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Oxide semiconductor gas sensors are widely used due to their low cost, rapid response, small footprint, and ease of integration. However, in complex gas mixtures their selectivity is often limited by inherent cross-sensitivity. To address this, we developed a reconfigurable sensor-array system that supports up to 12 chemiresistive sensors with four- or six-electrode configurations, independent thermal control, and programmable gas paths. As a representative case study, we designed a customized array for fish-spoilage biomarkers, intentionally leveraging the cross-sensitivity and broad-spectrum responses of metal-oxide sensors. Following principal component analysis (PCA) preprocessing, we evaluated convolutional neural network (CNN), random forest (RF), and particle swarm optimization–tuned support vector machine (PSO-SVM) classifiers. The RF model achieved 94% classification accuracy. Subsequent channel optimization (correlation analysis and feature-importance assessment) reduced the array from 12 to 8 sensors and improved accuracy to 96%, while simplifying the system. These results demonstrate that deliberately leveraging cross-sensitivity within a carefully selected array yields an information-rich odor fingerprint, providing a practical platform for complex gas-mixture identification and food-freshness assessment.

This study aims to continuously optimize the exhaust manifold to ensure long-term stability of reliable performance, and focused on exhaust manifold examining low and high cycle fatigue at high temperatures. The thermal stress and thermal modes under load conditions are analyzed using calculational results, subsequently, an optimal scheme is devised and its practicality is verified through finite element analysis. The results indicates that the equivalent plastic strain increment of the bracket in the base design is 1.22%, whereas the improved base design reduced this value by 26% and 21% respectively. These results enhance credibility to the design methodology and verification process, laying a solid theoretical foundation and reference framework for troubleshooting exhaust manifold failures under multiple-load scenarios.

Objective To determine the effectiveness and safety of nicotine replacement therapy assisted reduction to stop smoking.Design Systematic review of randomised controlled trials.Data sources Cochrane Library, Medline, Embase, CINAHL, PsychINFO, Science Citation Index, registries of ongoing trials, reference lists, the drug company that sponsored most of the trials, and clinical experts.Review methods Eligible studies were published or unpublished randomised controlled trials that enrolled smokers who declared no intention to quit smoking in the short term, and compared nicotine replacement therapy (with or without motivational support) with placebo, no treatment, other pharmacological therapy, or motivational support, and reported quit rates. Two reviewers independently applied eligibility criteria. One reviewer assessed study quality and extracted data and these processes were checked by a second reviewer. The primary outcome, six months sustained abstinence from smoking beginning during treatment, was assessed by individual patient data analysis. Other outcomes were cessation and reduction at end of follow-up, and adverse events.Data synthesis Seven placebo controlled randomised controlled trials were included (four used nicotine replacement therapy gum, two nicotine replacement therapy inhaler, and one free choice of therapy). They were reduction studies that reported smoking cessation as a secondary outcome. The trials enrolled a total of 2767 smokers, gave nicotine replacement therapy for 6-18 months, and lasted 12-26 months. 6.75% of smokers receiving nicotine replacement therapy attained sustained abstinence for six months, twice the rate of those receiving placebo (relative risk (fixed effects) 2.06, 95% confidence interval 1.34 to 3.15; (random effects) 1.99, 1.01 to 3.91; five trials). The number needed to treat was 29. All other cessation and reduction outcomes were significantly more likely in smokers given nicotine replacement therapy than those given placebo. There were no statistically significant differences in adverse events (death, odds ratio 1.00, 95% confidence interval 0.25 to 4.02; serious adverse events, 1.16, 0.79 to 1.50; and discontinuation because of adverse events, 1.25, 0.64 to 2.51) except nausea, which was more common with nicotine replacement therapy (8.7% v 5.3%; odds ratio 1.69, 95% confidence interval 1.21 to 2.36).Conclusions Available trials indicate that nicotine replacement therapy is an effective intervention in achieving sustained smoking abstinence for smokers who have no intention or are unable to attempt an abrupt quit. Most of the evidence, however, comes from trials with regular behavioural support and monitoring and it is unclear whether using nicotine replacement therapy without regular contact would be as effective.

