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"Wang, Dewei"
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A new literary history of modern China
A New Literary History of Modern China is a collective project that introduces the \"long\" modern period of Chinese literature from the late seventeenth century to the new millennium. The volume, with roughly 160 essays contributed by 145 authors on a wide spectrum of topics, is intended for readers who are interested in understanding modern China through its literary and cultural dynamics. At the same time, it takes up the challenge of rethinking the conceptual framework and pedagogical assumptions that underlie the extant paradigm of writing and reading literary history. Beyond the familiar canon of literature as representation, the volume seeks to include the tradition of literature as manifestation, on both textual and contextual levels, in a history of modern Chinese literature. In addition to familiar genres, A New Literary History features a diverse lineup of forms, from presidential speeches to pop song lyrics, from photographs to films, and from political treatises to prison house jottings--forms that not only represent the material world, but can also shape it and complete it. By combining both the pointillism of the chronicle and the comprehensiveness of grand recit, this revisionist endeavor introduces the four themes of \"worlding\" literary China: architectonics of temporalities; dynamics of travel and transculturation; contestation between wen and mediality; and remapping of the literary cartography of modern China.-- Provided by publisher
Book
Abnormality of m6A mRNA Methylation Is Involved in Alzheimer’s Disease
Alzheimer's disease (AD), the most common form of dementia, is highly prevalent in older adults. The main clinical feature is the progressive decline of memory function, which eventually leads to the decline of cognitive function. At present, the pathogenesis of AD is unclear. In the disease process, synaptic changes are the key. Recent studies have shown that the dysregulation of RNA methylation is related to many biological processes, including neurodevelopment and neurodegenerative diseases. N6-methyladenosine (m6A) is the most abundant modification in eukaryotic RNA. In this study, RNA m6A methylation was quantified in APP/PS1 transgenic mice, which is an AD mouse model, and C57BL/6 control mice, and data showed that m6A methylation was elevated in the cortex and the hippocampus of APP/PS1 transgenic mice. Next, the alterations of m6A RNA methylation in AD and in C57BL/6 mice were investigated using high-throughput sequencing. Genome-wide maps of m6A mRNA showed that the degrees of m6A methylation were higher in many genes and lower in others in AD mice. Interestingly, the expression of the m6A methyltransferase METTL3 was elevated and that of the m6A demethylase FTO was decreased in AD mice. The data were analyzed by gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses, and pathways that might be related to synaptic or neuron development and growth were constructed. The related pathways and genes predicted the potential roles of the differentially expressed m6A methylation RNA in AD. Collectively, our findings demonstrate that the m6A methylation of RNA promotes the development of AD.
Journal Article
Exosomes Isolated From Human Umbilical Cord Mesenchymal Stem Cells Alleviate Neuroinflammation and Reduce Amyloid-Beta Deposition by Modulating Microglial Activation in Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by excessive accumulation of the amyloid-β peptide (Aβ) in the brain, which has been considered to mediate the neuroinflammation process. Microglial activation is the main component of neuroimmunoregulation. In recent years, exosomes isolated from human umbilical cord mesenchymal stem cells (hucMSC-exosomes) have been demonstrated to mimic the therapeutic effects of hucMSCs in many inflammation-related diseases. In this study, exosomes from the supernatant of hucMSCs were injected into AD mouse models. We observed that hucMSC-exosomes injection could repair cognitive disfunctions and help to clear Aβ deposition in these mice. Moreover, we found that hucMSC-exosomes injection could modulate the activation of microglia in brains of the mice to alleviated neuroinflammation. The levels of pro-inflammatory cytokines in peripheral blood and brains of mice were increased and the levels of anti-inflammatory cytokines were decreased. We also treated BV2 cells with hucMSC-exosomes in culture medium. HucMSC-exosomes also had inflammatory regulating effects to alternatively activate microglia and modulate the levels of inflammatory cytokines in vitro.
Journal Article
Ecological and human health risk assessment of heavy metal(loid)s in agricultural soil in hotbed chives hometown of Tangchang, Southwest China
To determine the heavy metal(loid)s (HMs) contamination of agricultural soil in hotbed chives hometown of Tangchang, 788 topsoil samples were collected and analyzed for their heavy metal(loid)s concentration. The index of geo-accumulation (I
geo
), pollution index (PI) and potential ecological risk index (EI
i
) were used to assess the degree of pollution. Correlation analysis and principal component analysis (PCA) were used to determine the sources of soil HMs. Human health risks estimated with hazard index (HI) and carcinogenic risk (CR) indices based on ingestion, inhalation and dermal exposure pathways for adults and children. The mean values of Cd, Hg, As, Pb, Cr, Cu, Ni and Zn were 0.221, 0.155, 9.76, 32.2, 91.9, 35.2, 37.1 and 108.8 mg kg
−1
, respectively, which did not exceed the threshold values of the risk screening value for soil contamination. The potential ecological risk of soil heavy metal(loid)s was low level and there was no significant human health risk. Based on PCA, Pb and Hg may originate from transportation and atmospheric deposition, Zn, Cr and Ni may originate from natural sources and industrial activities, and Cu and Cd may originate from agricultural activities. Overall, from the perspective of HMs content, the soil quality in this study area was at a clean level. This study provides a reference and a basis for formulating effective measures to prevent and control HMs enrichment in agricultural soils.
