Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
2,848
result(s) for
"Walters, C"
Sort by:
الأديرة الأثرية في مصر
يتناول كتاب (الأديرة الأثرية في مصر) والذي قام بتأليفه (ك. ك. وولترز) في حوالي (489) صفحة من القطع المتوسط موضوع (الأديرة المصرية) مستعرضا المحتويات التالية : الفصل الأول نشأة التجمعات الرهبانية، الفصل الثاني العمارة السكنية، الفصل الثالث العمارة غير السكنية، الفصل الرابع اللوحات الفنية، الفصل الخامس الأعمال الحجرية وأشغال الخشب، الفصل السادس معالم الحياة اليومية، الفصل السابع عادات الفن.
Book
Childhood Adversity and Epigenetic Modulation of the Leukocyte Glucocorticoid Receptor: Preliminary Findings in Healthy Adults
A history of early adverse experiences is an important risk factor for adult psychopathology. Changes in stress sensitivity and functioning of the hypothalamic-pituitary-adrenal (HPA) axis may underlie the association between stress and risk for psychiatric disorders. Preclinical work in rodents has linked low levels of maternal care to increased methylation of the promoter region of the glucocorticoid receptor (GR) gene, as well as to exaggerated hormonal and behavioral responses to stress. Recent studies have begun to examine whether early-life stress leads to epigenetic modifications of the GR gene in humans.
We examined the degree of methylation of a region of the promoter of the human GR gene (NR3C1) in leukocyte DNA from 99 healthy adults. Participants reported on their childhood experiences of parental behavior, parental death or desertion, and childhood maltreatment. On a separate day, participants completed the dexamethasone/corticotropin-releasing hormone (Dex/CRH) test, a standardized neuroendocrine challenge test.
Disruption or lack of adequate nurturing, as measured by parental loss, childhood maltreatment, and parental care, was associated with increased NR3C1 promoter methylation (p<.05). In addition, NR3C1 promoter methylation was linked to attenuated cortisol responses to the Dex/CRH test (p<.05).
These findings suggest that childhood maltreatment or adversity may lead to epigenetic modifications of the human GR gene. Alterations in methylation of this gene could underlie the associations between childhood adversity, alterations in stress reactivity, and risk for psychopathology.
Journal Article
Aggressive behavior : genetic and neural approaches
Since the heyday of research on aggression in the late 1960s, developments in several varied areas had enabled us to take a new look at this important though difficult topic. Recent findings and sophisticated new techniques in behavior genetic analysis at the time had made it possible not only to enhance our understanding of the genetic mechanisms underlying aggressive behavior, but also to provide some reasonable suggestions as to the role of aggression in evolution. Originally published in 1983, there had been significant advances in genetic and neural research and a much more sophisticated and heuristic approach to the measurement and conceptualization of aggressive behavior had developed. The ten chapters in this volume provide a thorough overview of these new approaches and methodologies. There are also suggestions regarding the scope of future research on aggressive behavior, since much of what is presented describes the ongoing research activities of the contributors. This book is divided into four sections: The first provides a systematic foundation for research on aggression, and a description of some of the newer strategies for research in this area; the second concerns quantitative genetic analyses, selection data from both wild and laboratory populations, and situational determinants of aggressive behavior; the third section details new and exciting findings in neurochemical and neuropharmacological effects; and the last section contains a chapter that provides a summary and synthesis of all that has come before.
BOOK
Mitochondrial calcium cycling in neuronal function and neurodegeneration
Mitochondria are essential for proper cellular function through their critical roles in ATP synthesis, reactive oxygen species production, calcium (Ca 2+ ) buffering, and apoptotic signaling. In neurons, Ca 2+ buffering is particularly important as it helps to shape Ca 2+ signals and to regulate numerous Ca 2+ -dependent functions including neuronal excitability, synaptic transmission, gene expression, and neuronal toxicity. Over the past decade, identification of the mitochondrial Ca 2+ uniporter (MCU) and other molecular components of mitochondrial Ca 2+ transport has provided insight into the roles that mitochondrial Ca 2+ regulation plays in neuronal function in health and disease. In this review, we discuss the many roles of mitochondrial Ca 2+ uptake and release mechanisms in normal neuronal function and highlight new insights into the Ca 2+ -dependent mechanisms that drive mitochondrial dysfunction in neurologic diseases including epilepsy, Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. We also consider how targeting Ca 2+ uptake and release mechanisms could facilitate the development of novel therapeutic strategies for neurological diseases.
Journal Article
Biologic and Clinical Efficacy of LentiGlobin for Sickle Cell Disease
An unprespecified interim analysis of results from a phase 1–2 study of gene therapy for sickle cell disease shows resolution of severe vaso-occlusive events in 25 patients who could be evaluated. In the 24 months before enrollment, these patients had a median of 3.5 severe vaso-occlusive events per year.
