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مناشدة الحلم الفني
يتناول كتاب (مناشدة الحلم الفني) والذي قام بتأليفه (يوان مو، وانغ ويمينغ، بنغ بوه) في حوالي (56، 76) صفحة من القطع المتوسط موضوع (الفنون في الصين ودراسة وتعليم اللغة الصينية) مستعرضا ما يحويه الكتاب من موضوع سطع وهج النفوذ الصيني على الصعيد الدولي، وبات كثير من الناس يرغب في التعرف إلى الصين وإلى حياة شعبها اليومية، ومع انتشار معاهد كونفوشيوس في شتى أرجاء المعمورة، ازداد عدد الطالب وال سيما الصغار الذين يرغبون بتعلم اللغة الصينية.
Book
Prevalence of chronic kidney disease in China: a cross-sectional survey
The prevalence of chronic kidney disease is high in developing countries. However, no national survey of chronic kidney disease has been done incorporating both estimated glomerular filtration rate (eGFR) and albuminuria in a developing country with the economic diversity of China. We aimed to measure the prevalence of chronic kidney disease in China with such a survey.
We did a cross-sectional survey of a nationally representative sample of Chinese adults. Chronic kidney disease was defined as eGFR less than 60 mL/min per 1·73 m2 or the presence of albuminuria. Participants completed a lifestyle and medical history questionnaire and had their blood pressure measured, and blood and urine samples taken. Serum creatinine was measured and used to estimate glomerular filtration rate. Urinary albumin and creatinine were tested to assess albuminuria. The crude and adjusted prevalence of indicators of kidney damage were calculated and factors associated with the presence of chronic kidney disease analysed by logistic regression.
50 550 people were invited to participate, of whom 47 204 agreed. The adjusted prevalence of eGFR less than 60 mL/min per 1·73 m2 was 1·7% (95% CI 1·5–1·9) and of albuminuria was 9·4% (8·9–10·0). The overall prevalence of chronic kidney disease was 10·8% (10·2–11·3); therefore the number of patients with chronic kidney disease in China is estimated to be about 119·5 million (112·9–125·0 million). In rural areas, economic development was independently associated with the presence of albuminuria. The prevalence of chronic kidney disease was high in north (16·9% [15·1–18·7]) and southwest (18·3% [16·4–20·4]) regions compared with other regions. Other factors independently associated with kidney damage were age, sex, hypertension, diabetes, history of cardiovascular disease, hyperuricaemia, area of residence, and economic status.
Chronic kidney disease has become an important public health problem in China. Special attention should be paid to residents in economically improving rural areas and specific geographical regions in China.
The Ministry of Science and Technology (China); the Science and Technology Commission of Shanghai; the National Natural Science Foundation of China; the Department of Health, Jiangsu Province; the Sichuan Science and Technology Department; the Ministry of Education (China); the International Society of Nephrology Research Committee; and the China Health and Medical Development Foundation.
Journal Article
Acupuncture for uremic pruritus: A systematic review and meta-analysis protocol
Uremic pruritus (UP) or chronic kidney disease-associated pruritus (CKD-aP) is one of the most intractable dermatologic symptom in patients with chronic kidney disease. Several randomized controlled trials (RCTs) have been conducted to investigate the antipruritic effects of acupuncture on UP/CKD-aP and suggested a significant therapeutic effect, while the evidence supporting the application of acupuncture is limited.
This study will assess the efficacy and safety of acupuncture for patients with UP/CKD-aP.
Data Sources: RCTs will be searched in MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, Web of Science, the Chinese Biomedical Literature Database, the China National Knowledge Infrastructure, Wanfang Database, VIP Database, the WHO International Clinical Trials Registry Platform portal and www.ClinicalTrials.gov from inception to 31st August 2024. Study eligibility criteria: RCTs in English and Chinese conducted on UP/CKD-aP patients will be included. Participants: Adult patients diagnosed with UP/CKD-aP will be included. Interventions: All acupuncture interventions in the management of UP/CKD-aP will be included, compared with no treatment, placebo or sham acupuncture, or other treatment agents. Outcome measures: The primary outcome will be the change in the severity of itching evaluated by validated scales. Study appraisal and svnthesis methods: If necessary, a meta-analysis will be performed for the pooled therapeutic effect by Review Manager 5.3, or a qualitative descriptive analysis will be presented. The data will be transformed into the risk ratio (RR) for binary data and the mean difference (MD) or standardized MD for continuous data for analysis.
