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"Wang, Liang‐Yu"
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Toward Hydrogen‐Free and Dendrite‐Free Aqueous Zinc Batteries: Formation of Zincophilic Protective Layer on Zn Anodes
Rechargeable aqueous Zn‐ion batteries (ZIBs) are regarded as one of the most promising devices for the next‐generation energy storage system. However, the uncontrolled dendrite growth on Zn metal anodes and the side hydrogen evolution reaction, which has not yet been well considered, hinder the practical application of these batteries. Herein, a uniform and robust metallic Sb protective layer is designed based on the theoretic calculation and decorated on Zn plate via in situ replacement reaction. Compared with the bare Zn plate, the as‐prepared Zn@Sb electrode provides abundant zincophilic sites for Zn nucleation, and homogenizes the electric field around the Zn anode surface, both of which promote the uniform Zn deposition to achieve a dendrite‐free morphology. Moreover, the Gibbs free energy (∆GH) calculation and in situ characterization demonstrate that hydrogen evolution reaction can be effectively suppressed by the Sb layer. Consequently, Sb‐modified Zn anodes exhibit an ultralow voltage hysteresis of 34 mV and achieve excellent cycling stability over 1000 h with hydrogen‐ and dendrite‐free behaviors. This work provides a facile and effective strategy to suppress both hydrogen evolution reaction and dendrite growth. A uniform and robust metallic Sb protective layer is decorated on Zn plate via in situ replacement reaction. With rich zincophilic sites for Zn nucleation, improved electrolyte wettability and homogenized electric field, the Sb layer promotes the uniform Zn deposition with a dendrite‐free morphology. Moreover, the Gibbs free energy calculation and in situ characterization demonstrate that hydrogen evolution reaction can be effectively suppressed by the Sb layer.
Journal Article
Implementation of an Automatic Meeting Minute Generation System Using YAMNet with Speaker Identification and Keyword Prompts
Producing conference/meeting minutes requires a person to simultaneously identify a speaker and the speaking content during the course of the meeting. This recording process is a heavy task. Reducing the workload for meeting minutes is an essential task for most people. In addition, providing conference/meeting highlights in real time is helpful to the meeting process. In this study, we aim to implement an automatic meeting minutes generation system (AMMGS) for recording conference/meeting minutes. A speech recognizer transforms speech signals to obtain the conference/meeting text. Accordingly, the proposed AMMGS can reduce the effort in recording the minutes. All meeting members can concentrate on the meeting; taking minutes is unnecessary. The AMMGS includes speaker identification for Mandarin Chinese speakers, keyword spotting, and speech recognition. Transferring learning on YAMNet lets the network identify specified speakers. So, the proposed AMMGS can automatically generate conference/meeting minutes with labeled speakers. Furthermore, the AMMGS applies the Jieba segmentation tool for keyword spotting. The system detects the frequency of words’ occurrence. Keywords are determined from the highly segmented words. These keywords help an attendant to stay with the agenda. The experimental results reveal that the proposed AMMGS can accurately identify speakers and recognize speech. Accordingly, the AMMGS can generate conference/meeting minutes while the keywords are spotted effectively.
Journal Article
Comparative analysis of the diffusion kurtosis imaging and diffusion tensor imaging in grading gliomas, predicting tumour cell proliferation and IDH-1 gene mutation status
Introduction
Few studies have applied diffusion kurtosis imaging (DKI) and diffusion tensor imaging (DTI) for the comprehensive assessment of gliomas [tumour grade, isocitrate dehydrogenase-1 (
IDH-1
) mutation status and tumour proliferation rate (Ki-67)]. This study describes the efficacy of DKI and DTI to comprehensively evaluate gliomas, compares their results.
Methods
Fifty-two patients (18 females; median age, 47.5 years) with pathologically proved gliomas were prospectively included. All cases underwent DKI examination. DKI (mean kurtosis: MK, axial kurtosis: Ka, radial kurtosis: Kr) and DTI (mean diffusivity: MD, fractional anisotropy: FA) maps of each metric was derived. Three ROIs were manually drawn.
