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"Wang, You"
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تطوير الكفاءة في التجارة الصينية : (كتاب المحادثة)
يتوجه الكتاب بشكل خاص للمستخدمين الذين اكتسبوا سابقا بعض المهارات الأساسية في اللغة الصينية، ويرغبون بتعلم اللغة للقيام بالأعمال التجارية في سياق اللغة الصينية بعبارة أوضح، يستهدف الكتاب المتعلمين الذين أتقنوا حوالى 800 حرف من الأحرف الصينية الشائعة، وحوالى 1000 من التعابير أو الكلمات الصينية، بالإضافة إلى أساسيات القواعد في اللغة الصينية. يمكن أن يستخدم الكتاب ككتاب مدرسي للطلاب الأجانب في الصين الذين يأخذون مقررا اختياريا في التجارة الصينية.
Book
Single-atom tailored atomically-precise nanoclusters for enhanced electrochemical reduction of CO2-to-CO activity
The development of facile tailoring approach to adjust the intrinsic activity and stability of atomically-precise metal nanoclusters catalysts is of great interest but remians challenging. Herein, the well-defined Au
8
nanoclusters modified by single-atom sites are rationally synthesized via a co-eletropolymerization strategy, in which uniformly dispersed metal nanocluster and single-atom co-entrenched on the poly-carbazole matrix. Systematic characterization and theoretical modeling reveal that functionalizing single-atoms enable altering the electronic structures of Au
8
clusters, which amplifies their electrocatalytic reduction of CO
2
to CO activity by ~18.07 fold compared to isolated Au
8
metal clusters. The rearrangements of the electronic structure not only strengthen the adsorption of the key intermediates *COOH, but also establish a favorable reaction pathway for the CO
2
reduction reaction. Moreover, this strategy fixing nanoclusters and single-atoms on cross-linked polymer networks efficiently deduce the performance deactivation caused by agglomeration during the catalytic process. This work contribute to explore the intrinsic activity and stability improvement of metal clusters.
Tailoring catalytic performance of atomically-precise metal nanoclusters catalysts is of great interest but remains challenging. Here, the authors report a co-eletropolymerization strategy to modify well-defined Au
8
nanoclusters by single-atom sites to enhance its electrocatalytic activity for the reduction of CO
2
towards CO.
Journal Article
دراسات حول الفضاء العالمي و\الحزام والطريق\ : (مجلد السياحة)
إن استراتيجية \"الحزام والطريق\" هي عملية طويلة الأمد، ولا يمكن وصف دورها في تعزيز تنمية السياحة ببساطة. يحلل \"الفضاء العالمي و\"حزام واحد وطريق واحد\" حجم السياحة\" الوضع الحالي لتنمية السياحة العالمية في سياق استراتيجية \"حزام واحد وطريق واحد\"، ويقدم بالتفصيل تطور السياحة العالمية والخلفية السياحية. \"حزام وطريق\"، بما في ذلك نظرة عامة على صناعة السياحة العالمية، والاتجاهات الجديدة في تنمية السياحة العالمية ونمط السياحة العالمية، وما إلى ذلك، واستنادا إلى تحليل فرص وتحديات تنمية السياحة العالمية والصينية، والتأثير الترويجي لـ \"حزام واحد وطريق واحد\"، وتم تفسير استراتيجية \"الحزام والطريق\" لتنمية السياحة.
Book
Emerging role of hypoxia-inducible factor-1α in inflammatory autoimmune diseases: A comprehensive review
Hypoxia-inducible factor-1α (HIF-1α) is a primary metabolic sensor, and is expressed in different immune cells, such as macrophage, dendritic cell, neutrophil, T cell, and non-immune cells, for instance, synovial fibroblast, and islet β cell. HIF-1α signaling regulates cellular metabolism, triggering the release of inflammatory cytokines and inflammatory cells proliferation. It is known that microenvironment hypoxia, vascular proliferation, and impaired immunological balance are present in autoimmune diseases. To date, HIF-1α is recognized to be overexpressed in several inflammatory autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis, and function of HIF-1α is dysregulated in these diseases. In this review, we narrate the signaling pathway of HIF-1α and the possible immunopathological roles of HIF-1α in autoimmune diseases. The collected information will provide a theoretical basis for the familiarization and development of new clinical trials and treatment based on HIF-1α and inflammatory autoimmune disorders in the future.
Journal Article
تعرف إلى دماغك : لماذا تضيع مفاتيح سيارتك ولكنك لا تنسى أبدا كيفية الثيادة وغير ذلك من ألغاز الحياة اليومية
هذا الكتاب به يكشف عالما أعصاب بارزان هما ساندرا أمودت وسام وانغ عن الكيفية التي يقوم بها دماغك فعليا وكيف يمكنك أن تساعده ليعمل بطريقة أفضل وإن معرفة دماغك بشكل أفضل يمكن أن تكون ممتعة ومفيدة على حد سواء وفي هذا الكتاب ستتعرف إلى تغيرات بسيطة يمكن أن تتيح لك الاستفادة أكثر من دماغك وتساعدك على عيش حياة أكثر سعادة وإنتاجية وستجد عبر صفحاته حقائق ممتعة وقصصا جاهزة لتسلية أصدقائك في حفلات الكوكتيل فضلا عن أفكار مفيدة عملية لمساعدتك على استخدام دماغك بشكل أفضل.
