Explore the vast range of titles available.

Objective The aim of this study was to retrospectively investigate the efficacy of chemotherapy for neck lymph node metastasis (NLNM) by determining the characteristics and survival of patients with isolated NLNMs metastases from epithelial ovarian carcinoma (EOC) at stage IV of the Federation of Gynecology and Obstetrics (FIGO). Methods The clinicopathological characteristics and survival outcome of 24 cases with stage IV FIGO EOC with isolated NLNM were retrospectively analyzed between December 1, 2014, and November 30, 2021. Results Among the 24 patients, 2 (8.3%) underwent primary debulking surgery (PDS), 21 (87.5%) received neoadjuvant chemotherapy(NACT) followed by interval debulking surgery (IDS), and 1 (4.2%) received chemotherapy alone. Additionally, 13 (54.2%) cases achieved abdominal R0 debulking, while 11(45.8%) cases achieved R1/R2 debulking. The chemotherapy response of NLNMs included complete response (8/24, 33.3%), partial response (15/24,62.5%), or stable disease (1/24,41.7%). None of the patients received resection or radiotherapy of NLNMs. Recurrence was observed in 15 (62.5%) patients, with only 2 experiencing recurrence of NLNMs. The median progression-free survival (PFS) and overall survival (OS) were 35 months and 48 months, respectively. R0 debulking led to a significantly longer PFS (not reached) and OS (57 months) compared to non-R0 debulking (PFS: 10 months, P  = 0.001; OS: 22 months, P  = 0.001). Interestingly, patients with EOC with lymphatic recurrence had better OS ( 57 months) than did those with abdominal or distant recurrence (OS: 29 months; P  = 0.012). Conclusions Chemotherapy is an effective treatment for neck lymph nodes metastasis, and a favorable response to chemotherapy could eliminate the necessity for NLNM resection or radiotherapy. Effective control of abdominal disease with surgery may be a critical factor in managing FIGO stage IV EOC patients with isolated NLMNs.

In order to reduce the negative effect of lightweighting of suspension components on vehicle dynamic performance, the control arm and torsion beam widely used in front and rear suspensions were taken as research objects for studying the lightweight design method of suspension components. Mesh morphing technology was employed to define design variables. Meanwhile, the rigid–flexible coupling vehicle model with flexible control arm and torsion beam was built for vehicle dynamic simulations. The total weight of control arm and torsion beam was taken as optimization objective, as well as ride comfort and handling stability performance indexes. In addition, the fatigue life, stiffness, and modal frequency of control arm and torsion beam were taken as the constraints. Then, Kriging model and NSGA-II were adopted to perform the multi-objective optimization of control arm and torsion beam for determining the lightweight scheme. By comparing the optimized and original design, it indicates that the weight of the optimized control arm and torsion beam are reduced 0.505 kg and 1.189 kg, respectively, while structural performance and vehicle performance satisfy the design requirement. The proposed multi-objective optimization method achieves a remarkable mass reduction, and proves to be feasible and effective for lightweight design of suspension components.

Background Venous thromboembolism (VTE) is a common postoperative complication in patients undergoing surgery for gastric cancer (GC). Although VTE incidence may vary among cancers, guidelines rarely stratify preventive methods for postoperative VTE by cancer type. The risk of VTE in patients undergoing surgery for GC remains unclear. Methods A systematic review and meta-analysis was undertaken to determine the risk of VTE after GC surgery and discuss the clinical value of pharmacological thromboprophylaxis in these cases. Medline, Embase, Web of Science, and Cochrane Library databases were searched for articles published from their inception to September 2022. Results Overall, 13 studies (111,936 patients) were included. The overall 1-month incidence of VTE, deep vein thrombosis (DVT), and pulmonary embolism (PE) after GC surgery was 1.8% (95% CI, 0.8–3.1%; I²=98.5%), 1.2% (95% CI, 0.5–2.1%; I²=96.1%), and 0.4% (95% CI, 0.1–1.1%; I²=96.3%), respectively. The prevalence of postoperative VTE was comparable between Asian and Western populations (1.8% vs. 1.8%; P  > 0.05). Compared with mechanical prophylaxis alone, mechanical plus pharmacological prophylaxis was associated with a significantly lower 1-month rate of postoperative VTE and DVT (0.6% vs. 2.9% and 0.6% vs. 2.8%, respectively; all P <  0.05), but not PE ( P >  0.05). The 1-month postoperative incidence of VTE was not significantly different between laparoscopic and open surgery (1.8% vs. 4.3%, P >  0.05). Conclusion Patients undergoing GC surgery do not have a high risk of VTE. The incidence of VTE after GC surgery is not significantly different between Eastern and Western patients. Mechanical plus pharmacological prophylaxis is more effective than mechanical prophylaxis alone in postoperative VTE prevention. The VTE risk is comparable between open and laparoscopic surgery for GC.

