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"Wang, Ye"
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Parallel population and parallel human : a cyber-physical social approach
\"This book is a result of an ambitious research agenda I made for myself almost 30 years ago after reading Karl Popper's The Open Society and its Enemies. To me, the open society should have no enemies, we must find a way to build the bridge between Popper's utopian social engineering and piecemeal social engineering, perhaps through the Cyber-enabled Social Movement Organizations and Operations (CeSMO), and that would be my research for the rest of my professional career. I had promised myself to write a book entitled The Open Society and its Friends, and even created a new name for my ambition, Bemonad, for Becoming and Being Gottfried Leibniz's Monad, which was redefined as the atom of intelligence for Popper's Artificial World in the sense of ancient Greek philosopher Democritus' atom for matters in the Physical World. Of course, I realized very soon that it is simply a dream and a mission impossible. However, this had dramatically changed my career path from intelligent control for robotic systems to a mixture of science, technology, engineering, and social studies for complex intelligent systems, or an interdisciplinary approach by today's term, starting from my technical report at NASA/UA Space Engineering Research Center (SERC) on Shadow Systems in 1994 and ending up with the creation of the Program for Advanced Research in Complex Systems (PARCS) at the University of Arizona, Tucson, Arizona in 1999.\"-- Provided by publisher.
Book
UDP-glucosyltransferase regulates grain size and abiotic stress tolerance associated with metabolic flux redirection in rice
Grain size is an important component trait of grain yield, which is frequently threatened by abiotic stress. However, little is known about how grain yield and abiotic stress tolerance are regulated. Here, we characterize
GSA1
, a quantitative trait locus (QTL) regulating grain size and abiotic stress tolerance associated with metabolic flux redirection.
GSA1
encodes a UDP-glucosyltransferase, which exhibits glucosyltransferase activity toward flavonoids and monolignols.
GSA1
regulates grain size by modulating cell proliferation and expansion, which are regulated by flavonoid-mediated auxin levels and related gene expression. GSA1 is required for the redirection of metabolic flux from lignin biosynthesis to flavonoid biosynthesis under abiotic stress and the accumulation of flavonoid glycosides, which protect rice against abiotic stress.
GSA1
overexpression results in larger grains and enhanced abiotic stress tolerance. Our findings provide insights into the regulation of grain size and abiotic stress tolerance associated with metabolic flux redirection and a potential means to improve crops.
Increasing grain yield needs to be put in the context of environmental stress. Here, the authors reveal that a UDP-glucosyltransferase is associated with regulation of rice grain size, abiotic stress tolerance, flavonoid-mediated auxin signaling, and redirection of carbon flux to flavonoid glycosides synthesis.
Journal Article
Spatiotemporal Dynamics of the Eco-Innovation Level of China’s Marine Economy
This paper aims to provide a reliable basis for formulating, revising, and selecting sustainable marine economic development plans through a scientific and comprehensive evaluation of the eco-innovation level of China’s marine economy. Based on the analysis of the three-stage theoretical model of marine economic eco-innovation, an index system for evaluating the eco-innovation level of China’s marine economy is first constructed. Also, an integration EWM-HDEMATEL method that balances objective and subjective weighting is introduced to determine the index weights. The proposed methods are applied to analyze the temporal and spatial variations in the eco-innovation level of China’s marine economy in 2006–2021, and the following conclusions are drawn. First, between 2006 and 2021, the average level of marine economic ecological innovation across all regions exhibited a steady upward trajectory. Second, regional imbalances in ecological innovation intensified over the study period, with the maximum disparity widening from a 1.6-fold difference in 2006 to a 2.5-fold difference in 2021. Third, although differences among the three principal marine economic zones were not pronounced, significant heterogeneity persisted within each zone, underscoring the need for targeted policies and interventions to achieve coordinated development. Fourth, regions performed better on the support environment and performance dimensions of marine economic ecological innovation than on the capacity and activity dimensions. These findings identify critical leverage points for policy action and carry important implications for promoting the balanced and sustainable development of marine economic ecological innovation efficiency.