Results
MK, Ka, Kr and FA were significantly higher in HGGs than in LGGs, whereas MD was significantly lower in HGGs than in LGGs (
P
< 0.01). ROC analysis demonstrated that MK (specificity: 100% sensitivity: 79%) and Ka (specificity: 96% sensitivity: 82%) had the same and highest (AUC: 0.93) diagnostic value. Moreover, MK, Ka, and Kr were significantly higher in grade III than II gliomas (
P
≦ 0.01). Further, DKI and DTI can significantly identify
IDH-1
mutation status (
P
≦ 0.03). Ka (sensitivity: 74%, specificity: 75%, AUC: 0.72) showed the highest diagnostic value. In addition, DKI metrics and MD showed significant correlations with Ki-67 (
P
≦ 0.01) and Ka had the highest correlation coefficient (
r
s
= 0.72).
Conclusions
Compared with DTI, DKI has great advantages for the comprehensive assessment of gliomas. Ka might serve as a promising imaging index in predicting glioma grading, tumour cell proliferation rate and
IDH-1
gene mutation status.
Journal Article
Diffusion kurtosis imaging in evaluating gliomas: different region of interest selection methods on time efficiency, measurement repeatability, and diagnostic ability
Objectives
Comparing the diagnostic efficacy of diffusion kurtosis imaging (DKI) derived from different region of interest (ROI) methods in tumor parenchyma for grading and predicting
IDH-1
mutation and 1p19q co-deletion status of glioma patients and correlating with their survival data.
Methods
Sixty-six patients (29 females; median age, 45 years) with pathologically proved gliomas (low-grade gliomas, 36; high-grade gliomas, 30) were prospectively included, and their clinical data were collected. All patients underwent DKI examination. DKI maps of each metric were derived. Three groups of ROIs (ten spots, ROI-10s; three biggest tumor slices, ROI-3s; and whole-tumor parenchyma, ROI-whole) were manually drawn by two independent radiologists. The interobserver consistency, time spent, diagnostic efficacy, and survival analysis of DKI metrics based on these three ROI methods were analyzed.
Results
The intraexaminer reliability for all parameters among these three ROI methods was good, and the time spent on ROI-10s was significantly less than that of the other two methods (
p
< 0.001). DKI based on ROI-10s demonstrated a slightly better diagnostic value than the other two ROI methods for grading and predicting the
IDH-1
mutation status of glioma, whereas DKI metrics derived from ROI-10s performed much better than those of the ROI-3s and ROI-whole in identifying 1p19q co-deletion. In survival analysis, the model based on ROI-10s that included patient age and mean diffusivity showed the highest prediction value (C-index, 0.81).
Conclusions
Among the three ROI methods, the ROI-10s method had the least time spent and the best diagnostic value for a comprehensive evaluation of glioma. It is an effective way to process DKI data and has important application value in the clinical evaluation of glioma.
Key Points
• The intraexaminer reliability for all DKI parameters among different ROI methods was good, and the time spent on ROI-10 spots was significantly less than the other two ROI methods.
• DKI metrics derived from ROI-10 spots performed the best in ROI selection methods (ROI-10s, ten-spot ROIs; ROI-3s, three biggest tumor slices ROI; and ROI-whole, whole-tumor parenchyma ROI) for a comprehensive evaluation of glioma.
• The ROI-10 spots method is an effective way to process DKI data and has important application value in the clinical evaluation of glioma.
Journal Article
Characterization of the complete chloroplast genome of Euphorbia pekinensis Rupr. (Euphorbiaceae)
Euphorbia pekinensis Rupr. 1859 is a medicinal herb endemic to China and distributed throughout the country, particularly across the northern part of the mainland. However, the systematic classification of Euphorbiaceae remains controversial. Therefore, studying the chloroplast genome of E. pekinensis is crucial for the resolution of this taxonomic dispute, clarification of the systematic status of Euphorbia, and establishment of an accurate classification system for Euphorbiaceae. In this study, we sequenced the complete chloroplast genome of E. pekinensis using Illumina sequencing technology and annotated it using GeSeq. The complete chloroplast genome was 162,002-bp-long with a guanine-cytosine (GC) content of 35.7%. It included one large single-copy (LSC), one small single-copy (SSC), and two inverted repeat sequence regions (IRa and IRb), which were 90,225 bp, 18,067 bp, and 26,855 bp in length, respectively, and are indicative of a typical tetrad structure. The genome encoded 129 functional genes, comprising 85 protein-coding genes, 36 tRNA genes, and eight rRNA genes. According to the maximum-likelihood phylogenetic tree that was constructed using 16 complete chloroplast genomes, E. pekinensis was found to be closely related to E. ebracteolata. Therefore, the complete chloroplast genome of E. pekinensis provides a better understanding of Euphorbia genetics.
