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result(s) for
"Wang, Zi-Yu"
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Berberine a traditional Chinese drug repurposing: Its actions in inflammation-associated ulcerative colitis and cancer therapy
Berberine (BBR), an isoquinoline alkaloid extracted from Coptidis Rhizoma, has a long history of treating dysentery in the clinic. Over the past two decades, the polytrophic, pharmacological, and biochemical properties of BBR have been intensively studied. The key functions of BBR, including anti-inflammation, antibacterial, antioxidant, anti-obesity, and even antitumor, have been discovered. However, the underlying mechanisms of BBR-mediated regulation still need to be explored. Given that BBR is also a natural nutrition supplement, the modulatory effects of BBR on nutritional immune responses have attracted more attention from investigators. In this mini-review, we summarized the latest achievements of BBR on inflammation, gut microbes, macrophage polarization, and immune responses associated with their possible tools in the pathogenesis and therapy of ulcerative colitis and cancer in recent 5 years. We also discuss the therapeutic efficacy and anti-inflammatory actions of BBR to benefit future clinical applications.
Journal Article
Temporally separated pollen data track environmental changes in Northwestern Yunnan, Southwest China
Background
Surface pollen studies are extensively used to explore the relationships among pollen, vegetation, climate and human activities. However, whether observed differences in pollen assemblages at the same locality accurately reflect changes in vegetation, climate and human activities over time remains poorly investigated.
Results
Here, we present pollen assemblages from twenty-eight modern samples (soil and moss polsters) taken 17 years apart (2005–2022) at Wenhai and Haligu in northwestern Yunnan, Southwest China, to track environmental changes. We found that the changes in the relative abundance of
Abies
and evergreen
Quercus
pollen are potential indicators of climatic change, and an increase in
Artemisia
pollen and spores of terrestrial ferns such as Osmundaceae, together with a decrease in spores of epiphytic ferns such as Polypodiaceae, are strong signals of human activity in the area. In addition, a comparison of overall palynological richness suggested slightly greater changes at Wenhai than at Haligu.
Conclusion
Our study reveals the possible influence of climate change and human activities on vegetation, provides an easy-to-use field methodology to support rapid assessments of relatively short-term changes in biodiversity, and suggests a role for long-term comparative studies of surface soil samples in monitoring site-specific vegetation changes.
Journal Article
Curcumin derived from medicinal homologous foods: its main signals in immunoregulation of oxidative stress, inflammation, and apoptosis
It has been for thousands of years in China known medicinal homologous foods that can be employed both as foods and medicines to benefit human and animal health. These edible herbal materials perform divert roles in the regulation of metabolic disorders, cancers, and immune-related diseases. Curcumin, the primary component derived from medicinal homologous foods like curcuma longa rhizome, is reported to play vital actions in organic activities, such as the numerous pharmacological functions including anti-oxidative stress, anti-inflammation and anti/pro-apoptosis in treating various diseases. However, the potential mechanisms of curcumin-derived modulation still need to be developed and attract more attention worldwide. Given that these signal pathways are enrolled in important bioactive reactions, we collected curcumin’s last achievements predominantly on the immune-regulation signals with the underlying targetable strategies in the last 10 years. This mini-review will be helpful to accelerate curcumin and other extracts from medicinal homologous foods use in future human clinical applications.
Journal Article
The Relationship between Childhood Maltreatment and Risky Sexual Behaviors: A Meta-Analysis
Childhood maltreatment is associated with risky sexual behaviors (RSBs). Previous systematic reviews and meta-analysis focused only on the relationship between childhood sexual abuse and RSBs, thus the association between childhood maltreatment and RSBs has yet to be systematically and quantitatively reviewed. We aimed to provide a systematic meta-analysis exploring the effect of childhood maltreatment and its subtypes on subsequent RSBs in adolescence and adulthood. PubMed, Google Scholar, EMBASE, Medline were searched for qualified articles up to April 2019. We calculated the pooled risk estimates using either the random-effect model or fixed-effect model. The potential heterogeneity moderators were identified by subgroup and sensitivity analysis. Overall, childhood maltreatment was significantly associated with an early sexual debut (odds ratio (OR) = 2.22; 95% confidence interval (CI): 1.64–3.00), multiple sexual partners (OR = 2.22; 95% CI: 1.78–2.76), transactional sex (OR = 3.05; 95% CI: 1.92–4.86) and unprotected sex (OR = 1.59; 95% CI: 1.22-2.09). Additionally, different types of childhood maltreatment were also significantly associated with higher risk of RSBs. Relevant heterogeneity moderators have been identified by subgroup analysis. Sensitivity analysis yielded consistent results. Childhood maltreatment is significantly associated with risky sexual behaviors. The current meta-analysis indicates it is vital to protect children from any types of maltreatment and provide health education and support for maltreated individuals.
Journal Article
Hemline breakup of gel drops subjected to a continuous air flow
To explore the effect of yield stress on the secondary breakup of gel drops, experimental and theoretical investigations are carried out by employing a high-speed camera. A unique hemline-type breakup, as a modified behaviour of sheet-thinning breakup, occurs when the air velocity increases to a high region. The edges of the drops constantly deform into thin membranes when the high-velocity air skims over the gel drops. These membranes vibrate vertically, and breaking points occur at high amplitudes, causing the formation of reticular fragments. The results of linear stability analysis indicated that the yield stress of the gel drops has an influence on the formation and breakup of the gel membranes. The breakup regime map and breakup times are also studied.
