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"Wang, Lijuan"
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The effects of online service quality of e-commerce Websites on user satisfaction
Purpose
– The purpose of this paper is to investigate service quality of e-commerce Websites in online platform and their contribution on e-business promotion.
Design/methodology/approach
– The online survey was performed on a survey portal provided by Nepal Telecom in Nepal.
Findings
– The findings of this study suggest that information quality and online service quality were the key determinants for user satisfaction and sustainability of e-commerce technology.
Research limitations/implications
– Research opportunities of web services and e-commerce area are fruitful and important for both academics and practitioners.
Practical implications
– The findings on online service quality of e-commerce technology will be useful for current management practice such as making business policies and strategies and sharing information to managers and organization leaders. This study can be used for e-commerce Website operators wishing to enhance the competitiveness of their Websites in the highly competitive online market.
Originality/value
– E-commerce is considered an excellent alternative for individuals and companies to reach new customers. Service quality delivery through Internet is an essential strategy to success, more important than price and web presence. The e-commerce Website has been identified as having a significant impact on business activities in solving the geographical problem. A number of performance problems have been observed for e-commerce Websites, and much work has gone into characterizing the performance of web-servers and Internet applications.
Journal Article
Dynamics and mechanism of ultrafast water–protein interactions
Protein hydration is essential to its structure, dynamics, and function, but water–protein interactions have not been directly observed in real time at physiological temperature to our awareness. By using a tryptophan scan with femtosecond spectroscopy, we simultaneously measured the hydration water dynamics and protein side-chain motions with temperature dependence. We observed the heterogeneous hydration dynamics around the global protein surface with two types of coupled motions, collective water/side-chain reorientation in a few picoseconds and cooperative water/side-chain restructuring in tens of picoseconds. The ultrafast dynamics in hundreds of femtoseconds is from the outer-layer, bulk-type mobile water molecules in the hydration shell. We also found that the hydration water dynamics are always faster than protein side-chain relaxations but with the same energy barriers, indicating hydration shell fluctuations driving protein side-chain motions on the picosecond time scales and thus elucidating their ultimate relationship.
Journal Article
Engineering bunched Pt-Ni alloy nanocages for efficient oxygen reduction in practical fuel cells
Development of efficient and robust electrocatalysts is critical for practical fuel cells. We report one-dimensional bunched platinum-nickel (Pt-Ni) alloy nanocages with a Pt-skin structure for the oxygen reduction reaction that display high mass activity (3.52 amperes per milligram platinum) and specific activity (5.16 milliamperes per square centimeter platinum), or nearly 17 and 14 times higher as compared with a commercial platinum on carbon (Pt/C) catalyst. The catalyst exhibits high stability with negligible activity decay after 50,000 cycles. Both the experimental results and theoretical calculations reveal the existence of fewer strongly bonded platinum-oxygen (Pt-O) sites induced by the strain and ligand effects. Moreover, the fuel cell assembled by this catalyst delivers a current density of 1.5 amperes per square centimeter at 0.6 volts and can operate steadily for at least 180 hours.
Journal Article
Ethical perspectives on e-commerce: an empirical investigation
Purpose
– The purpose of this paper is to investigate the various factors that influence consumer trust and privacy on e-commerce system and identify different ethical factors that affect consumer perceptions toward e-commerce adoption.
Design/methodology/approach
– The theoretical background used in this study was critical theory on trust in e-commerce. Online survey from Second Life users was conducted to study ethical issues in e-commerce and their influencing factors.
Findings
– The results were focussed on significance of e-commerce ethics on consumer purchase and its influence on online marketing. The ethical performance of the e-commerce web site will facilitate an increase in trust, which in turn enhances customer commitment and loyalty.
Research limitations/implications
– The survey data in this study has some common method bias. The possibility of the existence of the common method bias cannot be completely eliminated. Security and privacy are the two major aspects that drive online businesses which lead online consumers to develop trust on the digital environment.
Practical implications
– The findings on e-commerce ethical research will be useful for current management practice such as making business policies and strategies and sharing information to managers and organization leaders.
Originality/value
– With the introduction of internet and e-commerce a large of companies has been performing their business transactions through electronic network. Increasing communication technologies has bought speedy changes in online business transactions. E-commerce networks are playing a pivotal role in online business and consumers are more concerned on ethical issues of e-commerce including security, privacy and trust.
Journal Article
Relationships between Motor Skills and Academic Achievement in School-Aged Children and Adolescents: A Systematic Review
Purpose: This review systematically summarizes the studies of the relationship between primary-to-secondary school students’ motor skills and academic achievement, and analyzes the relationship between gross and fine motor skills and performance in different subjects. Method: Five electronic databases, Web Of Science, PubMed, PsycINFO, SPORTDiscus, and Academic Search Premier, were searched in March 2023. Semi-quantitative assessment methods were used to analyze the results of the included studies. Results: Seventy-eight articles were included in this systematic review. The semi-quantitative assessment results showed that gross (+, 65.0/62.5%) and fine motor skills (+, 83.3/80%) were positively correlated with overall performance and language performance, with ≥60% of the associations in the same direction. For different subjects, fine motor skills were positively correlated with students’ mathematics (+, 75.0%), reading (+, 72.7%), writing (+, 66.7%), and spelling (+, 60.0%) scores. However, the association between gross motor skills and students’ mathematics achievement (?, 52.8%), reading (?, 53.8%), and spelling (?, 50.0%) is uncertain, with <60% of the associations in the same direction. Conclusions: It is wise to direct our gaze toward the evolution of motor skills among students, especially primary school students. Different motor skill intervention modes should be selected in a targeted manner according to different subject achievements.