Journal Article
MADS-box gene AaSEP4 promotes artemisinin biosynthesis in Artemisia annua
The plant Artemisia annua is well known for its production of artemisinin, a sesquiterpene lactone that is an effective antimalarial compound. Although remarkable progress has been made toward understanding artemisinin biosynthesis, the effect of MADS-box family transcription factors on artemisinin biosynthesis is still poorly understood. In this study, we identified a MADS transcription factor, AaSEP4, that was predominantly expressed in trichome. AaSEP4 acts as a nuclear-localized transcriptional activator activating the expression of AaGSW1 (GLANDULAR TRICHOME-SPECIFIC WRKY1) . Dual-luciferase and Yeast one-hybrid assays revealed that AaSEP4 directly bound to the CArG motif in the promoter region of AaGSW1 . Overexpression of AaSEP4 in A. annua significantly induced the expression of AaGSW1 and four artemisinin biosynthesis genes, including amorpha-4,11-diene synthase (ADS) , cytochrome P450 monooxygenase (CYP71AV1) , double-bond reductase 2 (DBR2) and aldehyde dehydrogenase 1 (ALDH1) . Furthermore, the results of high-performance liquid chromatography (HPLC) showed that the artemisinin content was significantly increased in the AaSEP4- overexpressed plants. In addition, RT-qPCR results showed that AaSEP4 was induced by methyl jasmonic acid (MeJA) treatment. Taken together, these results explicitly demonstrate that AaSEP4 is a positive regulator of artemisinin biosynthesis, which can be used in the development of high-artemisinin yielding A. annua varieties.
Journal Article
Experimental Study on Disintegration of Guilin Red Clay
In order to study the disintegration characteristics of red clay under different moisture content and temperature, red clay taken from Guilin was prepared into samples with different moisture content, and the disintegration test of red clay was carried out by self-made test equipment. Considering the influence of water absorption and weight gain in red clay, a parallel water absorption test was carried out for each disintegration test, and the disintegration amount–time relationship curve was corrected with the results of the water absorption test so as to propose a new disintegration amount calculation formula. In this experiment, the disintegration characteristics of red clay under different moisture content and temperature were investigated. The experimental results show that the disintegration amount decreases with the increase in moisture content, the moisture content exceeds 25%, and the red clay basically does not disintegrate within 2 h. The amount of disintegration increases with increasing temperature, but the disintegration of red clay in natural environments is not sensitive to temperature. The comprehensive analysis of moisture content and temperature shows that in the natural climate range, moisture content is the main influencing factor of soil disintegration.
Journal Article
In Vitro and in Vivo Imaging of Nitroxyl with Copper Fluorescent Probe in Living Cells and Zebrafish
Nitroxyl (HNO) plays a critical role in many physiological processes which includes vasorelaxation in heart failure, neuroregulation, and myocardial contractility. Powerful imaging tools are required to obtain information for understanding the mechanisms involved in these in vivo processes. In order to develop a rapid and high sensitive probe for HNO detection in living cells and the zebrafish model organism, 2-((2-(benzothiazole-2yl)benzylidene) amino)benzoic acid (AbTCA) as a ligand, and its corresponding copper(II) complex Cu(II)-AbTCA were synthesized. The reaction results of Cu(II)-AbTCA with Angeli’s salt showed that Cu(II)-AbTCA could detect HNO quantitatively in a range of 40–360 µM with a detection limit of 9.05 µM. Furthermore, Cu(II)-AbTCA is more selective towards HNO over other biological species including thiols, reactive nitrogen, and reactive oxygen species. Importantly, Cu(II)-AbTCA was successfully applied to detect HNO in living cells and zebrafish. The collective data reveals that Cu(II)-AbTCA could be used as a potential probe for HNO detection in living systems.
Journal Article