Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
86
result(s) for
"Wang, P.Y"
Sort by:
Driving cycle recognition neural network algorithm based on the sliding time window for hybrid electric vehicles
Driving cycles greatly influence the fuel economy and exhaust of the vehicle, especially in hybrid electric vehicles. The purpose of this study is to develop a method to identify the type of driving cycle with better accuracy and less sampling time than other driving cycle recognition algorithms. A driving cycle recognition algorithm based on Learning Vector Quantization neural network is first created to analyze four selected representative standard driving cycles. Micro-trip extraction and box-and-whisker plots are then applied to ensure the diversity and magnitude of training samples. Finally, a sample training simulation is conducted to determine the minimum neuron number of learning vector quantization network, using the simulation platform of Matlab/Simulink. Afterwards, we simplify the structure of the recognition model to reduce data convergence time. Simulation results show the feasibility and efficiency of the proposed algorithm, which decreases the time window length from 120 s to 60 s with acceptable accuracy. Furthermore, the driving cycle recognition algorithm is used in a series-parallel hybrid vehicle model to improve the fuel economy by about 6.29%.
Journal Article
Soy isoflavone intake inhibits bone resorption and stimulates bone formation in menopausal women: meta-analysis of randomized controlled trials
Objective: To clarify the effects of isoflavone intake on bone resorption and bone formation. Methods: We identified randomized controlled trials related to urinary deoxypyridinoline (Dpyr, a bone resorption marker) and serum bone-specific alkaline phosphatase (BAP, a bone formation marker) listed on MEDLINE (January 1966-April 2006), the Cochrane Controlled Trials Register, EMBASE (1985-January 2006), Science Citation Index and PUBMED (updated till April 2006). Results: Nine studies with a total of 432 subjects were selected for meta-analysis. The urinary Dpyr concentration in subjects who consumed isoflavones decreased significantly by -2.08 nmol/mmol (95% confidence interval (CI): -3.82 to -0.34 nmol/mmol) in comparison with that in subjects who did not consume isoflavones. Isoflavone intake vs placebo intake significantly increased serum BAP by 1.48 microgram/l (95% CI: 0.22-2.75 microgram/l). Decreases in the urinary Dpyr concentration with isoflavone intake of <90 mg/day and with treatment lasting less than 12 weeks were -2.34 nmol/mmol (95% CI: -4.46 to -0.22 nmol/mmol) and -2.03 nmol/mmol (95% CI: -3.20 to -0.85 nmol/mmol), respectively. Conclusions: Isoflavone intervention significantly inhibits bone resorption and stimulates bone formation. These favorable effects occur even if <90 mg/day of isoflavones are consumed or the intervention lasts less than 12 weeks.
Journal Article
Physical manufacturing: from the multidisciplinary perspective
PurposeIn order to promote the development of modern manufacturing towards high-precision, high-quality intelligence and precision, this paper puts forward the concept of physical manufacturing and conducts a more in-depth theoretical discussion on its basic connotation and characteristics, based on which the application of physical manufacturing in cutting and autoclave curing molding of composite material is briefly introduced.Design/methodology/approachAs a brand-new manufacturing concept, physical manufacturing determines the optimal process parameters according to multidisciplinary simulations, which emphasizes the physical characteristics about long life and high reliability of the processed products, and makes intelligent adjustment of process parameters according to the changes in the environment and equipment status during manufacturing.FindingsThe concept of physical manufacturing has pioneering significance for the basic research and development of advanced manufacturing technology, which helps to further improve production efficiency, reduce production costs and improve product quality.Originality/valueThe concept of physical manufacturing was first proposed, which emphasizes the analysis, reasoning, perception, and deduction during the manufacturing process, to achieve high-quality processing of products.
Journal Article
13 - PENTOSE FERMENTATION BY YEASTS
A method has been developed which overcomes the limitation possessed by yeasts of being unable to ferment aldopentoses. The method allows the conversion of D-xylose to ethanol. It depends on the isomerization in the growth medium of D-xylose to D-xylulose by the enzyme glucose isomerase, followed by fermentation of the D-xylulose to ethanol by selected yeasts.
KEYWORDS
Yeast pentose fermentation, yeast D-xylose fermentation, yeast D-xylulose fermentation
Book Chapter
Factors associated with home-based e-working and e-shopping in Nanjing, China
The widespread adoption of information and communication technology has facilitated frequent e-activities in people’s daily life. From the perspective of individual’s time use on e-working and e-shopping at home, this paper aims to enhance our understanding of the function of home beyond a living space for family life. Using a household survey of 608 full-time paid employees who conducted e-activities at home in Nanjing, China, we investigated the characteristics and patterns of home-based e-working and e-shopping. Only 7.9% of the respondents neither e-shopped nor e-worked at home. We find that the socio-demographic context, Internet use habits, attitudes towards e-working/e-shopping, and geographical accessibility have influenced the patterns of home-based e-working and e-shopping. The results indicate that the rich e-activities taking place at home have changed the time use at home and reinforced the function of home as a multifunctional hub.
Journal Article
AIM2 in regulatory T cells restrains autoimmune diseases
The inflammasome initiates innate defence and inflammatory responses by activating caspase-1 and pyroptotic cell death in myeloid cells
1
,
2
. It consists of an innate immune receptor/sensor, pro-caspase-1, and a common adaptor molecule, ASC. Consistent with their pro-inflammatory function, caspase-1, ASC and the inflammasome component NLRP3 exacerbate autoimmunity during experimental autoimmune encephalomyelitis by enhancing the secretion of IL-1β and IL-18 in myeloid cells
3
,
4
,
5
–
6
. Here we show that the DNA-binding inflammasome receptor AIM2
7
,
8
,
9
–
10
has a T cell-intrinsic and inflammasome-independent role in the function of T regulatory (T
reg
) cells.
