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"Wang, Fuming"
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Leadership through the classics : learning management and leadership from ancient East and West philosophy
The complex socio-economic and environmental challenges of the 21st century must be tackled by placing faith in the power of mankind to integrate established wisdom and new knowledge, and in our ability to collaborate for a sustainable future. Departing from this, a global 2011 conference debating papers devoted to the impact of ancient philosophy, focusing on Confucius and Aristotle, in modern leadership and management was organized by Hanban, the Athens University of Economics & Business, and the University of International Economics & Business, Beijing, China. This volume presents the wide array of conference contributions by international thought-leaders.
Book
Dynamic experimental study on anti-progressive collapse of polyline-shaped large-span double-layer grid space structure
This study investigates the dynamic response and failure mechanism of the polyline-shaped large-span double-layer grid space structures subjected to progressive collapse. A grid model was designed and fabricated to represent a typical area of a large-span double-layer grid space structure from a specific engineering project. Three representative locations were selected to simulate failure of the test model, and dynamic collapse tests were conducted. In the tests, four conditions were considered: D1 (120 kg, failure at A), D2 (120 kg, failure at B), D3 (120 kg, failure at C), and D4 (200 kg, failure at C). The dynamic response of the structure under various conditions was studied by comparing strain, displacement, and failure patterns derived from the test analysis. Furthermore, the collapse process and mechanism of the structure were analyzed. The results indicate that the upper chord rods are key components in collapse resistance design. Under test conditions D4, significant vertical displacement occurred, and out-of-plane deformation increased markedly after the lateral constraints were removed, causing the structure to tilt towards the side without a failure device. The strain and displacement changes were most significant under test conditions D3 and D4, especially near the failure locations. Under condition D3, the strain change is 1109 microstrain larger than that before the failure, with the maximum vertical displacement increase being 59.109 mm. Under condition D4, the strain change is -1126 microstrain larger than that before the failure, with the maximum vertical displacement increase being 74.795 mm. Through multi-condition testing, the collapse mechanisms at different failure locations in the structure were clarified. The failure of web members and lower chord rods led to a redistribution of internal forces, but the effect on the double-layer grid structure was minimal. After the failure of the upper chord rods, significant displacements occurred near the failure location, and buckling of surrounding members was observed.
Journal Article
A Fiber Bragg-Grating-Based Miniature Sensor for the Fast Detection of Soil Moisture Profiles in Highway Slopes and Subgrades
A fiber Bragg grating (FBG)-based aluminum oxide tube packed sensor (ATPS) was developed for the fast detection of the soil moisture profile in highway slopes and subgrades. The novel ATPS consists of an aluminum oxide tube with a diameter of 5 mm, an optical fiber containing a quasi-distributed FBG sensors, a “U”-shaped resistance wire, and a flange. There are four 0.9-mm diameter holes in the ATPS. Laboratory experiments were carried out to calibrate the relationship between the thermal response of ATPS and the soil moisture content. Two laboratory rainfall validation model tests were performed to validate the ATPS for capturing the soil moisture profile in highway slopes and subgrades. During the validations, the accuracy of the ATPS was quantified, and water infiltration through grassy and grassless ground surfaces were investigated. The calibrations indicate that the ATPS can detect and record real-time changes in the highway slope and subgrade moisture after rainfall, and reveal the most dangerous zones that occur at the connection between different construction materials. The average measurement accuracy of soil moisture monitoring was 0.015 m3/m3. Please note that the connection is where cracks form easily and the soil hydraulic conductivity increases significantly. The test results also indicate that grassy cover (lawn) significantly prevents water infiltration during the first few minutes of rainfall (twelve minutes in this study), after which, however, the infiltration rate drops sharply. The influence of lawn on water infiltration depends on the soil structure, hydraulic conductivity, and rainfall time. In summary, due to its small size and fast detection, the ATPS is a portable probe that can be used for moisture monitoring in highway slopes and subgrades.
Journal Article
Effects of Acupuncture at GV20 and ST36 on the Expression of Matrix Metalloproteinase 2, Aquaporin 4, and Aquaporin 9 in Rats Subjected to Cerebral Ischemia/Reperfusion Injury
Ischemic stroke is characterized by high morbidity and mortality worldwide. Matrix metalloproteinase 2 (MMP2), aquaporin (AQP) 4, and AQP9 are linked to permeabilization of the blood-brain barrier (BBB) in cerebral ischemia/reperfusion injury (CIRI). BBB disruption, tissue inflammation, and MMP/AQP upregulation jointly provoke brain edema/swelling after CIRI, while acupuncture and electroacupuncture can alleviate CIRI symptoms. This study evaluated the hypothesis that acupuncture and electroacupuncture can similarly exert neuroprotective actions in a rat model of middle cerebral artery occlusion (MCAO) by modulating MMP2/AQP4/APQ9 expression and inflammatory cell infiltration.
