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Polycyclic aromatic hydrocarbons (PAHs), as a class of important environmental pollutants, have received considerable concern due to their widespread existence and biological toxicity. The main purpose of this study was to determine concentrations, spatial distribution, possible sources, and potential health risk of PAHs in urban road dust in Shanghai, China. The concentration of Σ 26 PAHs ranged from 53.0 to 28,700 ng g −1 in road dust samples from Shanghai, which is at the low to medium level compared with other areas around the world. PAHs with 4–5 rings were predominant components in road dust. The level of PAHs in road dust was significantly higher than those in soil and river sediment in Shanghai. Six possible sources of PAHs were apportioned by PMF model. The contribution of pyrogenic PAHs accounted for 91.3% of the total PAHs in road dusts. The motor vehicular emission, natural gas, and coal combustion were main sources for urban road dust PAHs from Shanghai. Four dibenzopyrene (DBP) isomers were contributed averagely 75% of total TEQ BaP concentration. DBalP, BaP, DBaiP, BbF, and DBA were main contributors to total carcinogenic potency, which totally contributed from 69.6 to 91.8% (median 89.1%) to total TEQ BaP in urban road dusts of Shanghai. The results of incremental lifetime carcinogenic risk (ILCR) assessment showed that the total risk values exposed to 24 PAHs in road dust were lower than 10 −4 at all sampling sites, indicating that exposure to dust-bound PAHs at present level was unlikely to result in high carcinogenic risk for both children and adults in Shanghai.

It is well recognized that osteocytes communicate with each other via gap junctions and that connxin43 (Cx43) shows its great potential in gap junction for the contribution enabling transmission of small molecules and operating in an autocrine/a paracrine manner. Fibroblast growth factors (FGFs) play significant roles in new bone formation and adult bone remodeling, and FGF signaling is regulated by the precise spatiotemporal approaches. However, the influence of FGF7 on osteocyte cell processes is not well elucidated. In this study, we aimed to examine the impact of FGF7 on osteocyte cell processes by characterizing the expression of Cx43 and to reveal the underlying mechanism regulating this cell process. We first found that the mRNA level of FGF7 was higher relative to other FGF family members both in osteocytes cell line (MLO-Y4) and bone tissue. We then demonstrated that FGF7 could increase the expression of Cx43 in osteocytes and promote the cell processes in the form of gap junctions between osteocytes. This modulation was due to the FGF7-induced cytoplasmic accumulation and resultant nuclear translocation of β-catenin. Our results could help us to further understand the importance of FGF7 on bone cell behavior and bone physiology and even pathology.

Both bone morphogenetic protein 2（BMP2） and the wingless-type MMTV integration site（WNT）/p-catenin signalling pathway play important roles in odontoblast differentiation and dentinogenesis.Cross-talk between BMP2 and WNT/p-catenin in osteoblast differentiation and bone formation has been identified.However,the roles and mechanisms of the canonical WNT pathway in the regulation of BMP2 in dental pulp injury and repair remain largely unknown.Here,we demonstrate that BMP2 promotes the differentiation of human dental pulp cells（HDPCs） by activating WNT/p-catenin signalling,which is further mediated by p38mitogen-activated protein kinase（MAPK） in vitro.BMP2 stimulation upregulated the expression of p-catenin in HDPCs,which was abolished by SB203580 but not by Noggin or LDN193189.Furthermore,BMP2 enhanced cell differentiation,which was not fully inhibited by Noggin or LDN193189.Instead,SB203580 partially blocked BMP2-induced p-catenin expression and cell differentiation.Taken together,these data suggest a possible mechanism by which the elevation of p-catenin resulting from BMP2 stimulation is mediated by the p38 MAPK pathway,which sheds light on the molecular mechanisms of BMP2-mediated pulp reparative dentin formation.

For most practical quantum control systems, it is important and difficult to attain robustness and reliability due to unavoidable uncertainties in the system dynamics or models. Three kinds of typical approaches (e.g., closed-loop learning control, feedback control, and robust control) have been proved to be effective to solve these problems. This work presents a self-contained survey on the closed-loop and robust control of quantum systems, as well as a brief introduction to a selection of basic theories and methods in this research area, to provide interested readers with a general idea for further studies. In the area of closed-loop learning control of quantum systems, we survey and introduce such learning control methods as gradient-based methods, genetic algorithms (GA), and reinforcement learning (RL) methods from a unified point of view of exploring the quantum control landscapes. For the feedback control approach, the paper surveys three control strategies including Lyapunov control, measurement-based control, and coherent-feedback control. Then such topics in the field of quantum robust control as H∞ control, sliding mode control, quantum risk-sensitive control, and quantum ensemble control are reviewed. The paper concludes with a perspective of future research directions that are likely to attract more attention.

Topological phase transitions of a generalized two dimensional tight-binding Chern insulator with periodic δ -function kicks applied in x , y and z direction defined by the pseudo spin in the two-band systems, have been studied in this paper. The rich phase diagram characterized by Chern numbers as well as the critical lines in such system have been analyzed. This is an extended study about δ -function periodic kicks on topological systems as profound influences on periodic driven quantum systems.

