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Worldwide, the incidence of major depressive disorder (MDD) is increasing annually, resulting in greater economic and social burdens. Moreover, the pathological mechanisms of MDD and the mechanisms underlying the effects of pharmacological treatments for MDD are complex and unclear, and additional diagnostic and therapeutic strategies for MDD still are needed. The currently widely accepted theories of MDD pathogenesis include the neurotransmitter and receptor hypothesis, hypothalamic-pituitary-adrenal (HPA) axis hypothesis, cytokine hypothesis, neuroplasticity hypothesis and systemic influence hypothesis, but these hypothesis cannot completely explain the pathological mechanism of MDD. Even it is still hard to adopt only one hypothesis to completely reveal the pathogenesis of MDD, thus in recent years, great progress has been made in elucidating the roles of multiple organ interactions in the pathogenesis MDD and identifying novel therapeutic approaches and multitarget modulatory strategies, further revealing the disease features of MDD. Furthermore, some newly discovered potential pharmacological targets and newly studied antidepressants have attracted widespread attention, some reagents have even been approved for clinical treatment and some novel therapeutic methods such as phototherapy and acupuncture have been discovered to have effective improvement for the depressive symptoms. In this work, we comprehensively summarize the latest research on the pathogenesis and diagnosis of MDD, preventive approaches and therapeutic medicines, as well as the related clinical trials.

The brain-computer interface (BCI) provides an alternative means to communicate and it has sparked growing interest in the past two decades. Specifically, for Steady-State Visual Evoked Potential (SSVEP) based BCI, marked improvement has been made in the frequency recognition method and data sharing. However, the number of pubic databases is still limited in this field. Therefore, we present a nchmark database owards BCI pplication (BETA) in the study. The BETA database is composed of 64-channel Electroencephalogram (EEG) data of 70 subjects performing a 40-target cued-spelling task. The design and the acquisition of the BETA are in pursuit of meeting the demand from real-world applications and it can be used as a test-bed for these scenarios. We validate the database by a series of analyses and conduct the classification analysis of eleven frequency recognition methods on BETA. We recommend using the metric of wide-band signal-to-noise ratio (SNR) and BCI quotient to characterize the SSVEP at the single-trial and population levels, respectively. The BETA database can be downloaded from the following link http://bci.med.tsinghua.edu.cn/download.html.

The past 20 years have witnessed unprecedented progress in brain–computer interfaces (BCIs). However, low communication rates remain key obstacles to BCI-based communication in humans. This study presents an electroencephalogram-based BCI speller that can achieve information transfer rates (ITRs) up to 5.32 bits per second, the highest ITRs reported in BCI spellers using either noninvasive or invasive methods. Based on extremely high consistency of frequency and phase observed between visual flickering signals and the elicited single-trial steady-state visual evoked potentials, this study developed a synchronous modulation and demodulation paradigm to implement the speller. Specifically, this study proposed a new joint frequency-phase modulation method to tag 40 characters with 0.5-s-long flickering signals and developed a user-specific target identification algorithm using individual calibration data. The speller achieved high ITRs in online spelling tasks. This study demonstrates that BCIs can provide a truly naturalistic high-speed communication channel using noninvasively recorded brain activities.

Canonical correlation analysis (CCA) has been widely used in the detection of the steady-state visual evoked potentials (SSVEPs) in brain-computer interfaces (BCIs). The standard CCA method, which uses sinusoidal signals as reference signals, was first proposed for SSVEP detection without calibration. However, the detection performance can be deteriorated by the interference from the spontaneous EEG activities. Recently, various extended methods have been developed to incorporate individual EEG calibration data in CCA to improve the detection performance. Although advantages of the extended CCA methods have been demonstrated in separate studies, a comprehensive comparison between these methods is still missing. This study performed a comparison of the existing CCA-based SSVEP detection methods using a 12-class SSVEP dataset recorded from 10 subjects in a simulated online BCI experiment. Classification accuracy and information transfer rate (ITR) were used for performance evaluation. The results suggest that individual calibration data can significantly improve the detection performance. Furthermore, the results showed that the combination method based on the standard CCA and the individual template based CCA (IT-CCA) achieved the highest performance.

The nature of atomic vapors, their natural alignment with interatomic transitions, and their ease of use make them highly suited for spectrally narrow-banded optical filters. Atomic filters come in two flavors: a filter based on the absorption of light by the Doppler broadened atomic vapor, i.e. a notch filter, and a bandpass filter based on the transmission of resonant light caused by the Faraday effect. The notch filter uses the absorption of resonant photons to filter out a small spectral band around the atomic transition. The off-resonant part of the spectrum is fully transmitted. Atomic vapors based on the Faraday effect allow for suppression of the detuned spectral fraction. Transmission of light originates from the magnetically induced rotation of linear polarized light close to an atomic resonance. This filter constellation allows selective acceptance of specific light frequencies. In this manuscript, we discuss these two types of filters and elucidate the specialties of atomic line filters. We also present a practical guide on building such filter setups from scratch and discuss an approach to achieve an almost perfect atomic spectrum backed by theoretical calculations.