AIM2
is highly expressed by both human and mouse T
reg
cells, is induced by TGFβ, and its promoter is occupied by transcription factors that are associated with T
reg
cells such as RUNX1, ETS1, BCL11B and CREB. RNA sequencing, biochemical and metabolic analyses demonstrated that AIM2 attenuates AKT phosphorylation, mTOR and MYC signalling, and glycolysis, but promotes oxidative phosphorylation of lipids in T
reg
cells. Mechanistically, AIM2 interacts with the RACK1–PP2A phosphatase complex to restrain AKT phosphorylation. Lineage-tracing analysis demonstrates that AIM2 promotes the stability of T
reg
cells during inflammation. Although AIM2 is generally accepted as an inflammasome effector in myeloid cells, our results demonstrate a T cell-intrinsic role of AIM2 in restraining autoimmunity by reducing AKT–mTOR signalling and altering immune metabolism to enhance the stability of T
reg
cells.
The inflammasome receptor AIM2 acts independently of the inflammasome to reduce autoimmunity and stabilize regulatory T cells.
Journal Article
Protein kinetic signatures of the remodeling heart following isoproterenol stimulation
Protein temporal dynamics play a critical role in time-dimensional pathophysiological processes, including the gradual cardiac remodeling that occurs in early-stage heart failure. Methods for quantitative assessments of protein kinetics are lacking, and despite knowledge gained from single-protein studies, integrative views of the coordinated behavior of multiple proteins in cardiac remodeling are scarce. Here, we developed a workflow that integrates deuterium oxide (2H2O) labeling, high-resolution mass spectrometry (MS), and custom computational methods to systematically interrogate in vivo protein turnover. Using this workflow, we characterized the in vivo turnover kinetics of 2,964 proteins in a mouse model of β-adrenergic-induced cardiac remodeling. The data provided a quantitative and longitudinal view of cardiac remodeling at the molecular level, revealing widespread kinetic regulations in calcium signaling, metabolism, proteostasis, and mitochondrial dynamics. We translated the workflow to human studies, creating a reference dataset of 496 plasma protein turnover rates from 4 healthy adults. The approach is applicable to short, minimal label enrichment and can be performed on as little as a single biopsy, thereby overcoming critical obstacles to clinical investigations. The protein turnover quantitation experiments and computational workflow described here should be widely applicable to large-scale biomolecular investigations of human disease mechanisms with a temporal perspective.
Journal Article
Zinc cyclic di-AMP nanoparticles target and suppress tumours via endothelial STING activation and tumour-associated macrophage reinvigoration
The clinical utility of stimulator of interferon genes (STING) agonists has been limited due to poor tumour-targeting and unwanted toxicity following systemic delivery. Here we describe a robust tumour-targeted STING agonist, ZnCDA, formed by the encapsulation of bacterial-derived cyclic dimeric adenosine monophosphate (CDA) in nanoscale coordination polymers. Intravenously injected ZnCDA prolongs CDA circulation and efficiently targets tumours, mediating robust anti-tumour effects in a diverse set of preclinical cancer models at a single dose. Our findings reveal that ZnCDA enhances tumour accumulation by disrupting endothelial cells in the tumour vasculature. ZnCDA preferentially targets tumour-associated macrophages to modulate antigen processing and presentation and subsequent priming of an anti-tumour T-cell response. ZnCDA reinvigorates the anti-tumour activity of both radiotherapy and immune checkpoint inhibitors in immunologically ‘cold’ pancreatic and glioma tumour models, offering a promising combination strategy for the treatment of intractable human cancers.Activation of the stimulator of interferon genes (STING) can induce immunity in various cancer therapies, but delivery of STING agonists to tumours is challenging. Now a metal-based polymeric nanoparticle delivers STING agonists to tumours upon disruption of endothelial cells in tumour vasculature and targets tumour-associated macrophages, eliciting anti-tumour immune response in hard-to-treat cancer models.
Journal Article
Altered functional connectivity density and couplings in postpartum depression with and without anxiety
Abstract
Postpartum depression (PPD) is the most common psychological health issue among women, which often comorbids with anxiety (PPD-A). PPD and PPD-A showed highly overlapping clinical symptoms. Identifying disorder-specific neurophysiological markers of PDD and PPD-A is important for better clinical diagnosis and treatments. Here, we performed functional connectivity density (FCD) and resting-state functional connectivity (rsFC) analyses in 138 participants (45 unmedicated patients with first-episode PPD, 31 PDD-A patients and 62 healthy postnatal women, respectively). FCD mapping revealed specifically weaker long-range FCD in right lingual gyrus (LG.R) for PPD patients and significantly stronger long-range FCD in left ventral striatum (VS.L) for PPD-A patients. The follow-up rsFC analyses further revealed reduced functional connectivity between dorsomedial prefrontal cortex (dmPFC) and VS.L in both PPD and PPD-A. PPD showed specific changes of rsFC between LG.R and dmPFC, right angular gyrus and left precentral gyrus, while PPD-A represented specifically abnormal rsFC between VS.L and left ventrolateral prefrontal cortex. Moreover, the altered FCD and rsFC were closely associated with depression and anxiety symptoms load. Taken together, our study is the first to identify common and disorder-specific neural circuit disruptions in PPD and PPD-A, which may facilitate more effective diagnosis and treatments.
Journal Article