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Contemporary football demands exceptional cognitive abilities alongside physical prowess, yet current training methodologies lack precision for optimizing cognitive performance through objective neural monitoring. This computational study develops and validates a theoretical multimodal neural feedback collaborative training system that simultaneously enhances executive function and tactical cognition in football contexts. The proposed system integrates electroencephalography (EEG), eye-tracking, and physiological monitoring to provide real-time feedback during cognitive training protocols. Through computational validation utilizing synthetic neural signal datasets and algorithmic performance modeling, we evaluated the theoretical system’s efficacy across executive function components (working memory, inhibitory control, cognitive flexibility) and tactical cognition domains (pattern recognition, strategic planning, decision-making). Computational results demonstrated significant theoretical improvements in executive function capabilities averaging 23.7% and tactical cognition enhancements reaching 27.8% compared to baseline algorithmic performance. The collaborative training approach consistently outperformed isolated training modalities in simulations, with large effect sizes (Cohen’s d = 0.96 to d = 1.24, representing substantial theoretical effects) across cognitive domains. Neurophysiological simulations revealed enhanced theta-gamma coupling, increased alpha synchronization, and strengthened fronto-parietal connectivity patterns supporting improved cognitive performance. The mathematical frameworks and algorithmic validation establish theoretical foundations for understanding executive function-tactical cognition interactions while demonstrating the computational potential for neurotechnology-enhanced cognitive training. Future empirical studies with actual athletes are needed to validate these theoretical findings in practical settings.

N-myc downstream regulated gene 1 (NDRG1) is an intracellular protein involved in cell differentiation and was recently reported to exert various effects in several cancers. However, its expression and role in bladder cancer remain unclear. Our study enrolled 100 bladder cancer patients to detect NDRG1 expression in tumour tissues by immunohistochemistry. Correlations between NDRG1 expression and clinical factors were analysed. An NDRG1 overexpression plasmid and NDRG1 siRNAs were transfected into bladder cancer cell lines. Cell biological behaviours were assessed by CCK-8, flow cytometry, wound healing and Transwell assays. Additionally, the influence of NDRG1 on epithelial-mesenchymal transition (EMT) was investigated by western blotting and real-time PCR. NDRG1 expression in urine from bladder cancer patients was examined by ELISA. NDRG1 protein levels were significantly increased in bladder cancer patients and correlated with tumour stage (p = 0.025), lymph node metastasis (p = 0.034) and overall survival (p = 0.016). Patients with high NDRG1 expression had poorer outcomes than those with low NDRG1 expression. NDRG1 overexpression was associated with increased cell proliferation, migration, and invasion and decreased apoptotic cell numbers; NDRG1 knockdown resulted in the inverse effects. Moreover, upregulated NDRG1 expression was associated with downregulated Cytokeratin 7 and Claudin-1 expression and upregulated N-cad, β-catenin and slug expression. Downregulated NDRG1 expression was associated with the inverse effects. Urine protein levels could distinguish bladder cancer patients from healthy controls, with an area under the curve of 0.909. NDRG1 promoted EMT in bladder cancer and could be an effective diagnostic and prognostic biomarker in bladder cancer patients.

The rapid development of tourism promotes the study of tourism industry. It accumulates and summarizes a lot of relevant knowledge and theories. This paper takes the research literature of tourism industry retrieved and collected on the Web of Science as the research object. The research tool is the Citespace.5.6 R3 Software. The author combined data analysis and literature reading to summarize the knowledge of tourism industry research in the past five years from 2016 to 2020. Through the research, we get some knowledge and conclusions about the tourism industry research. We hope that these results will provide some basic references for travel industry practitioners and scholars.

With the urbanization level advancing in cities, increasingly significant urban ecological environment problems must be solved. The construction of a smart city with the overall development of information technology also regards environmental friendliness as the primary goal. The “smart” idea of urban environment innovation and governance has become a new model. In this paper, we first expound on the development process of low-carbon cities, eco-cities, and smart cities in Japan and China. Then, we analyze the coordinated development of intelligent environmental protection measures in government policies, transportation, energy utilization, resource recovery, and community management. Finally, we compare Japan and China’s smart city development characteristics. We discuss the improvement measures for energy utilization, urban transportation, and urban operation, including developing renewable energy systems, efficient energy use, and citizen participation policy. These experiences can provide feasible measures for constructing Asian smart cities and have great significance for the city’s sustainable applications and practice.

