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Cultivated land resources are crucial to food security and economic development. Exploring the spatiotemporal pattern of cultivated land non-agriculturalization and its drivers is a prerequisite for cultivated land conservation. This paper used GlobeLand30 data to reveal the spatial and temporal pattern, the shift of the gravity center and the drivers of cultivated land non-agriculturalization by employing spatial analysis, gravity center model and the geographical detector model. The results show a dramatic increase in the non-agriculturalization of cultivated land in the period of 2010–2020 compared to 2000–2010. Spatially, the cultivated land non-agriculturalization mainly occurred in areas with high urbanization levels, such as eastern Sichuan Province and western Chongqing Municipality, while the cultivated land non-agriculturalization in other areas was small-scale and spatially scattered. Furthermore, the speed of cultivated land non-agriculturalization showed spatial unevenness, and the gravity center of cultivated land non-agriculturalization shifted towards the northeast at a distance of 123.21 km. The cultivated land non-agriculturalization was affected by GDP per capita, population density, GDP per unit of land and total retail sales of social consumer goods. The key drivers for the cultivated land non-agriculturalization in the study area were the continuous expansion of urban space and the large-scale cultivation of economic fruit trees. The government should promote small-scale machinery suitable for agricultural cultivation in the mountainous and hilly areas of Southwest China, and appropriately develop economic fruit groves and livestock farming to reduce the phenomenon of cultivated land non-foodization.

Traditional Chinese Medicine (TCM) has been widely used in China and is regarded as the most important therapeutic. Polygonatum sibiricum (PS), a natural plant used in traditional Chinese medicine, has various functions associated with a number of its components. There are many compositions in PS including polysaccharides, steroids, anthraquinone, alkaloids, cardiac glycosides, lignin, vitamins, various acids, and so on. Of these, polysaccharides play a significant role in PS-based therapeutics. This article summarizes Polygonatum sibiricum polysaccharides (PSP) have many pharmacological applications and biological activities, such as their antioxidant activity, anti-aging activity, an anti-fatigue effect, immunity enhancement effect, antibacterial effect, anti-inflammatory effect, hypolipidemic and antiatherosclerotic effects, anti-osteoporosis effect, liver protection, treatment of diabetes mellitus (DM), anti-cancer effect, and may help prevent Alzheimer’s disease, and so on. This review summarized the extraction method, purification method, compositions, pharmacological applications, biological activities, biosynthesis, and prospects of PSP, providing a basis for further study of PS and PSP.

Deep learning has made significant advancements in speech enhancement, which plays a crucial role in improving the quality of speech signals in noisy conditions. In this paper, we propose a new approach called M-DGAN, which introduces a time (T)-domain encoder-decoder structure with rich channel representations into the time-frequency (TF)-domain generator framework, resulting in a new generator structure with mixed magnitude and phase representations in the T and TF-domains. The proposed mixed T-domain and TF-domain generator, incorporating the cascaded reworked conformer (CRC) structure, exhibits improved modeling capability and adaptability. Test results on the Voice Bank + DEMAND public dataset show that our method achieves the highest score with P S E Q = 3.52 and performs well on all the remaining metrics when compared to the current state-of-the-art methods. In addition, tests on the NISQA_TEST_LIVETALK real dataset of the NISQA Corpus show the breadth and robustness of our model on speech enhancement tasks.

Muscle atrophy is a common complication of chronic kidney disease (CKD). Irisin, a novel muscle cytokine, protects against muscle atrophy, but its specific role in CKD-associated muscle atrophy requires further elucidation. Because the ubiquitin–proteasome system (UPS) plays an important role in CKD muscle atrophy, our study will explore whether irisin affects UPS and alleviate CKD-associated muscle atrophy. In this study, an adenine-fed mouse model of CKD and urotension II (UII)-induced C2C12 myotubes were used as in vivo and in vitro models of muscle atrophy. The results showed that renal function, mouse weight, and the cross-sectional area (CSA) of skeletal muscles were significantly improved in CKD mice treated with irisin. Moreover, irisin effectively mitigated the decreases in phosphorylated Forkhead box O 3a (p-FOXO3A) levels and increases in the levels of E3 ubiquitin ligases, such as muscle RING finger 1 (MuRF1) and muscle atrophy F-box (MAFbx/atrogin1), in both the muscles of CKD mice and UII-induced C2C12 myotubes. In addition, irisin significantly increased the expression levels of myogenic differentiation factor D (MyoD) in the muscles of CKD mice. Our study is the first to demonstrate that irisin ameliorates skeletal muscle atrophy by inhibiting UPS upregulation and improving satellite cell differentiation in CKD.