Eighty 8-week-old Sprague-Dawley rats were randomly divided into sham group S, MCAO model group M, acupuncture group A, electroacupuncture group EA, and edaravone group ED. The MCAO model was established by placement of a suture to block the middle carotid artery, and reperfusion was triggered by suture removal in all groups except group S. Acupuncture and electroacupuncture were administered at acupoints GV20 (governing vessel-20) and ST36 (stomach-36). Rats in groups A, EA, and ED received acupuncture, electroacupuncture, or edaravone, respectively, immediately after MCAO. Neurological function (assessed using the Modified Neurological Severity Score), infarct volume, MMP2/AQP4/AQP9 mRNA and protein expression, and inflammatory cell infiltration were all evaluated at 24 h post-reperfusion.
Acupuncture and electroacupuncture significantly decreased infarct size and improved neurological function. Furthermore, target mRNA and protein levels and inflammatory cell infiltration were significantly reduced in groups A, EA, and ED vs. group M. However, MMP2/AQP levels and inflammatory cell infiltration were generally higher in groups A and EA than in group ED except MMP2 mRNA levels.
Acupuncture and electroacupuncture at GV20 and ST36 both exercised neuroprotective actions in a rat model of MCAO, with no clear differences between groups A and EA. Therefore, acupuncture and electroacupuncture might find utility as adjunctive and complementary treatments to supplement conventional therapy for ischemic stroke.
Journal Article
Extraction and Classification of Flood-Affected Areas Based on MRF and Deep Learning
Floods can cause huge damage to society, the economy, and the environment. As a result, it is vital to determine the extent and type of land cover in flooded areas quickly and accurately in order to facilitate disaster relief and mitigation efforts. Synthetic aperture radar (SAR) is an all-weather, 24 h data source used to extract information about flood inundations, and its primary aim is to extract water body information for flood monitoring. In this study, we have studied the backscattering characteristics of water and non-water, combined the threshold segmentation method with Markov random fields (MRF), and embedded simulated annealing (SA) in the process of image noise reduction, resulting in the development of a water extraction method KI-MRF-SA with high accuracy in classification and high automation. Furthermore, object-scale adaptive convolutional neural networks (OSA-CNN) are introduced for the classification of optical images before the flood in order to provide reference data for flood inundation analysis. The method proposed in this study consists of the following three steps: (1) The Kittler and Illingworth (KI) thresholding algorithm is used for the segmentation of SAR images in order to determine the initial flood inundation extent; (2) MRF and SA algorithms are employed as a means to optimize the initial flood inundation extent, and the results are combined across multiple polarizations by using an intersection operation to determine the final flood inundation extent; and (3) As part of the flood mapping process, land cover types before the flood are classified using OSA-CNN and combined with flood inundation extents. According to the experimental results, it is evident that the proposed KI-MRF-SA method is capable of distinguishing water from non-water with significantly higher accuracy (3–5% improvement in the overall accuracy) than conventional thresholding methods. Combined with the classification method of OSA-CNN proposed in our earlier research, the overall classification accuracy of flood-affected areas could reach 92.7%.
Journal Article
Effect of Solution Treatment Temperature on Microstructural Evolution, Precipitation Behavior, and Comprehensive Properties in UNS S32750 Super Duplex Stainless Steel
The changes of microstructures, element distribution, and comprehensive properties were studied to explore their interactions with each other, induced by solution treatment of UNS S32750 super duplex stainless steel. The results showed that the ferrite content improved, while the austenite content declined as the temperature increased. From 900 to 1000 °C, the σ phase existing at α/γ grain boundaries and in ferrite grains gradually dissolved. At 1050 °C, the microstructures consisted of only ferrite and austenite. From 1050 to 1300 °C, the Cr2N precipitated in ferrite and gradually grew and coarsened. The impact energy and pitting potential of UNS S32750 first improved and then weakened, while the hardness is the opposite, owing to the combined effects of element distribution, microstructures, and precipitates. In the presence of the σ phase, the corrosion resistance and mechanical properties of UNS S32750 correspond directly to the σ phase fraction. Subsequently, the rise in temperature promoted γ → α phase transformation, and the elements partitioning ratios of Cr and Mo declined, resulting in reduced toughness and corrosion resistance and a rise in hardness. Consequently, when the solution treatment temperature is 1050 °C, the α/γ ratio of UNS S32750 approached 1:1, with excellent overall properties.
Journal Article
Cucurbitacin E inhibits M1 macrophage polarization and attenuates rheumatoid arthritis: a multi-omics analysis and experimental validation
Background
Rheumatoid arthritis (RA) is a chronic autoimmune disease marked by joint inflammation and destruction. Current treatments often have side effects and resistance. Cucurbitacin E (CuE), a natural compound with anti-inflammatory properties, shows therapeutic potential but its role in RA is unclear. This study explores CuE’s mechanisms in RA, focusing on M1 macrophage polarization.
Methods
We used a multi-omics approach, integrating transcriptomics, single-cell sequencing, and network pharmacology. Key steps included immune infiltration analysis, WGCNA, machine learning-based biomarker discovery, and flow cytometry validation. Pseudotime trajectory and cell communication analyses were also employed.
