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"Wang, Meng"
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Applying Internet information technology combined with deep learning to tourism collaborative recommendation system
Recently, more personalized travel methods have emerged in the tourism industry, such as individual travel and self-guided travel. The service models of traditional tourism limit the diversity of service options and cannot fully meet the individual needs of tourists anymore. The aim is to integrate sparse tourism information on the Internet, thereby providing more convenient, faster, and more personalized tourism services. Based on the shortcomings of the traditional tourism recommendation system, a deep learning-based classification processing method of tourism product information is proposed. This method uses word embedding in the data preprocessing stage. The Convolutional Neural Network (CNN) is used to process review information of users and tourism service items. The Deep Neural Network (DNN) is used to process the necessary information of users and tourism service items. Also, factorization machine technology is used to learn the interaction between the extracted features to improve the prediction model. The results show that the proposed model can maintain an excellent precision of 64.2% when generating personalized recommendation lists for users. The sensitivity and accuracy of the recommendation list are better than other algorithms. By adding DNN, the word embedding method, and the factorization machine model, the precision is improved by 30%, 33.3%, and 40%, respectively. The model accuracy is the highest with 40 hidden factors, 100 convolutions, and a 100+50 combination hidden layer. Compared with traditional methods, the proposed algorithm can provide users with personalized travel products more accurately in personalized travel recommendations. The results have enriched and developed the theory of tourism service supply chain, providing a reference for constructing a personalized tourism service system.
Journal Article
Diplomacy of quasi-alliances in the Middle East
Quasi-alliance refers to the ideation, mechanism and behavior of policy-makers to carry out security cooperation through informal political and security arrangements. As a \"gray zone\" between alliance and neutrality, quasi-alliance is a hidden national security statecraft. Based on declassified archives and secondary sources, this book probes the theory and practice of quasi-alliances in the Middle East. Four cases are chosen to test the hypotheses of quasi-alliance, one of which is the Anglo-French-Israeli quasi-alliance during the Suez Canal War of 1956.
Book
Disease-induced changes in plant microbiome assembly and functional adaptation
Background
The plant microbiome is an integral part of the host and increasingly recognized as playing fundamental roles in plant growth and health. Increasing evidence indicates that plant rhizosphere recruits beneficial microbes to the plant to suppress soil-borne pathogens. However, the ecological processes that govern plant microbiome assembly and functions in the below- and aboveground compartments under pathogen invasion are not fully understood. Here, we studied the bacterial and fungal communities associated with 12 compartments (e.g., soils, roots, stems, and fruits) of chili pepper (
Capsicum annuum
L.) using amplicons (16S and ITS) and metagenomics approaches at the main pepper production sites in China and investigated how
Fusarium
wilt disease (FWD) affects the assembly, co-occurrence patterns, and ecological functions of plant-associated microbiomes.
Results
The amplicon data analyses revealed that FWD affected less on the microbiome of pepper reproductive organs (fruit) than vegetative organs (root and stem), with the strongest impact on the upper stem epidermis. Fungal intra-kingdom networks were less stable and their communities were more sensitive to FWD than the bacterial communities. The analysis of microbial interkingdom network further indicated that FWD destabilized the network and induced the ecological importance of fungal taxa. Although the diseased plants were more susceptible to colonization by other pathogenic fungi, their below- and aboveground compartments can also recruit potential beneficial bacteria. Some of the beneficial bacterial taxa enriched in the diseased plants were also identified as core taxa for plant microbiomes and hub taxa in networks. On the other hand, metagenomic analysis revealed significant enrichment of several functional genes involved in detoxification, biofilm formation, and plant-microbiome signaling pathways (i.e., chemotaxis) in the diseased plants.
Conclusions
Together, we demonstrate that a diseased plant could recruit beneficial bacteria and mitigate the changes in reproductive organ microbiome to facilitate host or its offspring survival. The host plants may attract the beneficial microbes through the modulation of plant-microbiome signaling pathways. These findings significantly advance our understanding on plant-microbiome interactions and could provide fundamental and important data for harnessing the plant microbiome in sustainable agriculture.
