Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
6,287
result(s) for
"Walter, Thomas"
Sort by:
Current Advances in Protein Import into Peroxisomes
Blobel and coworkers discovered in 1978 that peroxisomal proteins are synthesized on free ribosomes in the cytosol and thus provided the grounds for the conception of peroxisomes as self-containing organelles. Peroxisomes are highly adaptive and versatile organelles carrying out a wide variety of metabolic functions. A striking feature of the peroxisomal import machinery is that proteins can traverse the peroxisomal membrane in a folded and even oligomeric state via cycling receptors. We outline essential steps of peroxisomal matrix protein import, from targeting of the proteins to the peroxisomal membrane, their translocation via transient pores and export of the corresponding cycling import receptors with emphasis on the situation in yeast. Peroxisomes can contribute to the adaptation of cells to different environmental conditions. This is realized by changes in metabolic functions and thus the enzyme composition of the organelles is adopted according to the cellular needs. In recent years, it turned out that this organellar diversity is based on an elaborate regulation of gene expression and peroxisomal protein import. The latter is in the focus of this review that summarizes our knowledge on the composition and function of the peroxisomal protein import machinery with emphasis on novel alternative protein import pathways.
Journal Article
العراق وملاحظات شرقية في رحلة توماس هربرت سنة 1628
يمثل هذا الكتاب أول وصف أجنبي مفصل عن الشرق الإسلامي في القرن السابع عشر وصاحب الرحلة من أوائل الرحالة الذين زاروا العراق وبلاد فارس في تلك المرحلة، وبذلوا جهودا حثيثة في إقامة تحالف إنكليزي-فارسي ضد الدولة العثمانية، وتمثل رحلته أول سفارة رسمية إنكليزية من الملك شارل الأول إلى الشاه عباس الصفوي (1571-1628)
BOOK
The wise men : six friends and the world they made
A collective biography of six U.S. statesmen and the foreign policies which dominate our actions to this day: Averell Harriman, the diplomat and Roosevelt's special envoy to Churchill and Stalin; Dean Acheson, the secretary of state who was more responsible for the Truman Doctrine than Truman and for the Marshall Plan than General Marshall; George Kennan, self-cast outsider and intellectual darling of the Washington elite; Robert Lovett, assistant secretary of war, undersecretary of state, and secretary of defense througout the formative years of the Cold War; John McCloy, one of the nation's most influential private citizens; and Charles Bohlen, diplomat and ambassador to the Soviet Union.
Book
Hydrothermal alteration of andesitic lava domes can lead to explosive volcanic behaviour
Dome-forming volcanoes are among the most hazardous volcanoes on Earth. Magmatic outgassing can be hindered if the permeability of a lava dome is reduced, promoting pore pressure augmentation and explosive behaviour. Laboratory data show that acid-sulphate alteration, common to volcanoes worldwide, can reduce the permeability on the sample lengthscale by up to four orders of magnitude and is the result of pore- and microfracture-filling mineral precipitation. Calculations using these data demonstrate that intense alteration can reduce the equivalent permeability of a dome by two orders of magnitude, which we show using numerical modelling to be sufficient to increase pore pressure. The fragmentation criterion shows that the predicted pore pressure increase is capable of fragmenting the majority of dome-forming materials, thus promoting explosive volcanism. It is crucial that hydrothermal alteration, which develops over months to years, is monitored at dome-forming volcanoes and is incorporated into real-time hazard assessments.
The permeability of a dome exerts a control on the outgassing efficiency of the underlying magma. The authors investigate the role of hydrothermal alteration on this process in the laboratory and use these data to model whether the overpressures generated are capable of promoting explosive behaviour.
Journal Article
A review framework of how earthquakes trigger volcanic eruptions
It is generally accepted that tectonic earthquakes may trigger volcanic activity, although the underlying mechanisms are poorly constrained. Here, we review current knowledge, and introduce a novel framework to help characterize earthquake-triggering processes. This framework outlines three parameters observable at volcanoes, namely magma viscosity, open- or closed-system degassing and the presence or absence of an active hydrothermal system. Our classification illustrates that most types of volcanoes may be seismically-triggered, though require different combinations of volcanic and seismic conditions, and triggering is unlikely unless the system is primed for eruption. Seismically-triggered unrest is more common, and particularly associated with hydrothermal systems.
This review dives deep into how earthquakes affect volcanoes, specifically into the relation between tectonic seismic activity and subsequent eruptions. Activity may increase in any volcanic setting in the 2–5 years following an earthquake, and especially at volcanic centres featuring vigorous hydrothermal activity.
Journal Article
The renin–angiotensin system and cancer: old dog, new tricks
Key Points
This Review presents a contemporary update of the renin–angiotensin system (RAS), explaining its links to cancer through tissue remodelling, inflammation, angiogenesis and apoptosis.
In vitro
, animal and clinical studies indicate that the RAS is frequently dysregulated in malignancy and correlates with poor patient outcomes.
Antagonism of the RAS mostly suppresses tumour growth, metastasis and angiogenesis in a broad range of experimental models of malignancy.
Retrospective studies in humans provide some evidence that long-term use of angiotensin-converting enzyme inhibitors might modulate cancer growth and progression.
The potential for retooling current drugs that target the RAS for application to cancer therapy is discussed.
This Review describes the evidence linking the renin–angiotensin system (RAS) to cancer, through its roles in processes such as apoptosis, angiogenesis and tissue remodelling. Could RAS inhibitors currently used in the clinic be retooled to treat cancer?
For cancers to develop, sustain and spread, the appropriation of key homeostatic physiological systems that influence cell growth, migration and death, as well as inflammation and the expansion of vascular networks are required. There is accumulating molecular and
in vivo
evidence to indicate that the expression and actions of the renin–angiotensin system (RAS) influence malignancy and also predict that RAS inhibitors, which are currently used to treat hypertension and cardiovascular disease, might augment cancer therapies. To appreciate this potential hegemony of the RAS in cancer, an expanded comprehension of the cellular actions of this system is needed, as well as a greater focus on translational and
in vivo
research.
Journal Article