In the side supporting structure of a precipitator casing, the skeleton column is sometimes designed as a composite section composed of double H-shaped steel limbs and connecting wallboard. Column buckling is characterized by its special section and the stressed skin effect from wallboard. The influence of initial imperfections and structural parameters on column stability was investigated using the nonlinear finite element method. The residual stress has a slight adverse effect on column stability. The buckling modes can be categorized into two types: 1) buckling of connecting wallboard; 2) simultaneous buckling of connecting wallboard and flexural-torsional buckling of H-shaped limbs in top segment. Column stability significantly increases with increasing connecting wallboard thickness, decreasing connecting wallboard width, and decreasing distance between the connecting wallboard and the rear flange of H-shaped limbs. The structural parameters of the wallboard, angle steel stiffeners, and transverse brace interval have no noticeable effect. Column stability slightly increases with a decrease in the width-to-thickness ratio of flange, the height-to-thickness ratio of web, and torsional slenderness ratio. Based on the simulation results, a buckling capacity calculation recommendation was developed for an axial compressive double-limb column, which is important for the design of heavily stressed double-limb columns in box-type structures.

MYD88 is an IL-6 primary response gene and, its upregulation of expression has been shown to be a poor prognostic factor in epithelial ovarian cancer (EOC). We investigated the effects of CpG methylation at the proximal promoter/5’UTR and IL-6/SP1/IRF1 signaling on upregulation of MYD88 and prognosis in EOC. We assessed CpG methylation at the proximal promoter/5’UTR of MYD88 using bisulfite sequencing/PCR in 103 EOC patients, 28 normal ovarian tissues and two EOC cell lines with differential expression of MYD88 and identified the impact of the level of CpG methylation on MYD88 upregulation by SP1/IRF1 with knockdown or blockade of IL-6. The proximal promoter/5’UTR of MYD88 was significantly hypomethylated in 75 EOC tissues compared to 28 normal ovarian tissues ( P  < 0.001). CpG hypomethylation was relevant to MYD88 upregulation in 75 EOC cases (R 2  = 0.4376; P  < 0.001). Of them, 38 cases with m5CpG low /MYD88 high /IL-6 high were associated with reduced progression-free/overall survival compared to 37 cases with m5CpG high /MYD88 low /IL-6 low ( P  < 0.01). Knockdown of IL-6 or blockade with IL-6 receptor McAb attenuated MYD88 upregulation by SP1/IRF1 signaling in EOC cells with MYD88 high ( P  < 0.001). In conclusion, CpG hypomethylation at the proximal promoter/5’UTR contributes to MYD88 upregulation in EOC via IL-6/SP1/IRF1 pathway.

The RMS of weighted acceleration, wheel dynamic load and suspension dynamic deflection are determined as evaluation indices of vehicle ride comfort performance. A multi-body dynamic rigid-flexible coupling model of an in-wheel motor vehicle is built based on the multi-body system dynamics. The ride comfort results of ride comfort simulation and road test are well fitted. A kriging model is created to describe the relationship of vehicle ride comfort evaluation indices and suspension parameters. A multi-objective optimization using NSGA-II is processed using this model, and the vehicle ride comfort performance is improved by using the optimized suspension parameters.

This paper presents a hybrid method integrating modified NSGA-II and TOPSIS, used for lightweight design of the front sub-frame of a passenger car. Firstly, the FE model of the sub-frame is constructed and is validated by modal test. Then, the strength performance of the sub-frame is analyzed under four typical load conditions consisting of braking, acceleration, steady state cornering and vertical bump. After that, a parameterized model of the sub-frame, in which 12 geometric parameters are defined as design variables, is developed based on the mesh morphing technology. Subsequently, modified NSGA-II is employed for multi-objective optimization of the sub-frame considering weight, maximum von-Mises stress and first order natural frequency as three conflicting objective functions. Accordingly, a set of Pareto-optimal solutions are obtained from the optimization process. Finally, the entropy weight theory and TOPSIS method are adopted to rank all these solutions from the best to the worst for determining the best compromise solution. In addition, the effectiveness of the proposed hybrid lightweight design method is demonstrated by the comparisons among baseline design and optimum solutions.

