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دخلت الصين مرحلة جديدة من التطور خلال العقود الثلاثة، مع بدئها بتنفيذ سياسة الإصلاح والانفتاح، فاحتل اقتصادها في العام 2010 م، المرتبة الثانية لأكبر اقتصاد في العالم، نتيجة سنوات طويلة من العمل الشاق، لبناء دولة اشتراكية قوية، والترويج لحوكمة جديدة، إلى جانب التطور المتسارع لكل من العلوم والتكنولوجيا والتعليم، تحت قيادة الرئيس شي جين بينغ الحكيمة التي عكست وجهة نظره الثاقبة والمتمثلة في دمج النظرية بالممارسة لمواكبة الزمن. وبناء عليه، سيعالج هذا الكتاب أهم الخطوط العريضة التي قام عليها فكر شي جين بينغ في حوكمة الصين، وبناء دولة ابتكارية تعطي الأولوية لتطوير العلوم والتكنولوجيا والتعليم، وإغنائها بالمواهب الشابة، بهدف الحفاظ على استمرارية النهضة التي تشهدها الأمة الصينية حاليا، والشير أكثر فأكثر إلى الأمام.

Accumulating evidence indicated that activation of microglia and neuroinflammation reaction played a prominent role in Alzheimer's disease (AD). Inhibition of toll-like receptor 4 (TLR4) has been shown to be associated with immune responses and brain damage, but its effects on AD remain unclear. This study mainly aimed to investigate the protective effect of TAK-242 (TLR4 specific inhibitor) on the microglia polarization and neuroprotection in AD mouse model and the underlying mechanisms. We found that APP/PS1 transgenic AD mice exhibited a dramatic increase in TLR4 levels concomitant with a significantly higher expression of inflammatory microglia in contrast to C57BL/6 wild type mice. Furthermore, inhibiton of TLR4 by TAK-242 administration significantly improved neurological function, decreased the level of Bax and caused a significant reduction in the levels of M1-markers (iNOS and TNFα), while the expressions of M2-phenotype markers (Trem-2 and Arg-1) were increased both in vivo and in vitro. Furthermore, TAK-242 treatment enhanced BV2 microglial phagocytosis. Moreover, Aβ25-35 caused the upregulation of inflammatory cytokine production, MyD88, NF-kappaB-p65 and NLRP3, which could be ameliorated by NLRP3-siRNA or TAK-242, an inhibitor of TLR4. These findings indicated that TLR4 inhibition provided neuroprotection and promoted microglia switch from the inflammatory M1 phenotype to the protective M2 phenotype in AD. The mechanism may be related to modulation of the MyD88/NF-kappaB/NLRP3 signaling pathway.

Background Obesity is a major global health challenge. While aerobic and resistance exercises are commonly used for obesity management, the effects of concurrent training (CT, combining both modalities) on fat mass and its distribution in individuals with overweight or obesity remain unclear. This study examined the effects of CT’s on visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT), and tried to identify optimal exercise prescriptions. Methods Six databases were systematically searched through September 2025. Randomized controlled trials comparing CT interventions with sedentary or usual-care controls in individuals with overweight or obesity were included. Meta-analyses calculated standardized mean differences (SMD) for VAT and SAT reduction. The percentage ratio of visceral/subcutaneous fat loss (%ΔV/%ΔS) was calculated, and predictors were explored through regression analysis. Results Eighteen studies were included. CT significantly reduced VAT (SMD = -0.36, 95% CI: -0.59 to -0.13, P  < 0.01, I 2  = 57%) and SAT (SMD = -0.26, 95% CI: -0.40 to -0.12, P  < 0.01, I 2  = 1%), with greater percentage reduction in VAT than SAT (%ΔV/%ΔS = 1.96 ± 1.18). Optimal effects were observed with ≥ 3 sessions per week, ≥ 60 min per session, > 180 min per week, > 15 weeks, and vigorous-intensity aerobic exercise combined with moderate-to-low-intensity resistance training. Intervention frequency and baseline VAT/SAT ratio significantly predicted fat distribution changes. Conclusions Current evidence suggests that CT can effectively reduce fat mass and may preferentially decrease VAT compared to a sedentary lifestyle in individuals with overweight or obesity. Our findings support CT as a promising and scalable strategy for population-level obesity management, particularly for high-risk groups such as postmenopausal women and older adults. Furthermore, the identified exercise prescription parameters provide practical guidance for populations aiming to reduce adipose tissue. Trial registration CRD42024595992.