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Video abstract
Journal Article
Blunting TRPML1 channels protects myocardial ischemia/reperfusion injury by restoring impaired cardiomyocyte autophagy
Accumulating evidence suggests that autophagy dysfunction plays a critical role in myocardial ischemia/reperfusion (I/R) injury. However, the underling mechanism of malfunctional autophagy in the cardiomyocytes subjected to I/R has not been well defined. As a result, there is no effective therapeutic option by targeting autophagy to prevent myocardial I/R injury. Here, we used both an in vitro and an in vivo I/R model to monitor autophagic flux in the cardiomyocytes, by exposing neonatal rat ventricular myocytes to hypoxia/reoxygenation and by subjecting mice to I/R, respectively. We observed that the autophagic flux in the cardiomyocytes subjected to I/R was blocked in both in vitro and in vivo models. Down-regulating a lysosomal cationic channel, TRPML1, markedly restored the blocked myocardial autophagic flux induced by I/R, demonstrating that TRPML1 directly contributes to the blocked autophagic flux in the cardiomyocytes subjected to I/R. Mechanistically, TRPML1 is activated secondary to ROS elevation following ischemia/reperfusion, which in turn induces the release of lysosomal zinc into the cytosol and ultimately blocks the autophagic flux in cardiomyocytes, presumably by disrupting the fusion between autophagosomes and lysosomes. As a result, the inhibited myocardial autophagic flux induced by TRPML1 disrupted mitochondria turnover and resulted in mass accumulation of damaged mitochondria and further ROS release, which directly led to cardiomyocyte death. More importantly, pharmacological and genetic inhibition of TRPML1 channels greatly reduced infarct size and rescued heart function in mice subjected to I/R in vivo by restoring impaired myocardial autophagy. In summary, our study demonstrates that secondary to ROS elevation, activation of TRPML1 results in autophagy inhibition in the cardiomyocytes subjected to I/R, which directly leads to cardiomyocyte death by disrupting mitochondria turnover. Therefore, targeting TRPML1 represents a novel therapeutic strategy to protect against myocardial I/R injury.
Journal Article
Synergistic effects of chronic pain and diabetes on cardiovascular disease risk: findings from a nationwide cohort study
Background
Chronic pain is a significant risk factor for cardiovascular diseases (CVD). However, the impact of dynamic changes in pain site count and the interaction between pain and diabetes on CVD risk remain unclear.
Methods
The study was a prospective cohort analysis based on data from the China Health and Retirement Longitudinal Study (CHARLS, 2011–2020). Participants aged ≥ 45 years with follow-up data on pain, diabetes, and cardiovascular disease (CVD) were included, excluding those with CVD at baseline. Pain sites and counts were categorized, and changes in pain site count across waves 1 to 3 were assessed, dividing participants into four groups: Cluster 1 (
n
= 6477) with persistently low counts; Cluster 2 (
n
= 964) with a significant increase; Cluster 3 (
n
= 272) with consistently high counts; and Cluster 4 (
n
= 680) with a significant decrease. CVD was defined as self-reported physician-diagnosed heart disease (including myocardial infarction, angina, coronary heart disease, heart failure, or other heart problems) and stroke. Cox regression was used to assess the relationship between pain and CVD, and an additive interaction analysis evaluated the interaction between pain and diabetes.
Results
13,492 participants were enrolled. With a median follow-up of 9 years, 3,146 participants (23.32%) developed incident CVD. Cox regression showed that pain was associated with a 28% higher risk of CVD (HR 1.28, 95% CI 1.18–1.41). When pain affected more than six sites, CVD risk increased by 64% (HR 1.64, 95% CI 1.44–1.87). Participants with consistently high pain site count had the highest CVD risk compared to those with consistently low count (HR 1.94, 95% CI 1.53–2.46), while those with a decreasing trend in pain site count had a lower risk (HR 1.49, 95% CI 1.26–1.78). Interaction analysis revealed a significant interaction between pain and diabetes in predicting CVD, contributing an additional 35% risk (RERI 0.35, AP 0.2, S 1.9).
Conclusions
The number of pain sites and its dynamic changes are closely associated with CVD risk, and the synergistic effect of pain and diabetes requires more attention.
Journal Article
Up‐regulated TLR4 in cardiomyocytes exacerbates heart failure after long‐term myocardial infarction
It remains unclear whether and how cardiomyocytes contribute to the inflammation in chronic heart failure (CHF). We recently reviewed the capacity of cardiomyocytes to initiate inflammation, by means of expressing certain immune receptors such as toll‐like receptors (TLRs) that respond to pathogen‐ and damage‐associated molecular patterns (PAMP and DAMP). Previous studies observed TLR4‐mediated inflammation within days of myocardial infarction (MI). This study examined TLR4 expression and function in cardiomyocytes of failing hearts after 4 weeks of MI in rats. The increases of TLR4 mRNA and proteins, as well as inflammatory cytokine production, were observed in both the infarct and remote myocardium. Enhanced immunostaining for TLR4 was observed in cardiomyocytes but not infiltrating leucocytes. The injection of lentivirus shRNA against TLR4 into the infarcted heart decreased inflammatory cytokine production and improved heart function in vivo. Accordingly, in cardiomyocytes isolated from CHF hearts, increases of TLR4 mRNA and proteins were detected. More robust binding of TLR4 with lipopolysaccharide (LPS), a PAMP ligand for TLR4, and heat shock protein 60 (HSP60), a DAMP ligand for TLR4, was observed in CHF cardiomyocytes under a confocal microscope. The maximum binding capacity (Bmax) of TLR4 was increased for LPS and HSP60, whereas the binding affinity (Kd) was not significantly changed. Furthermore, both LPS and HSP60 induced more robust production of inflammatory cytokines in CHF cardiomyocytes, which was reduced by TLR4‐blocking antibodies. We conclude that the expression, ligand‐binding capacity and pro‐inflammatory function of cardiomyocyte TLR4 are up‐regulated after long‐term MI, which promote inflammation and exacerbate heart failure.