This study aims to systematically investigate the associations of varying volumes of vigorous-intensity physical activity (VPA) and its proportion to moderate-to-vigorous intensity physical activity (MVPA) with all-cause, cardiovascular disease (CVD), and cancer mortality. The review was registered in the PROSPERO (CRD42024525067). Web of Science, Embase, and PubMed were searched from inception to March 22, 2024. Empirical studies that investigated the effects of VPA compared to light-to-moderate intensity physical activities (LMPA) on all-cause, CVD, and cancer mortality were included. Additionally, studies that reported the effects of the proportion of VPA (relative to MVPA) on these mortality risks were also included. In total, 20 studies were included in the analyses. A curvilinear inverse dose-response relationship was observed between the volume of VPA and all-cause, CVD, and cancer mortality. Engaging in 180 minutes of VPA per week was associated with a substantial reduction in mortality risk: 22% for all-cause mortality, 23% for CVD mortality, and 14% for cancer mortality, compared to LMPA. Further increases in VPA volume yielded only modest additional benefits. Furthermore, a U-shaped inverse dose-response relationship was observed between the proportion of VPA (relative to MVPA) and all-cause as well as CVD mortality. Compared to 0% VPA, a 37.5% VPA (relative to MVPA) was associated with the greatest reduction in all-cause mortality (HR = 0.90, 95% CI [0.88-0.93]) and CVD mortality (HR = 0.88, 95% CI [0.83-0.94]) risk, and the size of the reduction remained stable when VPA constituted 30-60% of MVPA. Engaging in more than 180 minutes of VPA per week is associated with a substantial reduction in risks of all-cause, CVD, and cancer mortality. Maintaining VPA at 30-60% of total MVPA appears to be associated with maximal reduction in all-cause and CVD mortality risks.

It is challenging to precisely measure the slow interseismic crustal-deformation rate from Synthetic Aperture Radar (SAR) data. The long-wavelength orbital errors, owing to the uncertainties in satellite orbit vectors, commonly exist in SAR interferograms, which degrade the precision of the Interferometric SAR (InSAR) products and become the main barrier to extracting interseismic tectonic deformation. In this study, we propose a novel temporal-network orbital correction method that is able to isolate the far-fault tectonic deformation from the mixed long-wavelength signals based on its spatio–temporal characteristic. The proposed approach is straightforward in methodology but could effectively separate the subtle tectonic deformation from glaring orbital errors without ancillary data. Both synthetic data and real Sentinel-1 SAR images are used to validate the reliability and effectiveness of this method. The derived InSAR velocity fields clearly present the predominant left-lateral strike-slip motions of the Tuosuo Lake segment of the Kunlun fault in western China. The fault-parallel velocity differences of 5–6 mm/yr across the fault between areas ~50 km away from the fault trace are addressed. The proposed method presents a significantly different performance from the traditional quadratic approximate method in the far field. Through the implementation of the proposed method, the root mean square error (RMSE) between the LOSGPS and our derived descending InSAR LOS (line of sight) measurements is reduced to less than one-third of the previous study, suggesting its potential to enhance the availability of InSAR technology for interseismic crustal-deformation measurement.

Heavy metal pollution has been a major environmental issue in recent years, seriously threatening land, water sources, agriculture, and human health. The remediation of heavy metal pollution has been a continuously vital issue for current research. Bioremediation is an effective and cost-efficient approach to reduce heavy metal toxicity. Phosphate-solubilizing fungi (PSF) have shown promise in heavy metal bioremediation due to their high tolerance and activity levels. However, the full potential of PSF in bioremediation needs further exploration. PSF activity, metabolite production, and environmental conditions can influence their efficiency in remediating heavy metals. These factors play a critical role in the practical application of PSF and necessitate improvement pathways. This article reviews potential strategies to enhance heavy metal remediation using PSF and optimizing bioprocesses and applications.

