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Diabetes is a metabolic disease that raises the risk of microvascular and neurological disorders. Insensitivity to insulin is a characteristic of type II diabetes, which accounts for 85-90 percent of all diabetic patients. The fundamental molecular factor of insulin resistance may be impaired cell signal transduction mediated by the insulin receptor (IR). Several cell-signaling proteins, including IR, insulin receptor substrate (IRS), and phosphatidylinositol 3-kinase (PI3K), have been recognized as being important in the impaired insulin signaling pathway since they are associated with a large number of proteins that are strictly regulated and interact with other signaling pathways. Many studies have found a correlation between IR alternative splicing, IRS gene polymorphism, the complicated regulatory function of IRS serine/threonine phosphorylation, and the negative regulatory role of p85 in insulin resistance and diabetes mellitus. This review brings up-to-date knowledge of the roles of signaling proteins in insulin resistance in order to aid in the discovery of prospective targets for insulin resistance treatment.

Background Increasing evidences have found that the clinical importance of the interaction between hypoxia and immune status in gastric cancer microenvironment. However, reliable prognostic signatures based on combination of hypoxia and immune status have not been well-established. This study aimed to develop a hypoxia-immune-based gene signature for risk stratification in gastric cancer. Methods Hypoxia and immune status was estimated with transcriptomic profiles for a discovery cohort from GEO database using the t -SNE and ESTIMATE algorithms, respectively. The Cox regression model with the LASSO method was applied to identify prognostic genes and to develop a hypoxia-immune-based gene signature. The TCGA cohort and two independent cohorts from GEO database were used for external validation. Results Low hypoxia status ( p  < 0.001) and high immune status ( p  = 0.005) were identified as favorable factors for patients’ overall survival. By using the LASSO model, four genes, including CXCR6, PPP1R14A and TAGLN, were identified to construct a gene signature for risk stratification. In the discovery cohort (n = 357), patients with low risk yielded better outcomes than those with high risk regarding overall survival across and within TNM stage subgroups. Multivariate analysis identified the hypoxia-immune-based gene signature as an independent prognostic factor ( p  < 0.001). A nomogram integrating the gene signature and known risk factors yielded better performance and net benefits in calibration and decision curve analyses. Similar results were validated in the TCGA (n = 321) and two independent GEO (n = 300 and n = 136, respectively) cohorts. Conclusions The hypoxia-immune-based gene signature represents a promising tool for risk stratification tool in gastric cancer. It might serve as a prognostic classifier for clinical decision-making regarding individualized prognostication and treatment, and follow-up scheduling.

Chinese government has proposed ambitious targets to combat climate change. As carbon emissions of China’s transportation have been rapidly increasing in past decades, massive efforts for carbon reduction need to be taken by transportation sector. Research on practical action paths for transportation sector’s low-carbon development are critical to achieving the Paris Agreement goals and China’s “Dual-Carbon” Target. Based on the transportation’s historical carbon emissions and the new possible trends in the future, this paper uses a forecast model to predict transportation’s carbon emission. Then we adopt a scenario analysis to analyze the total transportation demand in the transportation sector from 2021 to 2060. We quantitatively simulated the emission reduction effects of different policy measures under different scenarios, such as optimization of transportation structure, application of energy-saving and emission-reduction technologies, and new energy vehicles. The results provide paths and measures for the low-carbon development of transportation, and provides policy suggestion for the scientific formulation of the low-carbon development.

The morphology and crystalline structure changes of cellulose during dissolution in 1-butyl-3-methylimidazolium chloride [(BMIM)Cl] were investigated by optical microscopy and synchrotron radiation wide-angle X-ray diffraction (WAXD). Neither swelling nor dissolution of cellulose was observed under the melting point of [BMIM]Cl. While the temperature was elevated to 70 °C, the swelling phenomenon of cellulose happened with the interplanar spacing of ( ) and (020) planes increased slightly. With the temperature further going up to 80 °C, cellulose was dissolved gradually with the crystallinity ( W c,x ) and crystalline index ( CrI ) of cellulose decreased rapidly, which indicated the crystalline structure of cellulose was destroyed completely and transformed into amorphous structure.