Diabetic retinopathy (DR) is a common complication of diabetes, with its prevalence increasing globally. While previous research has linked obesity indices such as body mass index (BMI) to DR, the association with weight-adjusted-waist index (WWI) remains unclear. Additionally, the relationship between WWI and DR has not been fully elucidated. This cross-sectional study analyzed data from the National Health and Nutrition Examination Survey (2005–2008) to investigate these associations in Americans aged 40 and above. The study included 5436 participants (2705 men and 2731 women). Weighted logistic regression analysis revealed a significant increase in DR prevalence with higher WWI and BMI values. Smooth curve analysis demonstrated a linear correlation between WWI and DR. The findings suggest that both WWI and BMI are independently associated with DR risk among older US adults, highlighting the importance of considering central obesity measures in assessing diabetic complications.

Amyloid plaques and neurofibrillary tangles are pathologic hallmarks of Alzheimer’s disease (AD). Endoplasmic reticulum (ER) stress has been implicated in the loss of neurons in AD. The phosphatase and tensin homolog deleted on chromosome ten (PTEN) plays an important role in regulating neuronal survival processes. However, the direct effects of the PTEN on ER stress and apoptosis in AD have not been elucidated. In this study, we demonstrate that the expression of PTEN and ER stress related proteins, GRP78 and CHOP, increased in APP/PS1 transgenic AD mice compared with WT mice. A PTEN inhibitor, dipotassium bisperoxo-(5-hydroxypyridine-2-carboxyl)-oxovanadate (bpv) could decrease apoptosis, induce AKT phosphorylation and inhibit the ER stress response proteins in hippocampus in APP/PS1 transgenic AD model mice. Furthermore, treatment with the specific PI3K inhibitor, LY294002, significantly blocked the anti-apoptotic effects of bpv in AD mice. The expression in GRP78, CHOP and apoptosis levels by bpv was reversed after PI3K inhibitor treatment. Taken together, our results indicate that the neuroprotective role of bpv involves the suppression of ER stress via the activation of the PI3K/AKT signalling pathways in APP/PS1 transgenic AD model mice.

Background Visual impairment (VI) poses an increasing global health burden, yet the long-term effects of fine particulate matter (PM 2.5 ) constituents on VI remain unclear. This study aimed to evaluate associations between long-term exposure to PM 2.5 and its constituents and the risk of VI. Methods We used data from the nationally representative China Health and Retirement Longitudinal Study (CHARLS, 2011–2018) including adults aged ≥ 45 years. Long-term exposure to PM 2.5 and its constituents (SO 4 2– , NO 3 – , NH 4 + , organic matter (OM), and black carbon (BC)) was obtained from the Tracking Air Pollution in China dataset and linked to participants’ residential cities. The 3-year moving average concentration was used as the primary exposure metric to capture cumulative effects, while the 1-year average concentration was applied for sensitivity analysis. VI was defined as self-reported fair or poor vision. Associations were estimated using time-dependent Cox models, with restricted cubic spline (RCS), stratified and interaction analyses to assess nonlinear and subgroup effects. Results Over 27,443 person-years of follow-up, 3,736 participants developed VI. Per interquartile range (IQR) increase in 3-year moving average concentrations, higher risks of VI were observed for PM 2.5 (HR = 1.09, 95% CI: 1.03–1.15), SO 4 2– (HR = 1.13, 95% CI: 1.05–1.22), NO 3 – (HR = 1.06, 95% CI: 1.00–1.13), NH 4 + (HR = 1.09, 95% CI: 1.02–1.17), OM (HR = 95% CI: 1.15, 1.07–1.24), and BC (HR = 1.24, 95% CI: 1.14–1.34). RCS analysis revealed non-linear associations for PM 2.5 , NO 3 – , NH 4 + , and OM, whereas SO 4 2– and BC showed approximately linear trends. Associations were more pronounced among older adults (> 60 years old), smokers, and those with hypertension. Conclusion Long-term exposure to PM 2.5 and its constituents significantly increases the risk of VI among middle-aged and older adults in China, highlighting the need for targeted environmental health policies.

Accurate trajectory prediction is an essential task in automated driving, which is achieved by sensing and analyzing the behavior of surrounding vehicles. Although plenty of research works have been invested in this field, it is still a challenging subject due to the environment’s complexity and the driving intention uncertainty. In this paper, we propose a joint learning architecture to incorporate the lane orientation, vehicle interaction, and driving intention in vehicle trajectory forecasting. This work employs a coordinate transform to encode the vehicle trajectory with lane orientation information, which is further incorporated into various interaction models to explore the mutual trajectory relations. Extracted features are applied in a dual-level stochastic choice learning to distinguish the trajectory modality at both the intention and motion levels. By collaborative learning of lane orientation, interaction, and intention, our approach can be applied to both highway and urban scenes. Experiments on the NGSIM, HighD, and Argoverse datasets demonstrate that the proposed method achieves a significant improvement in prediction accuracy compared with the baseline.

