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"Wappett, Matthew"
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Emerging perspectives on disability studies
A collection of essays from a diverse array of emerging scholars in the field of Disability Studies.
eBook
Foundations of disability studies
A collection of eight essays by scholars who have published extensively within the disability studies literature, and who have helped build the field to its current state. Includes contributions from Robert Bogdan, Doug Biklen, Susan Schweik, and more.
eBook
Self-Determination and Disability Rights
The methods employed by the women's rights movement are used in this article as a template for the future growth of the self-determination and disability rights movements. The focus is not on drawing parallels between these movements, but on looking at what specific methods were effective for the women's movement and then applying those methods to the self-determination movement. Specific methods and recommendations fall into 4 categories: academic/theoretical, leadership, political, and economic. The need for more direct involvement of individuals with disabilities in all of these areas is emphasized.
Journal Article
Self-determination and disability rights: Lessons from the women's movement
The methods employed by the women's rights movement are used as a template for the future growth of the self-determination and disability rights movements. The focus is not on drawing parallels between these movements, but on looking at what specific methods were effective for the women's movement and then applying those methods to the self-determination movement.
Journal Article
Developmental Denial
The “normal” development of the body, its sexual drive, and reproductive capacities in youth with intellectual disabilities provides an interesting challenge to traditional assumptions about disability, embodiment, and inclusion. This challenge lies in the fact that an individual who may never function cognitively above the level of a two or three year old can, at the same time, have a fully developed and sexually capable body.
Book Chapter
Preparing elementary teachers to work with students with disabilities: An examination of preservice education in seven research universities
The purpose of this study was to examine the amount and type of special-education-related training that is required in elementary teacher certification or licensure programs and interdepartmental collaboration at universities that belong to the Higher Education Consortium on Special Education (HECSE). The questions that guided this investigation were the following: (a) How much special-education-related training do elementary education teacher candidates receive at participating HECSE-member institutions? (b) Are the special-education-related courses offered to elementary education teacher candidates at participating HECSE institutions developed or taught in collaboration with a department of special education? and (c) Is there a correlation between a participating HECSE institution's accrediting organization and the amount and the type of special-education-related training offered in the general elementary education teacher certification/licensure program? The study included a matched sample of 7 universities, all of which are recognized as highly respected educational research institutions. The results of the study indicate that the amount of special-education-related training that general elementary education teacher candidates are receiving varies widely. Although there are a few models of combined teacher preparation among the sample, the results of this study suggest that elementary education teacher candidates still may not be receiving the preparation needed to effectively include students with disabilities in the general education classroom. The implications of these findings for current practice in teacher preparation are discussed.
Dissertation
USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF
Background Understanding how to modulate the microenvironment of tumors that are resistant to immune checkpoint inhibitors represents a major challenge in oncology.Here we investigate the ability of USP7 inhibitors to reprogram the tumor microenvironment (TME) by inhibiting secretion of vascular endothelial growth factor (VEGF) from fibroblasts. Methods To understand the role played by USP7 in the TME, we systematically evaluated the effects of potent, selective USP7 inhibitors on co‐cultures comprising components of the TME, using human primary cells. We also evaluated the effects of USP7 inhibition on tumor growth inhibition in syngeneic models when dosed in combination with immune checkpoint inhibitors (ICIs). Results Abrogation of VEGF secretion from fibroblasts in response to USP7 inhibition resulted in inhibition of tumor neoangiogenesis and increased tumor recruitment of CD8‐positive T‐lymphocytes, leading to significantly improved sensitivity to immune checkpoint inhibitors. In syngeneic models, treatment with USP7 inhibitors led to striking tumor responses resulting in significantly improved survival. Conclusions USP7‐mediated reprograming of the TME is not linked to its previously characterized role in modulating MDM2 but does require p53 and UHRF1 in addition to the well‐characterized VEGF transcription factor, HIF‐1α. This represents a function of USP7 that is unique to fibroblasts, and which is not observed in cancer cells or other components of the TME. Given the potential for USP7 inhibitors to transform “immune desert” tumors into “immune responsive” tumors, this paves the way for a novel therapeutic strategy combining USP7 inhibitors with immune checkpoint inhibitors (ICIs). The oral USP7 inhibitor, ADC‐159, reduces sVEGF from CAFs and impacts tumor vasculature. USP7 inhibition affects HIF‐1α transcriptional modulation, tumor hypoxia and remodeling of the tumor microenvironment creating a permissive immune micro‐climate for infiltrating lymphocytes turning immunologically ‘cold’ tumors, ‘hot’. In preclinical models, combination treatment of ADC‐159 with immunotherapy agents delivers improved anti‐tumor efficacy and survival.
Journal Article