The influence of plasma treatment on the wettability of carbon fiber was studied using the vacuum assisted resin transfer molding (VARTM) process. The influence of plasma treatment on the mechanical properties of carbon fiber-reinforced polymer (CFRP) composites, including interlaminar shear strength and tensile properties, were investigated. The carbon fiber surface chemistry analysis was carried out by Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and x-ray photoelectron spectroscopy (XPS). Results showed that low-temperature plasma treatment had little effect on the surface morphology of the carbon fiber; however, it changed the chemical surface state of the carbon fiber, which contributed to enhance the wettability of the carbon fiber by increasing the perfusion speed of the resin to be more than two times of the original speed. The fiber wettability improvements are of great significance to the preparation of the CFRP composite by the VARTM process. Compared to untreated carbon fiber, the plasma treatment caused an acceptable decrease in tensile properties and offered an increase in the interlaminar shear strength of the CFRP composite. Low-temperature plasma treatment played an important role in the effective preparation and application of the CFRP composite.

This paper utilizes the methods of effectiveness prediction and teaching decision-making to construct a precise teaching management framework based on artificial intelligence, and gives a specific plan for carrying out precise teaching interventions in educational practice. This paper investigates the cognition and demand of students in Z province for precise education in college civics and politics through a questionnaire survey. It also researches and verifies precision education through practical research to present its effectiveness. The results show that in terms of the needs and preferences of various aspects of ideological and political education, the majority of students accounted for between 40 and 60%, which is a relatively even distribution, reflecting the diversity of needs. The p-values of the entrance examination and the final examination of the second semester, the final examination of the first semester and the final examination of the second semester are 0.046, 0.004 and 0.18 respectively.Precision teaching can significantly improve students’ Civic and Political Learning Effect.

High-volume polyethylene glycol (PEG) solutions are commonly used for bowel preparation but are often poorly tolerated, reducing patient compliance. Shouhui Tongbian Capsules (SHTBC), a traditional Chinese medicine known to promote gastrointestinal motility, may offer an alternative approach. However, its role in bowel preparation remains unclear. To evaluate the efficacy, safety, and tolerability of a novel bowel preparation regimen combining SHTBC with low-volume PEG (2L) compared to conventional high-volume PEG (3L). Multicenter, randomized, single-blind, parallel-controlled trial. A total of 404 participants scheduled for colonoscopy across 34 medical centers in China were randomized into two groups: the experimental group (SHTBC + 2L PEG,  = 202) and the control group (3L PEG,  = 202). Bowel preparation quality was assessed using the Boston Bowel Preparation Scale (BBPS), with successful cleansing defined as a total BBPS score ⩾6. The secondary outcomes included time to adequate bowel movement, number of bowel movements, patient tolerance, acceptance, and incidence of adverse drug reactions (ADRs). The success rate of bowel preparation was comparable between groups (  = 0.7454). The experimental group had a slightly longer time to first adequate bowel movement on the day of colonoscopy (  = 0.0013) but experienced fewer bowel movements the day before (  < 0.0001). The experimental group reported significantly fewer ADRs (  = 0.0311) and better tolerance, including reduced bloating, nausea, and sleep disturbance (  < 0.01 for all). Patient acceptance was higher in the experimental group (92.89% vs 88.32%), although the difference was not statistically significant (  = 0.4170). SHTBC combined with 2L PEG is a safe, effective, and better-tolerated alternative to 3L PEG for bowel preparation before colonoscopy, offering a promising strategy to improve patient compliance. Chinese Clinical Trial Registry: ChiCTR2300069962.

