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هذا أول كتاب عن تاريخ الأدب الصيني المعاصر ترجم إلى العربية من الصينية مباشرة، بعد أن لاقى اهتماما كبيرا من الأوساط الثقافية في الصين، نظرا لما يتمتع به من موسوعية. يقسم الكتاب، الأدب الصيني المعاصر إلى جزأين من ناحية النقد. حيث يصف الجزء الأول كيفية حصول قواعد أدبية محددة على الهيمنة المطلقة، بالإضافة إلى الخصائص الأساسية لهذا الشكل الأدبي، أما الجزء الثاني فيكشف الضعف التدريجي، وتفكك هذه القواعد وموقعها المسيطر، وعملية التمايز الأدبي، وإعادة تنظيم البنية الأدبية في السياق التاريخي المتغير.

Accumulating research showed that ENC1 plays a critical role in maintaining the physiological functions. However, little is known about its role in predicting prognosis and immunotherapy response across cancers. In our results, compared to normal tissues, most cancer tissues exhibit increased ENC1 expression. We found that the most common type of genetic variation was gene mutation. In addition, a positive correlation was found between CNV and ENC1 expression. Moreover, the overexpression of ENC1 was positively correlated with poor clinical outcomes. The GSEA results showed that ENC1 is closely correlated with tumor-promoting biological functions in most cancers. ENC1 is also closely negatively associated with the infiltration levels of T cells, activated NK cells, and B cells. Most immunomodulators are positively associated with ENC1. Further, we verified that inhibition of ENC1 expression suppressed the proliferation and migration of breast cancer, pancreatic cancer and glioma cells. In conclusion, our study demonstrated that ENC1 plays a protumorigenic role in most cancers. Additionally, ENC1 is closely correlated with tumor microenvironment features and immune checkpoint inhibitors expression. Overall, ENC1 could serve as a promising potential prognostic biomarker in various tumors.

Alzheimer’s disease (AD) is one of the most common types of age-related dementia worldwide. In addition to extracellular amyloid plaques and intracellular neurofibrillary tangles, dysregulated microglia also play deleterious roles in the AD pathogenesis. Numerous studies have demonstrated that unbridled microglial activity induces a chronic neuroinflammatory environment, promotes β-amyloid accumulation and tau pathology, and impairs microglia-associated mitophagy. Thus, targeting microglia may pave the way for new therapeutic interventions. This review provides a thorough overview of the pathophysiological role of the microglia in AD and illustrates the potential avenues for microglia-targeted therapies, including microglial modification, immunoreceptors, and anti-inflammatory drugs.

The stormwater system is an important infrastructure for the city, playing an important safety role in reducing and removing water from roads and avoiding urban flooding. With the acceleration of urbanization and the accentuation of urban heat island effect, urban surface runoff shows the trend of high flow rate and fast flow rate, which leads to the increase of drainage load of urban stormwater system and the increase of risk of urban flooding. Therefore, it is necessary to adopt a scientific method to conduct a comprehensive analysis of the overall drainage capacity and safe conveyance capacity of the urban stormwater system, so as to do the preliminary paving work for the transformation of the existing stormwater system and improve the urban drainage capacity. In this paper, based on the analysis of the current status of urban stormwater system, the concept of urban stormwater system vulnerability is proposed and the indicators of stormwater system vulnerability are determined.

