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Ferroptosis is a recently identified, iron-regulated, non-apoptotic form of cell death. It is characterized by cellular accumulation of lipid reactive oxygen species that ultimately leads to oxidative stress and cell death. Although first identified in cancer cells, ferroptosis has been shown to have significant implications in several neurologic diseases, such as ischemic and hemorrhagic stroke, Alzheimer’s disease, and Parkinson’s disease. This review summarizes current research on ferroptosis, its underlying mechanisms, and its role in the progression of different neurologic diseases. Understanding the role of ferroptosis could provide valuable information regarding treatment and prevention of these devastating diseases.

Collapses and landslides are frequent in the southern mountainous areas of the economic zone on the northern slopes of the Tianshan Mountains in Xinjiang, and an accurate assessment of susceptibility can effectively avoid potential risks, which is crucial for the prevention and control of geological hazards. To obtain precise and reliable references for the prevention of landslide, a total of 10 landslide conditioning factors (e.g., elevation, slope degree, slope aspect, curvature, relief, engineering geological lithology, landform types, land use, distance to rivers, as well as distance to roads) were selected for the multicollinearity analysis. The evaluation index system was established in the present research to assess the landslide susceptibility with the combination of traditional statistical methods and machine learning models. Both the information value-maximum entropy coupled model (I-MaxEnt) and the information value-logistic regression coupled model (I-LR) were proposed to assess landslide susceptibility in the Tianshan northern slope economic belt after the detailed evaluation on the information value model (I), logistic regression model (LR), and maximum entropy model (MaxEnt). Comparative discussions on the receiver operating characteristic (ROC)curves revealed that the area under the curve(AUC) values of the I-MaxEnt and I-LR coupled models were 0.907 and 0.941, respectively, indicating the superior accuracy of the I-LR model. Furthermore, the results obtained from the I-LR model were more consistent with the actual situation as verified by field validation. That is, the I-LR model is much more suitable in assessing the landslide susceptibility in the given research region attributed to its high accuracy and reliability.The results of this research provide a reliable basis for disaster prevention and mitigation in this study area.

Wood is a naturally porous material prone to microbial erosion and degradation in outdoor environments. Therefore, the development of an environmentally friendly wood preservative with excellent antibacterial effects and low toxicity is urgently needed. In this study, nitrogen-doped carbon quantum dots (N-CQDs) with excellent antifungal performance and fluorescent properties were synthesized using a one-step hydrothermal method with chitosan quaternary ammonium salt (HACC) as the raw material. The fluorescence characteristics of N-CQD preservatives can help track their position and distribution in wood. The minimum inhibitory concentration (MIC) of N-CQDs is 1.8 mg/mL, which was nearly 22 times lower than that of HACC (40.0 mg/mL) in the PDA medium. The decay resistance test demonstrated that wood treated with N-CQDs showed a considerably reduced decay degree and its mass loss rate decreased from 46 ± 0.5% to 3.8 ± 0.5%. Biological transmission electron microscopy revealed that N-CQDs effectively destroyed fungal cell structures, thereby hindering the growth of Coriolus versicolor. N-CQDs synthesized using the one-step hydrothermal method can be used as an efficient wood preservative that can effectively improve the utilization and service life of wood.

Floods, the most common natural hazard in the world, cause serious loss in terms of lives, buildings, and infrastructures. As a consequence, the need for flood risk assessment has become critical. Using a semi-quantitative model and fuzzy analytic hierarchy process (FAHP) weighting approach, this paper assessed flood risk in the Dongting Lake region, Hunan Province, Central China, an area where flood hazards frequently occur. The model was designed using spatial multi-criteria analysis (SMCA) techniques in a Geographic Information System (GIS). A GIS database of indicators for the evaluation of hazard and vulnerability was created. Each indicator was analyzed, standardized, and weighted; after which, the weights of the indicators were combined to obtain the final flood risk index map. Using the flood risk index, the study area was classified into five categories of flood risk: very low, low, medium, high, and very high. The high and very high risk zones are mainly concentrated in the northern and central plains. The results obtained can provide useful information for decision makers and insurance companies.

