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The first 90 days : proven strategies for getting up to speed faster and smarter
\"Since its original release, The First 90 Days has become the bestselling globally acknowledged bible of leadership and career transitions. In this updated and expanded 10th anniversary edition, internationally known leadership transition expert Michael D. Watkins gives you the keys to successfully negotiating your next move-whether you're onboarding into a new company, being promoted internally, or embarking on an international assignment. In The First 90 Days, Watkins outlines proven strategies that will dramatically shorten the time it takes to reach what he calls the \"breakeven point\" - when your organization needs you as much as you need the job. This new edition includes a substantial new preface by the author on the new definition of a career as a series of transitions; and notes the growing need for effective and repeatable skills for moving through these changes. As well, updated statistics and new tools make this book more reader-friendly and useful than ever. As hundreds of thousands of readers already know, The First 90 Days is a road map for taking charge quickly and effectively during critical career transition periods-whether you are a first-time manager, a mid-career professional on your way up, or a newly minted CEO\"-- Provided by publisher.
Book
Contributions of GRACE to understanding climate change
Time-resolved satellite gravimetry has revolutionized understanding of mass transport in the Earth system. Since 2002, the Gravity Recovery and Climate Experiment (GRACE) has enabled monitoring of the terrestrial water cycle, ice sheet and glacier mass balance, sea level change and ocean bottom pressure variations, as well as understanding responses to changes in the global climate system. Initially a pioneering experiment of geodesy, the time-variable observations have matured into reliable mass transport products, allowing assessment and forecast of a number of important climate trends, and improvements in service applications such as the United States Drought Monitor. With the successful launch of the GRACE Follow-On mission, a multi-decadal record of mass variability in the Earth system is within reach.The Gravity Recovery and Climate Experiment (GRACE) mission, launched in 2002, allows monitoring of changes in hydrology and the cryosphere with terrestrial and ocean applications. This Review Article focuses on its contribution to the detection and quantification of climate change signals.
Journal Article
Gravity Field of the Moon from the Gravity Recovery and Interior Laboratory (GRAIL) Mission
Spacecraft-to-spacecraft tracking observations from the Gravity Recovery and Interior Laboratory (GRAIL) have been used to construct a gravitational field of the Moon to spherical harmonic degree and order 420. The GRAIL field reveals features not previously resolved, including tectonic structures, volcanic landforms, basin rings, crater central peaks, and numerous simple craters. From degrees 80 through 300, over 98% of the gravitational signature is associated with topography, a result that reflects the preservation of crater relief in highly fractured crust. The remaining 2% represents fine details of subsurface structure not previously resolved. GRAIL elucidates the role of impact bombardment in homogenizing the distribution of shallow density anomalies on terrestrial planetary bodies.
Journal Article
Master your next move : the essential companion to The first 90 days
\"In his [book] The First 90 Days, ... Watkins outlined a set of common principles for getting up to speed quickly in new professional roles. Since that book was published, [he] has worked with thousands of leaders helping them to accelerate their transitions. These leaders posed ... questions on how to apply the basic principles in real-life situations. The truth that emerged: The First 90 Days framework can be applied in every transition, but the way you apply it is entirely different when you have been promoted to a higher level than it is when you are joining a new organization, or taking a role in a different country. [This book] answers this distinct need, focusing on the most common types of transitions leaders face and the unique challenges posed by each\"-- Provided by publisher.
Book
Efficacy of umeclidinium/vilanterol versus umeclidinium and salmeterol monotherapies in symptomatic patients with COPD not receiving inhaled corticosteroids: the EMAX randomised trial
Background
Prospective evidence is lacking regarding incremental benefits of long-acting dual- versus mono-bronchodilation in improving symptoms and preventing short-term disease worsening/treatment failure in low exacerbation risk patients with chronic obstructive pulmonary disease (COPD) not receiving inhaled corticosteroids.
Methods
The 24-week, double-blind, double-dummy, parallel-group Early MAXimisation of bronchodilation for improving COPD stability (EMAX) trial randomised patients at low exacerbation risk not receiving inhaled corticosteroids, to umeclidinium/vilanterol 62.5/25 μg once-daily, umeclidinium 62.5 μg once-daily or salmeterol 50 μg twice-daily. The primary endpoint was trough forced expiratory volume in 1 s (FEV
1
) at Week 24. The study was also powered for the secondary endpoint of Transition Dyspnoea Index at Week 24. Other efficacy assessments included spirometry, symptoms, heath status and short-term disease worsening measured by the composite endpoint of clinically important deterioration using three definitions.
Results
Change from baseline in trough FEV
1
at Week 24 was 66 mL (95% confidence interval [CI]: 43, 89) and 141 mL (95% CI: 118, 164) greater with umeclidinium/vilanterol versus umeclidinium and salmeterol, respectively (both
p
< 0.001). Umeclidinium/vilanterol demonstrated consistent improvements in Transition Dyspnoea Index versus both monotherapies at Week 24 (vs umeclidinium: 0.37 [95% CI: 0.06, 0.68],
p
= 0.018; vs salmeterol: 0.45 [95% CI: 0.15, 0.76],
p
= 0.004) and all other symptom measures at all time points. Regardless of the clinically important deterioration definition considered, umeclidinium/vilanterol significantly reduced the risk of a first clinically important deterioration compared with umeclidinium (by 16–25% [
p
< 0.01]) and salmeterol (by 26–41% [
p
< 0.001]). Safety profiles were similar between treatments.