Journal Article
Wolbachia enhances ovarian development in the rice planthopper Laodelphax striatellus through elevated energy production
The endosymbiont
Wolbachia
can both benefit host nutrition and manipulate host reproduction to its own advantage. However, the mechanisms of its nutritional benefits remain unclear. We show that
Wolbachia
enhances ovarian development in the small brown planthopper
Laodelphax striatellus
by boosting energy production.
Wolbachia
-infected females have increased fecundity, accelerated ovarian development, and prolonged oviposition. Enhanced activity of mitochondrial complex I is linked to increased ATP production and the expression of energy metabolism-related genes. We further identify that
Wolbachia
-synthesized riboflavin is crucial for ATP production and ovarian development. A riboflavin transporter,
slc52a3a
, positively correlates with
Wolbachia
density and is required for normal ovarian maturation. Our findings demonstrate that
Wolbachia
-produced riboflavin drives energy production and accelerates ovarian maturation, thus improving host fecundity. This research reveals insights into symbiont-host metabolic interactions and underscores the role of nutrient delivery in symbiosis.
Wolbachia
affects host reproduction and nutrition, but the underlying mechanisms are unclear. This study suggests
Wolbachia
enhances ovarian development in
Laodelphax striatellus
via riboflavin synthesis, driving ATP production and ovarian maturation.
Journal Article
Socioeconomic status and ADL disability of the older adults: Cumulative health effects, social outcomes and impact mechanisms
Socioeconomic status (SES) is one of the important indicators affecting individual's social participation and resource allocation, and it also plays an important role in the health shock of individuals. Faced by the trend of aging society, more and more nations across the world began to pay attention to prevent the risk of health shock of old adults.
Based on the data of China Health and Retirement Longitudinal Study (CHARLS) in 2013, 2015 and 2018, this study uses path analysis and ologit model to empirically estimate the effects of SES and health shock on the activities of daily living (ADL) disability of old adults.
As a result, first, it was found that SES has significant impact on the disability of old adults. Specifically, economic conditions (income) plays dominant role. Economic status affects the risk of individual disability mainly through life security and health behavior. Secondly, SES significantly affecting health shock, with education and economic status showing remarkable impact, and there is an apparent group inequality. Furthermore, taking high education group as reference, the probability of good sight or hearing ability of the low education group was only 49.76% and 63.29% of the high education group, respectively, while the rates of no pain and severe illness were 155.50% and 54.69% of the high education group. At last, the estimation of path effect of SES on ADL disability indicates evident group inequality, with health shock plays critical mediating role.
SES is an important factor influencing residents' health shock, and health shocks like cerebral thrombosis and cerebral hemorrhage will indirectly lead to the risk of individual ADL disability. Furthermore, among the multi-dimensional indicators of SES, individual income and education are predominant factors affecting health shock and ADL disability, while occupation of pre-retirement have little impact.
Journal Article
The development and psychometric evaluation of the Chinese Big Five Personality Inventory-15
The Chinese Big Five Personality Inventory (CBF-PI), a 134-item self-report scale, and its 40-item brief version (CBF-PI-B) are sound psychometric instruments used to measure the Big Five personality domains in the Chinese population. However, their applicability is limited by their length, as well as restricted by assessment conditions. In this study, we developed and validated a new shortened version with 15 items (CBF-PI-15) through exploratory factor analysis and confirmatory factor analysis in a large sample (Sample 1) of 10,738 Chinese adults (mean = 33.90 years, SD = 9.39 years, range 17-57 years). Measurement invariance results suggested the CBF-PI-15 were invariant across gender and age groups. Convergent, discriminant and criterion validities were tested in Sample 2 (N = 256, mean = 21.62 years, SD = 3.06 years, range 18-35 years) and findings showed an expected correlational pattern with external variables. Results revealed positive correlations of Neuroticism with the Barratt Impulsiveness Scale Brief Version (BIS-Brief), the Patient Health Questionnaire, and the Generalized Anxiety Disorder Screener, as well as a strongly negative correlation between Conscientiousness and BIS-Brief. Additionally, Conscientiousness positively correlated with academic performance as expected. In conclusion, the CBF-PI-15 holds promise as an informative alternative for the original CBF-PI-B when administration time or conditions are limited, and our findings provide preliminary support for the utility of the CBF-PI-15.
Journal Article