In this study, submillimeter level accuracy K-band microwave ranging (MWR) equipment is demonstrated, aiming to verify the detection of the Earth’s gravity field (EGF) and digital elevation models (DEM), through spacecraft formation flying (SFF) in low Earth orbit (LEO). In particular, this paper introduces in detail an integrated BeiDou III B1C/B2a dual frequency receiver we designed and developed, including signal processing scheme, gain allocation, and frequency planning. The receiver matched the 0.1 ns precise synchronize time-frequency benchmark for the MWR system, verified by a static and dynamic test, compared with a time interval counter synchronization solution. Moreover, MWR equipment ranging accuracy is explored in-depth by using different ranging techniques. The test results show that MWR achieved 40 μm and 1.6 μm/s accuracy for ranging and range rate during tests, using synchronous dual one-way ranging (DOWR) microwave phase accumulation frame, and 6 μm/s range rate accuracy obtained through a one-way ranging experiment. The ranging error sources of the whole MWR system in-orbit are analyzed, while the relative orbit dynamic models, for formation scenes, and adaptive Kalman filter algorithms, for SFF relative navigation designs, are introduced. The performance of SFF relative navigation using MWR are tested in a hardware in loop (HIL) simulation system within a high precision six degree of freedom (6-DOF) moving platform. The final estimation error from adaptive relative navigation system using MWR are about 0.42 mm (range/RMS) and 0.87 μm/s (range rate/RMS), which demonstrated the promising accuracy for future applications of EGF and DEM formation missions in space.

Background Primary debulking surgery (PDS) is the main treatment for patients with advanced ovarian cancer, and neoadjuvant chemotherapy (NACT) is for bulky stage III-IV patients who are poor surgical candidates and/or for whom there is a low likelihood of optimal cytoreduction. NACT can increase the rate of complete cytoreduction, but this advantage has not translated to an improvement in survival. Therefore, we aimed to identify factors associated with the survival of patients who received NACT followed by interval debulking surgery (IDS). Methods A retrospective study was conducted in FIGO stage IIIC-IV epithelial ovarian cancer patients who underwent PDS or IDS in our center between January 1st, 2013, and December 31st, 2018. Results A total of 273 cases were included, of whom 20 were lost to follow-up. Progression-free survival (PFS) and overall survival (OS) of the IDS and PDS groups were found to be similar, although the proportion of patients in stage IV and serum carbohydrate antigen 125 (CA125) levels before treatment in the IDS group were significantly higher than that in the PDS group. Body mass index (BMI), CA125 level before IDS, residual disease after surgery, and the interval between preoperative and postoperative chemotherapy were all found to be independent prognostic factors for PFS; FIGO stage, residual disease after surgery, and CA125 level before IDS were independent prognostic factors for OS. We found that PFS and OS were both significantly longer in patients with normal CA125 levels before IDS and when the interval between preoperative and postoperative chemotherapy was < 35.5 days (IDS-3 group) than for patients in the PDS group. Conclusions The results suggested the importance of timely IDS and postoperative chemotherapy and potentially allowed the identification of patients who would benefit the most from NACT. Normal CA125 levels before IDS and an interval between preoperative and postoperative chemotherapy no longer than 5 weeks were associated with improved prognosis in advanced ovarian cancer patients.

Combined application of steel, aluminum, and carbon fiber reinforcement plastic (CFRP) is the main direction of future lightweight body development. However, the anisotropy and additional lamination design variables of CFRP parts pose significant challenges for the development of multi-material bodies. This study establishes a parametric design method for the variable-thickness lamination scheme based on non-uniform rational B-splines, it can be coupled with existing parametric design methods for structural shapes to formulate a complete parametric design and modeling of CFRP components. On this basis, a homogenized intermediate material property is derived from classic laminate theory by introducing lamination assumptions, it enables a stepwise multi-material body optimization method to solve the challenge that components’ material design variables switching between CFRP and alloy will introduce/eliminate lamination design variables iteratively, posing a great optimization convergence difficulty. The proposed parametric modeling method for CFRP components was validated by experimental tests of a fabricated roof beam, and the proposed optimization method was applied to a vehicle body, achieving 15.9%, 23.9%, 18.6%, and 12.2% increase in bending and torsional stiffness and modal frequencies; 20.2%, 9.3%, and 12.7% reduction of weight and peak acceleration in frontal and side collisions. This study enables the forward design of multi-material bodies compatible with CFRP parts. Graphical Abstract Graphical Abstract