Background The aim of this study was to assess the feasibility, safety and outcome of the embolization of non-gonadal collateral supplying gestational sac (GS) in addition to uterine artery embolization (UAE), followed by hysteroscopic curettage for the management of cesarean scar pregnancy (CSP). Methods A retrospective study was undertaken from January 2012 to September 2018 in 24 CSP patients in whom non-gonadal collaterals supplying GS were identified by arterial angiography performed immediately after UAE. These patients underwent attempt collateral embolization in addition to UAE, followed by hysteroscopic curettage for the management of CSP. The 24 patients were divided into two groups based on whether they underwent technically successful collateral embolization (UAE-SCE group) or failed collateral embolization (UAE-FCE group) in addition to UAE. The baseline characteristics and clinical outcomes including time for serum β-human chorionic gonadotropin (β-hCG) levels normalization, blood loss, secondary anemia, and pelvic pain were compared between the two groups. The paired t test and Man Whitney test were used for comparisons of discrete and numerical variables, respectively. Results Collateral embolization was techinically successful in 16 (66.7%, 16/24) patients and failed in the other 8 (33.3%, 8/24) patients. There were no significant differences between the two groups in baseline characteristics. The mean blood loss and secondary anemia in the UAE-SCE group were significantly less than UAE-FCE group. No significant difference was found between the two groups in the mean time for β-hCG levels normalization and pelvic pain. Conclusions During the management of UAE combined with hysteroscopic curettage for CSP, additional embolization of non-gonadal collateral supplying GS during UAE is feasible and safe in patients with non-gonadal collateral supplying GS, and the additional embolization of the collateral may reduce blood bloss related to hysteroscopic curettage.

Our objective was to accurately predict, from complex mutation patterns, human immunodeficiency virus type 1 resistance to the protease inhibitor lopinavir, by use of artificial intelligence. Two neural network models were constructed: 1 based on changes at 11 positions in the protease that were previously recognized as being significant for lopinavir resistance and another based on a newly derived set of 28 mutations that were identified by performing category prevalence analysis. Both models were trained, validated, and tested with 1322 clinical samples. A procedure of determining the optimal neural network parameters was proposed to speed up the training processes. The results suggested that the 28-mutation set was a more accurate predictor of lopinavir susceptibility (correlation coefficient, R2=0.88). We identified potentially significant new mutations associated with lopinavir resistance and demonstrated the utility of neural network models in predicting phenotypic susceptibility from complex genotypes

Gyirong basin and its adjacent area are located at a special position in the Himalayan orogen, where the south Tibetan detachment system (STDS) and N-S trending rift converged. The north Himalayan orogen here can be divided into five petrologic-tectonic units successively from south to north: 1) the Greater Himalayan crystalline complex (GHC); 2) the STDS shear zone; 3) the Tethyan Himalayan sedimentary sequence (THS); 4) the late Cenozoic sedimentary basins, such as Gyirong and Oma basins; and 5) the Malashan gneiss dome. Structural studies show that this area experienced four stages of deformation: 1) the earlier south-directed thrusting, preserved both in the GHC and THS; 2) top-down-to-north slip along the STDS, normal faults related to this slip formed the early controlling structures of the Cenozoic basins,and the tilted pattern of the blocks between the basins indicated a north-directed slip; 3) east-west extension, the resultant N-S trending normal fault formed the eastern boundary of the basins; and 4) late gravitational collapse. Zircon SHRIMP U-Pb dating on the syn-deformational (leuco-) granite along the STDS indicates that the major activity of the STDS occurred at ca. 26 Ma, but its onset may have begun as early as ca. 36 Ma.

Porous liquids (PLs), an emerging porous material with permanent cavities, have attracted extensive attention in recent years. However, the current construction methods are complicated and resulting PLs possess high viscosity values, which cannot meet the requirements of practical industrial applications. Herein, we demonstrate a generalizable and simple strategy to prepare type III PLs with low viscosity based on the rule of “like dissolves like”. Specifically, the monoglycidyl ether terminated polydimethylsiloxane (denoted by E-PDMS) is attached to the surface of Universitetet i Oslo (UiO)-66-NH 2 via covalent linkage, constructing the pore generator (UiO-66-NH 2 -E-PDMS, denoted by P-UiO-66). Then, P-UiO-66 is dispersed into different types and amounts of sterically hindered solvents (PDMS400 or PDMS6000), obtaining a series of type III PLs (denoted by P-UiO-66-PLs) with permanent cavities and low viscosities. The gas sorption-desorption test shows that P-UiO-66-PLs have an enormous potential for CO 2 /N 2 selective separation. Besides, the porosity of P-UiO-66-PLs and the CO 2 sorption mechanism are demonstrated by molecular simulation. Furthermore, the generality of the synthesis strategy is confirmed by the successful construction of PLs using two other amino-metal-organic frameworks (MOFs) (MIL-53(Al)-NH 2 and MIL-88B(Fe)-NH 2 ). Importantly, it’s worth noting that the strategy based on the rule of “like dissolves like” sheds light on the preparation of other types of PLs for task-specific applications.