BOOK
Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups
Systemic lupus erythematosus (SLE), a worldwide autoimmune disease with high heritability, shows differences in prevalence, severity and age of onset among different ancestral groups. Previous genetic studies have focused more on European populations, which appear to be the least affected. Consequently, the genetic variations that underlie the commonalities, differences and treatment options in SLE among ancestral groups have not been well elucidated. To address this, we undertake a genome-wide association study, increasing the sample size of Chinese populations to the level of existing European studies. Thirty-eight novel SLE-associated loci and incomplete sharing of genetic architecture are identified. In addition to the human leukocyte antigen (HLA) region, nine disease loci show clear ancestral differences and implicate antibody production as a potential mechanism for differences in disease manifestation. Polygenic risk scores perform significantly better when trained on ancestry-matched data sets. These analyses help to reveal the genetic basis for disparities in SLE among ancestral groups.
The presentation of systemic lupus erythematosus has been known to differ by ancestry, but the underlying genetic factors remain unclear. Here, the authors report ancestry-specific susceptibility loci and better risk prediction when using data from matched ancestral groups.
Journal Article
Rookie on love : 45 voices on romance, friendship, and self-care /
Collects articles, interviews, poems, and stories on romance, friendship, and self-care from the online magazine Rookie.
Book
Updated diagnosis, treatment and prevention of COVID-19 in children: experts’ consensus statement (condensed version of the second edition)
In the early February, 2020, we called up an experts’ committee with more than 30 Chinese experts from 11 national medical academic organizations to formulate the first edition of consensus statement on diagnosis, treatment and prevention of coronavirus disease 2019 (COVID-19) in children, which has been published in this journal. With accumulated experiences in the diagnosis and treatment of COVID-19 in children, we have updated the consensus statement and released the second edition recently. The current version in English is a condensed version of the second edition of consensus statement on diagnosis, treatment and prevention of COVID-19 in children. In the current version, diagnosis and treatement criteria have been optimized, and early identification of severe and critical cases is highlighted. The early warning indicators for severe pediatric cases have been summarized which is utmost important for clinical practice. This version of experts consensus will be valuable for better prevention, diagnosis and treatment of COVID-19 in children worldwide.
Journal Article
High-fat diet promotes renal injury by inducing oxidative stress and mitochondrial dysfunction
Obesity has been recognized as a major risk factor for chronic kidney disease, but the underlying mechanism remains elusive. Here, we investigated the mechanism whereby long-term high-fat diet (HFD) feeding induces renal injury in mice. The C57BL/6 mice fed HFD for 16 weeks developed obesity, diabetes, and kidney dysfunction manifested by albuminuria and blood accumulation of BUN and creatinine. The HFD-fed kidney showed marked glomerular and tubular injuries, including prominent defects in the glomerular filtration barrier and increased tubular cell apoptosis. Mechanistically, HFD feeding markedly increased triglyceride and cholesterol contents in the kidney and activated lipogenic pathways for cholesterol and triglyceride synthesis. HFD feeding also increased oxidative stress and induced mitochondrial fission in tubular cells, thereby activating the pro-apoptotic pathway. In HK-2 and mesangial cell cultures, high glucose, fatty acid, and TNF-α combination was able to activate the lipogenic pathways, increase oxidative stress, promote mitochondrial fission, and activate the pro-apoptotic pathway, all of which could be attenuated by an inhibitor that depleted reactive oxygen species. Taken together, these observations suggest that long-term HFD feeding causes kidney injury at least in part as a result of tissue lipid accumulation, increased oxidative stress, and mitochondrial dysfunction, which promote excess programmed cell death.
Journal Article
The Gibberellin Producer Fusarium fujikuroi: Methods and Technologies in the Current Toolkit
In recent years, there has been a noticeable increase in research interests on the
species, which includes prevalent plant pathogens and human pathogens, common microbial food contaminants and industrial microbes. Taken the advantage of gibberellin synthesis,
succeed in being a prevalent plant pathogen. At the meanwhile,
was utilized for industrial production of gibberellins, a group of extensively applied phytohormone.
has been known for its outstanding performance in gibberellin production for almost 100 years. Research activities relate to this species has lasted for a very long period. The slow development in biological investigation of
is largely due to the lack of efficient research technologies and molecular tools. During the past decade, technologies to analyze the molecular basis of host-pathogen interactions and metabolic regulations have been developed rapidly, especially on the aspects of genetic manipulation. At the meanwhile, the industrial fermentation technologies kept sustained development. In this article, we reviewed the currently available research tools/methods for
research, focusing on the topics about genetic engineering and gibberellin production.
Journal Article