The eukaryotic multisubunit Elongator complex has been shown to perform multiple functions in transcriptional elongation, histone acetylation and tRNA modification. However, the Elongator complex plays different roles in different organisms, and the underlying mechanisms remain unexplored. Moreover, the biological functions of the Elongator complex in human fungal pathogens remain unknown. In this study, we verified that the Elongator complex of the opportunistic fungal pathogen Aspergillus fumigatus consists of six subunits (Elp1-6), and the loss of any subunit results in similarly defective colony phenotypes with impaired hyphal growth and reduced conidiation. The catalytic subunit-Elp3 of the Elongator complex includes a S-adenosyl methionine binding (rSAM) domain and a lysine acetyltransferase (KAT) domain, and it plays key roles in the hyphal growth, biofilm-associated exopolysaccharide galactosaminogalactan (GAG) production, adhesion and virulence of A . fumigatus ; however, Elp3 does not affect H3K14 acetylation levels in vivo . LC–MS/MS chromatograms revealed that loss of Elp3 abolished the 5-methoxycarbonylmethyl-2-thiouridine (mcm 5 s 2 U) modification of tRNA wobble uridine (U 34 ), and the overexpression of tRNA Gln UUG and tRNA Glu UUC , which normally harbor mcm 5 s 2 U modifications, mainly rescues the defects of the Δ elp3 mutant, suggesting that tRNA modification rather than lysine acetyltransferase is responsible for the primary function of Elp3 in A . fumigatus . Strikingly, global proteomic comparison analyses showed significantly upregulated expression of genes related to amino acid metabolism in the Δ elp3 mutant strain compared to the wild-type strain. Western blotting showed that deletion of elp3 resulted in overexpression of the amino acid starvation-responsive transcription factor CpcA, and deletion of CpcA markedly reversed the defective phenotypes of the Δ elp3 mutant, including attenuated virulence. Therefore, the findings of this study demonstrate that A . fumigatus Elp3 functions as a tRNA-modifying enzyme in the regulation of growth, GAG production, adhesion and virulence by maintaining intracellular amino acid homeostasis. More broadly, our study highlights the importance of U 34 tRNA modification in regulating cellular metabolic states and virulence traits of fungal pathogens.

Brain derived neurotrophic factor (BDNF) has multiple biological functions which are mediated by the activation of two receptors, tropomyosin receptor kinase B (TrkB) receptor and the p75 neurotrophin receptor, involving in physiological and pathological processes throughout life. The diverse presence and activity of BDNF indicate its potential role in the pathogenesis, progression and treatment of both neurological and psychiatric disorders. This review is to provide a comprehensive assessment of the current knowledge and future directions in BDNF-associated research in the central nervous system (CNS), with an emphasis on the physiological and pathological functions of BDNF as well as its potential treatment effects in CNS diseases, including depression, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, multiple sclerosis, and cerebral ischemic stroke.

The problem of soil erosion is prominent in the arid region of northwest China, and the Kapo in Wensu County, Xinjiang is highly susceptible to erosion and damage disasters due to the formation of chalky high steep slopes affected by rivers. In order to provide theoretical support for slope prevention and control, this paper investigates the erosion damage characteristics of three different grain size compositions of nearly horizontal laminated soil slopes under rainfall by using rainfall simulation equipment in an indoor model box test. The results show that rainfall, slope soil properties and cracks are the main causes of erosion damage on slopes. As rainfall increases, the slope shows regressive damage from the foot of the slope to the top of the slope. Soil slopes with coarse-grained sand have less erosion damage due to good permeability of the sand layer; slopes with fine soil particles have weak erosion resistance and severe gully erosion. The dominant seepage channels formed by cracks play a significant role in the erosion damage of slopes.