Conclusions
Umeclidinium/vilanterol consistently provides early and sustained improvements in lung function and symptoms and reduces the risk of deterioration/treatment failure versus umeclidinium or salmeterol in symptomatic patients with low exacerbation risk not receiving inhaled corticosteroids. These findings suggest a potential for early use of dual bronchodilators to help optimise therapy in this patient group.
Journal Article
The first 90 days : proven strategies for getting up to speed faster and smarter
\"Since its original release, The First 90 Days has become the bestselling globally acknowledged bible of leadership and career transitions. In this updated and expanded 10th anniversary edition, internationally known leadership transition expert Michael D. Watkins gives you the keys to successfully negotiating your next move-whether you're onboarding into a new company, being promoted internally, or embarking on an international assignment. In The First 90 Days, Watkins outlines proven strategies that will dramatically shorten the time it takes to reach what he calls the \"breakeven point\" - when your organization needs you as much as you need the job. This new edition includes a substantial new preface by the author on the new definition of a career as a series of transitions; and notes the growing need for effective and repeatable skills for moving through these changes. As well, updated statistics and new tools make this book more reader-friendly and useful than ever. As hundreds of thousands of readers already know, The First 90 Days is a road map for taking charge quickly and effectively during critical career transition periods-whether you are a first-time manager, a mid-career professional on your way up, or a newly minted CEO\"-- Provided by publisher.
GRACE Measurements of Mass Variability in the Earth System
Monthly gravity field estimates made by the twin Gravity Recovery and Climate Experiment (GRACE) satellites have a geoid height accuracy of 2 to 3 millimeters at a spatial resolution as small as 400 kilometers. The annual cycle in the geoid variations, up to 10 millimeters in some regions, peaked predominantly in the spring and fall seasons. Geoid variations observed over South America that can be largely attributed to surface water and groundwater changes show a clear separation between the large Amazon watershed and the smaller watersheds to the north. Such observations will help hydrologists to connect processes at traditional length scales (tens of kilometers or less) to those at regional and global scales.
Journal Article
The eponym dictionary of birds
\"Birdwatchers often come across bird names that include a person's name, either in the vernacular (English) name or latinised in the scientific nomenclature. Such names are properly called eponyms, and few people will not have been curious as to who some of these people were (or are). Names such as Darwin, Wallace, Audubon, Gould and (Gilbert) White are well known to most people, and keener birders will have yearned to see Pallas's Warbler, Hume's Owl, Bicknell's Thrush, Steller's Sea Eagle and Ross's Gull. But few people today will have even heard of Albertina's Myna, Barraband's Parrot, Guerin's Helmetcrest or Savigny's Eagle Owl. This extraordinary new work lists more than 4,000 eponymous names covering 10,000 genera, species and subspecies of birds. Every taxon with an eponymous vernacular or scientific name (whether in current usage or not) is listed, followed by a concise biography of the person concerned. These entries vary in length from a few lines to several paragraphs, depending on the availability of information or the importance of the individual's legacy. The text is peppered with intriguing or little-known facts, unearthed in the course of the authors' extensive research. Ornithologists will find this an invaluable reference. It is especially helpful when sorting out birds named after people with identical surnames, or in situations where only a person's forename is used. But all birders will find much of interest in this fascinating volume, a book to dip into time and time again, whenever their curiosity is aroused.\"--Dust jacket.
Book
Determinants of Depression in the ECLIPSE Chronic Obstructive Pulmonary Disease Cohort
Depression is prevalent in patients with chronic obstructive pulmonary disease (COPD); however, its etiology and relationship to the clinical features of COPD are not well understood.
Using data from a large cohort, we explored prevalence and determinants of depression in subjects with COPD.
The Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints study is an observational 3-year multicenter study that enrolled smokers with and without COPD and nonsmoker controls. At baseline, several patient-reported outcomes were measured including the Center for Epidemiologic Studies of Depression Scale. For the purposes of this analysis, depression was defined as a score of 16 and higher on this scale, which reflects a high load of depressive symptoms and has a good correspondence with a clinical diagnosis of major depression.
The study cohort consisted of 2,118 subjects with COPD; 335 smokers without COPD (smokers); and 243 nonsmokers without COPD (nonsmokers). A total of 26%, 12%, and 7% of COPD, smokers, and nonsmokers, respectively, suffered from depression. In subjects with COPD, higher depression prevalence was seen in females, current smokers, and those with severe disease (Global Initiative for Obstructive Lung Disease [GOLD]-defined). Multivariate modeling of depression determinants in subjects with COPD revealed that increased fatigue, higher St. George's Respiratory Questionnaire for COPD patients score, younger age, female sex, history of cardiovascular disease, and current smoking status were all significantly associated with depression; physiologic and biologic measures were weak or nonsignificant descriptors.
Depression is more prevalent in subjects with COPD compared with smokers and nonsmokers without COPD. Clinical and biologic measures were less important determinants of depression in COPD than disease symptoms and quality-of-life. Clinical trial registered with www.clinicaltrials.gov (NCT 00292552).
Journal Article