Journal Article
Exagamglogene Autotemcel for Severe Sickle Cell Disease
Of 30 patients with severe sickle cell disease who were treated with gene-edited autologous hematopoietic stem and progenitor cells, 29 were free from vaso-occlusive crises for at least 12 consecutive months.
Journal Article
Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia
Gene therapy with CD34+ cells transduced with a lentivirus vector carrying a β-globin gene was performed in 22 patients. At a median of 26 months, all the patients were either transfusion-independent or had a major reduction in transfusion requirements.
Journal Article
Climate-driven tradeoffs between landscape connectivity and the maintenance of the coastal carbon sink
Ecosystem connectivity tends to increase the resilience and function of ecosystems responding to stressors. Coastal ecosystems sequester disproportionately large amounts of carbon, but rapid exchange of water, nutrients, and sediment makes them vulnerable to sea level rise and coastal erosion. Individual components of the coastal landscape (i.e., marsh, forest, bay) have contrasting responses to sea level rise, making it difficult to forecast the response of the integrated coastal carbon sink. Here we couple a spatially-explicit geomorphic model with a point-based carbon accumulation model, and show that landscape connectivity, in-situ carbon accumulation rates, and the size of the landscape-scale coastal carbon stock all peak at intermediate sea level rise rates despite divergent responses of individual components. Progressive loss of forest biomass under increasing sea level rise leads to a shift from a system dominated by forest biomass carbon towards one dominated by marsh soil carbon that is maintained by substantial recycling of organic carbon between marshes and bays. These results suggest that climate change strengthens connectivity between adjacent coastal ecosystems, but with tradeoffs that include a shift towards more labile carbon, smaller marsh and forest extents, and the accumulation of carbon in portions of the landscape more vulnerable to sea level rise and erosion.
Coastal connectivity between ecosystems increases with sea level rise but fails to maintain landscape carbon storage and marsh extent at extreme rates of sea level rise.
Journal Article
Correlation driven near-flat band Stoner excitations in a Kagome magnet
Among condensed matter systems, Mott insulators exhibit diverse properties that emerge from electronic correlations. In itinerant metals, correlations are usually weak, but can also be enhanced via geometrical confinement of electrons, that manifest as ‘flat’ dispersionless electronic bands. In the fast developing field of topological materials, which includes Dirac and Weyl semimetals, flat bands are one of the important components that can result in unusual magnetic and transport behaviour. To date, characterisation of flat bands and their magnetism is scarce, hindering the design of novel materials. Here, we investigate the ferromagnetic Kagomé semimetal Co
3
Sn
2
S
2
using resonant inelastic X-ray scattering. Remarkably, nearly non-dispersive Stoner spin excitation peaks are observed, sharply contrasting with the featureless Stoner continuum expected in conventional ferromagnetic metals. Our band structure and dynamic spin susceptibility calculations, and thermal evolution of the excitations, confirm the nearly non-dispersive Stoner excitations as unique signatures of correlations and spin-polarized electronic flat bands in Co
3
Sn
2
S
2
. These observations serve as a cornerstone for further exploration of band-induced symmetry-breaking orders in topological materials.
In flat band materials, the ’flat’ dispersion of the electronic states mean that interactions between electrons can be strong, potentially leading to a variety of interesting magnetic and transport properties. Here, Nag et al study the Kagomé semimetal Co3Sn2S2, and show a nearly flat Stoner excitation dispersion, a clear indication of spin-polarized and flat electronic bands.
Journal Article
Spectroscopic fingerprint of charge order melting driven by quantum fluctuations in a cuprate
Copper oxide high-TC superconductors possess a number of exotic orders that coexist with or are proximal to superconductivity. Quantum fluctuations associated with these orders may account for the unusual characteristics of the normal state, and possibly affect the superconductivity1–4. Yet, spectroscopic evidence for such quantum fluctuations remains elusive. Here, we use resonant inelastic X-ray scattering to reveal spectroscopic evidence of fluctuations associated with a charge order5–14 in nearly optimally doped Bi2Sr2CaCu2O8+δ. In the superconducting state, while the quasielastic charge order signal decreases with temperature, the interplay between charge order fluctuations and bond-stretching phonons in the form of a Fano-like interference increases, an observation that is incompatible with expectations for competing orders. Invoking general principles, we argue that this behaviour reflects the properties of a dissipative system near an order–disorder quantum critical point, where the dissipation varies with the opening of the pseudogap and superconducting gap at low temperatures, leading to the proliferation of quantum critical fluctuations, which melt charge order.X-ray scattering experiments show that the quantum fluctuations associated with charge order take a form that is incompatible with the idea of competition between charge order and superconductivity.
Journal Article