Nacre-mimetics hold great promise as mechanical high-performance and functional materials. Here we demonstrate large progress of mechanical and functional properties of self-assembled polymer/nanoclay nacre-mimetics by using synthetic nanoclays with aspect ratios covering three orders in magnitude (25–3,500). We establish comprehensive relationships among structure formation, nanostructuration, deformation mechanisms and mechanical properties as a function of nanoclay aspect ratio, and by tuning the viscoelastic properties of the soft phase via hydration. Highly ordered, large-scale nacre-mimetics are obtained even for low aspect ratio nanoplatelets and show pronounced inelastic deformation with very high toughness, while those formed by ultralarge nanoplatelets exhibit superb stiffness and strength, previously only reachable for highly crosslinked materials. Regarding functionalities, we report formerly impossible glass-like transparency, and excellent gas barrier considerably exceeding earlier nacre-mimetics based on natural nanoclay. Our study enables rational design of future high-performance nacre-mimetic materials and opens avenues for ecofriendly, transparent, self-standing and strong advanced barrier materials. Nacre-mimetics hold great promise as high-performance, functional materials. Here, the authors use synthetic nanoclays and demonstrate tuneable mechanical properties by varying the nanoclay aspect ratio, and suggest a transparent gas barrier application.

Colorectal cancer is a leading cause of cancer-related death in the world. Despite cisplatin is a commonly used chemotherapeutic drug for the colorectal cancer treatment, resistance of cancer cells to cisplatin restricts its clinical efficacy. It is important to explore the potential mechanisms and take strategies to sensitize colorectal cancer cells to cisplatin treatment. Differences of TRIM32 and miR-519d expression between colorectal cancer cells and human normal colon epithelial cells were evaluated by qRT-PCR and Western blot assays. Cytotoxicity of cisplatin against colorectal cancer cells was tested by CCK-8 assay. Generation of reactive oxygen species (ROS), mitochondrial membrane potential and apoptosis was measured by flow cytometry. Dual-luciferase reporter assay was used to validate the association between miR-519d and TRIM32. Significant increase of TRIM32 expression in colorectal cancer tissues and cell lines was observed. TRIM32 negatively regulated the cisplatin sensitivity in colorectal cancer cells. Mechanically, overexpression of TRIM32 was induced by decrease of miR-519d. Exogenous miR-519d can inhibit the expression of TRIM32 and thus promoted the cisplatin-induced apoptosis through the mitochondrial pathway. Overexpression of TRIM32 was induced by the absence of miR-519d in colorectal cancer. MiR-519d can be used as a sensitizer during the cisplatin-based chemotherapy of colorectal cancer.

Colon cancer remains one of the leading causes of cancer-related mortality globally. Tumor-associated macrophages (TAMs) are key contributors to tumor progression within the tumor microenvironment (TME). However, the role of secreted phosphoprotein 1 (SPP1), a critical regulator of macrophage-tumor interactions, in specific macrophage subsets in colon cancer remains unclear. We performed single-cell RNA sequencing (scRNA-seq) on tumor and adjacent normal tissues from three colon cancer patients. A comprehensive analysis integrating pseudotime trajectory, transcription factor network, cell-cell communication, and in silico SPP1 knockout modeling was conducted to characterize macrophage heterogeneity and function. Five macrophage subtypes were identified. Among them, the Macrophages_SPP1 was significantly enriched in tumors and exhibited enhanced glycolytic metabolism, lysosomal activity, angiogenesis, and immunosuppression functions. This subtype showed increased interactions with fibroblasts, particularly via FTL-SCARA5 and FTH1-SCARA5 ligand-receptor pairs, implicating roles in stromal remodeling. In silico SPP1 knockout identified 93 stable responsive genes enriched in MHC class II-related and immune regulatory pathways, highlighting the role of SPP1 in shaping an immunosuppressive TME. The Macrophages_SPP1 subtype may contribute to colon cancer progression through metabolic reprogramming and stromal interactions, suggesting that SPP1 and the FTL-SCARA5 axis could represent potential therapeutic targets.