Panel count data frequently occurs in follow-up studies, such as medical research, social sciences, reliability studies, and tumorigenicity experiences. This type data has been extensively studied by various statistical models with time-invariant regression coefficients. However, the assumption of invariant coefficients may be violated in some reality, and the temporal covariate effects would be of great interest in research studies. This motivates us to consider a more flexible time-varying coefficient model. For statistical inference of the unknown functions, the quantile regression approach based on the B-spline approximation is developed. Asymptotic results on the convergence of the estimators are provided. Some simulation studies are presented to assess the finite-sample performance of the estimators. Finally, two applications of bladder cancer data and US flight delay data are analyzed by the proposed method.

Brain-computer interfaces (BCIs) have attracted considerable attention in motor and language rehabilitation. Most devices use cap-based non-invasive, headband-based commercial products or microneedle-based invasive approaches, which are constrained for inconvenience, limited applications, inflammation risks and even irreversible damage to soft tissues. Here, we propose in-ear visual and auditory BCIs based on in-ear bioelectronics, named as SpiralE, which can adaptively expand and spiral along the auditory meatus under electrothermal actuation to ensure conformal contact. Participants achieve offline accuracies of 95% in 9-target steady state visual evoked potential (SSVEP) BCI classification and type target phrases successfully in a calibration-free 40-target online SSVEP speller experiment. Interestingly, in-ear SSVEPs exhibit significant 2 nd harmonic tendencies, indicating that in-ear sensing may be complementary for studying harmonic spatial distributions in SSVEP studies. Moreover, natural speech auditory classification accuracy can reach 84% in cocktail party experiments. The SpiralE provides innovative concepts for designing 3D flexible bioelectronics and assists the development of biomedical engineering and neural monitoring. In-ear visual and auditory brain-computer interfaces typically have issues with poor interfacial adhesion or user irritation. Here, Wang et al. presents an in-ear hollow bioelectronic device that adaptively conforms to the ear canal, under electrothermal actuation, for electroencephalogram sensing.

Implantable intracortical microelectrodes can record a neuron’s rapidly changing action potentials (spikes). In vivo neural activity recording methods often have either high temporal or spatial resolution, but not both. There is an increasing need to record more neurons over a longer duration in vivo. However, there remain many challenges to overcome before achieving long-term, stable, high-quality recordings and realizing comprehensive, accurate brain activity analysis. Based on the vision of an idealized implantable microelectrode device, the performance requirements for microelectrodes are divided into four aspects, including recording quality, recording stability, recording throughput, and multifunctionality, which are presented in order of importance. The challenges and current possible solutions for implantable microelectrodes are given from the perspective of each aspect. The current developments in microelectrode technology are analyzed and summarized.

In recent years, more and more frameworks have been applied to brain-computer interface technology, and electroencephalogram-based motor imagery (MI-EEG) is developing rapidly. However, it is still a challenge to improve the accuracy of MI-EEG classification. A deep learning framework termed IS-CBAM-convolutional neural network (CNN) is proposed to address the non-stationary nature, the temporal localization of excitation occurrence, and the frequency band distribution characteristics of the MI-EEG signal in this paper. First, according to the logically symmetrical relationship between the C3 and C4 channels, the result of the time-frequency image subtraction (IS) for the MI-EEG signal is used as the input of the classifier. It both reduces the redundancy and increases the feature differences of the input data. Second, the attention module is added to the classifier. A convolutional neural network is built as the base classifier, and information on the temporal location and frequency distribution of MI-EEG signal occurrences are adaptively extracted by introducing the Convolutional Block Attention Module (CBAM). This approach reduces irrelevant noise interference while increasing the robustness of the pattern. The performance of the framework was evaluated on BCI competition IV dataset 2b, where the mean accuracy reached 79.6%, and the average kappa value reached 0.592. The experimental results validate the feasibility of the framework and show the performance improvement of MI-EEG signal classification.

Brain-computer interfaces (BCIs) provide humans a new communication channel by encoding and decoding brain activities. Steady-state visual evoked potential (SSVEP)-based BCI stands out among many BCI paradigms because of its non-invasiveness, little user training, and high information transfer rate (ITR). However, the use of conductive gel and bulky hardware in the traditional Electroencephalogram (EEG) method hinder the application of SSVEP-based BCIs. Besides, continuous visual stimulation in long time use will lead to visual fatigue and pose a new challenge to the practical application. This study provides an open dataset, which is collected based on a wearable SSVEP-based BCI system, and comprehensively compares the SSVEP data obtained by wet and dry electrodes. The dataset consists of 8-channel EEG data from 102 healthy subjects performing a 12-target SSVEP-based BCI task. For each subject, 10 consecutive blocks were recorded using wet and dry electrodes, respectively. The dataset can be used to investigate the performance of wet and dry electrodes in SSVEP-based BCIs. Besides, the dataset provides sufficient data for developing new target identification algorithms to improve the performance of wearable SSVEP-based BCIs.