Journal Article
Biomaterials mediated 3R (remove-remodel-repair) strategy: holistic management of Helicobacter pylori infection
Helicobacter pylori
(HP) is a major etiological agent of gastric cancer, with a global prevalence of around 50%. Current treatments, primarily based on antibiotics, face challenges such as increasing drug resistance and disruption of the gut microbiota. This review proposes a holistic integrative medicine (HIM) approach, guided by the 3R concept (Remove, Remodel, and Repair), to address these limitations. The 3R concept offers a novel paradigm for the integrated prevention and treatment of HP infections: Remove targets the direct eradication of HP by overcoming antibiotic resistance, Remodel focuses on reshaping the immune microenvironment to clear pathogens, and Repair emphasizes the restoration of the gastric mucosa and protection of the gut microbiota. We discuss the potential of biomaterials, including nanoparticles for targeted drug delivery and ROS generation, hydrogels for sustained release and mucosal repair, microspheres for enhanced drug loading and controlled release, and probiotics for microbiota restoration. Additionally, multimodal therapies such as phototherapy, sonodynamic therapy, and magnetic hyperthermia provide non-invasive, targeted treatments. These innovations align with HIM principles, integrating pathogen eradication with mucosal healing and microbiome protection. Future research should focus on optimizing these materials and validating their clinical applicability to improve patient outcomes and combat antibiotic resistance.
Journal Article
Evaluating the Vertical Accuracy of Global DEMs Using ICESat-2 and Its Cascading Impact on HAND-Based Flood Modeling in a Low-Gradient Coastal Plain
Driven by climate change and population growth, coastal flood risk is rising, making high-precision Digital Elevation Models (DEMs) essential for inundation simulation and risk assessment. Although global open-source DEMs are increasingly available, their regional applicability and uncertainty still require quantitative evaluation. Taking Lianyungang, a coastal city in eastern China, as the study area, this study used ICESat-2 ATL08 laser altimetry as the reference to assess the vertical accuracy of eight mainstream open-source DEMs: the ASTER GDEM, FABDEM, AW3D30 DEM, SRTM DEM, MERIT DEM, NASA DEM, Copernicus DEM, and TanDEM-X DEM. The effects of slope, aspect, and land cover on DEM errors were analyzed, and the Height Above Nearest Drainage (HAND) model was used to evaluate how DEM vertical accuracy and spatial resolution affect flood inundation simulation. The results show that the FABDEM has the highest accuracy (RMSE = 1.24 m; NMAD = 0.49 m), followed by the Copernicus DEM GLO-30 (RMSE = 1.56 m; NMAD = 0.65 m), whereas the ASTER GDEM performs worst (RMSE = 5.36 m; NMAD = 3.69 m). The SRTM DEM systematically underestimates ICESat-2 elevations, with mean and median errors of −1.85 m and −1.80 m, mainly due to acquisition time differences and land-use changes in Lianyungang. DEM errors generally increase with slope, are higher on west-facing slopes, and are larger over water bodies than over cropland and impervious surfaces. HAND simulations show that DEM-derived inundation differences are greatest under low-threshold conditions. At the 1 m HAND threshold, the MERIT DEM produces the largest inundation area (4370.28 km2), while the ASTER GDEM produces the smallest area (3330.53 km2); these differences decrease as the threshold increases. Overall, the FABDEM provides the most accurate flood inundation representation in Lianyungang, while the Copernicus DEM GLO-30 is a reliable alternative.
Journal Article
Adsorption Equilibrium and Mechanism and of Water Molecule on the Surfaces of Molybdenite (MoS2) Based on Kinetic Monte-Carlo Method
The oxidation/weathering of molybdenite (MoS2) is too slow to be monitored, even under pure oxygen and high temperatures, while it proceeds rapidly through humid air. The adsorption of water molecules on molybdenite is necessary for the wet oxidation/weathering of molybdenite. Therefore, we employ kinetic Monte Carlo modeling to clarify the adsorption isotherm, site preferences and kinetics of water on different surfaces of molybdenite. Our results indicate that (1) the adsorption capacity and adsorption rate coefficient of H2O on the (110) surface are significantly larger than those on the (001) surface at a temperature of 0~100 °C and a relative humidity of 0~100%, suggesting that the (110) surface is the predominant surface controlling the reactivity and solubility of molybdenite in its interaction with water; (2) the kinetic Monte Carlo modeling considering the adsorption/desorption rate of H2O, dissociation/formation rate of H2O and adsorption/desorption of dissociated H indicates that the adsorption and dissociation of H2O on the (110) surface can be completed in one microsecond (ms) at 298 K and in wet conditions; (3) the adsorption and dissociation of H2O on molybdenite are not the rate-limiting steps in the wet oxidation/weathering of molybdenite; and (4) kinetic Monte Carlo modeling explains the experimental SIMS observation that H2O and OH (rather than H+/H− or H2O) occupy the surface of MoS2 in a short time. This study provides new molecular-scale insights to aid in our understanding of the oxidation/weathering mechanism of molybdenite as the predominant mineral containing molybdenum in the Earth’s crust.
Journal Article