Anthocyanins biosynthesized from the flavonoid pathway are types of pigments that are involved in the protection of poplar from biotic and abiotic stresses. Previous researchers studying anthocyanin-related transcription factors and structural genes in poplar have made significant discoveries. However, little is known about the regulatory role of microRNAs in anthocyanin biosynthesis in poplar. Here, we overexpressed miR156 in poplar to study the comprehensive effects of the miR156- SPL module on the biosynthesis of anthocyanins. Small RNA sequencing analysis revealed 228 microRNAs differentially expressed in transgenic poplar plants with dramatically increased miR156 levels. Furthermore, integrated microRNAomic and transcriptomic analysis suggested that two microRNAs, miR160h, and miR858, have the potential to affect anthocyanin accumulation in poplar by regulating auxin response factors and MYB transcription factors, respectively. Additionally, the accumulation of miR160h and miR858 displayed a positive correlation with miR156 levels, suggesting a possible interaction between the miR156- SPL module and these microRNAs in poplar. Last, metabolomics analysis revealed that the levels of anthocyanins, flavones, and flavonols were substantially elevated in transgenic poplar plants overexpressing miR156 compared with the wild type, whereas the total lignin content was reduced in the transgenic plants. Taken together, our results indicate that miR156 can fine tune the anthocyanin biosynthetic pathway via multiple factors, including microRNAs, transcription factors, and the levels of structural genes, in poplar. This provides additional clues for understanding the complex regulatory network of anthocyanin biosynthesis in woody plants.

Oligodendrocyte progenitor cells (OPCs) differentiate to myelin-producing mature oligodendrocytes and enwrap growing or demyelinated axons during development and post central nervous diseases. Failure of remyelination owing to cell death or undifferentiation of OPCs contributes to severe neurologic deficits and motor dysfunction. However, how to prevent the cell death of OPCs is still poorly understood, especially in hemorrhagic diseases. In the current study, we injected autologous blood into the mouse lateral ventricular to study the hemorrhage-induced OPC cell death in vivo. The integrity of the myelin sheath of the corpus callosum was disrupted post intraventricular hemorrhage (IVH) assessed by using magnetic resonance imaging, immunostaining, and transmission electron microscopy. Consistent with the severe demethylation, we observed massive cell death of oligodendrocyte lineages in the periventricular area. In addition, we found that ferroptosis is the major cell death form in Hemin-induced OPC death by using RNA-seq analysis, and the mechanism was glutathione peroxidase 4 activity reduction-resulted lipid peroxide accumulation. Furthermore, inhibition of ferroptosis rescued OPC cell death in vitro, and in vivo attenuated IVH-induced white matter injury and promoted recovery of neurological function. These data demonstrate that ferroptosis is an essential form of OPC cell death in hemorrhagic stroke, and rescuing ferroptotic OPCs could serve as a therapeutic target for stroke and related diseases.

Background Congenital abdominal aortic aneurysm (AAA) is distinctly rare in infants and children and carries a high mortality rate. Our objective was to summarize the experience of the diagnosis and treatment in patients with congenital AAA. Methods Reported cases of congenital AAA published prior to November 8, 2014, were identified through PubMed, EMBASE, Web of Science, and reference lists. All selected cases were evaluated for main clinical characteristics. Results Twenty-six cases of congenital AAA were identified in the English language literature. Congenital AAA occurred primarily in children under three years old, but it was also found in young adults and fetuses. With regards to the localization, the great majority of congenital AAA was infrarenal AAA. The majority of the AAA patients lacked specific symptoms, and a painless pulsatile abdominal mass was the most common clinical presentation. The diagnosis of AAA was based on ultrasound scanning in twenty-five cases, multi-slice spiral computed tomography angiography (MSCTA) in sixteen cases, and magnetic resonance angiography (MRA) in nine cases. Histopathological analyses were available in seven cases. Seven patients received conservative management. Surgical treatment was performed in seventeen cases, and open repair with an artificial graft was the main surgical intervention. The mortality associated with congenital AAA was high (30.76%). Ruptured aneurysm and renal failure were the main causes of death. Conclusions Good outcomes can be achieved in children with early identification of congenital AAA and individualized surgical repair with grafts.