Explore the vast range of titles available.

As video platforms such as Douyin, also known as TikTok’s Chinese version, continue to grow, there is an increasing interest in the study of green advertising videos to understand their audiovisual features and their impact on audience engagement. In this research, we specifically focus on green advertising within the automotive industry. Drawing on literature from sustainability, green advertising, and communication studies, we identified seven audiovisual aspects and three persuasive strategies pertinent to green automotive advertising videos. Utilizing a mixed-methods video analysis framework, we analyzed a dataset of 2,553 green automotive advertising videos on Douyin over three years from 15 June 2020 to 15 June 2023. These videos exhibited higher loudness, a faster pace, and longer durations compared to their non-green counterparts. We categorized three distinct types of green advertising videos on Douyin and established that specific audiovisual features and persuasive strategies are significantly correlated with audience engagement levels. This study not only delineates the audiovisual characteristics of green automotive advertising in China’s digital space but also contributes to the broader discourse on sustainable marketing practices on social networks like TikTok. The findings extend image-centric research to video content and provide marketers with data-driven insights for crafting effective content creation strategies on Douyin.

Genetically engineered T cells expressing a chimeric antigen receptor (CAR) are rapidly emerging a promising new treatment for haematological and non-haematological malignancies. CAR-T therapy can induce rapid and durable clinical responses but is associated with unique acute toxicities. Moreover, CAR-T cells are vulnerable to immunosuppressive mechanisms. Here, we report that CAR-T cells release extracellular vesicles, mostly in the form of exosomes that carry CAR on their surface. The CAR-containing exosomes express a high level of cytotoxic molecules and inhibit tumour growth. Compared with CAR-T cells, CAR exosomes do not express Programmed cell Death protein 1 (PD1), and their antitumour effect cannot be weakened by recombinant PD-L1 treatment. In a preclinical in vivo model of cytokine release syndrome, the administration of CAR exosomes is relatively safe compared with CAR-T therapy. This study supports the use of exosomes as biomimetic nanovesicles that may be useful in future therapeutic approaches against tumours. Genetically engineered T cells expressing a chimeric antigen receptor (CAR-T cells) are a promising new treatment for cancer, but are associated with unique toxicities. Here, the authors test CAR-T-cell-derived exosomes as a surrogate for CAR-T cells and show that they can elicit a potent antitumour immune response in preclinical models of breast cancer with reduced signs of cytokine release syndrome compared with CAR-T therapy.

Rapid industrialization has led to a substantial increase in waste salts containing Na2SO4/NaCl mixtures, posing significant challenges for their phase separation and resource recovery. This study pioneers an integrated process combining frozen crystallization with stepwise decompression evaporation for Na2SO4/NaCl separation. Through the systematic investigation of phase transition behaviors under varying ionic ratios, the optimal combined processes corresponding to mixed salts with different compositions were identified. The experimental results demonstrate that brines with NaCl > 80.0% should preferentially undergo vacuum evaporation, while those below this threshold are suitable for prioritizing frozen crystallization for Na2SO4 recovery. Utilizing the complementary advantages of both processes, the mixture was prepared with a mass ratio of NaCl to Na2SO4 of 3:1. The frozen crystallization of the brine yielded 90.0% pure Na2SO4 crystals while concentrating NaCl to 92.0% in the residual liquor. Subsequent stepwise evaporation yielded 98.5% pure NaCl crystals. Finally, the removal effect and lifecycle evaluation of the process for impurity ions provide new insights for the zero liquid discharge system in industrial waste salt management.

The Qinghai-Tibetan Plateau region has been significantly affected by climate change. The adaptive behaviors of local farmers play a pivotal role in maintaining the ecological balance and the well-being of residents. This study employs a mixed-method approach that combines in-depth interviews and questionnaire surveys to explore the adaptive behaviors of farmers on the Qinghai-Tibetan Plateau in response to climate change, as well as the factors influencing these behaviors. The findings from the in-depth interviews indicate that the farmers primarily cope with the challenges posed by climate change through six types of adaptive behaviors, which include adjusting the planting time of crops, optimizing the planting structure, engaging in livestock farming, adopting plastic coverings, purchasing agricultural insurance, and participating in non-agricultural activities. Survey results confirm that climate change beliefs positively influence adaptive behaviors, with risk perception serving as a mediator, and climate change benefits and self-efficacy acting as moderators. Additionally, experienced benefits of climate change and self-efficacy moderate this relationship, whereby farmers who experience greater benefits tend to underestimate risks, resulting in fewer adaptive actions. This study advances the understanding of climate-adaptive behaviors by elucidating the underlying psychological mechanisms among farmers in extreme climatic environments.

T‐cell ageing may be a key factor in the disproportionate severity of coronavirus disease 2019 (COVID‐19) in older populations. For hospitalized COVID‐19 patients, treatment involving the use of monoclonal antibodies with the ability to neutralize SARS‐CoV‐2 usually involves the administration of high doses but has not been very effective at preventing complications or fatality, highlighting the need for additional research into anti‐SARS‐CoV‐2 therapies, particularly for older populations. In this study, it is discovered that older persons with a severe SARS‐CoV‐2 infection has weaker T‐cell responses. Therefore the development and characterization of spike‐targeting T‐cell‐dependent bispecific (TDB) full‐length human immunoglobulin Gs with enhanced efficacy in the treatment of COVID‐19 is described. Using S‐targeting TDBs, polyclonal T cells are guided to target and destroy S‐expressing cells, preventing the cell‐to‐cell transmission of SARS‐CoV‐2 and thereby eliminating the need for SARS‐CoV‐2‐specific immunity. Using animal models of COVID‐19, it is shown that the selective activation of T cells improves the efficiency of treatment in preinfected mice by attenuating disease‐induced weight loss and death. The significance of T‐cell‐based immunity during infection is highlighted by the findings. These results have implications for better clinical effectiveness of therapies for COVID‐19 and the development of T‐cell‐dependent medicines for the elderly population. This study describes the development of spike‐targeting T‐cell‐dependent bispecific full‐length human immunoglobulin Gs with enhanced efficacy in the treatment of COVID‐19. The significance of T‐cell‐based immunity during infection is highlighted. These results have significant implications for better clinical effectiveness of therapies for COVID‐19 and the development of T‐cell‐dependent medicines for the elderly population.

