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"Wang, Chen-Chen"
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Role of macrophages in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a severe cardiopulmonary vascular disease characterized by progressive pulmonary artery pressure elevation, increased pulmonary vascular resistance and ultimately right heart failure. Studies have demonstrated the involvement of multiple immune cells in the development of PAH in patients with PAH and in experimental PAH. Among them, macrophages, as the predominant inflammatory cells infiltrating around PAH lesions, play a crucial role in exacerbating pulmonary vascular remodeling in PAH. Macrophages are generally polarized into (classic) M1 and (alternative) M2 phenotypes, they accelerate the process of PAH by secreting various chemokines and growth factors (CX3CR1, PDGF). In this review we summarize the mechanisms of immune cell action in PAH, as well as the key factors that regulate the polarization of macrophages in different directions and their functional changes after polarization. We also summarize the effects of different microenvironments on macrophages in PAH. The insight into the interactions between macrophages and other cells, chemokines and growth factors may provide important clues for the development of new, safe and effective immune-targeted therapies for PAH.
Journal Article
GRB 221009A: An Ordinary Nearby GRB with Extraordinary Observational Properties
The gamma-ray burst GRB 221009A, known as the “brightest of all time,” is the closest energetic burst detected so far, with an energy of E γ,iso ∼ 1055 erg. This study aims to assess its compatibility with known GRB energy and luminosity distributions. Our analysis indicates that the energy/luminosity function of GRBs is consistent across various redshift intervals, and that the inclusion of GRB 221009A does not significantly impact the function at low redshifts. Additionally, our evaluation of the best-fitting result of the entire GRB sample suggests that the expected number of GRBs with energy greater than 1055 erg at a low redshift is 0.2, so that the emergence of GRB 221009A is consistent with expected energy/luminosity functions within ∼2σ Poisson fluctuation error, still adhering to the principles of small number statistics. Furthermore, we find that GRB 221009A and other energetic bursts, defined as E γ,iso ≳ 1054 erg, exhibit no significant differences in terms of distributions of T 90, minimum timescale, Amati relation, E γ,iso–E X,iso relation, L γ,iso–Γ0 relation, E γ,iso–Γ0 relation, L γ,iso–E p,i–Γ0 relation, and host galaxy properties, compared to normal long GRBs. This suggests that energetic GRBs (including GRB 221009A) and other long GRBs likely have similar progenitor systems and undergo similar energy dissipation and radiation processes. The generation of energetic GRBs may be due to more extreme central engine properties or, more likely, a rarer viewing configuration of a quasi-universal structured jet.
Journal Article
Autophagy and multidrug resistance in cancer
Multidrug resistance (MDR) occurs frequently after long‐term chemotherapy, resulting in refractory cancer and tumor recurrence. Therefore, combatting MDR is an important issue. Autophagy, a self‐degradative system, universally arises during the treatment of sensitive and MDR cancer. Autophagy can be a double‐edged sword for MDR tumors: it participates in the development of MDR and protects cancer cells from chemotherapeutics but can also kill MDR cancer cells in which apoptosis pathways are inactive. Autophagy induced by anticancer drugs could also activate apoptosis signaling pathways in MDR cells, facilitating MDR reversal. Therefore, research on the regulation of autophagy to combat MDR is expanding and is becoming increasingly important. We summarize advanced studies of autophagy in MDR tumors, including the variable role of autophagy in MDR cancer cells.
Journal Article
الأساطير الصينية
يجمع الكتاب المعطيات المفترقة في المؤلفات القديمة الصينية وترتب الأساطير المعينة في المكان المناسب مما يشكل نظام متفق مع سرد الأساطير العادية لتسهيل القراءة للأساطير الصينية الوفيرة بشكل عام. ويتميز الكتاب بتنظيم المواد التاريخية، وتجميع الحكايات، وإنشاء الهيكل العام لتاريخ الأساطير الصينية. من ناحية أخرى، يقارن بينها وبين الأساطير الغربية (خاصة اليونانية)، ويعرض كل منها على حدة. صدر الكتاب ضمن سلسلة «الصين الثقافية».
BOOK
Observation of spectral lines in the exceptional GRB 221009A
As the brightest gamma-ray burst ever observed, GRB 221009A provided a precious opportunity to explore spectral line features. In this article, we performed a comprehensive spectroscopy analysis of GRB 221009A jointly with GECAM-C and
Fermi
/GBM data to search for emission and absorption lines. For the first time we investigated the line feature throughout this GRB including the most bright part where many instruments suffered problems, and identified prominent emission lines in multiple time intervals. The central energy of the Gaussian emission line evolves from about 37 to 6 MeV, with a nearly constant ratio (about 10%) between the line width and central energy. Particularly, we find that both the central energy and the energy flux of the emission line evolve with time as a power law decay with power law index of −1 and −2, respectively. We suggest that the observed emission lines most likely origin from the blue-shifted electron positron pair annihilation 511 keV line. We find that a standard high latitude emission scenario cannot fully interpret the observation, thus we propose that the emission line comes from some dense clumps with electron positron pairs traveling together with the jet. In this scenario, we can use the emission line to directly, for the first time, measure the bulk Lorentz factor of the jet (Γ) and reveal its time evolution (i.e., Γ ∼
t
−1
) during the prompt emission. Interestingly, we find that the flux of the annihilation line in the co-moving frame keeps constant. These discoveries of the spectral line features shed new and important lights on the physics of GRB and relativistic jet.
Journal Article
Reading development and difficulties in monolingual and bilingual Chinese children
This volume explores Chinese reading development, focusing on children in Chinese societies and bilingual Chinese-speaking children in Western societies. The book is structured around four themes: psycholinguistic study of reading, reading disability, bilingual and biliteracy development, and Chinese children's literature. It discusses issues that are pertinent to improving language and literacy development, and complex cognitive, linguistic, and socio-cultural factors that underlie language and literacy development. In addition, the book identifies instructional practices that can enhance literacy development and academic achievement. This volume offers an integrative framework of Chinese reading, and deepens our understanding of the intricate processes that underlie Chinese children's literacy development. It promotes research in reading Chinese and celebrates the distinguished and longstanding career of Richard C. Anderson.
Book
A Subclass of Gamma-Ray Burst Originating from Compact Binary Merger
Type I gamma-ray bursts (GRBs) are believed to originate from compact binary mergers usually with a duration of main emission less than 2 s. However, recent observations of GRB 211211A and GRB 230307A indicate that some merger-origin GRBs could last much longer. Since they show strikingly similar properties (indicating a common mechanism), which are different from the classic “long”-short burst (e.g., GRB 060614), we find they form an interesting subclass of type I GRBs, and we suggest to name them as type IL GRB. We find that the prompt emission of type IL GRB is composed of three episodes: (1) a precursor followed by a short quiescent (or weak emission) period, (2) a long-duration main emission, and (3) an extended emission. With this burst pattern, a good candidate, GRB 170228A, was found in the Fermi/Gamma-ray Burst Monitor archive data. Temporal and spectral analyses indeed show that GRB 170228A falls in the same group with GRB 211211A and GRB 230307A in many diagnostic figures. Thus, this burst pattern could be a good reference for rapidly identifying type IL GRBs and very helpful for conducting low-latency follow-up observation. We estimated the occurrence rate and discussed the physical origins and implications for the three emission episodes of type IL GRBs. Our analysis suggests the premerger precursor model, especially the magnetar super flare model, is more favored for type IL GRBs. More observations in multiwavelength and multimessenger are required to deepen our understanding of this subclass of GRB.
Journal Article