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"Warner, Megan"
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“Therefore a Man Leaves His Father and His Mother and Clings to His Wife”: Marriage and Intermarriage in Genesis 2:24
In recent decades the opponents of same-sex marriage have mounted a “second front” in the debate, shifting their focus from the so-called clobber texts to the creation narratives of Genesis. These scholars argue that Gen 2:24 presents a normative definition of marriage that precludes same-sex marriage. I argue that Gen 2:24 offers not a normative definition of the institution of marriage but a description of the powerful draw to relationship that is the result of God's actions in creation. Just as interpreters of Gen 2:24 across centuries and traditions have approached the verse against the background of a wide range of presenting social issues (e.g., divorce, incest, polygamy, bestiality, and, more recently, homosexuality), so the authors of Gen 2:24 were influenced by a pressing social issue, namely, intermarriage. I explore this hypothesis by means of a word study focusing on the verse's two verbs. The results of the word study are further tested by consideration of the historical and literary contexts of the verse and of the earliest instances of reuse of Gen 2:24 in canonical and noncanonical texts. I conclude that, far from presenting a normative definition of heterosexual marriage, Gen 2:24 is an acknowledgment of the powerful attraction that causes human beings to seek relationship in opposition to the wishes of their parents, society, and religion.
Journal Article
1H-NMR Guided Isolation of Bioactive Compounds from Species of the Genus Piper
The discovery of bioactive natural products is often challenged by the complexity of isolating and characterizing active compounds within diverse mixtures. Previously, we introduced a 1H NMR-based weighted gene correlation network analysis (WGCNA) approach to identify spectral features linked to growth inhibitory activity of Piper (Piperaceae) leaf extracts against model plant, fungal, and bacterial organisms. This method enabled us to prioritize specific spectral features linked to bioactivity, offering a targeted approach to natural product discovery. In this study, we validate the predictive capacity of the WGCNA by isolating the compounds responsible for the bioactivity-associated resonances and confirming their antifungal efficacy. Using growth inhibition assays, we verified that the isolated compounds, including three novel antifungal agents, exhibited significant bioactivity. Notably, one of these compounds contains a rare imidazolium heterocyclic motif, marking a new structural class in Piper. These findings substantiate the 1H NMR-based WGCNA as a reliable tool for identifying structural types associated with biological activity, streamlining the process of discovering bioactive natural products in complex extracts.
Journal Article
YOU SHALL NOT DO AS THEY DO IN THE LAND OF EGYPT
This paper considers the Joseph novella through the lens of trauma, exploring an apparent disconnect between Joseph’s experience of involuntary migration and his meteoric rise to power once in Egypt. It begins with a focus on Genesis 39, as the place where Joseph’s vulnerability, post-trafficking, is most clearly reflected. It then goes on to explore how the application of trauma theory, as a heuristic tool, suggests other places in the narrative where the impact of trauma might be recognised. A focus on patterns of compulsive repetition and inversion in the narrative leads into the beginnings of a trauma-focussed critique of the exodus and conquest traditions. The main body of the argument is book-ended with an account of recent developments in the Australian responses to asylum seekers arriving by boat/people-smuggling that point to similar patterns of repetition and inversion.
Journal Article
Evaluation of dihydrofolate reductase and dihydropteroate synthetase genotypes that confer resistance to sulphadoxine-pyrimethamine in Plasmodium falciparum in Haiti
Background
Malaria caused by
Plasmodium falciparum
infects roughly 30,000 individuals in Haiti each year. Haiti has used chloroquine (CQ) as a first-line treatment for malaria for many years and as a result there are concerns that malaria parasites may develop resistance to CQ over time. Therefore it is important to prepare for alternative malaria treatment options should CQ resistance develop. In many other malaria-endemic regions, antifolates, particularly pyrimethamine (PYR) and sulphadoxine (SDX) treatment combination (SP), have been used as an alternative when CQ resistance has developed. This study evaluated mutations in the dihydrofolate reductase (
dhfr
) and dihydropteroate synthetase (
dhps
) genes that confer PYR and SDX resistance, respectively, in
P. falciparum
to provide baseline data in Haiti. This study is the first comprehensive study to examine PYR and SDX resistance genotypes in
P. falciparum
in Haiti.
Methods
DNA was extracted from dried blood spots and genotyped for PYR and SDX resistance mutations in
P. falciparum
using PCR and DNA sequencing methods. Sixty-one samples were genotyped for PYR resistance in codons 51, 59, 108 and 164 of the
dhfr
gene and 58 samples were genotyped for SDX resistance codons 436, 437, 540 of the
dhps
gene in
P. falciparum
.