Objective To explore the anesthetic and analgesic effects of remimazolam and propofol in elderly patients undergoing hip replacement and their effects on respiratory and circulatory systems, stress and cognitive function. Methods Sixty elderly patients undergoing elective hip replacement in the hospital were selected as the research subjects, and they were divided into the remimazolam group and the propofol group according to the admission sequence of patients. The remimazolam group was anesthetized with remimazolam, and the propofol group was anesthetized with propofol. The anesthesia-related indicators, perioperative pain degree [Visual Analogue Scale (VAS)], circulatory indicators [heart rate, mean arterial pressure (MAP)] before anesthesia (T 0 ), immediately before laryngeal mask insertion (T 1 ), at 5 min after laryngeal mask insertion (T 2 ), at 30 min after laryngeal mask insertion (T 3 ) and at 5 min after laryngeal mask removal (T 4 ), stress response indicators (plasma epinephrine, norepinephrine, cortisol) before anesthesia induction and at 24 h and 72 h after surgery, cognitive function [Mini-Mental State Examination (MMSE)] and adverse reactions were compared between the two groups. Results Among the 60 enrolled patients, only 1 case was excluded due to withdrawal, thus 30 cases in the remimazolam group and 29 cases in the propofol group were included. There were statistically significant differences in the heart rate, MAP, plasma epinephrine, norepinephrine, cortisol and VAS score in the two groups from the aspects of interaction effect and time-point effect ( P  < 0.05). The heart rate and MAP at T 1 , T 2 and T 3 in the two groups were significantly decreased compared with those at T 0 , but the heart rate and MAP in the remimazolam group at T 1 , T 2 and T 3 were significantly higher than those in the propofol group ( P  < 0.05). There were no statistical differences in the anesthesia time, awakening time and extubation time between the remimazolam group and the propofol group ( P  > 0.05). The levels of plasma epinephrine, norepinephrine and cortisol in the two groups were significantly higher at 24 h and 72 h after surgery than those before anesthesia induction, and the above levels were significantly lower in the remimazolam group than those in the propofol group ( P  < 0.05). The VAS scores at each time point in the two groups were significantly reduced compared to before surgery, but there was no statistically significant difference between the two groups after surgery ( P  > 0.05). The MMSE scores of the two groups were significantly lower at 1 d and 3 d after surgery compared with those before anesthesia induction, but the score in the remimazolam group was significantly higher than that in the propofol group ( P  < 0.05). In addition, the incidence rates of adverse reactions were significantly lower in the remimazolam group compared to the propofol group ( P  < 0.05). Conclusion Compared with propofol, remimazolam can achieve equivalent anesthetic and analgesic effects in elderly patients undergoing hip replacement. However, the latter one can significantly relieve respiratory and circulatory suppression, stress response and cognitive dysfunction, with good safety. Trial registration This single-center, prospective, RCT has completed the registration of the Chinese Clinical Trial Center at 31/12/2021 with the registration number ChiCTR2100055039 .

Highlights Hierarchical polyimide (PI) nonwoven fabric is fabricated by alkali treatment, in-situ growth of magnetic particles, and \"self-activated\" electroless Ag plating process. Impedance matching structure by assembling Fe 3 O 4 /Ag-loaded PI nonwoven fabric (PFA) and pure Ag-coated PI nonwoven fabric (PA) induces more electromagnetic waves enter PFA/PA and be dissipated. The fluffy 3D space structure of PFA with strong adhesion interaction and low infrared emissivity of PA endow PFA/PA with excellent thermal stability in electromagnetic interference shielding and high-temperature resistant infrared stealth performance. Designing and fabricating a compatible low-reflectivity electromagnetic interference (EMI) shielding/high-temperature resistant infrared stealth material possesses a critical significance in the field of military. Hence, a hierarchical polyimide (PI) nonwoven fabric is fabricated by alkali treatment, in-situ growth of magnetic particles and \"self-activated\" electroless Ag plating process. Especially, the hierarchical impedance matching can be constructed by systematically assembling Fe 3 O 4 /Ag-loaded PI nonwoven fabric (PFA) and pure Ag-coated PI nonwoven fabric (PA), endowing it with an ultralow-reflectivity EMI shielding performance. In addition, thermal insulation of fluffy three-dimensional (3D) space structure in PFA and low infrared emissivity of PA originated from Ag plating bring an excellent infrared stealth performance. More importantly, the strong bonding interaction between Fe 3 O 4 , Ag, and PI fiber improves thermal stability in EMI shielding and high-temperature resistant infrared stealth performance. Such excellent comprehensive performance makes it promising for military tents to protect internal equipment from electromagnetic interference stemmed from adjacent equipment and/or enemy, and inhibit external infrared detection.

Lipid metabolic reprogramming is a prominent feature of clear cell renal cell carcinoma (ccRCC). Lipid accumulation affects cellular energy homeostasis, biofilm synthesis, lipid signal transduction, and phenotypic transformation in ccRCC. Herein, a prognostic‐related model was constructed, and the prognostic utility of AUP1, a lipid droplet–regulating very low–density lipoprotein assembly factor, in ccRCC was determined through multiparameter analysis. AUP1 expression was significantly higher in clinical samples than in normal tissues and was closely associated with the clinical stage. The inhibition of AUP1 expression impaired the proliferation, migration, and invasion of ACHN and A498 ccRCC cells in vitro and in vivo. RNA‐seq analysis revealed that AUP1 inhibition can significantly reduce the contents of intracellular triglyceride and cholesterol and regulate cell growth by cell cycle arrest, promoting apoptosis and reversing epithelial‐mesenchymal transition. AUP1 regulated the synthesis of cholesterol esters and fatty acids (FAs) in ccRCC cells by targeting sterol O‐acyltransferase 1 and partially promoted the progression of ccRCC. AUP1 also induced lipid accumulation in ccRCC by promoting the de novo synthesis of FAs (inhibiting protein kinase AMP‐activated catalytic subunit alpha 2), inhibiting the rate‐limiting enzyme of FA β oxidation (carnitine palmitoyltransferase 1A), regulating the key enzyme of lipolysis (monoglyceride lipase, MGLL), and inhibiting the lipid transporter StAR‐related lipid transfer domain containing 5 (STARD5). However, it did not affect the intracellular cholesterol synthesis pathway. The differential expression and prognostic significance of MGLL and STARD5 in ccRCC should be further studied. AUP1 may serve as a new and effective potential target and prognostic marker for ccRCC. We used a publicly available database to construct a prognostic risk model for ccRCC, and through subsequent verification and multi‐parameter analysis, we screened and extracted that AUP1 is significantly highly expressed in ccRCC and is closely related to the clinical prognosis. Combined with RNA‐seq, in vivo, in vitro experiments and clinical samples, we revealed that AUP1 induced lipid accumulation in ccRCC by mediating fatty acid and cholesterol pathways, and realized lipid reprogramming, thus promoting the progression of ccRCC.

