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Work function (WF) influences electron transport and intermediates adsorption, enabling charge balance and catalytic optimization for the hydrogen evolution reaction (HER). However, the understanding of the role of mesopores and the relationship between composition and WF in pristine Pt‐based alloys remains lacking. Herein, various mesoporous binary Pt‐M alloy films (m‐Pt‐M, M = Pd, Rh, and Ru) with uniform pores and elemental distributions are synthesized, providing an experimental platform to investigate this relationship. It has been demonstrated that the WFs of m‐Pt‐M catalysts are strongly influenced by their compositions and mesoporous structures, thereby impacting HER activities. Among them, m‐Pt‐Ru with tailored WF lowers the thermodynamic energy barrier and accelerates the kinetic processes of HER. The mass activity of m‐Pt‐Ru in alkaline media is 17.8× and 5.1× higher, compared to Pt black and m‐Pt, respectively. This work not only provides a simple method for the fabrication of well‐defined binary metallic alloy films but also offers experimental insights into the rational design of highly efficient electrocatalysts with tunable WFs. This study presents mesoporous binary Pt‐M alloy films (m‐Pt‐M, M = Pd, Rh, and Ru) with uniform porosity and tailored work functions (WFs) as an experimental study platform. The WFs of the m‐Pt‐M films exhibit a volcano‐type relationship with their HER performance. Among them, the m‐Pt‐Ru demonstrates superior activity, requiring only 16 mV overpotential to reach 10 mA cm−2 in alkaline media.

Fog harvesting through bionic strategies to solve water shortage has drawn considerable attention. Recently, an ultrafast fog harvesting and transport mode was identified in Sarracenia trichome, which is mainly attributed to its superslippery capillary force induced by its unique hierarchical microchannel. However, the underlying effect of hierarchical microchannel‐induced ultrafast transport on fog harvesting and the multiscale structural coupling effect on highly efficient fog harvesting are still great challenges. Herein, a bionic Sarracenia trichome (BST) with an on‐demand regular hierarchical microchannel is designed using a one‐step thermoplastic stretching approach on a glass fiber bundle. The BST is engineered to harbor major channels confined by an inner gear pattern along with junior microchannels that are automatically assembled by the glass fiber monofilaments. The BST shows enhanced capillary condensation and fog harvesting performance, in part due to its coupling effect with a Janus membrane (JM). Hence, a highly efficient multiscale fog collector is developed, in which a gradient high‐pressure field is purposely formed to improve by threefold fog harvesting performance compared with a single‐scale structure. This easy manufacturing and low‐cost fog collector may represent a useful tool for harvesting fog water for production and living and pave the way for further investigations. A bionic Sarracenia trichome with an on‐demand regular hierarchical microchannel is designed to achieve excellent fog harvesting and transport properties as the real one. With the combination of Janus membrane, a highly efficient multiscale fog collector is developed, in which a gradient high‐pressure field is purposely formed to improve by threefold fog harvesting performance compared with a single‐scale structure.

Single-cell studies have replaced bulk TCGA “subtypes” with a dynamic model in which multiple malignant programs interconvert in glioblastoma, and the balance among these programs is shaped by genetic lesions and local ecological cues. These programmes mirror distorted developmental gene programmes, and their intrinsic developmental plasticity fuels state switching and therapeutic escape. Spatial multi-omics now anchors these programs to anatomy, revealing a reproducible, hypoxia-graded five-layer architecture from necrotic core to infiltrative rim and identifying hypoxia as a long-range organizer. Whole-tumour 3D sampling links clonal evolution to territory, showing that early driver events can span the lesion, while later changes remain regionally restricted. This geography-aware view helps explain why single agents often fail and points to niche-targeted combinations and delivery strategies tailored to the blood-tumour barrier states. We outline how an integrated, spatially resolved multi-omics atlas can guide compartment-specific therapy and prospective monitoring in precision neuro-oncology.

Doxorubicin (Dox) is an effective anticancer drug, however, its clinical application is restricted by the life-threatening cardiotoxic effects. Secreted Frizzled-related protein 1 (sFRP1) has been reported to participate in both the cancer and cardiovascular diseases and was one of the differential expression genes in normal hearts compared with Dox-treated hearts. Thus, it is important to reveal the potential role of sFRP1 in Dox-induced cardiotoxicity. Here, we show that sFRP1 has a biphasic effect on Dox-induced cardiotoxicity in a location-dependent manner. The secretion of sFRP1 was significantly increased in Dox-treated neonatal rat cardiomyocytes (NRCMs) (1 µM) and SD rats (5 mg/kg/injection at day 1, 5, and 9, i.p.). Adding the anti-sFRP1 antibody (0.5 µg/ml) and inhibiting sFRP1 secretion by caffeine (5 mM) both relieved Dox-induced cardiotoxicity through activating Wnt/β-catenin signaling, whereas increasing the secretion of sFRP1 by heparin (100 µg/ml) had the opposite effect. The intracellular level of sFRP1 was significantly decreased after Dox treatment both in vitro and in vivo. Knockdown of sFRP1 by sgRNA aggravated Dox-induced cardiotoxicity, while moderate overexpression of sFRP1 by Ad-sFRP1 exhibited protective effect. Besides, poly(ADP-ribosyl) polymerase-1 (PARP1) was screened as an interacting partner of sFRP1 in NRCMs by mass spectrometry. Our results suggested that the intracellular sFRP1 protected NRCMs from Dox-induced cardiotoxicity by interacting with PARP1. Thus, our results provide a novel evidence that sFRP1 has a biphasic effect on Dox-induced cardiotoxicity. In addition, the oversecretion of sFRP1 might be used as a biomarker to indicate the occurrence of cardiotoxicity induced by Dox treatment.

In article 2100087, Huawei Chen and co‐workers design a bionic Sarracenia trichome with an on‐demand regular hierarchical microchannel to achieve excellent fog harvesting and transport properties. With the combination of a Janus membrane, a highly efficient multiscale fog collector is developed, in which a gradient high‐pressure field is purposely formed to improve, by threefold, fog harvesting performance compared with a single‐scale structure.

Level Set interface treatment method is introduced into Euler method, which is employed for interface treatment method for multi-materials. Combined with the ghost fluid method, the moving interface is tracked. Fifth-order WENO spatial discretization and third-order TVD Runge-Kutta time discretization methods are used. Shock-wave action on bubble, implosion and velocity field Shock effect bubbles; implosion and velocity field are simulated by means of LS-MMIC3D programmed by C++. Numerical results show that the Level Set interface treatment method is effective and feasible for multi-material interface treatment in comparison with the WENO method.