In this study we explored the effect of the discrete emotions of short-video presenters on audience engagement with climate-change videos on Chinese TikTok (Douyin). We performed an automated content analysis of 510 science communication videos, with a focus on the emotional expression of the presenter and interactions of emotions. Our findings revealed that the negative emotion ofanger dominated climate-change videos and significantly influenced audience engagement. To our surprise, the presence of the emotion of happiness in the audio led to decreased engagement. We also uncovered the critical role of complex emotional interactions in affecting audience engagement, with combinations of positive and negative emotions being particularly influential. Furthermore, we employed facial emotion recognition and the SpeechBrain machine-learning technique for emotion detection in the videos, a methodological approach that is innovative and ensures objective and accurate analysis, as well as offering new possibilities for research.

In this study we explored the effect of the discrete emotions of short-video presenters on audience engagement with climate-change videos on Chinese TikTok (Douyin). We performed an automated content analysis of 510 science communication videos, with a focus on the emotional expression of the presenter and interactions of emotions. Our findings revealed that the negative emotion of anger dominated climate-change videos and significantly influenced audience engagement. To our surprise, the presence of the emotion of happiness in the audio led to decreased engagement. We also uncovered the critical role of complex emotional interactions in affecting audience engagement, with combinations of positive and negative emotions being particularly influential. Furthermore, we employed facial emotion recognition and the SpeechBrain machine-learning technique for emotion detection in the videos, a methodological approach that is innovative and ensures objective and accurate analysis, as well as offering new possibilities for research.

The world is experiencing one of the most difficult moments in history with COVID‐19, which has rapidly developed into a worldwide pandemic with a significant health and economic burden. Efforts to fight the virus, including prevention and treatment, have never stopped. However, no specific drugs or treatments have yet been found. Antibody drugs have never been absent in epidemics such as SARS, MERS, HIV, Ebola, and so on in the past two decades. At present, while research on the SARS‐CoV‐2 vaccine is in full swing, antibody drugs are also receiving widespread attention. Several antibody drugs have successfully entered clinical trials and achieved impressive therapeutic effects. Here, we summarize the therapeutic antibodies against SARS‐CoV‐2, as well as the research using ACE2 recombinant protein or ACE2‐Ig fusion protein. Several antibody drugs have successfully entered clinical trials and achieved impressive therapeutic effects. Due to the rapid progress in the field of therapeutic antibodies for COVID‐19 treatment, the authors summarize the neutralizing antibody drugs and fusion protein drugs that have attracted high attention at present, discuss the existing problems in the current application of antibodies drugs for COVID‐19, and prospect the future research direction in this field.

Mutation in p53 is the most frequent event in cancer development and a leading cause of cancer therapy resistance due to evasion of the apoptosis cascade. Beyond chemotherapies and radiation therapies, growing evidence indicates that p53-mutant tumors are resistant to a broad range of immune-based therapies, such as immune checkpoint inhibitors, chimeric antigen receptor (CAR) T, and hematopoietic stem cell transplantation (HSCT). This highlights the role of p53 mutations in driving immune evasion of tumor cells. In this review, we first summarize recent studies revealing mechanisms by which p53-mutant tumors evade immune surveillance from T cells, natural killer (NK) cells, and macrophages. We then review how these mutant tumor cells reshape the tumor microenvironment (TME), modulating bystander cells such as macrophages, neutrophils, and regulatory T (Treg) cells to foster immunosuppression. Additionally, we review clinical observations indicative of immune evasion associated with p53 loss or mutations. Finally, we discuss therapeutic strategies to enhance immune response in p53 wild-type (WT) or mutant tumors.

Rapid industrialization has led to a substantial increase in waste salts containing Na[sub.2] SO[sub.4] /NaCl mixtures, posing significant challenges for their phase separation and resource recovery. This study pioneers an integrated process combining frozen crystallization with stepwise decompression evaporation for Na[sub.2] SO[sub.4] /NaCl separation. Through the systematic investigation of phase transition behaviors under varying ionic ratios, the optimal combined processes corresponding to mixed salts with different compositions were identified. The experimental results demonstrate that brines with NaCl > 80.0% should preferentially undergo vacuum evaporation, while those below this threshold are suitable for prioritizing frozen crystallization for Na[sub.2] SO[sub.4] recovery. Utilizing the complementary advantages of both processes, the mixture was prepared with a mass ratio of NaCl to Na[sub.2] SO[sub.4] of 3:1. The frozen crystallization of the brine yielded 90.0% pure Na[sub.2] SO[sub.4] crystals while concentrating NaCl to 92.0% in the residual liquor. Subsequent stepwise evaporation yielded 98.5% pure NaCl crystals. Finally, the removal effect and lifecycle evaluation of the process for impurity ions provide new insights for the zero liquid discharge system in industrial waste salt management.