Journal Article
LncRNA BCRT1 promotes breast cancer progression by targeting miR-1303/PTBP3 axis
Long noncoding RNAs (lncRNAs) play crucial roles in tumor progression and are aberrantly expressed in various cancers. However, the functional roles of lncRNAs in breast cancer remain largely unknown.
Based on public databases and integrating bioinformatics analyses, the overexpression of lncRNA BCRT1 in breast cancer tissues was detected and further validated in a cohort of breast cancer tissues. The effects of lncRNA BCRT1 on proliferation, migration, invasion and macrophage polarization were determined by in vitro and in vivo experiments. Luciferase reporter assay and RNA immunoprecipitation (RIP) were carried out to reveal the interaction between lncRNA BCRT1, miR-1303, and PTBP3. Chromatin immunoprecipitation (ChIP) and RT-PCR were used to evaluate the regulatory effect of hypoxia-inducible factor-1α (HIF-1α) on lncRNA BCRT1.
LncRNA BCRT1 was significantly upregulated in breast cancer tissues, which was correlated with poor prognosis in breast cancer patients. LncRNA BCRT1 knockdown remarkably suppressed tumor growth and metastasis in vitro and in vivo. Mechanistically, lncRNA BCRT1 could competitively bind with miR-1303 to prevent the degradation of its target gene PTBP3, which acts as a tumor-promoter in breast cancer. LncRNA BCRT1 overexpression could promote M2 polarization of macrophages, mediated by exosomes, which further accelerated breast cancer progression. Furthermore, lncRNA BCRT1 was upregulated in response to hypoxia, which was attributed to the binding of HIF-1α to HREs in the lncRNA BCRT1 promoter.
Collectively, these results reveal a novel HIF-1α/lncRNA BCRT1/miR-1303/PTBP3 pathway for breast cancer progression and suggest that lncRNA BCRT1 might be a potential biomarker and therapeutic target for breast cancer.
Journal Article
Cell Stiffness Is a Biomarker of the Metastatic Potential of Ovarian Cancer Cells
The metastatic potential of cells is an important parameter in the design of optimal strategies for the personalized treatment of cancer. Using atomic force microscopy (AFM), we show, consistent with previous studies conducted in other types of epithelial cancer, that ovarian cancer cells are generally softer and display lower intrinsic variability in cell stiffness than non-malignant ovarian epithelial cells. A detailed examination of highly invasive ovarian cancer cells (HEY A8) relative to their less invasive parental cells (HEY), demonstrates that deformability is also an accurate biomarker of metastatic potential. Comparative gene expression analyses indicate that the reduced stiffness of highly metastatic HEY A8 cells is associated with actin cytoskeleton remodeling and microscopic examination of actin fiber structure in these cell lines is consistent with this prediction. Our results indicate that cell stiffness may be a useful biomarker to evaluate the relative metastatic potential of ovarian and perhaps other types of cancer cells.
Journal Article
US CDC Real-Time Reverse Transcription PCR Panel for Detection of Severe Acute Respiratory Syndrome Coronavirus 2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified as the etiologic agent associated with coronavirus disease, which emerged in late 2019. In response, we developed a diagnostic panel consisting of 3 real-time reverse transcription PCR assays targeting the nucleocapsid gene and evaluated use of these assays for detecting SARS-CoV-2 infection. All assays demonstrated a linear dynamic range of 8 orders of magnitude and an analytical limit of detection of 5 copies/reaction of quantified RNA transcripts and 1 x 10
50% tissue culture infectious dose/mL of cell-cultured SARS-CoV-2. All assays performed comparably with nasopharyngeal and oropharyngeal secretions, serum, and fecal specimens spiked with cultured virus. We obtained no false-positive amplifications with other human coronaviruses or common respiratory pathogens. Results from all 3 assays were highly correlated during clinical specimen testing. On February 4, 2020, the Food and Drug Administration issued an Emergency Use Authorization to enable emergency use of this panel.
Journal Article
Fast hierarchical processing of orthographic and semantic parafoveal information during natural reading
In reading, information from parafoveal words is extracted before direct fixation; however, it is debated whether this processing is restricted to orthographic features or also encompasses semantics. Moreover, the neuronal mechanisms supporting parafoveal processing remain poorly understood. We co-registered MEG and eye-tracking data in a natural reading paradigm to uncover the timing and brain regions involved in parafoveal processing. Representational similarity analysis revealed that parafoveal orthographic neighbours (e.g., “writer” vs. “waiter”) showed higher representational similarity than non-neighbours (e.g., “writer” vs. “police”), emerging ~68 ms after fixation onset on the preceding word (e.g., “clever”) in the visual word form area. Similarly, parafoveal semantic neighbours (e.g., “writer” vs. “author”) exhibited increased representational similarity at ~137 ms in the left inferior frontal gyrus. Importantly, the degree of orthographic and semantic parafoveal processing was correlated with individual reading speed. Our findings suggest fast hierarchical processing of parafoveal words across distinct brain regions, enhancing reading efficiency.
Combining MEG, eye-tracking, and representational similarity analysis, this study shows that readers rapidly and sequentially extract orthographic and semantic information from upcoming words before fixation, supporting efficient reading.
Journal Article