This review will update evidence of RCTs evaluating acupuncture for UP/CKD-aP.
Anticipated challenges contain the methodological and clinical heterogeneity in terms of evaluation tools and acupuncture interventions within included studies.
It will benefit patients and impact health-care decision-making regarding the models of care that are feasible for patients.
PROSPERO CRD42021257001.
Journal Article
Fluorescence spectroscopy combined with molecular docking to study the interaction between folic acid derivatives from wheat grains and bovine trypsin
Folic acid is an essential substance for the growth and reproduction of human cells. This study employs fluorescence spectroscopy and molecular docking to investigate the interactions between trypsin and four primary folic acid derivatives present in wheat grains: tetrahydrofolic acid (THF), 5-methyl-tetrahydrofolic acid (5-CH
3
-THF), 5-formyl-tetrahydrofolic acid (5-CHO-THF), and 5,10-methylene-tetrahydrofolic acid (5,10-CH
2
-THF). All derivatives effectively quenched trypsin’s intrinsic fluorescence via distinct mechanisms: THF and 5-CH
3
-THF followed dynamic quenching, while 5-CHO-THF and 5,10-CH
2
-THF exhibited static-dynamic combined quenching. Notably, 5-CHO-THF demonstrated the strongest binding affinity across all tested temperatures. Thermodynamic analysis revealed that the binding of THF and 5-CH
3
-THF (ΔH > 0, ΔS > 0) was primarily driven by hydrophobic interactions, whereas 5-CHO-THF and 5,10-CH
2
-THF (ΔH < 0, ΔS < 0) interacted mainly through hydrogen bonding and van der Waals forces. Molecular docking confirmed these findings, identifying specific binding residues and interaction types. These results provide crucial insights for developing folic acid-fortified staple crops.
Journal Article
UPLC/Q-TOF MS Screening and Identification of Antibacterial Compounds in Forsythia suspensa (Thunb.) Vahl Leaves
Forsythia suspensa (Thunb.) Vahl ( F. suspensa ) is a traditional Chinese medical herb and only its fruit is currently used in clinical therapies. However, the discarded parts like leaves also contain a large number of active components. In this study, we used macroporous adsorption resin to enrich the effective components from F. suspensa leaves. The separated active compounds were then identified and quantified by ultra-performance liquid chromatography coupled with quadrupole time of flight mass spectrometry (UPLC/Q-TOF MS) and high-performance liquid chromatography Active components with antibacterial properties extracted from F. suspensa leaves were confirmed in vitro and the corresponding mechanisms were explored. In sum, a stable and effective method for extracting antibacterial active components from F. suspensa leaves was established in this study, which proved the practicability of F. suspensa leaves as traditional Chinese medicine and is conducive to the more comprehensive utilization of the plant.