Chronic low back pain (CLBP), lasting >3 months, is the end result of multiple pathogenic factors. Unfortunately, little is known about CLBP pathogenesis, which limits its advancements in clinical therapy and disease management. This paper summarizes the known pathological axes of CLBP, involving both peripheral and central systems. In particular, this paper details injurious nerve stimulation, inflammation-induced peripheral pathway, and central sensitization. Lumbar components, such as intervertebral disc (IVD), facet joints, muscles, fascia, ligaments, and joint capsules, contain pain receptors called nociceptors. Degeneration of the aforementioned lumbar components activates inflammatory pathways, which can directly damage nerves, lower nociceptor threshold to fire action potentials (AP), and cause pain. Additionally, damaged lumbar IVDs and endplates can also lead to the pathologic invasion of nerve growth and innervation, followed by the compression of herniated IVDs on nerve roots, thereby causing traumatic neuropathic pain. The central mechanism of CLBP involves alteration of the sensory processing of the brain and malfunction of the descending pain modulatory system, which facilitates pain amplification in the center nervous system (CNS). Lastly, abnormalities in the brain biochemical metabolism, activation of glial cells, and subsequent inflammation also play important roles in CLBP development. Taken together, inflammation plays an important role in both peripheral and central sensitization of CLBP. Due to the heterogeneity of CLBP, its pathological mechanism remains complex and difficult to understand. Therefore, it is a worthy field for future research into the subcomponents of CLBP pathogenesis, in order to distinguish the specific form of the disease, identify its origins, and develop corresponding highly effective comprehensive therapy against CLBP. Keywords: chronic low back pain, inflammation, degeneration, nerve innervation, central sensitization

Although acute exercise has been demonstrated to modulate endogenous testosterone levels, existing studies have reached conflicting conclusions regarding the pattern of response of testosterone levels after exercise. The objective of this study was to examine the dynamic effects of acute exercise on testosterone levels and to analyze the differences in the role of factors such as exercise mode, intensity, sample source, and gender. A comprehensive search of articles published up to March 2025 was conducted in five database systems, including PubMed and Web of Science, in accordance with the PRISMA guidelines. A total of 15 randomized controlled trials assessing the effect of acute exercise on testosterone levels were included, with a total sample size of 251 participants. (1) Testosterone levels demonstrate a greater increase following resistance training, with a delayed return to baseline levels; in contrast, testosterone levels typically recover within 1 h after aerobic exercise. (2) Moderate to high-intensity exercise stimulates the hypothalamic-pituitary-gonadal axis (HPG), leading to a transient rise in testosterone, but extended high-intensity exercise causes testosterone suppression during recovery due to cortisol antagonism for up to 72 h. The testosterone concentration during the active phase exceeds that during the recovery period. (3) A significant disparity in baseline testosterone levels exists between males and females, with males exhibiting higher levels. Additionally, males demonstrate a more pronounced response to exercise compared to females. (4) Blood tests exhibit greater sensitivity than saliva tests, although the latter is more reactive to high-intensity exercise; (5) The response is more pronounced in younger males compared to older adults, with negligible response observed in adolescents. Variations in testosterone level modulation due to acute exercise are predominantly influenced by exercise mode, intensity, sample source, and subject characteristics (gender and age). While resistance training and high-intensity exercise might temporarily increase testosterone levels, it is essential to consider the potential for hormonal imbalance after recovery; age and sex variations, along with assay standardization, are critical areas for further investigation. This review was registered PROSPERO with registration number CRD420251007222.

Metal organic frameworks (MOFs) with their large surface area and numerous active sites have attracted significant research attention. Recently, the application of MOFs for the catalytic degradation of organic pollutants has provided effective solutions to address diverse environmental problems. In this review, the latest progress in MOF-based removal and degradation of organic pollutants is summarized according to the different roles of MOFs in the removal reaction systems, such as physical adsorbents, enzyme-immobilization carriers, nanozymes, catalysts for photocatalysis, photo-Fenton and sulfate radical based advanced oxidation processes (SR-AOPs). Finally, the opportunities and challenges of developing advanced MOFs for the removal of organic pollutants are discussed and anticipated.