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Summer heat waves with persistent extreme high temperatures have been occurring with increasing frequency in recent decades. These extreme events have disastrous consequences for human health, economies, and ecosystems. In this study, we examine three summers with intense and protracted heat waves: the summers of 2003, 2006, and 2013, with high temperatures located mainly in southeastern, southwestern, and eastern China, respectively. The synoptic-scale characteristics of these heat waves and associated atmospheric circulation anomalies are investigated. In the early heat wave episode of 2003, a heat center was located in the southeast coastal provinces during the first 20 days of July. The maximum southward displacement of the East Asian jet stream (EAJS) induced anticyclonic anomalies to the south, associated with southwestward intensification of the western North Pacific subtropical high (WNPSH), and extreme high temperatures were found only to the south of the Yangtze River. In the later episode, a poleward displacement of the EAJS and an enhanced WNPSH over the midlatitudes of eastern China resulted in a “heat dome” over the region, and the heat wave extended northward to cover a larger area of eastern China. The coupling between the westward-enhanced WNPSH and poleward-displaced EAJS was found in the East China heat wave of 2013 as well. But the area of high temperatures reached far to the north in August 2013, with below-normal temperatures located in a small region of South China. In the 2006 southwestern drought and heat wave, extreme poleward displacement of the EAJS, associated with extraordinary westward extension of the WNSPH, resulted in further blocking of the moisture supply from the southwest monsoon. Large-scale moisture deficiencies, dry conditions, and downslope winds were common features of all investigated heat wave episodes. But in 2006, low-level heat lows associated with a well-mixed layer due to intensive daytime heating and atmospheric turbulence were emphasized.

Modulation recognition methods with real-valued deep network models fail to fully leverage the complex nature of in-phase/quadrature(I/Q) signals. Automatic modulation recognition based on complex-valued operations has attracted the attention of researchers. A Complex-valued hybrid deep learning models for automatic modulation recognition is proposed, which is named CCTL-Net. The CCTL-Net employs a complex-valued Convolutional Neural Network (CNN) to extract local features from I/Q signals, thereby effectively preserving the complex-related information inherent to I/Q signals. To enhance the correlation of different channels with CNN, a complex-valued Squeeze-and-Excitation module is designed. The complex-valued Transformer and complex-valued LSTM are employed to extract global features from both the attention and temporal relation perspectives. To reduce mode complexity, a light model with smaller channels and complex-valued 1D convolutional networks was designed. CCTL-Net achieved average accuracy rates of 70.71% and 62.97% on the RML22 and RML2016.10a datasets, respectively. Compared with real-valued hybrid model and complex-valued convolutional networks, the experimental results show that CCTL-Net can improve recognition accuracy under lower complexity conditions.

K1/K2 hvKP strains acquire carbapenem-resistance plasmids, known as CR-hvKp, and carbapenem-resistant Klebsiella pneumoniae (CRKP) strains obtain virulence plasmids, recognized as hv-CRKP. The two different evolution patterns of hypervirulent combined carbapenem-resistant Klebsiella pneumoniae may lead to their different prevalence in hospitals. Our study aimed to investigate the prevalence of hv-CRKP and CR-hvKp strains and to analyze factors influencing their evolution and prevalence. We collected 890 K. pneumoniae genomes from GenBank and 530 clinical K. pneumoniae isolates from nine hospitals. Our study found that hv-CRKP strains were more prevalent than CR-hvKp strains and both were dominated by bla KPC-2 gene. The bla KPC-2 -carrying plasmids could mobilize non-conjugative virulence plasmids from hvKp strains to CRKP strains. The conserved oriT of virulence plasmids and the widespread of conjugative helper plasmids were potential factors for the mobilization of non-conjugative virulence plasmids. HvKp strains with KPC plasmid could hardly simultaneously exhibit hypervirulence and carbapenem resistance as CRKP strains with virulence plasmid, and we found that rfaH mutation reduced capsular synthesis and increased carbapenem resistance of the CR-hvKp strain. In summary, this study revealed that hv-CRKP strains were more suitable for survival in hospital settings than CR-hvKp strains and the widespread conjugative KPC-producing plasmids contributed to the emergence and prevalence of hv-CRKP strains.

