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The first critical work to attempt the mammoth undertaking of reading Badiou's Being and Event as part of a sequence has often surprising, occasionally controversial results.Looking back on its publication Badiou declared: \"I had inscribed my name in the history of philosophy\".

Encrusted cystitis is a rare condition characterized by encrustation of the bladder mucosa with associated chronic inflammation induced by urea-splitting bacterial infection—most commonly, Corynebacterium urealyticum. Moreover, it usually occurs in immunocompromised patients, especially recipients of renal transplants or patients with a history of previous urological procedures. Due to the rarity of the entity and the slow growth of Corynebacterium species, appropriate treatment is often delayed due to difficulties in diagnosis and resistance to numerous antibiotics. We report a case of encrusted cystitis caused by Corynebacterium glucuronolyticum, another urea-splitting microbe, in a 57-year-old previously healthy Caucasian man with no known predisposing factors. The timely diagnosis and management in this otherwise healthy patient was facilitated by characteristic imaging, cystoscopy, and histologic findings confirmed by results of prolonged urine cultures and 16S ribosomal RNA (rRNA) gene sequencing of the microbe.

[...]metastatic disease has typically been treated through aggressive surgical resection. Whole-lung radiation for the treatment of lung metastasis in patients where surgical resection is not possible demonstrated some positive results in a limited case series with two of three patients achieving resolution of detectable disease [5]. The most promising chemotherapeutic agent in the treatment of GCTB is denosumab, a monoclonal antibody that inhibits osteoclast function via the receptor activator of nuclear factor ? B (RANK) and RANK-ligand pathway.

This in depth exploration is the first part of a two part study of the two volumes of Alain Badiou’s seminal Being and Event project. Badiou and Indifferent Being is an original, systematic study of Being and Event that takes into consideration the dramatic modifications to Badiou’s philosophy since the publication of Logics of Worlds (2006). In that central elements of Badiou’s philosophy, such as the situation, the event and the subject, are incomplete in Being and Event, this is the only fully up-to-date and accurate consideration of Badiou’s overall philosophy yet published. At the same time as presenting an up-to-date account of Badiou’s overall philosophy, the book is the first to draw out the central component of Badiou’s ontology namely its relation to the category of indifference. Concentrating on the use of indifference across all the core elements of ontology, in particular the void, the pure multiple, the concept of set and the event, the book demonstrates that because set theory as such is a mathematics of indifference and for Badiou ontology is mathematics, no account of Badiou’s ontology is complete unless it accepts that Badiou’s theory of being is a presentation of indifferent being. The book provides a detailed and lively section by section reading of Badiou’s foundational work, presenting all his concepts for all Badiou readers from undergraduates to researchers. It is a seminal source text for all future readings of Badiou.

Glioblastoma (GBM) rarely presents as an infratentorial tumor in adults. The authors present a case of concomitant supratentorial and infratentorial GBM in an adult. A 72-year-old man presented with headache, nausea, vomiting, and lightheadedness. Initial MR images revealed enhancing masses in the right cerebellum and right posterior periventricular region. The patient underwent a suboccipital craniotomy and resection of the cerebellar lesion. Final histopathology was consistent with glioblastoma. The patient went on to receive standard radiation treatment for GBM with concurrent and adjuvant temozolomide. However, the patient experienced clinical deterioration within a few days after starting radiotherapy. He and his family decided to forego treatment and pursue palliative care. The patient expired three months after the initial diagnosis. Autopsy findings supported the diagnosis of GBM with leptomeningeal gliomatosis and involvement of the cerebrum, cerebellum, and spinal cord. The authors review the literature and propose that the pathogenesis of multiple and multicentric GBM may involve neural stem cells within the subventricular zone or could result from tumor dissemination along established CNS routes, such as white matter tracts and CSF pathways.

Pembrolizumab is used in patients with metastatic head and neck squamous cell carcinoma contingent upon the programmed death ligand-1 (PD-L1) combined positive score (CPS). To compare PD-L1 CPS scores derived from paired resected primary tumors (PTs) and lymph node metastases (LMs) in patients with p16+ oropharyngeal squamous cell carcinoma (OPSCC). We identified 38 resected p16+ OPSCCs for which paired PTs and LMs were available. PD-L1 immunohistochemistry using the SP263 antibody clone was done on both the PT and the LM. CPS scoring was performed by 4 observers, and data were analyzed at the CPS cut points of greater than or equal to 1 and 20 in regard to interobserver and interspecimen agreement. Overall agreement between consensus CPS scoring of PT and LM was seen in 76% of paired specimens (κ = 0.53). No specimen received a negative consensus score. Interobserver agreement for both PT and LM was fair to substantial (κ = 0.54 and 0.51, respectively) and was inferior to that seen in a prospective series of unselected head and neck squamous carcinoma cases evaluated at our institution (κ = 0.84). Given the high rates of interobserver and interspecimen variability, evaluation of additional material or by additional observers may be of value in performing CPS scoring in cases of p16+ OPSCC. This is particularly the case when a negative or low-positive result is being evaluated in a patient who is otherwise a good candidate for immunotherapy.

Abstract Introduction Eosinophilic myenteric ganglionitis (EMG) is a rare cause of chronic intestinal pseudo-obstruction (CIPO) characterized histopathologically by infiltration of the myenteric plexus by eosinophils. There are only five reported cases in the literature, four occurring in children and one in an elderly woman. Herein we present an additional case of this rare entity and discuss the clinicopathological features. Methods A 49-year-old man presented to the emergency room with signs and symptoms of intestinal obstruction with obstipation. CT imaging demonstrated features suggestive of colonic obstruction at the level of sigmoid colon and a distal sigmoidectomy with colostomy was performed. Gross examination revealed a few shallow diverticula. Histopathological examination demonstrated marked eosinophilic inflammation concentrated within nerves and ganglia of the myenteric plexus, and focally in the adjacent muscularis propria and submucosa. Mucosal eosinophilia was not present and peripheral blood eosinophilia was absent too. His symptoms resolved after the resection and the patient is currently well after 25 months. Conclusions EMG is a type of eosinophilic gastroenteropathy in which functional gastrointestinal obstruction is associated with eosinophilic inflammation involving nerves of the myenteric plexus. In contrast to more common forms of eosinophilic gastroenteritis, the mucosa, muscularis propria, and serosa are not significantly involved in EMG. It has been proposed that EMG results from myenteric neuronal expression of interleukin-5, a powerful chemoattractant for eosinophils. Similar to our case, all five previously reported cases have clinically demonstrated intestinal pseudo-obstruction. All pediatric cases were responsive to steroids with or without immunosuppressants. EMG should be considered in the clinical and histopathological differential diagnosis of motility and eosinophilic disorders of the bowel. The diagnosis can only be made in a full-thickness biopsy as mucosal involvement is typically absent.

Agamben’s methodological mix of philosophy and philology has inspired, but for some it is also the source of deep anxiety. With the publication of The Signature of All Things , this article suggests, we finally have an unequivocal statement as to the true nature of the Agamben method. The paper systematically details the component parts of what Agamben calls philosophical archaeology: the controversy over the method, the use of paradigms, and the development of a theory of signatures. The paper then ends with a delineation of philosophical archaeology itself with its combination of moments of arising of signatures, distribution through time and space via paradigms and their messianic suspension in a moment of indifference.