A case-control study was conducted to evaluate the relationship between endothelial nitric oxide synthase (NOS3) gene polymorphism and essential hypertension in the Han, Miao, and Buyi populations in Guizhou China. DNA was collected from the blood samples of 353 essential hypertension patients and 342 healthy controls from Guizhou province of China. Eight polymorphisms of the NOS3 gene were genotyped using the Sequenom MassARRAY platform. For genetic analysis, SPSS 26.0, Haploview, SNPStats, SHEsis, and MDR were utilized. All SNPs (rs11771443, rs1808593, rs753482, rs3918186, rs3918188, rs3918227, rs7830, and rs891512) satisfied the Hardy-Weinberg equilibrium test (P > 0.05). The allele and genotype frequencies of rs7830 and rs1808593 in case-control groups demonstrated significant differences (P < 0.05). Compared to the TT genotype of rs1808593, the TG or GG genotype reduced the risk of hypertension in the Miao population (OR = 0.410, 95% CI: 0.218-0.770, P = 0.006). Compared to the GG or GT genotype of rs7830, the TT genotype increased the risk of hypertension in the overall populations (OR = 1.716, 95%CI: 1.139-2.586, P = 0.010). The CATT (rs3918227-rs391818186-rs1808593-rs7830) haplotype was a risk factor for hypertension in the Miao and Han populations (OR = 1.471, 95%CI: 1.010-2.143, P = 0.044 and OR = 1.692, 95%CI: 1.124-2.545, P = 0.011). The CAGG haplotype in the Miao population was a protective factor against hypertension (OR = 0.555, 95%CI: 0.330-0.934, P = 0.025). The rs3918188, rs1808593, and rs7830 in the Miao population showed an interaction effect on hypertension (P < 0.001). The rs11771443, rs3918188, and rs7830 in the Buyi and Han populations showed an interaction effect on hypertension (P = 0.013 and P < 0.001). The single nucleotide polymorphisms rs1808593 and rs7830 of NOS3 gene are associated with essential hypertension in Guizhou ethnic populations.

Sox2 is a key transcriptional factor for maintaining pluripotency of stem cells. Sox2 deficiency causes neurodegeneration and impairs neurogenesis. Although the transcriptional regulation of Sox2 has been extensively studied, the mechanisms that control Sox2 protein turnover are yet to be clarified. Here we show that the RING-finger ubiquitin ligase complex CUL4A DET1-COP1 and the deubiquitylase OTUD7B govern Sox2 protein stability during neural progenitor cells (NPCs) differentiation. Sox2 expression declines concordantly with OTUD7B and reciprocally with CUL4A and COP1 levels upon NPCs differentiation. COP1, as the substrate receptor, interacts directly with and ubiquitylates Sox2, while OTUD7B removes polyUb conjugates from Sox2 and increases its stability. COP1 knockdown stabilizes Sox2 and prevents differentiation, while OTUD7B knockdown destabilizes Sox2 and induces differentiation. Thus, CUL4A DET1-COP1 and OTUD7B exert opposite roles in regulating Sox2 protein stability at the post-translational level, which represents a critical regulatory mechanism involved in the maintenance and differentiation of NPCs. Sox2 regulates pluripotency in neural progenitor cells (NPC) but how protein stability affects this is unclear. Here, the authors identify changes in ubiquitylation of Sox2 (by CUL4A-DET1-COP1 ligase and OTUD7B deubiquitylase) as controlling protein stability and so the differentiation state of NPCs.

Background: The treatment modalities for testicular appendage torsion in children are classified as conservative or surgical, and the choice is controversial. Objectives: This study aimed to identify ultrasound-based indicators influencing the outcome of conservative treatment in children with testicular appendage torsion to divide the boundaries between conservative and surgical management. Methods: A retrospective analysis was conducted on testicular appendage torsion data of children from November 2022 and November 2023 in the Children’s Hospital of Zhejiang University School of Medicine to compare the conservatively successful and conservatively unsuccessful groups’ clinical and ultrasound characteristics. Furthermore, we constructed a logistic regression model and evaluated its predictive ability. Results: We observed 405 (88.62%) and 52 (11.38%) cases of conservative success and failure, respectively. Univariate analysis indicated significant differences between these groups in testicular appendage torsion nodule size, terminology for hydrocele, scrotal wall edema, and increased epididymal blood flow (p

China's aging population is a pressing issue, with the need for comfortable living environments for older adults being paramount to their health and well-being. A study was conducted in Dalian, China, involving physical environment measurements and surveys in nursing homes and residential buildings. The investigation focused on changing indoor thermal environments and older adults' subjective sensations. The study explored physical environment satisfaction and actual thermal comfort ranges in different aging modes and space characteristics. The results show that older people spend most time in bedrooms, and dissatisfaction with the thermal environment in winter and summer is high, reaching 42% and 74%, respectively. Residential buildings generally have higher indoor temperatures than nursing homes, with a mean PMV difference of 0.9 in winter. Furthermore, thermal comfort models show that the comfort zones for nursing homes are more comprehensive in winter but smaller in summer. This study provides valuable information for future research on thermal comfort of older adults in different aging modes, facilitating the creation of healthier indoor thermal environments.