Results
Immune infiltration analysis revealed increased M1 macrophage infiltration in RA patients. WGCNA identified gene modules related to macrophage polarization. Machine learning identified five key biomarkers (CCR2, NFKB1, NT5E, PIK3R1, TYRO3). A diagnostic model based on these biomarkers achieved high accuracy (AUC = 0.94). Pseudotime and cell communication analyses suggested CuE may regulate M1 polarization and signaling networks. Flow cytometry showed high CuE concentrations inhibited M1 macrophage polarization.
Conclusion
CuE inhibits M1 macrophage polarization and related pathways, offering a promising RA treatment strategy. The identified biomarkers may serve as diagnostic and therapeutic targets. Future research should validate CuE’s clinical effects.
Journal Article
Experimental and Numerical Investigation on Repairing Effect of Polymer Grouting for Settlement of High-Speed Railway Unballasted Track
Uneven settlement of high-speed railway subgrade leads to the irregularity of high-speed railway line, which seriously affects high-speed train operation. The skylight point of high-speed railway operation is short and the maintenance time is limited. Therefore, how to quickly lift and repair the ballastless track slab in the subsidence section is an urgent problem to be solved in the maintenance of high-speed railways. The two-component non-aqueous reactive polymer material has the advantages of strong expansive force, fast reaction speed, and wide application range, which is extremely suitable for the repair of high-speed railway track slab subsidence and lifting. In this study, the expansion force characteristics of different density polymer materials and the stress-deformation curves at corresponding density are tested in laboratory to propose the mechanical parameters of polymer. Then, a three-dimensional finite element (FE) model of high-speed railway train ballastless-track subgrade is established based on ABAQUS. The mechanical characteristics of CRTS III ballastless track under different repair materials, different elevation, and different density of polymer grouting materials are analyzed. The results show that, under the dynamic load of the train, the stress value of polymer repairing material is less than that of cement slurry, presenting a compressive stress state, which is similar to that of the complete subgrade surface. In addition, within a certain thickness range, increasing the thickness of polymer is beneficial to reducing the difference of stress variation between polymer filling layer and complete pavement. Once beyond this range, the thickness of polymer has little effect on the force variation.
Journal Article
Seismic performance of steel frame joint with dumbbell-type replaceable energy-consuming beam sections
This research proposes a steel frame joint that addresses the issues of low lateral stiffness and the difficult replacement of traditional flange weakening joints. The proposed solution involves a steel frame joint with dumbbell-type replaceable energy-consuming beam sections (DREBS). Using DREBS with weakened webs, rather than weakening the flanges, improves the overall lateral stiffness of beam sections and enhances resistance to out-of-plane deformation. The replaceable energy-consuming girder section of the joint is connected using high-strength bolts, making it more convenient to replace. In addition, more steel can be saved using a large girder section instead of the entire girder. This study investigates the seismic performance of the proposed connection by examining the effects of various parameters, including the weakening length and weakening depth of web. Stress–strain diagrams and hysteresis curves are compared and analyzed with the weakening length and weakening depth of web. Also, the initial rotational stiffness is investigated using the component method, and the error between the stiffness from the equation and that from finite element calculations was compared. The results show that the length and depth of web weakening affect the structural performance; the longer the weakening length of web and the greater the weakening depth of web, the stronger the structure. Recommended values for the weakening length of webs are 0.24 to 0.48 times the length of the “dumbbell” beam. Similarly, the recommended values for the weakening depth of web are 0.07 to 0.21 times the height of the “dumbbell” beam section. The relative error between the theoretical and finite element values is 6.9%.
Journal Article
Postoperative analgesic effectiveness of quadratus lumborum block: systematic review and meta-analysis for adult patients undergoing hip surgery
Background
Quadratus lumborum block is a truncal block with several technique variations. It has been reported as providing effective analgesia for postoperative pain. The aim of this study is to determine the efficacy of the QL block in providing postoperative analgesia for hip surgery when compared with placebo or no block or other analgesic techniques.
Methods
Randomized trials evaluating quadratus lumborum block benefits in elective hip surgery were sought. The primary outcome was the 24 h opioid requirement after surgery. Two independent reviewers selected the studies and extracted the data.
Results
Thirteen randomized-controlled trials were included in this study. The included studies had significant heterogeneity regarding comparator groups; therefore, a limited quantitative analysis was undertaken for the comparison of QL block versus no block or placebo only. QL block reduced the opioid use by 15.78 (95% CI, 2.31 to 29.26) mg IME in the first postoperative 24 h compared with no block or placebo with no difference in static pain scores, pain grade was reduced by 2.95 (95% CI, 2.40 to 3.60) in the QL block group compared with placebo or no block in the first postoperative 24 h during movement.
Conclusions
Our meta-analysis indicates that QL block may be effective for analgesia in patients after hip surgery compared with placebo or no block. There is currently limited evidence comparing QL block with other analgesic techniques for hip surgery.
Journal Article