The Belt and Road initiative is a comprehensive strategic initiative initiated by the Chinese government; it encompasses a significant segment of geo-territory, interaction of economy, investment, environment and ecology worldwide. In recent years, much has been said and written about the Belt and Road initiative’s economic and investment prospectus; however, relatively little attention has been paid to the comprehensive quest of its emergent ecological and sustainable environmental spares. This paper aims to investigate the association of forest resources, agricultural expansion, and financial development with energy demand and environment; based on ecological footprints among selected ninety-seven nations of Belt and Road initiative from 1995 to 2018 by employing a Generalized Method of Moments and Driscoll and Kraay approaches. Empirical outcomes of the study have revealed that GDP growth reduces the environmental burden, and agricultural expansion deteriorates the environment. Contrarily, finance, foreign direct investment, and forest resources are providing solutions for environmental improvement in the study area. Similarly, the role of forests, agriculture, and finance remain positive determinants of energy demand in the study area. From the causal test, we found that the indicators of environment, energy, forest, agriculture, and finance all have bidirectional linkages. Based on our research results, we have concluded some policy implications for policymakers within the Belt and Road initiative framework.

This study investigates summer high temperature extremes (HTEs) in southeast China and their linkage with the El Niño–Southern Oscillation (ENSO) and atmospheric circulations in the East Asian summer monsoon (EASM). An interdecadal change in HTEs associated with the abrupt shift of the ENSO–monsoon climate in the late 1980s is demonstrated. Before this interdecadal shift, the interannual variability of HTEs was linked mainly to temperature adjustments associated with the meridional displacement of the East Asian jet stream (EAJS), whereas after the shift HTEs were found to follow an ENSO cycle, which may be due to intensified and persistent ENSO activities, tropical Indian Ocean (TIO) warming, and changes in atmospheric teleconnections. Impacts of the EAJS, the South Asian high (SAH), and the western North Pacific subtropical high (WNPSH) on HTEs are further investigated based on empirical orthogonal function (EOF) analysis. It is found that mainly the first leading EOF mode with a homogeneous spatial pattern shows dominance before the interdecadal shift, whereas both of the first two leading EOF modes show dominance after the interdecadal shift. A possible mechanism of how HTEs in southeast China are linked to the EAJS, the SAH, and the WNPSH in the ENSO–monsoon coupled system is proposed.

Background Chloroplasts are organelles that conduct photosynthesis in plant and algal cells. The information chloroplast genome contained is widely used in agriculture and studies of evolution and ecology. Correctly assembling chloroplast genomes can be challenging because the chloroplast genome contains a pair of long inverted repeats (10–30 kb). Typically, it is simply assumed that the gross structure of the chloroplast genome matches the most commonly observed structure of two single-copy regions separated by a pair of inverted repeats. The advent of long-read sequencing technologies should remove the need to make this assumption by providing sufficient information to completely span the inverted repeat regions. Yet, long-reads tend to have higher error rates than short-reads, and relatively little is known about the best way to combine long- and short-reads to obtain the most accurate chloroplast genome assemblies. Using Eucalyptus pauciflora , the snow gum, as a test case, we evaluated the effect of multiple parameters, such as different coverage of long-(Oxford nanopore) and short-(Illumina) reads, different long-read lengths, different assembly pipelines, with a view to determining the most accurate and efficient approach to chloroplast genome assembly. Results Hybrid assemblies combining at least 20x coverage of both long-reads and short-reads generated a single contig spanning the entire chloroplast genome with few or no detectable errors. Short-read-only assemblies generated three contigs (the long single copy, short single copy and inverted repeat regions) of the chloroplast genome. These contigs contained few single-base errors but tended to exclude several bases at the beginning or end of each contig. Long-read-only assemblies tended to create multiple contigs with a much higher single-base error rate. The chloroplast genome of Eucalyptus pauciflora is 159,942 bp, contains 131 genes of known function. Conclusions Our results suggest that very accurate assemblies of chloroplast genomes can be achieved using a combination of at least 20x coverage of long- and short-reads respectively, provided that the long-reads contain at least ~5x coverage of reads longer than the inverted repeat region. We show that further increases in coverage give little or no improvement in accuracy, and that hybrid assemblies are more accurate than long-read-only or short-read-only assemblies.