Background To explore the impact of anti-vascular epithelial growth factor (ant-VEGF) on the thickness of each retinal layer in patients with macular edema (ME) secondary to the branch retinal vein occlusion (BRVO). Methods This retrospective study included patients with ME secondary to monocular BRVO who received anti-VEGF therapy in Ningxia Eye Hospital between January-December 2020. Results Forty-three patients (25 males) were included, with 31 showed > 25% reduction in central retinal thickness (CRT) after anti-VEGF therapy (response group), and the others showed a ≤25% reduction in CRT (no-response group). The response group showed significantly smaller mean changes in the ganglion cell layer (GCL) (after 2 months) and inner plexiform layer (IPL) (after 1, 2, and 3 months) and significantly greater mean changes in the inner nuclear layer (INL) (after 2 and 3 months), outer plexiform layer (OPL) (after 3 months), outer nuclear layer (ONL) (after 2 and 3 months), and CRT (after 1 and 2 months) (all P < 0.05) as compared to the no-response group. The mean change in the thickness of each retinal layer IPL (P = 0.006) between the two groups was significantly different after controlling for a time and with a significant time trend (P < 0.001). Additionally, patients in the response group were more likely to have an improvement in IPL (43.68 ± 6.01 at 1 month and 41.52 ± 5.45 at 2 months vs. 39.9 ± 6.86 at baseline) after anti-VEGF therapy, while those in no response group might show improvement in GCL (45.75 ± 8.24 at 1 month, 40.00 ± 8.92 at 2 months, and 38.83 ± 9.93 at 3 months vs. 49.67 ± 6.83 at baseline). Conclusions Anti-VEGF therapy might help restore the retinal structure and function in patients with ME secondary to BRVO, and those who have a response after anti-VEGF therapy are more likely to improve IPL, while those having no response might show improvement in GCL.

Background Coal-burning fluorosis is a chronic poisoning resulting from the prolonged use of locally available high-fluoride coal for heating and cooking. Prolonged fluoride exposure has been demonstrated to decrease PPARGC1A levels. Therefore, this case-control aims to evaluate the genetic association of PPARGC1A gene polymorphisms and methylation of the mitochondrial D-loop region with coal-burning fluorosis. Result The results showed that the TT genotype at rs13131226 and the AA genotype at rs1873532 increased the risk of coal-burning fluorosis ( OR  = 1.84, P  = 0.004; OR  = 1.97, P  = 0.007), the CT and CC genotypes at rs7665116 decreased the risk of coal-burning fluorosis ( OR  = 0.54, P  = 0.003). The TT genotype at the rs2970847 site and the AA genotype at the rs2970870 site increase the risk of developing skeletal fluorosis ( OR  = 4.12, P  = 0.003; OR  = 2.22, P  = 0.011). Haplotype AG constructed by rs3736265-rs1873532 increased the risk of the prevalence of coal-burning fluorosis ( OR  = 1.465, P  = 0.005); CG decreased the risk of the prevalence of coal-burning fluorosis ( OR  = 0.726, P  = 0.020). Haplotype CGGT constructed by rs6821591-rs768695-rs3736265-rs2970847 increased the risk of the prevalence of skeletal fluorosis (OR = 1.558, P  = 0.027). A 1% increase in CpG_4 methylation levels in the mtDNA D-loop region is associated with a 2.3% increase in the risk of coal-burning fluorosis. Additionally. There was a significant interaction between rs13131226 and rs1873532; CpG_4 and CpG_8.9; rs13131224,rs6821591 and rs7665116 were observed in the occurrence of fluorosis in the Guizhou population ( χ 2  = 16.917, P  < 0.001; χ 2  = 21.198, P  < 0.001; χ 2  = 36.078, P  < 0.001). Conclusion PPARGC1A polymorphisms rs13131226 and rs1873532 and the mitochondrial DNA D-loop methylation site CpG_4 have been associated with an increased risk of fluorosis, conversely polymorphism rs7665116 was associated with a decreased risk of fluorosis. Polymorphisms rs2970870 were associated with increased risk of skeletal fluorosis, and polymorphism rs2970847 was associated with decreased risk of skeletal fluorosis. These SNPs and CpG can be used as potential targets to assess fluorosis risk.