Chlorinated paraffins (CPs) are ubiquitous anthropogenic contaminants that have been found in various environmental media. The objective of this study was to determine concentrations, spatial distribution, possible sources and potential health risk of SCCPs and MCCPs in urban road dust collected from Shanghai, China. The concentrations ranged from 9.74 to 11,400 ng g−1 for ΣSCCPs, 44.1 to 49,900 ng g−1 for ΣMCCPs and 53.9 to 61,400 ng g−1 for total CPs, respectively. MCCPs were the dominant component in all road dust, averagely accounting for 82.8% of total CPs. The concentrations of CPs in dust collected from traffic and commercial areas were significantly higher than those from campus, industrial, park and residential areas (p < 0.01), which could be attributed to tire wear in heavy traffic. All dust samples were divided into two groups by hierarchical cluster analysis for both SCCPs and MCCPs, and the most abundant homologue groups in most samples were C10Cl7−10 and C13Cl7−9 for SCCPs, and C14Cl7−9 and C15Cl8−9 for MCCPs. Correlation analysis showed that all carbon homologues in road dusts were highly correlated each other, suggesting SCCPs and MCCPs in dust maybe came from similar sources. Three sources for CPs in dust samples were apportioned by the PMF model; their relative contributions to the total CPs burden in dust were 25.6% for factor 1 (commercial CP mixture), 13.7% for factor 2 (long-distance transport) and 60.7% for factor 3 (commercial CP mixture). The median estimated daily intakes of total CPs via road dust were 1.78 × 10−5 for children and 3.0 × 10−6 mg kg−1 day−1 for adults, respectively. Quantitative risk assessment using non-cancer hazard index and total margin of exposure of total CPs indicated that total CPs at the present level in road dust pose no significant risk for both children and adults in Shanghai.

In this work, ceramic particles were wrapped with PVA and then combined with polypropylene (PP) or polycarbonate (PC) to fast-track the preparation of PVA-based composites with water-degradation characteristics at low firing temperature of 225 °C. Simultaneously, the physical properties (e.g. flexural strengths, dielectric properties, and thermal conductivities) of the PVA-based composites were investigated in relation to the physical characteristics of fillers and their content in the composite. The results indicate that the ceramic fillers with varying particle sizes, such as AlN and SiO 2 , enhances the thermal conductivity of PVA-based composites by forming effective heat-conduction pathways. Moreover, low ε ceramic filler (SiO 2 ) up to 30% can improve the dielectric properties of the composites. By filling the pores created by the ceramic fillers, around 10% of polymer fillers (PP, PC) with good interface compatibility can strengthen the interfacial bonding with the PVA matrix, thus improving the physical properties of the PVA-based composites. Particularly, based on the formation of a porous PP-layer structure caused by slight over-firing, the degradability of the PVA-based composites can be controlled, since the porous layer slows down the contact of water and PVA. Finally, the PVA-based composite materials with excellent properties and water-degradation characteristics have been obtained. The PVA-based composites exhibit flexural strengths ranging from 60 to 180 MPa, dielectric loss of about 10 –2 , dielectric constant of 1.5 to 4, and thermal conductivity of 0.09 to 0.6. Therefore, PVA-based composites fulfill the basic physical property requirements of electronic packaging materials. Due to the increasing severity of environmental problems caused by e-waste, the development of green and degradable PVA-based composites is expected to alleviate the issue.

Oxaliplatin (OXA) is a third-generation platinum compound with clinical activity in multiple solid tumors. Due to the repetition of chemotherapy cycle, OXA-induced chronic neuropathy presenting as paresthesia and pain. This study explored the neuropathy of chemotherapy pain and investigated the analgesic effect of 2-bromopalmitate (2-BP) on the pain behavior of OXA-induced rats. The chemotherapy pain rat model was established by the five consecutive administration of OXA (intraperitoneal, 4 mg/kg). After the establishment of OXA-induced rats, the pain behavior test, inflammatory signal analysis and mitochondrial function measurement were conducted. OXA-induced rats exhibited mechanical allodynia and spinal inflammatory infiltration. Our fluorescence and western blot analysis revealed spinal astrocytes were activated in OXA rats with up-regulation of astrocytic markers. In addition, NOD-, LRR- and pyrin domain-containing 3 (NLRP3) inflammasome mediated inflammatory signal cascade was also activated. Inflammation was triggered by dysfunctional mitochondria which represented by increase in cyclooxygenase-2 (COX-2) level and manganese superoxide dismutase (Mn-SOD) activity. Intrathecally injection of 2-BP significantly attenuated dynamin-related protein 1 (Drp1) mediated mitochondrial fission, recovered mitochondrial function, suppressed NLRP3 inflammasome cascade, and consequently decreased mechanical pain sensitivity. For cell research, 2-BP treatment significantly reversed tumor necrosis factor-α (TNF-α) induced mitochondria membrane potential deficiency and high reactive oxygen species (ROS) level. These findings indicate 2-BP decreases spinal inflammation and relieves OXA-induced neuropathic pain via reducing Drp1-mediated mitochondrial dysfunction.

Numerical simulation was conducted to study the particle breakage of rock in rolling compaction (RC) test based on discrete element method (DEM). Different shapes of particles were formed to represent the real particle shape. A quantitative analysis method of particle breakage was proposed according to the grading curve before and after compaction. The numerical results had a good agrrement with the field test, which indicated that the method adopted in this paper was feasibile and could consider the influence of the particle shape on the particle breakage in RC test.