Results
Thirty-three percent (20/61) of the samples carried a mutation at codon 108 (S108N) of the
dhfr
gene. No mutations in
dhfr
at codons 51, 59, 164 were observed in any of the samples. In addition, no mutations were observed in
dhps
at the three codons (436, 437, 540) examined. No significant difference was observed between samples collected in urban
vs
rural sites (Welch’s T-test p-value = 0.53 and permutations p-value = 0.59).
Conclusion
This study has shown the presence of the S108N mutation in
P. falciparum
that confers low-level PYR resistance in Haiti. However, the absence of SDX resistance mutations suggests that SP resistance may not be present in Haiti. These results have important implications for ongoing discussions on alternative malaria treatment options in Haiti.
Journal Article
H-NMR Guided Isolation of Bioactive Compounds from Species of the Genus Piper
The discovery of bioactive natural products is often challenged by the complexity of isolating and characterizing active compounds within diverse mixtures. Previously, we introduced a [sup.1]H NMR-based weighted gene correlation network analysis (WGCNA) approach to identify spectral features linked to growth inhibitory activity of Piper (Piperaceae) leaf extracts against model plant, fungal, and bacterial organisms. This method enabled us to prioritize specific spectral features linked to bioactivity, offering a targeted approach to natural product discovery. In this study, we validate the predictive capacity of the WGCNA by isolating the compounds responsible for the bioactivity-associated resonances and confirming their antifungal efficacy. Using growth inhibition assays, we verified that the isolated compounds, including three novel antifungal agents, exhibited significant bioactivity. Notably, one of these compounds contains a rare imidazolium heterocyclic motif, marking a new structural class in Piper. These findings substantiate the [sup.1]H NMR-based WGCNA as a reliable tool for identifying structural types associated with biological activity, streamlining the process of discovering bioactive natural products in complex extracts.
Journal Article
Adherence to positive airway pressure therapy in patients with Down syndrome: assessing cloud-based monitoring data
Study Objectives:
Obstructive sleep apnea is common in Down syndrome (DS) with many patients prescribed positive airway pressure (PAP) therapy. This study evaluates PAP adherence and identifies factors influencing adherence.
Methods:
Retrospective analysis of electronic health records and cloud-based PAP therapy data from patients with DS at Rady Children’s Hospital, San Diego, CA. Cloud data were evaluated cross-sectionally at 30- and 90-night post-clinic visit and longitudinally in patients with ≥ 2 90-night data downloads. Outcomes included adherence (percentage of nights with ≥ 4 hours of use) and usage (percentage of nights with any PAP usage). The impact of demographic and PAP therapy factors (eg, mask leak) on these outcomes was also assessed.
Results:
Forty-seven patients with DS with cloud-based PAP therapy data over a 90-night period and 46 over a 30-night period were analyzed. The mean age was 17.7 ± 4.6 years (21 females). Median adherence was significantly higher at 30 nights (56.7%, interquartile range: 0.0, 90.8%) than at 90 nights (34.4%, interquartile range: 0.0, 86.7%) (
P
< .05). Median usage did not differ between the 30-night and 90-night periods. Demographic characteristics and PAP therapy parameters were not associated with adherence or usage. Among the longitudinal cohort (n = 32), median adherence was 69.7% (interquartile range: 19.2, 90.0%), and median usage was 78.2% (interquartile range: 45.2, 95.7%). Compared to an age- and sex-matched cohort without DS, patients with DS demonstrated higher PAP adherence (
P
< .05).
Conclusions:
Cross-sectional and longitudinal analyses reveal that many patients with DS successfully adhere to PAP therapy, challenging the misconception that they struggle with adherence and proving they may be as successful, if not more, than non-DS patients.
Citation:
Bhattacharjee R, Warner M, Nokes B, et al. Adherence to positive airway pressure therapy in patients with Down syndrome: assessing cloud-based monitoring data.
J Clin Sleep Med
. 2025;21(4):675–681.
Journal Article
1 H-NMR Guided Isolation of Bioactive Compounds from Species of the Genus Piper
The discovery of bioactive natural products is often challenged by the complexity of isolating and characterizing active compounds within diverse mixtures. Previously, we introduced a
H NMR-based weighted gene correlation network analysis (WGCNA) approach to identify spectral features linked to growth inhibitory activity of
(
) leaf extracts against model plant, fungal, and bacterial organisms. This method enabled us to prioritize specific spectral features linked to bioactivity, offering a targeted approach to natural product discovery. In this study, we validate the predictive capacity of the WGCNA by isolating the compounds responsible for the bioactivity-associated resonances and confirming their antifungal efficacy. Using growth inhibition assays, we verified that the isolated compounds, including three novel antifungal agents, exhibited significant bioactivity. Notably, one of these compounds contains a rare imidazolium heterocyclic motif, marking a new structural class in
. These findings substantiate the
H NMR-based WGCNA as a reliable tool for identifying structural types associated with biological activity, streamlining the process of discovering bioactive natural products in complex extracts.
Journal Article