Journal Article
Genome-wide analysis of the cotton COBRA-like gene family and functional characterization of GhCOBL22 in relation to drought tolerance
Background
The COBRA-like (COBL) gene family is a crucial glycosylphosphatidylinositol (GPI)-anchored proteins that participate in various biological processes in plants by regulating the arrangement of cell wall microfibrils. While the functions of
COBL
genes have been analyzed in several plant species, their roles in cotton’s response to abiotic stress remain unexplored.
Results
This study identified and characterized the COBL gene family in
Gossypium hirsutum
, revealing a total of 39 COBL family members classified into five subgroups. Transcriptome analysis indicated that the transcription levels of several
GhCOBL
genes were upregulated following PEG treatment, with
GhCOBL22
being significantly induced. Further silencing of the
GhCOBL22
gene through virus-induced gene silencing (VIGS) technology demonstrated that this gene’s silencing reduced cotton’s drought stress tolerance. Under drought stress conditions, the activities of superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT) enzymes, along with proline (PRO) content, were lower in
GhCOBL22
-silenced plants compared to control plants, while the accumulation of malondialdehyde (MDA) was significantly higher. Moreover, silencing the
GhCOBL22
gene also led to reductions in the levels of cellulose, hemicellulose, and lignin content in cotton leaves.
Conclusion
A systematic survey of gene structure, motif composition, and evolutionary relationships of the
COBL
gene family was conducted in
Gossypium hirsutum
. Subsequent expression and functional studies indicated that
GhCOBL22
plays a significant role in cotton’s drought tolerance. These findings enhance our understanding of the biological functions of the COBL family and highlight the critical role of the
GhCOBL22
gene in cotton’s response to drought stress.
Journal Article
Laparoscopic versus open major liver resection for hepatocellular carcinoma: systematic review and meta-analysis of comparative cohort studies
Background
The application of laparoscopic liver resection (LLR) has expanded rapidly in recent decades. Although multiple authors have reported LLR shows improved safety and efficacy in treating hepatocellular carcinoma (HCC) compared with open liver resection (OLR), laparoscopic (LMLR) and open (OMLR) major liver resections for HCC treatment remain inadequately evaluated. This work aimed to test the hypothesis that LMLR is safer and more effective than OMLR for HCC.
Methods
Comparative cohort and registry studies on LMLR and OMLR, searched in PubMed, the Science Citation Index, EMBASE, and the Cochrane Library, and published before March 31, 2018, were collected systematically and meta-analyzed. Fixed- and random-effects models were employed for generating pooled estimates. Heterogeneity was assessed by the Q-statistic.
Results
Nine studies (1173 patients) were included. Although the pooled data showed operation time was markedly increased for LMLR in comparison with OMLR (weighted mean difference [WMD] 74.1, 95% CI 35.1 to 113.1,
P
= 0.0002), blood loss was reduced (WMD = − 107.4, 95% CI − 179.0 to − 35.7,
P
= 0.003), postoperative morbidity was lower (odds ratio [OR] 0.47, 95% CI 0.35 to 0.63,
P
< 0.0001), and hospital stay was shorter (WMD = − 3.27, 95% CI − 4.72 to − 1.81,
P
< 0.0001) in the LMLR group. Although 1-year disease-free survival (DFS) was increased in patients administered LMLR (OR = 1.55, 95% CI 1.04 to 2.31,
P
= 0.03), other 1-, 3-, and 5-year survival outcomes (overall survival [OS] and/or DFS) were comparable in both groups.
Conclusions
Compared with OMLR, LMLR has short-term clinical advantages, including reduced blood loss, lower postsurgical morbidity, and shorter hospital stay in HCC, despite its longer operative time. Long-term oncological outcomes were comparable in both groups.
Journal Article
Well control technology and digital intelligent management practice in Zhaodong Oilfield
Zhao-dong Oilfield is an offshore cooperation project in the mode of “international operation and PetroChina control”, adheres to the principle of “safety and environmental protection first, equal emphasis on production and efficiency”, practices the well control management concept of the whole life cycle, and consolidates the foundation of well control management by continuously optimizing the system and system, adheres to the integrated design of geology and engineering to control the source risk, implements fine trajectory control and anti-collision management to control the process risk, and The digital and intelligent production monitoring system is applied to control dynamic risks and realize the safe, efficient and sustainable development of Zhao-dong Oilfield.
Journal Article
Genome-wide identification of Tomato Golden 2-Like transcription factors and abiotic stress related members screening
Background
Golden 2-Like (G2-like) transcription factors play an important role in plant development. However, the roles of these
G2-like
regulatory genes in response to abiotic stresses in tomato are not well understood.
Results
In this study, we identified 66 putative
G2-like
genes in tomato (
Solanum lycopersicum)
and classified them into 5 groups (I to V) according to gene structure, motif composition and phylogenetic analysis. The
G2-like
genes were unevenly distributed across all 12 chromosomes. There were nine pairs of duplicated gene segments and four tandem duplicated
SlGlk
genes. Analysis of the cis-regulatory elements (CREs) showed that the promoter regions of
SlGlk
s contain many kinds of stress- and hormone-related CREs. Based on RNA-seq,
SlGlk
s were expressed in response to three abiotic stresses. Thirty-six differentially expressed
SlGlk
s were identified; these genes have multiple functions according to Gene Ontology (GO) analysis and are enriched mainly in the zeatin biosynthesis pathway. Further studies exhibited that silencing
SlGlk16
in tomato would reduce drought stress tolerance by earlier wilted, lower superoxide dismutase (SOD), peroxidase (POD) activities, less Pro contents and more MDA contents.
Conclusions
Overall, the results of this study provide comprehensive information on G2-like transcription factors and
G2-like
genes that may be expressed in response to abiotic stresses.
Journal Article