Journal Article
Universal mechanical exfoliation of large-area 2D crystals
Two-dimensional materials provide extraordinary opportunities for exploring phenomena arising in atomically thin crystals. Beginning with the first isolation of graphene, mechanical exfoliation has been a key to provide high-quality two-dimensional materials, but despite improvements it is still limited in yield, lateral size and contamination. Here we introduce a contamination-free, one-step and universal Au-assisted mechanical exfoliation method and demonstrate its effectiveness by isolating 40 types of single-crystalline monolayers, including elemental two-dimensional crystals, metal-dichalcogenides, magnets and superconductors. Most of them are of millimeter-size and high-quality, as shown by transfer-free measurements of electron microscopy, photo spectroscopies and electrical transport. Large suspended two-dimensional crystals and heterojunctions were also prepared with high-yield. Enhanced adhesion between the crystals and the substrates enables such efficient exfoliation, for which we identify a gold-assisted exfoliation method that underpins a universal route for producing large-area monolayers and thus supports studies of fundamental properties and potential application of two-dimensional materials.
Here, the authors develop a one-step, contamination-free, Au-assisted mechanical exfoliation method for 2D materials, and isolate 40 types of single-crystalline monolayers, including elemental 2D crystals, metal-dichalcogenides, magnets and superconductors with millimetre size.
Journal Article
GRAIN SIZE AND NUMBER1 Negatively Regulates the OsMKKK10-OsMKK4-OsMPK6 Cascade to Coordinate the Trade-off between Grain Number per Panicle and Grain Size in Rice
Grain number and size are interactive agronomic traits that determine grain yield. However, the molecular mechanisms responsible for coordinating the trade-off between these traits remain elusive. Here, we characterized the rice (Oryza sativa) grain size and number1 (gsn1) mutant, which has larger grains but sparser panicles than the wild type due to disordered localized cell differentiation and proliferation. GSN1 encodes the mitogen-activated protein kinase phosphatase OsMKP1, a dual-specificity phosphatase of unknown function. Reduced expression of GSN1 resulted in larger and fewer grains, whereas increased expression resulted in more grains but reduced grain size. GSN1 directly interacts with and inactivates the mitogen-activated protein kinase OsMPK6 via dephosphorylation. Consistent with this finding, the suppression of mitogen-activated protein kinase genes OsMPK6, OsMKK4, and OsMKKK10 separately resulted in denser panicles and smaller grains, which rescued the mutant gsn1 phenotypes. Therefore, OsMKKK10-OsMKK4-OsMPK6 participates in panicle morphogenesis and acts on a common pathway in rice. We confirmed that GSN1 is a negative regulator of the OsMKKK10-OsMKK4-OsMPK6 cascade that determines panicle architecture. The GSN1-MAPK module coordinates the trade-off between grain number and grain size by integrating localized cell differentiation and proliferation. These findings provide important insights into the developmental plasticity of the panicle and a potential means to improve crop yields.
Journal Article
Therapeutic Potential and Biological Applications of Cordycepin and Metabolic Mechanisms in Cordycepin-Producing Fungi
Cordycepin (3′-deoxyadenosine), a cytotoxic nucleoside analogue found in Cordyceps militaris, has attracted much attention due to its therapeutic potential and biological value. Cordycepin interacts with multiple medicinal targets associated with cancer, tumor, inflammation, oxidant, polyadenylation of mRNA, etc. The investigation of the medicinal drug actions supports the discovery of novel targets and the development of new drugs to enhance the therapeutic potency and reduce toxicity. Cordycepin may be of great value owing to its medicinal potential as an external drug, such as in cosmeceutical, traumatic, antalgic and muscle strain applications. In addition, the biological application of cordycepin, for example, as a ligand, has been used to uncover molecular structures. Notably, studies that investigated the metabolic mechanisms of cordycepin-producing fungi have yielded significant information related to the biosynthesis of high levels of cordycepin. Here, we summarized the medicinal targets, biological applications, cytotoxicity, delivery carriers, stability, and pros/cons of cordycepin in clinical applications, as well as described the metabolic mechanisms of cordycepin in cordycepin-producing fungi. We posit that new approaches, including single-cell analysis, have the potential to enhance medicinal potency and unravel all facets of metabolic mechanisms of cordycepin in Cordyceps militaris.