Myocardial fibrosis represents the primary pathological change associated with diabetic cardiomyopathy and heart failure, and it leads to decreased myocardial compliance with impaired cardiac diastolic and systolic function. Quercetin, an active ingredient in various medicinal plants, exerts therapeutic effects against cardiovascular diseases. Here, we investigate whether SIRT5- and IDH2-related desuccinylation is involved in the underlying mechanism of myocardial fibrosis in heart failure while exploring related therapeutic drugs for mitochondrial quality surveillance. Mouse models of myocardial fibrosis and heart failure, established by transverse aortic constriction (TAC), were administered with quercetin (50 mg/kg) daily for 4 weeks. HL-1 cells were pretreated with quercetin and treated with high glucose (30 mM) in vitro. Cardiac function, western blotting, quantitative PCR, enzyme-linked immunosorbent assay, and immunofluorescence analysis were employed to analyze mitochondrial quality surveillance, oxidative stress, and inflammatory response in myocardial cells, whereas IDH2 succinylation levels were detected using immunoprecipitation. Myocardial fibrosis and heart failure incidence increased after TAC, with abnormal cardiac ejection function. Following high-glucose treatment, HL-1 cell activity was inhibited, causing excess production of reactive oxygen species and inhibition of mitochondrial respiratory complex I/III activity and mitochondrial antioxidant enzyme activity, as well as increased oxidative stress and inflammatory response, imbalanced mitochondrial quality surveillance and homeostasis, and increased apoptosis. Quercetin inhibited myocardial fibrosis and improved cardiac function by increasing mitochondrial energy metabolism and regulating mitochondrial fusion/fission and mitochondrial biosynthesis while inhibiting the inflammatory response and oxidative stress injury. Additionally, TAC inhibited SIRT5 expression at the mitochondrial level and increased IDH2 succinylation. However, quercetin promoted the desuccinylation of IDH2 by increasing SIRT5 expression. Moreover, treatment with si-SIRT5 abolished the protective effect of quercetin on cell viability. Hence, quercetin may promote the desuccinylation of IDH2 through SIRT5, maintain mitochondrial homeostasis, protect mouse cardiomyocytes under inflammatory conditions, and improve myocardial fibrosis, thereby reducing the incidence of heart failure.

Since modern rural development results from a complex interaction between various exogenous forces, the sustainable development of rural communities in ecologically fragile areas is inherently a systemic endeavor. This study, guided by the social-ecological system theory, examines the impact of social, economic, political, natural, and other external factors on the sustainable development of rural communities in these areas. The goal is to gain a deeper understanding of the underlying causes of delayed development in these communities. The results are as follows: First, labor outflow, ecological fragility, and informal institutions significantly hinder the sustainable development of rural communities, while regional economic development demonstrates a strong positive relationship with the sustainability of rural communities. Second, regional economic development primarily influences the sustainability of communities through its impact on locational conditions. Communities closer to the county and town experience a more pronounced positive effect from regional economic development. Thirdly, informal institutions inhibit the sustainable development of rural communities by obstructing the land rights reform process. Finally, for small-scale communities, the inhibitory effect of ecological fragility and the facilitating effects of regional economic development are more substantial, while labor outflow and informal institutions exert a pronounced inhibitory effect primarily on large-scale communities. For low-poverty communities, labor outflow exerts a more significant inhibitory effect on community sustainability. In contrast, for high-poverty communities, the regional economic development contributes more significantly to sustainability, while ecological fragility and informal institutions have a stronger inhibitory effect.

