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"Wang, Jia"
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Regulation of flowering time by the miR156-mediated age pathway
Precise flowering time is critical to reproductive success. In response to diverse exogenous and endogenous cues including age, hormones, photoperiod, and temperature, the floral transition is controlled by a complex regulatory network, which involves extensive crosstalks, feedback, or feedforward loops between the components within flowering time pathways. The newly identified age pathway, which is controlled by microRNA156 (miR156) and its target SQUAMOSA PROMOTER BINDING-LIKE (SPL) transcription factors, ensures plants flower under non-inductive conditions. In this review, I summarize the recent advance in understanding of the age pathway, focusing on the regulatory basis of the developmental decline in miR156 level by age and the molecular mechanism by which the age pathway is integrated into other flowering time pathways.
Journal Article
إدارة الأزمات في زمن الأوبئة : مقالات لـ 56 عالما في الإدارة
يضم هذا الكتاب خلاصة تجارب وعصارة أفكار 56 عالما، هم من أبرز علماء الإدارة في الصين، وقد حملوا على عاتقهم مسؤولية قيادة المؤسسات الصينية لسنوات عديدة، وهو كتاب مرجعي لكل المؤسسات على المستوى العالمي والتي إن حدث لها ضرر في فترات الأزمات أو الأوبئة، فلن يتوقف هذا الضرر عند ملاكها أو المنتفعين منها، بل سيمتد أثره إلى قطاعات عريضة من العمالة، وسيضرب القوة الإنتاجية ولا سيما الصادرات والواردات وغيرها من الموارد. ومن ثم فهم محاربون على الخطوط الأولى، مثلهم مثل الأطباء في أزمة انتشار فيروس كورونا المستجد، وإن كان مجال تخصص كل مختلفا منهم عن الآخر، ففريق منهم ينقذ حياة الناس، بينما الفريق الآخر ينقذ أقواتهم. ولغة الكتاب لغة سهلة وبسيطة، تنطلق أفكاره من مواقف عامة وليست من مواقف خاصة محددة، ومن هنا تعد أفكاره صالحة للتطبيق على المؤسسات الصغيرة والمتوسطة في كل مكان، والتي أصبح لزاما عليها أن تلجأ للابتكار والإبداع إن أرادت الاستمرار على قيد الحياة، وبات عليها أن تبحث وسط ركام الأزمة عن الإيجابيات التي يمكن أن تهب لها حياة جديدة وسبلا مبتكرة للخلاص.
Book
Natural products: potential treatments for cisplatin-induced nephrotoxicity
Cisplatin is a clinically advanced and highly effective anticancer drug used in the treatment of a wide variety of malignancies, such as head and neck, lung, testis, ovary, breast cancer, etc. However, it has only a limited use in clinical practice due to its severe adverse effects, particularly nephrotoxicity; 20%–35% of patients develop acute kidney injury (AKI) after cisplatin administration. The nephrotoxic effect of cisplatin is cumulative and dose dependent and often necessitates dose reduction or withdrawal. Recurrent episodes of AKI result in impaired renal tubular function and acute renal failure, chronic kidney disease, uremia, and hypertensive nephropathy. The pathophysiology of cisplatin-induced AKI involves proximal tubular injury, apoptosis, oxidative stress, inflammation, and vascular injury in the kidneys. At present, there are no effective drugs or methods for cisplatin-induced kidney injury. Recent in vitro and in vivo studies show that numerous natural products (flavonoids, saponins, alkaloids, polysaccharide, phenylpropanoids, etc.) have specific antioxidant, anti-inflammatory, and anti-apoptotic properties that regulate the pathways associated with cisplatin-induced kidney damage. In this review we describe the molecular mechanisms of cisplatin-induced nephrotoxicity and summarize recent findings in the field of natural products that undermine these mechanisms to protect against cisplatin-induced kidney damage and provide potential strategies for AKI treatment.
Journal Article
Piezoelectric Materials and Sensors for Structural Health Monitoring: Fundamental Aspects, Current Status, and Future Perspectives
Structural health monitoring technology can assess the status and integrity of structures in real time by advanced sensors, evaluate the remaining life of structure, and make the maintenance decisions on the structures. Piezoelectric materials, which can yield electrical output in response to mechanical strain/stress, are at the heart of structural health monitoring. Here, we present an overview of the recent progress in piezoelectric materials and sensors for structural health monitoring. The article commences with a brief introduction of the fundamental physical science of piezoelectric effect. Emphases are placed on the piezoelectric materials engineered by various strategies and the applications of piezoelectric sensors for structural health monitoring. Finally, challenges along with opportunities for future research and development of high-performance piezoelectric materials and sensors for structural health monitoring are highlighted.
Journal Article
Unsupervised Scale-Consistent Depth Learning from Video
We propose a monocular depth estimation method SC-Depth, which requires only unlabelled videos for training and enables the scale-consistent prediction at inference time. Our contributions include: (i) we propose a geometry consistency loss, which penalizes the inconsistency of predicted depths between adjacent views; (ii) we propose a self-discovered mask to automatically localize moving objects that violate the underlying static scene assumption and cause noisy signals during training; (iii) we demonstrate the efficacy of each component with a detailed ablation study and show high-quality depth estimation results in both KITTI and NYUv2 datasets. Moreover, thanks to the capability of scale-consistent prediction, we show that our monocular-trained deep networks are readily integrated into ORB-SLAM2 system for more robust and accurate tracking. The proposed hybrid Pseudo-RGBD SLAM shows compelling results in KITTI, and it generalizes well to the KAIST dataset without additional training. Finally, we provide several demos for qualitative evaluation. The source code is released on GitHub.
Journal Article
Recent advances in nickel-catalyzed reductive hydroalkylation and hydroarylation of electronically unbiased alkenes
The use of simple and easily available feedstock to quickly and efficiently obtain compounds with complex molecular structures through the transition-metal-catalyzed construction of C(sp
3
)-C bonds has important significance. As traditional C(sp
3
)-C coupling reagents, alkylmetallic reagents often have limitations such as air and moisture sensitivity and difficulties in storage. Nickel-catalyzed reductive olefin hydrocarbonation reactions use alkenes to replace organometallic reagents, reduce the synthesis steps, improve the functional group compatibility, and expand the substrate scope This minireview discusses important progress in the hydroalkylation and hydroarylation of electronically unbiased alkenes in recent years and describes the key mechanism and applications.
Journal Article