Journal Article
Sitagliptin activates the p62–Keap1–Nrf2 signalling pathway to alleviate oxidative stress and excessive autophagy in severe acute pancreatitis-related acute lung injury
Acute lung injury (ALI) is a complication of severe acute pancreatitis (SAP). Sitagliptin (SIT) is a DPP4 inhibitor that exerts anti-inflammatory and antioxidant effects; however, its mechanism of action in SAP-ALI remains unclear. In this study, we investigated the effects of SIT on SAP-ALI and the specific pathways involved in SAP-induced lung inflammation, including oxidative stress, autophagy, and p62–Kelch-like ECH-associated protein 1 (Keap1)–NF-E2-related factor 2 (Nrf2) signalling pathways. Nrf2 knockout (Nrf2
−/−
) and wild-type (WT) mice were pre-treated with SIT (100 mg/kg), followed by caerulein and lipopolysaccharide (LPS) administration to induce pancreatic and lung injury. BEAS-2B cells were transfected with siRNA-Nrf2 and treated with LPS, and the changes in inflammation, reactive oxygen species (ROS) levels, and autophagy were measured. SIT reduced histological damage, oedema, and myeloperoxidase activity in the lung, decreased the expression of pro-inflammatory cytokines, and inhibited excessive autophagy and ROS production via the activation of the p62–Keap1–Nrf2 signalling pathway and promotion of the nuclear translocation of Nrf2. In Nrf2-knockout mice, the anti-inflammatory effect of SIT was reduced, resulting in ROS accumulation and excessive autophagy. In BEAS-2B cells, LPS induced ROS production and activated autophagy, further enhanced by Nrf2 knockdown. This study demonstrates that SIT reduces SAP-ALI-associated oxidative stress and excessive autophagy through the p62–Keap1–Nrf2 signalling pathway and nuclear translocation of Nrf2, suggesting its therapeutic potential in SAP-ALI.
Journal Article
A Two-Stage MLP-LSTM Network-Based Task Planning Method for Human–Robot Collaborative Assembly Scenarios
In many current assembly scenarios, efficient collaboration between humans and robots can improve collaborative efficiency and quality. However, the efficient arrangement of human–robot collaborative (HRC) tasks constitutes a significant challenge. In a collaborative workspace where humans and robots collaborate on assembling a shared product, the determination of task allocation between them is of crucial importance. To address this issue, offline feasible HRC paths are established based on assembly task constraint information. Subsequently, the HRC process is simulated within a virtual environment leveraging these feasible paths. Human assembly intentions are explicitly expressed through human assembly trajectories, and implicitly expressed through simulation results such as assembly time and human–robot resource allocation. Furthermore, a two-stage MLP-LSTM network is employed to train and optimize the assembly simulation database. In the first stage, a sequence generation model is trained using high-quality HRC processes. Then, the network learns human evaluation patterns to score the generated sequences. Ultimately, task allocation for HRC is performed based on the high-scoring generated sequences. The effectiveness of the proposed method is demonstrated through assembly scenarios of two products. Compared with traditional optimization methods like DFS and Greedy, the human collaboration ratio has been optimized by 10%, while the collaborative quality evaluation has been improved by 3%.
Journal Article
The dual role of TRPV1 in peripheral neuropathic pain: pain switches caused by its sensitization or desensitization
The transient receptor potential vanilloid 1 (TRPV1) channel plays a dual role in peripheral neuropathic pain (NeuP) by acting as a “pain switch” through its sensitization and desensitization. Hyperalgesia, commonly resulting from tissue injury or inflammation, involves the sensitization of TRPV1 channels, which modulates sensory transmission from primary afferent nociceptors to spinal dorsal horn neurons. In chemotherapy-induced peripheral neuropathy (CIPN), TRPV1 is implicated in neuropathic pain mechanisms due to its interaction with ion channels, neurotransmitter signaling, and oxidative stress. Sensitization of TRPV1 in dorsal root ganglion neurons contributes to CIPN development, and inhibition of TRPV1 channels can reduce chemotherapy-induced mechanical hypersensitivity. In diabetic peripheral neuropathy (DPN), TRPV1 is involved in pain modulation through pathways including reactive oxygen species and cytokine production. TRPV1’s interaction with TRPA1 channels further influences chronic pain onset and progression. Therapeutically, capsaicin, a TRPV1 agonist, can induce analgesia through receptor desensitization, while TRPV1 antagonists and siRNA targeting TRPV1 show promise in preclinical studies. Cannabinoid modulation of TRPV1 provides another potential pathway for alleviating neuropathic pain. This review summarizes recent preclinical research on TRPV1 in association with peripheral NeuP.
Journal Article