In this study, we aimed to investigate the association between handgrip strength (HGS) and cognitive performance in stage 3-5 chronic kidney disease (CKD) patients aged ≥ 60 years. This cross-sectional study analyzed data from National Health and Nutrition Examination Survey (NHANES) database 2011–2014. Three tests were used to assess the cognitive performance, including consortium to establish a registry for Alzheimer’s disease (CERAD), animal fluency test (AFT), and digit symbol substitution test (DSST). The multivariate linear regression analyses adjusting for confounding factors were utilized to evaluate the association of HGS with cognitive performance. A total of 678 older stage 3-5 CKD patients were included in this study. After adjusting for multiple factors, a higher HGS was positively associated with a higher CERAD-delayed recall and DSST score. In addition, our analysis indicated that HGS probably correlated with better performance of immediate learning ability in male, while working memory, sustained attention, and processing speed in female. HGS may be an important indicator for cognitive deficits in stage 3-5 CKD patients, especially for learning ability and executive function. Further research to explore the sex-specific and domain-specific and possible mechanisms are required.

Large oil-immersed power transformers are core equipment in power grids, and the use of robots for internal inspection can significantly enhance efficiency. However, existing research has primarily focused on the development of robotic bodies, neglecting the potential impact of their operation on the transformer’s oil–paper insulation system. This paper addresses this issue, evaluates the risk of underwater inspection robots colliding with internal structures, and finds that the maximum elongation rate of insulation paperboard at a speed of 0.1 m/s is far below the damage limit. Simultaneously, it analyzes the process by which propellers induce bubbles in oil, pointing out the need to optimize propeller design to ensure insulation safety. The study also extends the classical cavitation theory in water to the oil medium, reveals the conditions for gas generation by the propeller and the variation in the patterns of gas components (such as C2H2, H2, etc.) through experiments, and discusses the gas source issue of cavitation in oil.

In order to explore the influence of the thermal management system (TMS) on vehicle energy management and tap the energy saving potential of TMS, this study establishes a vehicle energy management strategy control model oriented to reduce energy consumption of the TMS based on MATLAB/Simulink for a plug-in hybrid electric vehicle with planetary hybrid configuration. Firstly, a simulation model of vehicle dynamic machine - electric - thermal coupling working process is introduced, to evaluate the impact of TMS in the high and low temperature environment on energy consumption of the vehicle running. Then, based on the equivalent fuel consumption minimum strategy (ECMS) and considering the influence of TMS on energy consumption, an adaptive equivalent consumption minimum strategy model considering thermal characteristics (TAECMS) is established, which propose an improved adaptive equivalent factor adjustment method considering the thermal characteristics of the system is proposed. By establishing the Hamiltonian function to achieve the goal of minimum equivalent fuel consumption, considering the temperature penalty, the power of the engine and the power of the battery is reasonably allocated. Finally, the TAECMS control strategy achieves fuel saving of 6.2 % and 8.4 % respectively in high and low temperature environments through simulation verification and comparison.

The objectives of the survey were to identify the level of influenza vaccination coverage in China in three influenza seasons 2009/10 to 2011/12, and to find out potential predictors for seasonal influenza vaccination. In September and October 2011, representative urban household telephone surveys were conducted in five provinces in China with a response rate of 6%. Four target groups were defined for analysis: 1) children ≤ 5 years old; 2) elderly persons aged ≥ 60 years old; 3) health care workers (persons working in the medical field) and 4) chronically ill persons. The overall mean vaccination rate was 9.0%. Among the four target groups, the rate of vaccination of children aged ≤ 5 years old (mean = 26%) was highest and the rate of elderly people aged ≥ 60 years old (mean = 7.4%) was the lowest, while the rates of persons who suffer from a chronic illness (mean = 9.4%) and health care workers (9.5%) were similar. A subsidy for influenza vaccination, age group, health care workers, suffering from a chronic illness and living in Eastern China were independent significant predictors for influenza vaccination. The seasonal influenza vaccination coverage rates among urban populations in selected cities and provinces in China were far below previously reported rates in developed countries. Influenza vaccination coverage rates differed widely between different target groups and provinces in China. Subsidy policy might have a positive effect on influenza vaccination rate, but further cost-effectiveness studies, as well as the vaccination rate associated factors studies are still needed to inform strategies to increase coverage.