Journal Article
New insights into the regulatory role of microRNA in tumor angiogenesis and clinical implications
Angiogenesis is essential for tumor growth and metastasis. Understanding the regulation of tumor angiogenesis has become increasingly important. MicroRNAs (miRNAs) are small noncoding RNAs that function in diverse biological processes via post-transcriptional regulation. Extensive studies have revealed two important regulatory roles of miRNAs in tumor angiogenesis: miRNAs in tumor cells affect the activity of endothelial cells via non-cell-autonomous mechanisms, and miRNAs in endothelial cells regulate the cell-autonomous behavior. Recent advances have further highlighted the role of tumor-derived extracellular vesicles in the regulation of tumor angiogenesis via transferring miRNAs to endothelial cells. In this review, we summarize the regulatory role of miRNA in tumor angiogenesis, with a highlight on clinical implications of miRNAs as biomarkers for anti-angiogenic therapy response, and as therapeutic interventions against tumor angiogenesis in vivo.
Journal Article
Precision synthesis versus bulk-scale fabrication of graphenes
Graphene is a fascinating material with unique properties, such as extreme mechanical strength, ultrahigh electrical and thermal conductivities and remarkable transparency. Further reduction in the dimensionality of graphene in the form of graphene quantum dots and graphene nanoribbons has compensated for the lack of a bandgap in the extended 2D material. These nanoscale graphenes exhibit finite bandgaps because of quantum confinement, making them attractive as next-generation semiconductors. Numerous fabrication methods for various types of graphenes have been developed, which can generally be categorized into ‘top-down’ and ‘bottom-up’ procedures. These methods afford, on different production scales, a wide range of graphene structures of different sizes, shapes and quality (defect density, edge roughness and so on). Atomically precise syntheses are indispensable for fundamental research and future technological development, but the projection of the existing methods to cost-effective bulk-scale fabrication techniques is required for upcoming industrial applications of graphenes.
Numerous fabrication methods have been developed so far for the production of graphenes and nanographenes. However, how practical is the bulk production of these fascinating materials? This Perspective discusses recent advances in graphene fabrication and possibilities for translation to large-scale production.
Journal Article
Polycyclic aromatic hydrocarbons in the graphene era
Polycyclic aromatic hydrocarbons (PAHs) have been the subject of interdisciplinary research in the fields of chemistry, physics, materials science, and biology. Notably, PAHs have drawn increasing attention since the discovery of graphene, which has been regarded as the “wonder” material in the 21st century. Different from semimetallic graphene, nanoscale graphenes, such as graphene nanoribbons and graphene quantum dots, exhibit finite band gaps owing to the quantum confinement, making them attractive semiconductors for next-generation electronic applications. Researches based on PAHs and graphenes have expanded rapidly over the past decade, thereby posing a challenge in conducting a comprehensive review. This study aims to interconnect the fields of PAHs and graphenes, which have mainly been discussed separately. In particular, by selecting representative examples, we explain how these two domains can stimulate each other. We hope that this integrated approach can offer new opportunities and further promote synergistic developments in these fields.
Journal Article
Coarse-grained molecular dynamics investigation on the interaction between κ- and β-casein aggregates and curcumin
Through coarse-grained (CG) modeling, the study investigates the stable structure of an aggregate composed of -casein and β-casein after 1 μs of CG simulation, highlighting a loose arrangement with water molecules in the cavity. According to this model, αS- and β-caseins combine with calcium phosphate to form the internal structure, while κ-casein, which lacks a phosphate group, is located on the surface, providing steric and electrostatic repulsions that stabilize the micelle [13]. The findings from this study aim to elucidate the formation mechanisms of casein micelles and provide theoretical guidance for the use of β- and κ-caseins as encapsulation materials for functional ingredients. 2. The structure of curcumin molecules is shown in Fig 2a, consisting of two symmetrical structures similar to two connected tyrosines (TYRs). [...]the MARTINI model we built for curcumin (see Fig 2b) is composed of two TYRs.
Journal Article