emergence of a globalized ‘knowledge economy’. Through six contributions from around the world, this forum explores how the emergence of a more diffuse, interconnected ethnographic field is impacting fieldwork's status as a rite of passage, creating new affective entanglements and shifting power relationships between researchers and participants. Despite the potential for influence and surveillance that new technologies cede to already powerful institutions, the discussions underline how ethnographic interlocutors are auteurs in their own right—and that ethnographers are also often bit characters in other people's stories.

For terrestrial plant communities, the increase in frequency and intensity of drought events is considered as one of the most severe consequences of climate change. While single‐species studies demonstrate that drought can lead to relatively rapid adaptive genetic changes, the evolutionary potential and constraints to selection need to be assessed in comparative approaches to draw more general conclusions. In a greenhouse experiment, we compare the phenotypic response and evolutionary potential of two co‐occurring grassland plant species, Bromus erectus and Trifolium pratense, in two environments differing in water availability. We quantified variation in functional traits and reproductive fitness in response to drought and compared multivariate genetic variance–covariance matrices and predicted evolutionary responses between species. Species showed different drought adaptation strategies, reflected in both their species‐specific phenotypic plasticity and predicted responses to selection indicating contrasting evolutionary potential under drought. In T. pratense we found evidence for stronger genetic constraints under drought compared to more favourable conditions, and for some traits plastic and predicted evolutionary responses to drought had opposing directions, likely limiting the potential for adaptive change. Our study contributes to a more detailed understanding of the evolutionary potential of species with different adaptive strategies in response to climate change and may help to inform future scenarios for semi‐natural grassland ecosystems. In a greenhouse experiment, we compare the phenotypic response and evolutionary potential of two co‐occurring grassland plant species, Bromus erectus and Trifolium pratense, in two environments differing in water availability. We quantified variation in functional traits and reproductive fitness in response to drought and compared multivariate genetic variance–covariance matrices and predicted evolutionary responses between species. Species showed different drought adaptation strategies, reflected in both their species‐specific phenotypic plasticity and predicted responses to selection indicating contrasting evolutionary potential under drought.

Background The rapid diffusion of digital technologies throughout the healthcare system has created new opportunities to improve the use, efficiency and continuity of healthcare services. The academic debate has largely explored the implementation of digital tools and their impact on clinical processes and health outcomes. Despite the potential benefits, the digital evolution of the healthcare system could generate or aggravate existing inequalities. Although existing studies on digital technologies in healthcare are consolidated and numerous, little attention has been paid to the emergence of inequalities at individual, organisational and system levels. To fill this gap, this study aims to focus on how emerging inequalities are framed in the academic debate, with a focus on the socio-demographic, technological and organisational factors of digital evolution of the healthcare system. This study is based on a knowledge management perspective. Methods This study uses a scoping review approach and is carried out following the PRISMA-ScR guidelines. The search was conducted without time limits on three databases, and only peer-reviewed articles in English were included. The review included qualitative, quantitative and mixed-methods studies. Three analysis domains were identified: sociodemographic factors, technological factors and health and healthcare-related factors. A bibliometric and co-occurrence analysis was also conducted using VOSviewer to visualise the structure of the research landscape and identify thematic clusters. Results From 3,303 reviewed articles, 64 studies met the inclusion criteria. The results highlight that the digital evolution of the healthcare system can exacerbate the exposure of new social categories to inequalities. The factors of emerging inequalities in the digital evolution of healthcare have been identified and classified into three areas: (1) socio-demographic factors, (2) technological factors and (3) organisational and systemic factors. Three different historical periods have been identified within the academic debate. In fact, through in-depth analysis and bibliometric analysis, we have observed an increasing diversification of the topics. Conclusion Digitalisation of healthcare can generate inequalities. Although research on this topic in the literature is scarce, a growing number of scholars have begun to address it. Future research should explore user experiences, the effectiveness of healthcare provider training, coordination mechanisms and public reimbursement policies to reduce inequalities.