Signal transduction plays a pivotal role in modulating a myriad of critical processes, including the tumour microenvironment (TME), cell cycle arrest, proliferation and apoptosis of tumour cells, as well as their migration, invasion, and the epithelial–mesenchymal transition (EMT). Epigenetic mechanisms are instrumental in the genesis and progression of tumours. The Chromobox (CBX) family proteins, which serve as significant epigenetic regulators, exhibit tumour-specific expression patterns and biological functionalities. These proteins are influenced by a multitude of factors and could modulate the activation of diverse signalling pathways within tumour cells through alterations in epigenetic modifications, thereby acting as either oncogenic agents or tumour suppressors. This review aims to succinctly delineate the composition, structure, function, and expression of CBXs within tumour cells, with an emphasis on synthesizing and deliberating the CBXs-mediated activation of intracellular signalling pathways and the intricate mechanisms governing tumourigenesis and progression. Moreover, a plethora of contemporary studies have substantiated that CBXs might represent a promising target for the diagnosis and therapeutic intervention of tumour patients. We have also compiled and scrutinized the current research landscape concerning inhibitors targeting CBXs, aspiring to aid researchers in gaining a deeper comprehension of the biological roles and mechanisms of CBXs in the malignant evolution of tumours, and to furnish novel perspectives for the innovation of targeted tumour therapeutics.

Despite the increasing interest in understanding the mechanism of household livelihood decisions to increase household livelihood welfare, the combined role of livelihood capitals and human settlements in livelihood decisions is unclear. Therefore, in this paper we carried out extensive empirical research to explore the causal pathway between human settlements (including infrastructure, public services, and social governance) and livelihood capitals (including human, natural, physical, financial, and social capitals) on agricultural land transfer, taking employment choices as an intermediary factor. On this basis, this study analyzed the regional differences in the decision-making mechanisms of agricultural land transfer behaviors in eastern, central, and western regions of China through a multi-group structural equation model. The results demonstrated that capital accumulation can directly increase the possibility of agricultural land inflow (β = 0.130, p < 0.01), but can indirectly reduce the dependence on agricultural land by stimulating non-agricultural employment (β = −0.613, p < 0.01). The improvement in human settlement promotes the agricultural land inflow (outside the western region) and indirectly enhances the willingness to enter into agriculture. The employment choices play a significant mediating role by strengthening the livelihood capitals and weakening human settlements. To achieve the intense agricultural development and sustainable development of rural areas, the improvement of both rural human settlements and household livelihood capitals should be considered.

Background Despite the biological and economic significance of scleractinian reef-building corals, the lack of large molecular datasets for a representative range of species limits understanding of many aspects of their biology. Within the Scleractinia, based on molecular evidence, it is generally recognised that there are two major clades, Complexa and Robusta, but the genomic bases of significant differences between them remain unclear. Results Draft genome assemblies and annotations were generated for three coral species: Galaxea fascicularis (Complexa), Fungia sp. , and Goniastrea aspera (Robusta). Whilst phylogenetic analyses strongly support a deep split between Complexa and Robusta, synteny analyses reveal a high level of gene order conservation between all corals, but not between corals and sea anemones or between sea anemones. HOX-related gene clusters are, however, well preserved across all of these combinations. Differences between species are apparent in the distribution and numbers of protein domains and an apparent correlation between number of HSP20 proteins and stress tolerance. Uniquely amongst animals, a complete histidine biosynthesis pathway is present in robust corals but not in complex corals or sea anemones. This pathway appears to be ancestral, and its retention in the robust coral lineage has important implications for coral nutrition and symbiosis. Conclusions The availability of three new coral genomes enabled recognition of a de novo histidine biosynthesis pathway in robust corals which is only the second identified biosynthetic difference between corals. These datasets provide a platform for understanding many aspects of coral biology, particularly the interactions of corals with their endosymbionts.

Glioblastoma (GBM) is the most frequent malignant brain tumor, the relapse of which is unavoidable following standard treatment. However, the effective treatment for recurrent GBM is lacking, necessitating the understanding of key mechanisms driving tumor recurrence and the identification of new targets for intervention. Here, we integrated single-cell RNA-sequencing data spanning 36 patient-matched primary and recurrent GBM (pGBM and rGBM) specimens, with 6 longitudinal GBM spatial transcriptomics to explore molecular alterations at recurrence, with each cell type characterized in parallel. Genes involved in extracellular matrix (ECM) organization are preferentially enriched in rGBM cells, and MAFK is highlighted as a potential regulator. Notably, we uncover a unique subpopulation of GBM cells that is much less detected in pGBM and highly expresses ECM and mesenchyme related genes, suggesting it may contribute to the molecular transition of rGBM. Further regulatory network analysis reveals that transcription factors, such as NFATC4 and activator protein 1 members, may function as hub regulators. All non-tumor cells alter their specific sets of genes as well and certain subgroups of myeloid cells appear to be physically associated with the mesenchyme-like GBM subpopulation. Altogether, our study provides new insights into the molecular understanding of GBM relapse and candidate targets for rGBM treatment.