Chrysanthemum is a well-known ornamental plant with numerous uses. WRKY is a large family of transcription factors known for a variety of functions ranging from stress resistance to plant growth and development. Due to the limited research on the WRKY family in chrysanthemums, we examined them for the first time in Chrysanthemum lavandulifolium . A total of 138 ClWRKY genes were identified, which were classified into three groups. Group III in C. lavandulifolium contains 53 members, which is larger than group III of Arabidopsis . The number of introns varied from one to nine in the ClWRKY gene family. The “WRKYGQK” motif is conserved in 118 members, while other members showed slight variations. AuR and GRE responsive cis -acting elements were located in the promoter region of WRKY members, which are important for plant development and flowering induction. In addition, the W box was present in most genes; the recognition site for the WRKY gene may play a role in autoregulation and cross-regulation. The expression of the most variable 19 genes in terms of different parameters was observed at different stages. Among them, 10 genes were selected due to the presence of CpG islands, while nine genes were selected based on their close association with important Arabidopsis genes related to floral traits. ClWRKY36 and ClWRKY45 exhibit differential expression at flowering stages in the capitulum, while methylation is detected in three genes, including ClWRKY31, ClWRKY100 , and ClWRKY129. Our results provide a basis for further exploration of WRKY members to find their functions in plant growth and development, especially in flowering traits.

Background Rural migrants usually suffer from major disease risks, but little attention had been paid toward the relationship between self-employment behavior and health status of rural migrants in China. Present study aims to explore the causal effect of self-employment behavior on rural migrants’ sub-health status and chronic disease. Two research questions are addressed: does self-employment status affect the sub-health status and chronic disease of rural migrants? What is potential mechanism that links self-employment behavior and health status among rural migrants in China? Methods The dataset from the 2017 National Migrants Population Dynamic Monitoring Survey (NMPDMS-2017) was used to explore the causal effect. Logit regression was performed for the baseline estimation, and linear probability model with instrument variable estimation (IV-LPM) was applied to correct the endogeneity of self-employment. Additionally, logit regression was conducted to explore the transmission channel. Results Self-employed migrants were more susceptible to sub-health status and chronic disease, even when correcting for endogeneity. Moreover, self-employed migrants were less likely to enroll in social health insurance than their wage-employed counterparts in urban destinations. Conclusion Self-employed migrants were more likely to suffer from sub-health status and chronic disease; thus, their self-employment behavior exerted a harmful effect on rural migrants’ health. Social health insurance may serve as a transmission channel linking self-employment and rural migrants’ health status. That is, self-employed migrants were less prone to participate in an urban health insurance program, a situation which leaded to insufficient health service to maintain health.

Financial supply side structural reform (FSSR) serves as a key for advancing the low-carbon transformation of industrial energy (LTIE) and supporting the dual carbon strategic goals. By using provincial panel data from China for the period of 2008–2022 and leveraging the national financial comprehensive reform pilot zones as a quasi-natural experiment, this study uses the difference-in-differences method to examine empirically the effect of FSSR on the LTIE and the underlying mechanisms. Research findings indicate that, first, FSSR can significantly advance the LTIE, which remained unchanged after other policies, omitted variables, and other potential influencing factors were controlled. Second, the mechanism tests indicate that FSSR can drive the LTIE by increasing green financial support, fostering green industrial development, and promoting green technological innovation. Third, the heterogeneity tests reveal that the benchmark effect is pronounced in regions with weak environmental regulation and a low level of financial development. This study provides theoretical and empirical evidence to understand the crucial role of FSSR in advancing the LTIE and insights for relevant policy formulation.