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"Wang, Jin"
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TFTF: An R-Based Integrative Tool for Decoding Human Transcription Factor–Target Interactions
Transcription factors (TFs) are crucial in modulating gene expression and sculpting cellular and organismal phenotypes. The identification of TF–target gene interactions is pivotal for comprehending molecular pathways and disease etiologies but has been hindered by the demanding nature of traditional experimental approaches. This paper introduces a novel web application and package utilizing the R program, which predicts TF–target gene relationships and vice versa. Our application integrates the predictive power of various bioinformatic tools, leveraging their combined strengths to provide robust predictions. It merges databases for enhanced precision, incorporates gene expression correlation for accuracy, and employs pan-tissue correlation analysis for context-specific insights. The application also enables the integration of user data with established resources to analyze TF–target gene networks. Despite its current limitation to human data, it provides a platform to explore gene regulatory mechanisms comprehensively. This integrated, systematic approach offers researchers an invaluable tool for dissecting the complexities of gene regulation, with the potential for future expansions to include a broader range of species.
Journal Article
Born naughty : my childhood in China
\"Share in the joyful, adventure-filled shenanigans of a child growing up in a small mud hut in Inner Mongolia in this charming, illustrated memoir for young middle grade readers\"-- Provided by publisher.
Book
Lipid metabolic reprogramming in tumor microenvironment: from mechanisms to therapeutics
Lipid metabolic reprogramming is an emerging hallmark of cancer. In order to sustain uncontrolled proliferation and survive in unfavorable environments that lack oxygen and nutrients, tumor cells undergo metabolic transformations to exploit various ways of acquiring lipid and increasing lipid oxidation. In addition, stromal cells and immune cells in the tumor microenvironment also undergo lipid metabolic reprogramming, which further affects tumor functional phenotypes and immune responses. Given that lipid metabolism plays a critical role in supporting cancer progression and remodeling the tumor microenvironment, targeting the lipid metabolism pathway could provide a novel approach to cancer treatment. This review seeks to: (1) clarify the overall landscape and mechanisms of lipid metabolic reprogramming in cancer, (2) summarize the lipid metabolic landscapes within stromal cells and immune cells in the tumor microenvironment, and clarify their roles in tumor progression, and (3) summarize potential therapeutic targets for lipid metabolism, and highlight the potential for combining such approaches with other anti-tumor therapies to provide new therapeutic opportunities for cancer patients.
Journal Article
Magnetic micro and nanorobot swarms : from fundamentals to applications
Focused on the attractive emerging field of micro-/nanorobot swarms (microswarms). It introduces fundamental understandings of various microswarms, including pattern generation, transformation, locomotion, and imaging. This book also demonstrates applications of micro-/nanorobot swarms in different fields, such as biomedical, environmental, and electrical applications. The detailed theoretical analysis and experimental demonstrations in this book provide readers ranging from students to researchers with a realistic picture of progress achieved in the field of micro-/nanorobot swarms.
Book
Islands and Page curves of Reissner-Nordström black holes
A
bstract
We apply the recently proposed quantum extremal surface construction to calculate the Page curve of the eternal Reissner-Nordström black holes in four dimensions ignoring the backreaction and the greybody factor. Without the island, the entropy of Hawking radiation grows linearly with time, which results in the information paradox for the eternal black holes. By extremizing the generalized entropy that allows the contributions from the island, we find that the island extends to the outside the horizon of the Reissner-Nordström black hole. When taking the effect of the islands into account, it is shown that the entanglement entropy of Hawking radiation at late times for a given region far from the black hole horizon reproduces the Bekenstein-Hawking entropy of the Reissner-Nordström black hole with an additional term representing the effect of the matter fields. The result is consistent with the finiteness of the entanglement entropy for the radiation from an eternal black hole. This facilitates to address the black hole information paradox issue in the current case under the above-mentioned approximations.
Journal Article
Non-Alcoholic Fatty Liver Disease (NAFLD) Pathogenesis and Natural Products for Prevention and Treatment
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease, affecting approximately one-quarter of the global population, and has become a world public health issue. NAFLD is a clinicopathological syndrome characterized by hepatic steatosis, excluding ethanol and other definite liver damage factors. Recent studies have shown that the development of NAFLD is associated with lipid accumulation, oxidative stress, endoplasmic reticulum stress, and lipotoxicity. A range of natural products have been reported as regulators of NAFLD in vivo and in vitro. This paper reviews the pathogenesis of NAFLD and some natural products that have been shown to have therapeutic effects on NAFLD. Our work shows that natural products can be a potential therapeutic option for NAFLD.
Journal Article
The role of the Yangtze River Protection Law in the emergence of adaptive water governance in China
The Yangtze River Basin faces unprecedented challenges in harmonizing competing interests in its ecological and social systems. The central government of China, in response to the need for change in governance arrangements and cooperation, passed the Yangtze River Protection Law. It is China's first legislation at the basin scale and for a specific river basin. Ecological disturbances caused by industrial and other human activity, followed by political support for environmental protection, catalyzed the passage of this law. As the first tentative effort to regulate a complex and changing social-ecological system, it has incorporated multiple legal and institutional design principles identified in the adaptive governance and law scholarship: scaled approaches to social-ecological systems, cooperation to address geographical and sectoral fragmentation, and participatory capacity. These commonalities show that designs are fundamental to tackle geographic and sectoral fragmentation of complex systems and catalyze the emergence of adaptive water governance.
Journal Article