The face of hepatitis C virus (HCV) therapy is changing dramatically. Direct-acting antiviral agents (DAAs) specifically targeting HCV proteins have been developed and entered clinical practice in 2011. However, despite high sustained viral response (SVR) rates of more than 90%, a fraction of patients do not eliminate the virus and in these cases treatment failure has been associated with the selection of drug resistance mutations (RAMs). RAMs may be prevalent prior to the start of treatment, or can be selected under therapy, and furthermore they can persist after cessation of treatment. Additionally, certain DAAs have been approved only for distinct HCV genotypes and may even have subtype specificity. Thus, sequence analysis before start of therapy is instrumental for managing DAA-based treatment strategies. We have created the interpretation system geno2pheno[HCV] (g2p[HCV]) to analyse HCV sequence data with respect to viral subtype and to predict drug resistance. Extensive reviewing and weighting of literature related to HCV drug resistance was performed to create a comprehensive list of drug resistance rules for inhibitors of the HCV protease in non-structural protein 3 (NS3-protease: Boceprevir, Paritaprevir, Simeprevir, Asunaprevir, Grazoprevir and Telaprevir), the NS5A replicase factor (Daclatasvir, Ledipasvir, Elbasvir and Ombitasvir), and the NS5B RNA-dependent RNA polymerase (Dasabuvir and Sofosbuvir). Upon submission of up to eight sequences, g2p[HCV] aligns the input sequences, identifies the genomic region(s), predicts the HCV geno- and subtypes, and generates for each DAA a drug resistance prediction report. g2p[HCV] offers easy-to-use and fast subtype and resistance analysis of HCV sequences, is continuously updated and freely accessible under http://hcv.geno2pheno.org/index.php. The system was partially validated with respect to the NS3-protease inhibitors Boceprevir, Telaprevir and Simeprevir by using data generated with recombinant, phenotypic cell culture assays obtained from patients' virus variants.

Nonhygienic products for managing menstruation are reported to cause reproductive tract infections. Menstrual cups are a potential solution. We assessed whether menstrual cups would reduce bacterial vaginosis (BV), vaginal microbiome (VMB), and sexually transmitted infections (STIs) as studies have not evaluated this. A cluster randomized controlled trial was performed in 96 Kenyan secondary schools, randomized (1:1:1:1) to control, menstrual cup, cash transfer, or menstrual cup plus cash transfer. This substudy assessing the impact of menstrual cups on BV, VMB, and STIs, included 6 schools from the control (3) and menstrual cup only (3) groups, both receiving BV and STI testing and treatment at each visit. Self-collected vaginal swabs were used to measure VMB (16S rRNA gene amplicon sequencing), BV (Nugent score), and STIs. STIs were a composite of Chlamydia trachomatis and Neisseria gonorrhoeae (nucleic acid amplification test) and Trichomonas vaginalis (rapid immunochromatographic assay). Participants were not masked and were followed for 30 months. The primary outcome was diagnosis of BV; secondary outcomes were VMB and STIs. Intention-to-treat blinded analyses used mixed effects generalized linear regressions, with random effects term for school. The study was conducted between May 2, 2018, and February 7, 2021. A total of 436 participants were included: 213 cup, 223 control. There were 289 BV diagnoses: 162 among control participants and 127 among intervention participants (odds ratio 0.76 [95% CI 0.59 to 0.98]; p = 0.038). The occurrence of Lactobacillus crispatus-dominated VMB was higher among cup group participants (odds ratio 1.37 [95% CI 1.06 to 1.75]), as was the mean relative abundance of L. crispatus (3.95% [95% CI 1.92 to 5.99]). There was no effect of intervention on STIs (relative risk 0.82 [95% CI 0.50 to 1.35]). The primary limitations of this study were insufficient power for subgroup analyses, and generalizability of findings to nonschool and other global settings. Menstrual cups with BV and STI testing and treatment benefitted adolescent schoolgirls through lower occurrence of BV and higher L. crispatus compared with only BV and STI testing and treatment during the 30 months of a cluster randomized menstrual cup intervention. ClinicalTrials.gov NCT03051789.

A variety of Magnetic Resonance Imaging (MRI) techniques are known to be sensitive to brain iron content. In principle, iron sensitive MRI techniques are based on local magnetic field variations caused by iron particles in tissue. The purpose of this study was to investigate the sensitivity of MR relaxation and magnetization transfer parameters to changes in iron oxidation state compared to changes in iron concentration. Therefore, quantitative MRI parameters including R1, R2, R2∗, quantitative susceptibility maps (QSM) and magnetization transfer ratio (MTR) of post mortem human brain tissue were acquired prior and after chemical iron reduction to change the iron oxidation state and chemical iron extraction to decrease the total iron concentration. All assessed parameters were shown to be sensitive to changes in iron concentration whereas only R2, R2∗ and QSM were also sensitive to changes in iron oxidation state. Mass spectrometry confirmed that iron accumulated in the extraction solution but not in the reduction solution. R2∗ and QSM are often used as markers for iron content. Changes in these parameters do not necessarily reflect variations in iron content but may also be a result of changes in the iron’s oxygenation state from ferric towards more ferrous iron or vice versa. •Iron extraction decreases R1, R2 and R2∗ in brain tissue.•R2 and R2∗ are sensitive to changes in iron oxidation state.•Iron reduction from Fe3+ to Fe2+ decreases R2 and R2∗, but not R1.